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Effects of intranasal oxytocin on emotional face processing in women
Open accessAbstract
The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity to social and emotional stimuli in healthy men. The present study aimed to investigate the effect of intranasally administered OXT on brain activity in response to social emotional stimuli of varying valence in women. In a functional magnetic-resonance imaging study, sixteen women were presented with fearful, angry, happy and neutral facial expressions after a single dose of 24IU OXT or a placebo administration in a within-subject design. Group analysis revealed that the blood-oxygen-level-dependent (BOLD) signal was enhanced in the left amygdala, the fusiform gyrus and the superior temporal gyrus in response to fearful faces and in the inferior frontal gyrus in response to angry and happy faces following OXT treatment. This effect was independent of fixation pattern to specific sections of the facial stimuli as revealed by eye tracking and independent of basal plasma levels of OXT, estradiol, and progesterone. The results are at odds with the previously reported effects found in men. Future studies should include both sexes to determine a possible sexual dimorphism in the neural effects of OXT, considering gonadal steroids and OXT receptor affinity.
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In the citing paper
“task-based fMRI has often shown opposite findings in males and females namely in terms of amygdala activation.14, 15”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes.13, 14, 47, 48, 49”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes.13, 14, 47, 48, 49”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“while it has been demonstrated that OXT decreases amygdala activity in response to fear in men (Kirsch et al., 2005), it appears to increase amygdala activity to similar stimuli in women (Domes et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Domes et al., 2010
In the citing paper
“separate OXT-application studies in humans have indicated that there may be differential amygdala reactivity to fearful faces and fearful/threatening scenes in men (14, 15) and women (16, 17).”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [16]
In the citing paper
“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [16]
In the citing paper
“Generally, in healthy subjects pro-social feelings, including generosity and trust (6–8), social communication and emotional recognition (9,10), self-perception (11), and social interactions with offspring are altered by OT(12).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [9]
In the citing paper
“our sample was restricted to males, given the role of sex hormones on OXT neural effect's (Domes et al, 2010), and may not generalize to females.”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Domes et al, 2010
In the citing paper
“but increases it in women (11, 12).”
From Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice (2018) · cites this paper as [11]
In the citing paper
“Second, OXT has been shown to have differential effects on emotional responding in males and females (Domes et al, 2010).”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Domes et al, 2010
In the citing paper
“Interestingly, one study on human participants found that the BOLD signals in the amygdala in women, unlike in men, actually increase when viewing fearful faces (Domes et al., 2010).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Domes et al., 2010
In the citing paper
“Moreover, previous studies have shown differential effects of OT on male and female participants (e.g.Domes et al., 2010;Feldman et al., 2010).”
From OT promotes closer interpersonal distance among highly empathic individuals (2015) · cites this paper as Domes et al., 2010
In the citing paper
“We cannot exclude the possibility that this may have influenced our results, although similar effects of OT on amygdala reactivity previously were found in females tested in the follicular phase (Domes et al, 2010) and luteal phase (Bertsch et al, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Domes et al, 2010
In the citing paper
“even to increase reactivity in the amygdala during the processing of fearful faces in females [19].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [19]
In the citing paper
“is in agreement with recent experimental evidence pointing to the sex-dimorphic effects of OT nasal spray in humans [19], [45] [56], [57].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [19]
In the citing paper
“Third, our study used only male subjects, and there is evidence that male and female subjects respond differently to oxytocin (Domes et al., 2010).”
From Oxytocin decreases aversion to angry faces in an associative learning task (2010) · cites this paper as Domes et al., 2010
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Neuroimaging and behavioral evidence of sex-specific effects of oxytocin on human sociality
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“However, replication efforts utilizing the same experimental paradigms and oxytocin doses in all-female samples found the opposite effect: oxytocin increased amygdala activation when viewing social or non-social threat stimuli [16 – 18].”
