EFfect of anodal and cathodal transcranial direct current stimulation on DLPFC on modulation of inhibitory control in ADHD
Abstract
Objective: The purpose of this study was to improve the inhibitory control functions through transcranial direct current stimulation (tDCS) in adolescents with ADHD symptoms. Method: Twenty high school students with ADHD symptoms participated in this single-blinded, crossover, sham-controlled study. All the participants were tested during the application of Stroop and Go/No-Go tasks that is used to measure inhibitory control, using 1.5 mA of tDCS for 15 min over the left dorsolateral prefrontal cortex (DLPFC). Results: Anodal stimulation on left DLPFC had no effect on interference inhibition during the Stroop task and increased the proportion of correct responses in the “Go stage” of the Go/No-Go test compared with sham condition. Cathodal stimulation on the left DLPFC increased the inhibition accuracy in the inhibition stage during Go/No-Go task in comparison with sham. Conclusion: tDCS over the left DLPFC of adolescents who suffer from ADHD symptoms can improve inhibitory control in prepotent response inhibition.
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mA of left DLPFC improved inhibitory performance in a Go/no-go task, while anodal stimulation of left DLPFC improved the go process, compared with each other and sham.
“mA of left DLPFC improved inhibitory performance in a gonogo task, while anodal stimulation of left DLPFC improved the go process of the task, both compared against each other and against sham stimulation.”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Soltaninejad et al., 2015
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“The authors argue that cathodal stimulation of left DLPFC due to interhemispheric inhibition processes may have enhanced right DLPFC activation which is mediating inhibitory performance (Soltaninejad et al., 2015).”
BackgroundNejati, V., Salehinejad, M. A., Nitsche, M. A., Najian, A., & Javadi, A.-H. (2020) · Journal of Attention Disorders · doi:10.1177/1087054717730611 · Cited by 163 · see citing works
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“In all studies, blinding of participants was reported, but blinding of experimenters was not reported in two studies [70, 73].”
ResultSelf-citationSalehinejad, M. A., Nejati, V., Mosayebi-Samani, M., Mohammadi, A., Wischnewski, M., Kuo, M.-F., Avenanti, A., Vicario, C. M., & Nitsche, M. A. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00501-x · Cited by 118 · see citing works
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Cachoeira, C. T., Leffa, D. T., Mittelstadt, S. D., Mendes, L. S. T., Brunoni, A. R., Pinto, J. V., Blazius, V., Machado, V., Bau, C. H. D., Rohde, L. A., et al. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2016.11.009 · Cited by 79 · see citing works
- Authors
- Soltaninejad, Z., Nejati, V., & Ekhtiari, H.
- Affiliations
- Shahid Beheshti University (IR)
- Institute for Cognitive Science Studies (IR)
- Corresponding author
- Nejati, Vahid
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2015-12-20
- Volume
- 23
- Issue
- 4
- Pages
- 325-332
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- OpenAlex
- W2407827039
- Semantic Scholar
- ff1ca398304b9fde1a65cb66844cfcfc02f2998e
- Cited by
- 133
- References
- 50
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 13 · 2023: 10 · 2022: 13 · 2021: 25 · 2020: 16 · 2019: 8 · 2018: 14 · 2017: 5 · 2016: 10
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- transcranial direct current stimulation, anodal stimulation, cathodal stimulation, dorsolateral prefrontal cortex, inhibitory control, attention deficit hyperactivity disorder, adolescents, Stroop task, go/no-go task, prepotent response inhibition, non-invasive brain stimulation
- MeSH terms
- Adolescent, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Humans, Inhibition, Psychological, Prefrontal Cortex, Cross-Over Studies, Stroop Test, Transcranial Direct Current Stimulation
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