Amygdala hyperreactivity in restrictive anorexia nervosa
Abstract
Functional imaging studies had often investigated heterogeneous samples of anorexia nervosa (AN) patients with varying paradigms and methodologies that had resulted in divergent results. The present study aimed to examine these issues by studying a well-defined sample of restrictive AN patients with a disorder-specific paradigm which had been used previously. Subjects showed increased blood oxygen level dependent responses of the cingulate, frontal, insular and parietal cortices. Group comparisons demonstrated increased activity of the right amygdala in the sample of restrictive AN patients. Our results are in support of other recently published functional imaging studies and point to a pivotal role of the right amygdala in AN. Signals of the midcingulum were reduced in comparison to healthy controls. The constellation of increased activity of the amygdala and decreased activity of the cingulate cortex likely represents parts of a negative feedback loop of emotional processing. Disgust ratings correlated with the amygdala signal negatively, which points to the complex role of this structure within eating disorders.
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Several studies have reported reduced reward motivation for food rewards in eating disorders.
“Several studies have reported reduced reward motivation for food rewards in eating disorders.”
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Individuals with concurrent BN show reduced ACC activation during presentation of visual food cues.
“Joos and colleagues [321] found reduced activation of the ACC in individuals with concurrent BN during the presentation of visual food cues”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [321]
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cZy to MożLiWe, żeby pSychoterApiA nie ZMieniAłA MóZGu?*
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- Authors
- Joos, A. A. B., Saum, B., van Elst, L. T., Perlov, E., Glauche, V., Hartmann, A., Freyer, T., Tüscher, O., & Zeeck, A.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Joos, Andreas A.B.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 191
- Issue
- 3
- Pages
- 189-195
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2126841876
- Cited by
- 124
- References
- 57
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 3 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 12
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Albert-Ludwigs-Universität Freiburg
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- anorexia nervosa, restrictive anorexia nervosa, right amygdala, midcingulate cortex, emotional processing, disgust, eating disorders, brain activity
- MeSH terms
- Adult, Amygdala, Anorexia Nervosa, Brain Mapping, Cerebral Cortex, Emotions, Female, Food, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Oxygen, Photic Stimulation, Young Adult
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