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Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers
Labuschagne, I., Poudel, G. R., Kordsachia, C. C., Wu, Q., Thomson, H. M., Georgiou‐Karistianis, N., & Stout, J. C. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.023 · Cited by 30
“…samples, by extending the protocol to females given known gender differences in the neural effects of oxytocin using a similar pharmaco-fMRI design (Domes et al., 2010), and by assessing effects of oxytocin on behaviour given known evidence of severe emotion recognition difficulties in HD…”
MethodOxytozin: Evidenz für ein therapeutisches Potenzial des sozialen Neuromodulators
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“, 2005), whereas intranasal OT increased activity in the amygdala in response to fear in young women (Domes et al., 2010) (see also Bethlehem et al.”
BackgroundLe, J., Kou, J., Zhao, W., Fu, M., Zhang, Y., Becker, B., & Kendrick, K. M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0830-x · Cited by 29
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Luo, P. X., Zakharenkov, H. C., Torres, L. Y., Rios, R. A., Gegenhuber, B., Black, A. M., Xu, C. K., Minie, V. A., Tran, A. M., Tollkuhn, J., et al. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105203 · Cited by 27
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“…disturbances typically found in the presence of the A allele might be tied to difficulties in perceiving social cues (e.g., emotional expressions; Domes et al., 2010; Guastella, Mitchell, & Mathews, 2008; Lischke et al., 2012; Marsh, Henry, Pine, & Blair, 2010) that impede the protective and…”
BackgroundOxytocin increases bias, but not accuracy, in face recognition line-ups
Bate, S., Bennetts, R. J., Parris, B. A., Bindemann, M., Udale, R. C., & Bussunt, A. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu150 · Cited by 33
“It is possible that oxytocin acts upon visuocognitive mechanisms within the core face-processing system (Haxby et al. , 2000), and some neuroimaging evidence supports this possibility (e.g. Domes et al. , 2010; Labuschagne et al. , 2010).”
Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study
Orihashi, R., Mizoguchi, Y., Imamura, Y., Yamada, S., Ueno, T., & Monji, A. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa081 · Cited by 27
“In response to facial threat, amygdala activity was potentiated in women (Domes et al. , 2010) while was suppressed in men (Kanat et al. , 2015).”
Divergent effects of oxytocin on eye contact in bonobos and chimpanzees
Brooks, J., Kano, F., Sato, Y., Yeow, H., Morimura, N., Nagasawa, M., Kikusui, T., & Yamamoto, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105119 · Cited by 28
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Oxytocin Normalizes Approach–Avoidance Behavior in Women With Borderline Personality Disorder
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Self-citationA randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome
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“In humans, oxytocin is known as a strong modulator of social behavior and increases gaze to eye regions, social cognition, social memory, empathy, perceptions of trustworthiness, and cooperation within one’s own group (Bartz et al., 2010; Baumgartner et al., 2008; De Dreu et al., 2010; Domes et al., 2010; Di Simplicio…”
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“We included male and female participants which is especially important given that sex differences in brain activity during face processing [74, 75] and in neural effects of OT [76] have been reported.”
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“…males and females in other animal species (Wang et al. 1996) and early indications that human neural responses to oxytocin are different between men and women (Domes et al. 2010), further information about gender-specific effects of oxytocin in humans will be required to address these concerns.”
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Oxytocin and Vasopressin: Social Neuropeptides
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“For example, oxytocin could encourage social approach to strangers by: decreasing amygdala activation and the stress response associated with social threat [9-12], increasing accuracy in reading others’ emotions [13], increasing eye-contact [14], and increasing trust and cooperative behaviours [15, 16].”
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Serotonin and Female Psychopathology
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“Furthermore, neuroimaging studies have suggested that there is possible sexual dimorphism in the neural effects of oxytocin in that this neuropeptide enhances amygdala reactivity to social and emotional stimuli in females [121].”
