The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Effects of intranasal oxytocin on emotional face processing in women
Open accessAbstract
The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity to social and emotional stimuli in healthy men. The present study aimed to investigate the effect of intranasally administered OXT on brain activity in response to social emotional stimuli of varying valence in women. In a functional magnetic-resonance imaging study, sixteen women were presented with fearful, angry, happy and neutral facial expressions after a single dose of 24IU OXT or a placebo administration in a within-subject design. Group analysis revealed that the blood-oxygen-level-dependent (BOLD) signal was enhanced in the left amygdala, the fusiform gyrus and the superior temporal gyrus in response to fearful faces and in the inferior frontal gyrus in response to angry and happy faces following OXT treatment. This effect was independent of fixation pattern to specific sections of the facial stimuli as revealed by eye tracking and independent of basal plasma levels of OXT, estradiol, and progesterone. The results are at odds with the previously reported effects found in men. Future studies should include both sexes to determine a possible sexual dimorphism in the neural effects of OXT, considering gonadal steroids and OXT receptor affinity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“task-based fMRI has often shown opposite findings in males and females namely in terms of amygdala activation.14, 15”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes.13, 14, 47, 48, 49”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes.13, 14, 47, 48, 49”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“while it has been demonstrated that OXT decreases amygdala activity in response to fear in men (Kirsch et al., 2005), it appears to increase amygdala activity to similar stimuli in women (Domes et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Domes et al., 2010
In the citing paper
“separate OXT-application studies in humans have indicated that there may be differential amygdala reactivity to fearful faces and fearful/threatening scenes in men (14, 15) and women (16, 17).”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [16]
In the citing paper
“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [16]
In the citing paper
“Generally, in healthy subjects pro-social feelings, including generosity and trust (6–8), social communication and emotional recognition (9,10), self-perception (11), and social interactions with offspring are altered by OT(12).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [9]
In the citing paper
“our sample was restricted to males, given the role of sex hormones on OXT neural effect's (Domes et al, 2010), and may not generalize to females.”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Domes et al, 2010
In the citing paper
“but increases it in women (11, 12).”
From Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice (2018) · cites this paper as [11]
In the citing paper
“Second, OXT has been shown to have differential effects on emotional responding in males and females (Domes et al, 2010).”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Domes et al, 2010
In the citing paper
“Interestingly, one study on human participants found that the BOLD signals in the amygdala in women, unlike in men, actually increase when viewing fearful faces (Domes et al., 2010).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Domes et al., 2010
In the citing paper
“Moreover, previous studies have shown differential effects of OT on male and female participants (e.g.Domes et al., 2010;Feldman et al., 2010).”
From OT promotes closer interpersonal distance among highly empathic individuals (2015) · cites this paper as Domes et al., 2010
In the citing paper
“We cannot exclude the possibility that this may have influenced our results, although similar effects of OT on amygdala reactivity previously were found in females tested in the follicular phase (Domes et al, 2010) and luteal phase (Bertsch et al, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Domes et al, 2010
In the citing paper
“even to increase reactivity in the amygdala during the processing of fearful faces in females [19].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [19]
In the citing paper
“is in agreement with recent experimental evidence pointing to the sex-dimorphic effects of OT nasal spray in humans [19], [45] [56], [57].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [19]
In the citing paper
“Third, our study used only male subjects, and there is evidence that male and female subjects respond differently to oxytocin (Domes et al., 2010).”
From Oxytocin decreases aversion to angry faces in an associative learning task (2010) · cites this paper as Domes et al., 2010
Citations
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
The distributed human neural system for face perception
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01482-0 · Cited by 4,891
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
A unifying view of the basis of social cognition
GALLESE, V, KEYSERS, C., & RIZZOLATTI, G. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.002 · Cited by 2,236
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Self-citationA differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
The fusiform face area: a cortical region specialized for the perception of faces
Kanwisher, N., & Yovel, G. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1934 · Cited by 1,718
Cited by
Sorted by citations
Items 201–300 of 523
Lucht, M. J., Barnow, S., Sonnenfeld, C., Ulrich, I., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., John, U., Herrmann, F. H., et al. (2012) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2012.700731 · Cited by 67
Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis
Williams, D. R., & Bürkner, P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.013 · Cited by 58
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 61
The impact of oxytocin on stress: the role of sex
Love, T. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.018 · Cited by 56
Laursen, H. R., Siebner, H. R., Haren, T., Madsen, K., Grønlund, R., Hulme, O., & Henningsson, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00423 · Cited by 56
Oxytocin sharpens self-other perceptual boundary
Colonnello, V., Chen, F. S., Panksepp, J., & Heinrichs, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.010 · Cited by 58
“Moreover, considering gender differences in face processing and oxytocin-induced modulation of amygdala activity (Proverbio et al., 2006; Domes et al., 2010; Lischke et al., 2012a), future studies should directly compare men and women’s responses on a self-recognition task following oxytocin administration.”
