Processing of decision-making and social threat in patients with history of suicidal attempt: A neuroimaging replication study
Abstract
Suicidal vulnerability has been related to impaired value-based decision-making and increased sensitivity to social threat, mediated by the prefrontal cortex. Using functional magnetic resonance imaging, we aimed at replicating these previous findings by measuring brain activation during the Iowa Gambling Task and an emotional faces viewing task. Participants comprised 15 euthymic suicide attempters (history of depression and suicidal behavior) who were compared with 23 euthymic patient controls (history of depression without suicidal history) and 35 healthy controls. The following five model-based regions of interest were investigated: the orbitofrontal cortex (OFC), ventrolateral prefrontal cortex (VLPFC), anterior cingulate cortex (ACC), medial (MPFC) and dorsal prefrontal cortex (DPFC). Suicide attempters relative to patient controls showed (1) increased response to angry vs. neutral faces in the left OFC and the VLPFC, as previously reported; (2) increased response to wins vs. losses in the right OFC, DPFC and ACC; (3) decreased response to risky vs. safe choices in the left DPFC; and (4) decreased response to sad vs. neutral faces in the right ACC. This study links impaired valuation processing (here for signals of social threat, sadness and reward) to prefrontal cortex dysfunction in suicide attempters. These long-term deficits may underlie the impaired decision-making and social difficulties found in suicide attempters.
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Suicide attempters have less OFC and rACC activity in response to positive facial expressions and greater lateral OFC activity in response to angry facial expressions.
“Suicide attempters also have less OFC and rACC activity in response to positive facial expressions (78) and greater lateral OFC activity in response to angry facial expressions (95, 97, 104).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [95]
Compared with suicide nonattempters, suicide attempters with the same diagnosis show less activity in the dlPFC, rACC, dACC, thalamus, and insula during decision-making tasks.
“Compared with suicide nonattempters, suicide attempters having the same diagnosis manifest less activity in the dlPFC, rACC, dACC, thalamus, and insula while performing decision-making tasks (e.g., the Iowa Gambling Task) (95-99).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [95]
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- Authors
- Olié, E., Ding, Y., Le Bars, E., de Champfleur, N. M., Mura, T., Bonafé, A., Courtet, P., & Jollant, F.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Inserm (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 234
- Issue
- 3
- Pages
- 369-377
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2134425460
- Cited by
- 123
- References
- 53
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 7 · 2023: 15 · 2022: 8 · 2021: 11 · 2020: 16 · 2019: 10 · 2018: 28 · 2017: 5 · 2016: 5
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Projet Hospitalier de Recherche Clinique
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- suicide attempts, value-based decision making, social danger, prefrontal cortex dysfunction, orbitofrontal cortex, ventrolateral prefrontal cortex, anterior cingulate cortex, medial prefrontal cortex, dorsal prefrontal cortex, Iowa Gambling Task, emotional face processing, reward processing, depression, replication
- MeSH terms
- Adolescent, Adult, Anger, Choice Behavior, Decision Making, Emotions, Female, Gambling, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reward, Suicide, Attempted, Case-Control Studies, Prefrontal Cortex, Young Adult, Suicidal Ideation, Neuroimaging
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