Mapping working memory-specific dysfunction using a transdiagnostic approach
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BACKGROUND: Working memory (WM) is an executive ability that allows one to hold and manipulate information for a short period of time. Schizophrenia and mood disorders are severe psychiatric conditions with overlapping genetic and clinical symptoms. Whilst WM has been suggested as meeting the criteria for being an endophenotype for schizophrenia and mood disorders, it still unclear whether they share overlapping neural circuitry. OBJECTIVE: The n-back task has been widely used to measure WM capacity, such as maintenance, flexible updating, and interference control. Here we compiled studies that included psychiatric populations, i.e., schizophrenia, bipolar disorder and major depressive disorder. METHODS: We performed a coordinate-based meta-analysis that combined 34 BOLD-fMRI studies comparing activity associated with n-back working memory between psychiatric patients and healthy controls. We specifically focused our search using the n-back task to diminish study heterogeneity. RESULTS: All patient groups showed blunted activity in the striatum, anterior insula and frontal lobe. The same brain networks related to WM were compromised in schizophrenia, major depressive disorder and bipolar disorder. CONCLUSION: Our findings support the suggestion of commonal functional abnormalities across schizophrenia and mood disorders related to WM.
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Impairments in executive functioning, such as working memory or attention, could potentially explain the effects of information presentation and number of decisions on capacity.
“Both factors could be potentially explained by impairments in executive functioning, such as working memory or attention, that has been widely reported in psychiatric patients (Testa & Pantelis, 2009;Yaple et al., 2021).”
From Decision making capacity for treatment in psychiatric inpatients: a systematic review and meta-analysis (2024) · cites this paper as Yaple et al., 2021
The Introduction reports working-memory abnormalities in psychiatric populations, and the Discussion (Bipolar disorder) describes decreased working-memory abilities. Neither passage examines whether such impairments explain the effects of information presentation or the number of decisions on capacity; the paper also does not establish an attention impairment as that explanation. Page numbers are not available in our copy. (LLM, conf=0.84)
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Cited by
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Marcó-García, S., Ariyo, K., Owen, G. S., & David, A. S. (2024) · Psychological Medicine · doi:10.1017/s0033291724000242 · Cited by 18 · see citing works
- Authors
- Yaple, Z. A., Tolomeo, S., & Yu, R.
- Affiliations
- York University (CA)
- National University of Singapore (SG)
- Hong Kong Baptist University (HK)
- Corresponding author
- Yu, Rongjun
- Venue
- NeuroImage: Clinical
- Publisher
- Elsevier BV
- Published
- 2021
- Volume
- 31
- Pages
- 102747
- ISSN
- 2213-1582 (ISSN-L)
- PMC
- PMC8278205
- OpenAlex
- W3176823270
- Cited by
- 26
- References
- 155
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 1
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Social Science Research Council (MOE2017-SSRTG-026)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- working memory, schizophrenia, bipolar disorder, major depressive disorder, n-back task, striatum, anterior insula, frontal lobe, endophenotypes, neural circuits, BOLD fMRI
- MeSH terms
- Bipolar Disorder, Brain, Brain Mapping, Major Depressive Disorder, Depressive Disorder, Major, Humans, Magnetic Resonance Imaging, Memory, Short-Term, Schizophrenia
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