ResultSelf-citationRupp, H. A., James, T. W., Ketterson, E. D., Sengelaub, D. R., Ditzen, B., & Heiman, J. R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.10.007 · Cited by 58
“, 2011) as well as increased amygdala activation in women in response to fearful faces (Domes et al., 2010).”
InfluentialHormones as “difference makers” in cognitive and socioemotional aging processes
Ebner, N. C., Kamin, H. S., Diaz, V. G., Cohen, R. A., & MacDonald, K. S. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01595 · Cited by 59
“…oxytocin’s impact on emotional empathy responses (Hurlemann et al., 2010), amygdala response to emotional images and faces (Guastella et al., 2009; Domes et al., 2010; Marsh et al., 2010; Rupp et al., 2014), conversational intimacy and eye contact (Liu et al., 2012), risk taking (Patel et al.,…”
BackgroundOxytocin effects on neural correlates of self-referential processing
Liu, Y., Sheng, F., Woodcock, K. A., & Han, S. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.08.003 · Cited by 55
Silva, R. C., Pisanu, C., Maffioletti, E., Menesello, V., Bortolomasi, M., Gennarelli, M., Baune, B. T., Squassina, A., & Minelli, A. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.07.012 · Cited by 53
Ellenbogen, M. A., Linnen, A.-M., Cardoso, C., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.016 · Cited by 53
“Changes in brain activation in the anterior cingulate and frontal cortex have also been found following intranasal oxytocin administration (Baumgartner et al., 2008; Petrovic et al., 2008; Domes et al., 2010), consistent with our speculation that oxytocin alters inhibition in dysphoric participants through its effects…”
BackgroundEffects of Oxytocin and Vasopressin on Preferential Brain Responses to Negative Social Feedback
Gozzi, M., Dashow, E. M., Thurm, A. E., Swedo, S. E., & Zink, C. F. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.248 · Cited by 54
Johansson, A., Bergman, H., Corander, J., Waldman, I. D., Karrani, N., Salo, B., Jern, P., Ålgars, M., Sandnabba, K. N., Santtila, P. O., et al. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00744.x · Cited by 59
“The results can not be generalized to women without explicitly testing both genders, based on the previous studies indicating potential sex differences related to the effects of OXT (Domes et al. 2010; Kirsch et al. 2005).”
InfluentialMothers' amygdala response to positive or negative infant affect is modulated by personal relevance
Strathearn, L., & Kim, S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00176 · Cited by 59
“Oxytocin is a neuropeptide with a localized effect within the amygdala (Kirsch et al., 2005; Baumgartner et al., 2008; Petrovic et al., 2008; Domes et al., 2010).”
BackgroundOxytocin, Tolerance, and the Dark Side of Addiction
Pedersen, C. A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.08.003 · Cited by 58
Oxytocin Selectively Improves Empathic Accuracy: A Replication in Men and Novel Insights in Women
Bartz, J. A., Nitschke, J. P., Krol, S. A., & Tellier, P. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.01.014 · Cited by 64
Pratt, M., Zeev‐Wolf, M., Goldstein, A., & Feldman, R. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.03.005 · Cited by 54
Oxytocin secretion is pulsatile in men and is related to social-emotional functioning
Baskaran, C., Plessow, F., Silva, L., Asanza, E., Marengi, D., Eddy, K. T., Sluss, P. M., Johnson, M. L., Misra, M., & Lawson, E. A. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.07.486 · Cited by 50
“Further, OXT’s socioemotional effects may be sexually dimorphic (Domes et al., 2007b; Domes et al., 2010; Dumais et al., 2013; Murai et al., 1998).”