Intranasal oxytocin reduces social perception in women: Neural activation and individual variation
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“To date, evidence that intranasal oxytocin blocks or reverses social processing in women comes mainly from studies on negative-valence emotional stimuli [23-25] and social economic games [11, 21].”
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“, 2010) and many other characteristics associated with the empathizing trait, such as mentalizing (Domes, Heinrichs, Michel, Berger, & Herpertz, 2007), trust (Kosfeld, Heinrichs, Zak, Fischbacher, & Fehr, 2005), emotion recognition (Domes et al., 2010) and eye gaze (Guastella, Mitchell, & Dadds, 2008).”
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“102,103 The effect, at least in men, may be potentially useful in mitigating or attenuating the expression of PTSD. 104 efficacy of particular pharmaceutical agents in the treatment of clinical anxiety has directed exploration of candidate genes and common variants in receptors and transporter…”
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“The few studies conducted with women have found varying oxytocin effects on eye gaze (Bertsch et al., 2013; Domes et al., 2010; Lischke et al., 2012a) and oxytocin may have different effects on amygdala reactivity to emotional stimuli in men and women (Lischke et al.”
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“In line with work in rodents, these findings suggest that, in humans, naturally occurring endogenous modulation of OXTR function affects social recognition through an amygdala-dependent mechanism.”
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“, 2009), whereas in women, increased levels of oxytocin were related to increased amygdala activity to fearful faces (Domes et al., 2010).”
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“In view of recent OT studies that suggest possible sex differences in oxytocinergic functioning (e.g. Domes et al., 2010; Lischke et al., 2012b), these differences should be considered and further investigated in future research.”
BackgroundTracy, L. M., Labuschagne, I., Georgiou‐Karistianis, N., Gibson, S. J., & Giummarra, M. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.028 · Cited by 23
Oxytocin eliminates the own-race bias in face recognition memory
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“Di Simplicio et al., (2009) reported that OT induced a slower processing speed for fearful facial expressions compared to other basic expressions.”
InfluentialEffects of Intranasal Oxytocin on Steroid Hormones in Men and Women
Wirth, M. M., Gaffey, A. E., & Martinez, B. S. (2015) · Neuropsychobiology · doi:10.1159/000381023 · Cited by 22
The effect of oxytocin on the anthropomorphism of touch
Peled‐Avron, L., Perry, A., & Shamay‐Tsoory, S. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.015 · Cited by 20
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“In fact, studies directly testing the effect of oxytocin on different measures of social cognition while taking gaze behaviour into account, have countered this notion, showing that oxytocin-related improvements can occur independently of oxytocin effects on eye-gaze patterns (Domes et al., 2010; Lischke et al., 2012;…”
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Oxytocin and vasopressin increase male-directed threats and vocalizations in female macaques
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Chronic intranasal oxytocin reverses stress-induced social avoidance in female prairie voles
Hale, L. H., Tickerhoof, M. C., & Smith, A. S. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108770 · Cited by 19
Oxytocin and the Biopsychology of Performance in Team Sports
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“[87] investigated the effect of intranasally administered oxytocin on brain activity in response to social emotional stimuli of varying valence in women.”
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Survival, Selection, and Sex Differences in Fear
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“More work needs to be done considering the suggestion that the association between oxytocin and pain may interact with endogenous sex hormones(72) and that sex differences may be implicated in oxytocin mechanisms.(81,96)”
BackgroundOxytocin's impact on social face processing is stronger in homosexual than heterosexual men
Thienel, M., Heinrichs, M., Fischer, S., Ott, V., Jan Born, A., & Hallschmid, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.013 · Cited by 18
“In contrast, increased amygdala activation in response to fearful faces was found in female subjects (Domes et al., 2010).”
Self-citationConcept of Suicide: Neurophysiological/Genetic Theories and Possible Oxytocin Relevance
Pădurariu, M., Prepelita, R., Ciobica, A. S., Dobrin, R., Timofte, D. V., Ștefănescu, C., & Chiriță, R. (2016) · Neurophysiology · doi:10.1007/s11062-016-9603-9 · Cited by 18
“plasma, as was in the two studies mentioned above), different medication, or the fact that suicidal behavior can exhibit extremely important gender differences [60, 62].”
