Cited by 124Eating Disorders and BehaviorsNutrition, Health and Food BehaviorRegulation of Appetite and Obesity

Amygdala hyperreactivity in restrictive anorexia nervosa

Joos, Andreas A.B., Saum, Barbara, van Elst, Ludger Tebartz, Perlov, Evgeniy, Glauche, Volkmar, Hartmann, Armin, Freyer, Tobias, Tüscher, Oliver +1 more·2011·Psychiatry Research: Neuroimaging

Abstract

Functional imaging studies had often investigated heterogeneous samples of anorexia nervosa (AN) patients with varying paradigms and methodologies that had resulted in divergent results. The present study aimed to examine these issues by studying a well-defined sample of restrictive AN patients with a disorder-specific paradigm which had been used previously. Subjects showed increased blood oxygen level dependent responses of the cingulate, frontal, insular and parietal cortices. Group comparisons demonstrated increased activity of the right amygdala in the sample of restrictive AN patients. Our results are in support of other recently published functional imaging studies and point to a pivotal role of the right amygdala in AN. Signals of the midcingulum were reduced in comparison to healthy controls. The constellation of increased activity of the amygdala and decreased activity of the cingulate cortex likely represents parts of a negative feedback loop of emotional processing. Disgust ratings correlated with the amygdala signal negatively, which points to the complex role of this structure within eating disorders.

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Crossref · 10.1016/j.pscychresns.2010.11.008

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Authors
Joos, A. A. B., Saum, B., van Elst, L. T., Perlov, E., Glauche, V., Hartmann, A., Freyer, T., Tüscher, O., & Zeeck, A.
Affiliations
University of Freiburg (DE)
Corresponding author
Joos, Andreas A.B.
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2011-03
Volume
191
Issue
3
Pages
189-195
ISSN
0925-4927 (ISSN-L)
OpenAlex
W2126841876
Cited by
124
References
57
Citations by year
2026: 5 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 3 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 12
FWCI
10.35
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
Albert-Ludwigs-Universität Freiburg
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
anorexia nervosa, restrictive anorexia nervosa, right amygdala, midcingulate cortex, emotional processing, disgust, eating disorders, brain activity
MeSH terms
Adult, Amygdala, Anorexia Nervosa, Brain Mapping, Cerebral Cortex, Emotions, Female, Food, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Oxygen, Photic Stimulation, Young Adult

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