BackgroundThe interplay of oxytocin and sex hormones
Quintana, D. S., Glaser, B. D., Kang, H., Kildal, E. S.-M., Audunsdottir, K., Sartorius, A. M., & Barth, C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105765 · Cited by 54
“In humans, intranasal oxytocin administration does not seem to influence testosterone or progesterone levels under basal conditions (Domes et al., 2010; Wirth et al., 2015).”
Oxytocin and social cognition in affective and psychotic disorders
Pérez-Rodríguez, M. M., Mahon, K., Russo, M., Ungar, A. K., & Burdick, K. E. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.012 · Cited by 58
“Furthermore, the effects of oxytocin appear to be modulated by other factors, including gender, context, attachment style, and history of childhood adversity (Bakermans-Kranenburg and van, 2013; Bartz et al., 2011b; Domes et al., 2010).”
BackgroundPain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit
Filippa, M., Poisbeau, P., Mairesse, J., Monaci, M. G., Baud, O., Hüppi, P. S., Grandjean, D., & Kuhn, P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00715 · Cited by 56
Theodoridou, A., Penton-Voak, I. S., & Rowe, A. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058113 · Cited by 51
“Indeed, this finding fits with the crucial function of OT as a female hormone in labor, bonding and parenting both in human- [54], [4] and nonhuman mammals [55] and is in agreement with recent experimental evidence pointing to the sex-dimorphic effects of OT nasal spray in humans [19], [45] [56], [57].”
ResultPlasma oxytocin explains individual differences in neural substrates of social perception
Lancaster, K., Carter, C. S., Pournajafi‐Nazarloo, H., Karaoli, T., Lillard, T. S., Jack, A., Davis, J. M., Morris, J. P., & Connelly, J. J. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00132 · Cited by 53
“This is problematic since sex differences in the effects of OT administration on social cognition have been observed (Domes et al., 2010), potentially due to interactions with female sex steroids (McCarthy and Pfaus, 1996).”
BackgroundHarony, H., & Wagner, S. (2010) · Neurosignals · doi:10.1159/000321035 · Cited by 62
“Another mechanism by which OT may reduce anxiety is via modulation of amygdala-mediated autonomic fear responses through amygdala OT receptors. fMRI studies have shown that exogenous OT infusion reduces fear responses in the amygdala [”
BackgroundHarvey, B. H., Regenass, W., Dreyer, W., & Möller, M. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119826783 · Cited by 50
“In anxiety-related conditions specifically, oxytocin exerts contrasting sex-dependent effects on amygdala activity (Domes et al., 2010) while for vasopressin prenatal stress-induced social memory deficits are more prominent in females than males, with vasopressin-1a receptor mRNA expression in the…”
BackgroundHow does oxytocin modulate human behavior?
Yao, S., & Kendrick, K. M. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02898-1 · Cited by 61
“Initial studies restricted to females reported increased amygdala responses to emotional faces [130] and to social and non-social threatening scenes [131].”
Neurobiological Aspects of Face Recognition: The Role of Oxytocin
Lopatina, O. L., Komleva, Y. K., Gorina, Y. V., Higashida, H., & Salmina, A. B. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00195 · Cited by 53
Vizeli, P., Straumann, I., Duthaler, U., Varghese, N., Eckert, A., Paulus, M. P., Risbrough, V. B., & Liechti, M. E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.906639 · Cited by 47
Riem, M. M. E., Bakermans‐Kranenburg, M. J., Voorthuis, A., & van IJzendoorn, M. H. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.014 · Cited by 51
Strauss, G. P., Keller, W. R., Koenig, J. I., Sullivan, S. K., Gold, J. M., & Buchanan, R. W. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.01.022 · Cited by 46
Shou, X., Xu, X., Zeng, X., Liu, Y., Yuan, H., Xing, Y., Jia, M., Wei, Q.-Y., Han, S., Zhang, R., et al. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0109-2 · Cited by 45
An oxytocin receptor polymorphism predicts amygdala reactivity and antisocial behavior in men
Waller, R. E., Corral-Frías, N. S., Vannucci, B., Bogdan, R., Knodt, A. R., Hariri, A. R., & Hyde, L. W. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw042 · Cited by 45
“For example, OXT administration was associated with decreased amygdala reactivity to fear-inducing stimuli among men (Kirsch et al., 2005; Domes et al., 2007) but increased reactivity women (Domes et al., 2010; Lischke et al., 2012).”