BackgroundRomero‐Martínez, Á., Sarrate‐Costa, C., & Moya‐Albiol, L. (2021) · Biology · doi:10.3390/biology10121334 · Cited by 19
“The rest of the studies failed to report significant results for changes in rating the intensity or arousal of facial emotional expressions [31,50,63].”
BackgroundO’Connell, G., Whalley, H. C., Mukherjee, P., Stanfield, A. C., Montag, C., Hall, J., & Reuter, M. (2012) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2012.21007 · Cited by 17
“In light of previous reports that exogenously administered oxytocin increases responses in this area to facial affect [32], these findings convergently suggest a negative association of the C allele with both oxytocin signaling and the depth of processing of social affective information.”
BackgroundInfluentialA common variant in OXTR rs53576 impacts topological patterns of brain functional networks
Wang, J., Zhang, Y., Zhu, D., Yang, Z., Liu, F., Qin, W., Zhu, J., Liu, B., Jiang, T., & Yu, C. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-019-01414-5 · Cited by 16
Vehlen, A., Kellner, A., Normann, C., Heinrichs, M., & Domes, G. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.01.016 · Cited by 18
Self-citationGenomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone
Mökkönen, M., & Crespi, B. J. (2015) · Evolutionary Applications · doi:10.1111/eva.12244 · Cited by 18
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16
Koven, N. S., & Max, L. K. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.018 · Cited by 16
“Even though no sex differences emerged in OT level or MSCEIT Experiential EI scores in our study, other research suggests that OT operates in a sexually dimorphic way (Domes et al., 2010).”
ResultHosseini, S. E., Asadi, N., & Zarei, F. (2013) · Zahedan Journal of Research in Medical Sciences · Cited by 16
Oxytocin effects on self-referential processing: behavioral and neuroimaging evidence
Liu, Y., Wu, B., Wang, X., Li, W., Zhang, T., Wu, X., & Han, S. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx116 · Cited by 15
“For example, OT (vs placebo) administration decreased amygdala responses to emotional faces (Kirsch et al., 2005; Domes et al., 2007) but enhanced amygdala activity in response to fearful faces and threatening pictures in women (Domes et al., 2010; Wittfoth-Schardt et al., 2012).”
BackgroundEffects of oxytocin administration and conditioned oxytocin on brain activity: An fMRI study
Skvortsova, A., Veldhuijzen, D. S., de Rover, M., Pacheco‐López, G., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., Chavannes, N. H., van Middendorp, H., & Evers, A. W. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229692 · Cited by 17
“In this randomized placebo-controlled trial, we investigated the effects of oxytocin administration and conditioned oxytocin in comparison to a placebo-control group on brain activation in response to fMRI tasks that have previously shown to be affected by exogenous oxytocin administration: presentation of emotional f…”
BackgroundInfluentialMakhanova, A., McNulty, J. K., Eckel, L. A., Nikonova, L. V., Bartz, J. A., & Hammock, E. A. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-82307-z · Cited by 15
Moussa, S. S., Fawaz, L., Ibrahim, W., Elsayed, M. F., & Ahmed, M. (2021) · Journal of Primary Care & Community Health · doi:10.1177/21501327211012942 · Cited by 19
Tseng, H. C., Chi, M. H., Lee, L.-T., Tsai, H. C., Lee, I. H., Chen, K. C., Yang, Y. K., & Chen, P. S. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.12.011 · Cited by 14
Turcsán, B., Range, F., Rónai, Z., Koller, D., & Virányi, Z. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.02232 · Cited by 14
“For example, oxytocin administration decreases amygdala reactivity to emotional faces in men (Domes et al., 2007) and increases it in women (Domes et al., 2010).”
