Cited by 79Transcranial Magnetic Stimulation StudiesAttention Deficit Hyperactivity DisorderObsessive-Compulsive Spectrum Disorders

Positive effects of transcranial direct current stimulation in adult patients with attention-deficit/hyperactivity disorder–a pilot randomized controlled study

Cachoeira, Carolina Tosetto, Leffa, Douglas Teixeira, Mittelstadt, Suzana Doneda, Mendes, Lorenna Sena Teixeira, Brunoni, Andre R., Pinto, Jairo Vinicius, Blazius, Vtor, Machado, Vitoria +4 more·2017·Psychiatry Research

Abstract

Almost 30% of adult patients with attention-deficit/hyperactivity disorder (ADHD) do not respond or tolerate standard pharmacological interventions. Few clinical investigations addressed the efficacy and tolerability of transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory technique, in the disorder. We performed a double-blind, sham-controlled randomized clinical trial in 17 patients with ADHD. The set up for tDCS was the following: 2mA/20min/day for 5 days with the anode over the right dorsolateral prefrontal cortex and cathode over the left dorsolateral prefrontal cortex. ADHD symptoms were measured by the Adult ADHD Self-Report Scale (ASRS) and impairment with the Sheehan Disability Scale (SDS) in four different time points after stimulation. Participants achieved significant lower ASRS inattention and SDS scores after active tDCS in comparison with sham stimulation group. In addition, we detected a trend for a lower ASRS total score in the active tDCS group. Follow up data analysis revealed a positive interaction between time and treatment in both ASRS inattention, SDS and ASRS total scores. Short-term application of tDCS in adult patients with ADHD improved their symptoms, and this improvement persisted after the end of the stimulation. Future studies with larger sample sizes are needed.

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Crossref · 10.1016/j.psychres.2016.11.009

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Authors
Cachoeira, C. T., Leffa, D. T., Mittelstadt, S. D., Mendes, L. S. T., Brunoni, A. R., Pinto, J. V., Blazius, V., Machado, V., Bau, C. H. D., Rohde, L. A., Grevet, E. H., & Schestatsky, P.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Cachoeira, Carolina Tosetto
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2017-01
Volume
247
Pages
28-32
ISSN
0165-1781 (ISSN-L)
OpenAlex
W2555971849
Cited by
79
References
45
Citations by year
2026: 6 · 2025: 10 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 14 · 2020: 11 · 2019: 6 · 2018: 5 · 2017: 5
FWCI
2.92
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords
transcranial direct current stimulation, adult ADHD, non-invasive brain stimulation, neuromodulation, dorsolateral prefrontal cortex, inattention, functional disability, treatment tolerability
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Double-Blind Method, Female, Humans, Male, Pilot Projects, Treatment Outcome, Prefrontal Cortex, Self Report, Transcranial Direct Current Stimulation

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