BackgroundAmygdala responses to salient social cues vary with oxytocin receptor genotype in youth
Marusak, H. A., Furman, D. J., Kuruvadi, N., Shattuck, D. W., Joshi, S. H., Joshi, A. A., Etkin, A., & Thomason, M. E. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.10.015 · Cited by 47
“Next, prior studies in adults using acute oxytocin administration have identified sex differences (Domes et al., 2010; Weisman et al., 2013) that were not replicated here.”
BackgroundFemale psychopharmacology matters! Towards a sex-specific psychopharmacology
Bolea-Alamanac, B. M., Bailey, S., Lovick, T. A., Scheele, D., & Valentino, R. J. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117747578 · Cited by 46
“amygdala responses to fearful faces (Domes et al., 2010) and aversive scenes (Lischke et al.”
BackgroundOxytocin promotes face-sensitive neural responses to infant and adult faces in mothers
Peltola, M. J., Strathearn, L., & Puura, K. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.012 · Cited by 45
“The available evidence points to potential sexually dimorphic effects of intranasal OT on neural activation to social stimuli (e.g., Domes et al., 2010; Kirsch et al., 2005; Wigton et al., 2015), indicating that the effects of OT are not universal, and especially in females, OT may function to…”
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.002 · Cited by 48
Lischke, A., Herpertz, S. C., Berger, C., Domes, G., & Gamer, M. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx107 · Cited by 47
“points to control for interactions between participants’ estrogen, progesterone and oxytocin levels during the experimental task (Domes et al., 2010; Lischke et al., 2012c).”
BackgroundMethodResultInfluentialSelf-citationAcheson, D. T., Feifel, D., Kamenski, M., Mckinney, R., & Risbrough, V. B. (2015) · Depression and Anxiety · doi:10.1002/da.22362 · Cited by 44
“[53] Domes et al.[54] showed that intranasal OT administration enhanced amygdala activation to fearful faces in women, opposite to the effect in men.”
ResultThe impact of breastfeeding on mothers' attentional sensitivity towards infant distress
Pearson, R. M., Lightman, S. L., & Evans, J. (2011) · Infant Behavior and Development · doi:10.1016/j.infbeh.2010.12.009 · Cited by 44
Amygdala response to negative images in postpartumvsnulliparous women and intranasal oxytocin
Rupp, H. A., James, T. W., Ketterson, E. D., Sengelaub, D. R., Ditzen, B., & Heiman, J. R. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss100 · Cited by 44
Flanagan, J. C., Hand, A., Jarnecke, A. M., Maria, M. M. M., Brady, K. T., & Joseph, J. E. (2018) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000197 · Cited by 47
“The dose of intranasal oxytocin used in this study (24 IU) was chosen based on previous literature examining the effect of acute oxytocin administration on neural circuitry where dosages of 24 and 27 IU were given (Domes et al., 2007, 2010; Kirsch et al., 2005).”
Functional topography of anger and aggression in the human cerebellum
Klaus, J., & Schutter, D. J. L. G. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117582 · Cited by 48
Ma, X., Luo, L., Geng, Y., Zhao, W., Zhang, Q., & Kendrick, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00266 · Cited by 44
Gender differences in oxytocin-associated disruption of decision bias during emotion perception
Lynn, S. K., Hoge, E. A., Fischer, L., Barrett, L. F., & Simon, N. M. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.031 · Cited by 44
“An exception is Domes et al. (2010), who studied women only.”