BackgroundIntranasal oxytocin modulates the salience network in aging
Liu, P., Lin, T., Feifel, D., & Ebner, N. C. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119045 · Cited by 13
“Furthermore, given the growing literature about sex-dimorphic effects of oxytocin on brain activity (Domes et al., 2010; Ebner et al., 2016; Rilling et al., 2014) and social function (Campbell et al.”
BackgroundOxytocin Modulates Semantic Integration in Speech Comprehension
Ye, Z., Stolk, A., Toni, I., & Peter Hagoort, A. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01044 · Cited by 17
“However, previous animal and human studies have reported gender-specific responses to oxytocin (Kubzansky, Mendes, Appleton, Block, & Adler, 2012; Domes et al., 2007, 2010) and an interaction between estrogen and oxytocin (McCarthy, McDonald, Brooks, & Goldman, 1996).”
ResultSauer, C., Montag, C., Reuter, M., & Kirsch, P. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.06.005 · Cited by 13
Haram, M., Bettella, F., Brandt, C. L., Quintana, D. S., Nerhus, M., Bjella, T., Djurovic, S., Westlye, L. T., Andreassen, O. A., Melle, I., et al. (2016) · BJPsych Open · doi:10.1192/bjpo.bp.116.003376 · Cited by 13
“3,4 7 The results from oxytocin trials are inconsistent in general, 3,4,8 and this inconsistency has been attributed to individual differences, including genetically based differences in the oxytocin system, 9,10 and a poor understanding of drug targets and mechanisms.”
Corbett, B. A., Bales, K. L., Swain, D. M., Sanders, K. B., Weinstein, T. A. R., & Muglia, L. J. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9165-6 · Cited by 14
“OT treatments have been shown to increase the ability of adults with autism to evaluate emotional significance in speech [81, 82], reduce repetitive behaviors [11], and improve emotion recognition in youth [44, 83, 84] and adults [85] with ASD.”
BackgroundYue, T., Yue, C., Liu, G., & Huang, X. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00205 · Cited by 13
“However, there are also some studies that do not support the OXT’s sexual dimorphism, such as on approach-avoidance tendency to emotional facial stimuli (Theodoridou et al., 2013) and the dampening of basic physiological arousal (Ellenbogen et al., 2014).”
ResultEye-Tracking Reveals a Role of Oxytocin in Attention Allocation Towards Familiar Faces
Marsh, N., Scheele, D., Postin, D., Onken, M., & Hurlemann, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.629760 · Cited by 13
“Mechanistically, these effects may result from OXT acting upon visuo-cognitive mechanisms within the core faceprocessing system (20) – an assumption that is further substantiated by findings from neuroimaging studies (11, 21).”
ResultInvolvement of oxytocin receptor deficiency in psychiatric disorders and behavioral abnormalities
Wei, J., Zheng, H., Li, G., Chen, Z., Fang, G., & Yan, J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1164796 · Cited by 13
“In addition, other studies in humans indicated that OXT could increase social memory, social recognition, gaze-to-eye regions, perceptions of trustworthiness and attractiveness, empathy, and cooperation within one’s own group (Kosfeld et al., 2005; Baumgartner et al., 2008; Guastella et al., 2008a,b; Unkelbach et al.,…”
BackgroundOxytocin facilitates socially directed attention
Le, J., Zhao, W., Kou, J., Fu, M., Zhang, Y., Becker, B., & Kendrick, K. M. (2021) · Psychophysiology · doi:10.1111/psyp.13852 · Cited by 13
Lan, C., Chen, Y., Zhang, Y., Kou, J., Huang, L., Xu, T., Yang, X., Xu, D., Yang, W., Kendrick, K. M., et al. (2023) · Neuroendocrinology · doi:10.1159/000531064 · Cited by 12
Pedersen, C. A. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.050 · Cited by 11
Boyle, A., Johnson, A. P., & Ellenbogen, M. A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105796 · Cited by 12
A Protective Mechanism against Illusory Perceptions Is Amygdala-Dependent
Spengler, F. B., Scheele, D., Kaiser, S., Heinrichs, M., & Hurlemann, R. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2577-18.2019 · Cited by 13
“Depending on the chosen task and administration protocol, previous studies have even reported diminished or contrary effects in women compared with men (Domes et al., 2010).”