InfluentialSex Hormones and Pain: The Evidence From Functional Imaging
Vincent, K., & Tracey, I. (2010) · Current Pain and Headache Reports · doi:10.1007/s11916-010-0139-1 · Cited by 43
“[49] fMRI RA Face recognition N/I No No N/I”
BackgroundMartins, D., Paduraru, M., & Paloyelis, Y. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15451 · Cited by 42
Hubble, K., Daughters, K., Manstead, A. S. R., Rees, A., Thapar, A., & van Goozen, S. H. M. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.10.019 · Cited by 41
“…of OXT have been found to differ in males and females, such that collapsing across gender would not be appropriate (Domes et al., 2010; Kirsch et al., 2005); and (2) administering OXT to females entails additional ethical and logistical considerations (e.g., controlling for menstrual cycle phase…”
BackgroundInfluentialEffects of Oxytocin on Women's Aggression Depend on State Anxiety
Campbell, A. C., & Hausmann, M. (2013) · Aggressive Behavior · doi:10.1002/ab.21478 · Cited by 42
“…scenes and faces (Domes et al., 2007; Gamer, Zurowski, & Buchel, 2010; Kirsch et al., 2005; Petrovic, Kalisch, Singer, & Dolan, 2008) but two recent studies found that in women,under similar conditions, amygdala activation is increased by OT (Domes et al., 2010; Lischke et al., 2012).”
ResultHuffmeijer, R., Alink, L. R. A., Tops, M., Grewen, K., Light, K. C., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.008 · Cited by 43
“Our results are thus consistent with findings of enhanced activity in various brain areas involved in face processing after oxytocin administration in healthy women (Domes et al., 2010).”
The Effect of Oxytocin on Third-Party Altruistic Decisions in Unfair Situations: An fMRI Study
Hu, Y., Scheele, D., Becker, B., Voos, G., David, B., Hurlemann, R., & Weber, B. (2016) · Scientific Reports · doi:10.1038/srep20236 · Cited by 44
Oxytocin Reduces Face Processing Time but Leaves Recognition Accuracy and Eye-Gaze Unaffected
Hubble, K., Daughters, K., Manstead, A. S. R., Rees, A., Thapar, A., & van Goozen, S. H. M. (2016) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617716000886 · Cited by 42
A human tendency to anthropomorphize is enhanced by oxytocin
Scheele, D., Schwering, C., Elison, J. T., Spunt, R., Maier, W., & Hurlemann, R. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.05.009 · Cited by 41
Fischer-Shofty, M., Shamay‐Tsoory, S., & Levkovitz, Y. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00127 · Cited by 41
“Domes et al. (2010) reported a different neural activation pattern, including the amygdala, following IN OT administration in women, as opposed to men.”
BackgroundHuffmeijer, R., Alink, L. R. A., Tops, M., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2012) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-011-0082-6 · Cited by 42
“Many effects of oxytocin on socio-emotional information processing (e.g., increased processing of facial expressions; Domes et al., 2010; Huffmeijer, Alink, et al., 2011) and behav-”
BackgroundOxytocin Enhances the Neural Efficiency of Social Perception
Tillman, R. M., Gordon, I., Naples, A. J., Rolison, M. J., Leckman, J. F., Feldman, R., Pelphrey, K. A., & McPartland, J. C. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00071 · Cited by 43
Oxytocin interference in the effects induced by inhalation of 7.5% CO2 in healthy volunteers
de Oliveira, D. C. G., Chagas, M. H. N., Garcia, L. V., Crippa, J. A. S., & Zuardi, A. W. (2012) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2237 · Cited by 39
“OT has also been shown to be involved in the regulation of social behavior (Campbell, 2010, Insel, 2010, Domes et al., 2010; Kirsch et al., 2005).”
BackgroundHerzmann, G., Bird, C. W., Freeman, M., & Curran, T. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.002 · Cited by 40
“In addition, human studies that investigated the effect of oxytocin on amygdala reactivity reported sex differences in oxytocin effectiveness (Domes et al., 2007, 2010; Zink and Meyer-Lindenberg, 2012); therefore, sex differences might emerge in the present study because the amygdala plays a role…”
Comparative and developmental perspectives on oxytocin and vasopressin.
Bales, K. L. (2013) · American Psychological Association eBooks · doi:10.1037/14250-002 · Cited by 40
“Intranasal OT has been shown to affect reactions to facial expression (Domes et al., 2010; Domes et al., 2007; Goldman, Gomes, Carter, & Lee, 2011; Marsh, Yu, Pine, & Blair, 2010), as well as facial recognition memory (Savaskan, Ehrhardt, Schulz, Walter, & Schachinger, 2008), trust (Kosfeld, Heinrichs, Zak, Fischbache…”
BackgroundOxytocin modulates meta-mood as a function of age and sex
Ebner, N. C., Horta, M., Lin, T., Feifel, D., Fischer, H., & Cohen, R. A. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00175 · Cited by 40
“Of note, the present study did not directly control for the influence of levels of gonadal hormones on the reported effects (Domes et al., 2010; Lischke et al., 2012).”
BackgroundResultGazeAlyze: a MATLAB toolbox for the analysis of eye movement data
Berger, C., Winkels, M., Lischke, A., & Höppner, J. (2011) · Behavior Research Methods · doi:10.3758/s13428-011-0149-x · Cited by 40
“Research into visual behavior is motivated by applied psychological questions; the main topics of such research include the processing of facial expressions in social cognition (Brassen, Gamer, Rose, & Buchel, 2010; Domes et al., 2010; Gamer, Zurowski, & Buchel, 2010), the flexibility in the cognitive control of the o…”
BackgroundSelf-citationDumais, K. M., Alonso, A. G., Bredewold, R., & Veenema, A. H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.036 · Cited by 42
“For example, human fMRI studies have shown that exogenous OT modulates amygdala activation in response to social stimuli differently in men compared to women (Domes et al., 2007; Domes et al., 2010; Rilling et al., 2012; Rilling et al., 2014).”
Intranasal oxytocin modulates neural functional connectivity during human social interaction
Rilling, J. K., Chen, X., Chen, X., & Haroon, E. (2018) · American Journal of Primatology · doi:10.1002/ajp.22740 · Cited by 40
“Whereas INOT decreased amygdala activation to threatening faces in men, it increased amygdala activation in women (Domes et al., 2007, 2010).”
BackgroundThe impact of sex as a biological variable in the search for novel antidepressants
Williams, A. V., & Trainor, B. C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.05.003 · Cited by 42
Sadigh‐Eteghad, S., Geranmayeh, M. H., Majdi, A., Salehpour, F., Mahmoudi, J., & Farhoudi, M. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.07.002 · Cited by 40
Child brain exhibits a multi-rhythmic response to attachment cues
Pratt, M., Goldstein, A., & Feldman, R. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy062 · Cited by 44
“These regions activate during emotion understanding and social decision-making and participate in the embodiment of others’ emotions (Gallese et al., 2004; Paulus et al., 2005; Domes et al., 2010).”
BackgroundThe oxytocinergic system mediates synchronized interpersonal movement during dance
Josef, L., Goldstein, P., Mayseless, N., Ayalon, L., & Shamay-Tsoory, S. G. (2019) · Scientific Reports · doi:10.1038/s41598-018-37141-1 · Cited by 43
Social withdrawal and gender differences: Clinical phenotypes and biological bases
Masi, G., Berloffa, S., Milone, A., & Brovedani, P. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24802 · Cited by 45
Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39
“…decreases amygdala activity in males (Domes et al., 2007; Kirsch et al., 2005; Labuschagne et al., 2010; Petrovic et al., 2008; Quintana et al., 2016b), it appears to increase amygdala activity in females, even when controlling for menstrual cycle phase (Domes et al., 2010; Lischke et al., 2012).”
BackgroundTops, S., Habel, U., & Radke, S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.03.002 · Cited by 42
Kumar, J., Vӧllm, B., & Palaniyappan, L. K. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu051 · Cited by 40
“Even a single-dose administration of OXT has a notable influence on the stimulus-induced responses and connectivity of the amygdala (Kirsch et al., 2005; Domes et al., 2007; Domes et al., 2010; Gamer et al., 2010).”
BackgroundInvestigating the effect of music on labor pain and progress in the active stage of first labor.
Hosseini, S. E., Bagheri, M., & Honarparvaran, N. (2013) · PubMed · Cited by 38
Oxytocin improves compassion toward women among patients with PTSD
Palgi, S., Klein, E., & Shamay‐Tsoory, S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.008 · Cited by 42
“Moreover, recent studies have shown gender differences in behavioral and neural responses to intranasal OT (Domes et al., 2010; Rilling et al., 2014).”