ResultSelf-citationOpposing sex-dependent effects of oxytocin on the perception of gaze direction
Shi, Y., Liu, J., Hu, Z., & Gao, S. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05423-9 · Cited by 14
Women's Competition and Aggression
Campbell, A. C. (2015) · Wiley eBooks · doi:10.1002/9781119125563.evpsych227 · Cited by 12
Intranasal oxytocin as a treatment for anxiety and autism: From subclinical to clinical applications
Yin, H., Jiang, M., Han, T., & Xu, X. (2024) · Peptides · doi:10.1016/j.peptides.2024.171211 · Cited by 11
Hohl, C. H., Zilcha‐Mano, S., & Delgadillo, J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105935 · Cited by 13
“Despite evidence suggesting sex-specific roles of oxytocin (Domes et al., 2010; Lieberz et al., 2020), most human research has not accounted for potential sex differences in their analyses (Dumais and Veenema, 2016).”
BackgroundThe awareness of the scared - context dependent influence of oxytocin on brain function
Baettig, L., Baeumelt, A., Ernst, J., Boeker, H., Grimm, S., & Richter, A. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00143-2 · Cited by 13
Borowiak, K., & von Kriegstein, K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00903-5 · Cited by 11
Facial threat affects trust more strongly than facial attractiveness in women than it does in men
Brustkern, J., Heinrichs, M., Walker, M., & Schiller, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-01775-5 · Cited by 11
Self-citationOxytocin regulation of maternal behavior
Pedersen, C. A. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.012 · Cited by 11
Campbell, A. C. (2012) · Zeitschrift für Psychologie · doi:10.1027/2151-2604/a000105 · Cited by 11
Declerck, C. H., Lambert, B., & Boone, C. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.04.010 · Cited by 9
Dumais, K. M., & Veenema, A. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00011-1 · Cited by 11
Empathy: The genetics-environment-endocrine-brain mechanism
Yang, Y., Yi, T. A. N. G., Peng, W., Lu, X., Hu, L., & Chen, J. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972017-00832 · Cited by 10
SocialStress and Social Approach
Heinrichs, M., Chen, F. S., Domes, G., & Kumsta, R. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9780511843716.028 · Cited by 10
Self-citation
Metadata
- Authors
- Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C.
- Affiliations
- University of Freiburg (DE)
- University of Rostock (DE)
- Universitätsmedizin Rostock (DE)
- Heidelberg University (DE)
- Corresponding author
- Domes, Gregor
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 35
- Issue
- 1
- Pages
- 83-93
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2038181972
- Cited by
- 521
- References
- 58
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 14 · 2023: 18 · 2022: 13 · 2021: 27 · 2020: 21 · 2019: 25 · 2018: 29 · 2017: 45 · 2016: 41 · 2015: 45 · 2014: 53 · 2013: 64 · 2012: 44
- FWCI
- 44.39
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Bundesministerium für Bildung und Forschung (01GW0784)
- Universität Zürich
- Deutsche Forschungsgemeinschaft (Do1312/1-1)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP001-114788)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, intranasal administration, emotional face processing, amygdala, sexual dimorphism, women, facial expressions, fusiform gyrus, superior temporal gyrus, inferior frontal gyrus, estradiol, progesterone, sex steroids, BOLD signal
- MeSH terms
- Administration, Intranasal, Adult, Anger, Emotions, Estradiol, Eye Movements, Facial Expression, Fear, Female, Hormones, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Oxytocin, Photic Stimulation, Progesterone, Social Perception, Young Adult
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