BackgroundOxytocin and emotion processing
Simplicio, M. C. D., & Harmer, C. J. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116641872 · Cited by 40
“Increased eye-gaze exploration of the eye region of faces following oxytocin administration has also been reported, although results are inconsistent and possibly task, population or sex dependent (Andari et al., 2010; Domes et al., 2010; Gamer et al., 2010; Guastella et al., 2008).”
ResultLübke, K. T., Croy, I., Hoenen, M., Gerber, J. C., Pause, B. M., & Hummel, T. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094314 · Cited by 37
“The inferior frontal gyrus has been shown to be involved in social perception, as it is activated when viewing (emotional) faces (for a review see [39,40]), during implicit facial judgments [41] or when observing positive and negative social encounters [42].”
BackgroundVasopressin modulates neural responses during human reactive aggression
Brunnlieb, C., Münte, T. F., Krämer, U. M., Tempelmann, C., & Heldmann, M. (2013) · Social Neuroscience · doi:10.1080/17470919.2013.763654 · Cited by 38
“However, the oxytocin treatment related effects in the superior temporal cortex were found in women (Domes et al., 2010), while the present investigation and the study by Zink et al.”
ResultIntranasal administration of oxytocin increases compassion toward women
Palgi, S., Klein, E., & Shamay‐Tsoory, S. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu040 · Cited by 36
“Although some of the studies found that OT affects similarly women and men both genders (e.g. Ditzen et al., 2009; Theodoridou et al., 2009; Feldman et al., 2010), other find some gender-differential effects (e.g. Domes et al., 2010; Fischer-Shofty et al., 2013; Prehn et al., 2013).”
BackgroundMethodResultInfluentialBuilding a Social Neuroscience of Autism Spectrum Disorder
Pelphrey, K. A., Yang, D. Y. ‐., & McPartland, J. C. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_253 · Cited by 45
Modulating amygdala responses to emotion: Evidence from pharmacological fMRI
Patin, A., & Hurlemann, R. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.10.004 · Cited by 36
The role of oxytocin in empathy in PTSD.
Palgi, S., Klein, E., & Shamay‐Tsoory, S. (2016) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000142 · Cited by 37
Kim, S., & Strathearn, L. (2017) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.2016.1277897 · Cited by 38
“A growing number of studies have used intranasal OT to show that OT reduces levels of self-reported anxiety, cortisol, and AMY reactivity to fearful stimuli (Heinrichs et al. 2003; Kirsch et al. 2005; Domes et al. 2010).”
BackgroundLambert, B., Declerck, C. H., & Boone, C. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.015 · Cited by 34
“The latter is included because recent publications indicate that sex can be a moderator of the effect of OT (Domes et al., 2010; Lischke et al., 2012b).”
Oxytocin and Behavior: Evidence for Effects in the Brain
Stevens, F. L., Wiesman, O., Feldman, R., Hurley, R. A., & Taber, K. H. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13030061 · Cited by 38
“amygdala activation was increased in most studies utilizing similar negative emotional stimuli in women (Figure 2).(12,13,57,65) Several studies have also reported alterations in functional coupling between areas of the”
ResultBernaerts, S., Boets, B., Steyaert, J. G., Wenderoth, N., & Alaerts, K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01069-w · Cited by 36
From Oxytocin to Compassion: The Saliency of Distress
Kucerova, B., Levit‐Binnun, N., Gordon, I., & Golland, Y. (2023) · Biology · doi:10.3390/biology12020183 · Cited by 36
Reduced frontal cortex thickness and cortical volume associated with pathological narcissism
Mao, Y., Sang, N., Wang, Y., Hou, X., Huang, H., Wei, D., Zhang, J., & Qiu, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.025 · Cited by 35
Dumais, K. M., Kulkarni, P. P., Ferris, C. F., & Veenema, A. H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.04.003 · Cited by 34
Oxytocin attenuates social and non-social avoidance: Re-thinking the social specificity of Oxytocin
Harari-Dahan, O., & Bernstein, A. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.04.005 · Cited by 34
“In contrast to genderspecific or mixed effects between men and women (e.g., Domes et al., 2010; Fischer-Shofty et al., 2013), the present findings may provide important insight regarding the hypothesized common cross-gender biological mechanism of action subserving effects of OT (Geary and Flinn,…”
Kotani, M., Shimono, K., Yoneyama, T., Nakako, T., Matsumoto, K., Ogi, Y., Konoike, N., Nakamura, K., & Ikeda, K. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.009 · Cited by 37
Quintana, D. S., Westlye, L. T., Alnæs, D., Kaufmann, T., Mahmoud, R. A., Smerud, K. T., Djupesland, P. G., & Andreassen, O. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0241-3 · Cited by 34
“Brain imaging research has demonstrated that oxytocin increases amygdala activity in females [77, 78], so it is unclear if this would also correspond with pupil dilation in females as well.”
Althammer, F., Muscatelli, F., Grinevich, V., & Schaaf, C. P. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02054-1 · Cited by 35
Oxytocin and Facial Emotion Recognition
Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 34
Alaerts, K., Bernaerts, S., Prinsen, J., Dillen, C., Steyaert, J. G., & Wenderoth, N. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0653-8 · Cited by 36
Oxytocin and Human Sensitive and Protective Parenting
Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_23 · Cited by 36
“Several studies have pointed to the differential consequences of experimentally manipulated oxytocin levels in males vs. females (Domes et al. 2007, 2010), and although hardly studied in relation to parenting behavior, the combined correlational and experimental evidence from Feldman et al. (2010)…”
ResultCommon and dissociable effects of oxytocin and lorazepam on the neurocircuitry of fear
Kreuder, A., Scheele, D., Schultz, J., Hennig, J., Marsh, N., Dellert, T., Ettinger, U., Philipsen, A., Babasiz, M., Herscheid, A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920147117 · Cited by 27
“Considering the evidence for a more prevalent use of anxiolytics in females (52, 53) and for sexspecific effects of OXT on amygdala activity (54), which might be based on interactions with sexual steroids (55, 56), future research is needed to examine the effects of OXT and LZP on amygdalar subarchitecture responses i…”
BackgroundRubin, L. H., Li, Y., Keedy, S., Reilly, J. L., Bishop, J. R., Carter, C. S., Pournajafi‐Nazarloo, H., Drogos, L. L., Tamminga, C. A., Pearlson, G. D., et al. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23820 · Cited by 32
“, 2008), whereas the converse is seen in women (Domes et al., 2010; Lischke et al., 2012).”
BackgroundBrambilla, M., Cotelli, M., Manenti, R., Dagani, J., Sisti, D., Rocchi, M., Balestrieri, M., Pini, S., Raimondi, S., Saviotti, F. M., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.08.001 · Cited by 32
Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach
Zhu, R., Liu, C., Li, T., Xu, Z., Fung, B. J., Feng, C., Wu, H., Luo, Y., & Wang, L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.06.016 · Cited by 30
Sciabola, S., Goetz, G. H., Bai, G., Rogers, B. N., Gray, D. L., Duplantier, A. J., Fonseca, K. R., Vanase-Frawley, M. A., & Kablaoui, N. M. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.05.062 · Cited by 31
Effects of Intranasal Oxytocin on Long‐Term Memory in Healthy Humans: A Systematic Review
Brambilla, M., Manenti, R., de Girolamo, G., Adenzato, M., Bocchio‐Chiavetto, L., & Cotelli, M. (2016) · Drug Development Research · doi:10.1002/ddr.21343 · Cited by 33
Patin, A., & Hurlemann, R. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-16522-6_10 · Cited by 37
Metadata
- Authors
- Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C.
- Affiliations
- University of Freiburg (DE)
- University of Rostock (DE)
- Universitätsmedizin Rostock (DE)
- Heidelberg University (DE)
- Corresponding author
- Domes, Gregor
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 35
- Issue
- 1
- Pages
- 83-93
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2038181972
- Cited by
- 521
- References
- 58
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 14 · 2023: 18 · 2022: 13 · 2021: 27 · 2020: 21 · 2019: 25 · 2018: 29 · 2017: 45 · 2016: 41 · 2015: 45 · 2014: 53 · 2013: 64 · 2012: 44
- FWCI
- 44.39
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Bundesministerium für Bildung und Forschung (01GW0784)
- Universität Zürich
- Deutsche Forschungsgemeinschaft (Do1312/1-1)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP001-114788)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, intranasal administration, emotional face processing, amygdala, sexual dimorphism, women, facial expressions, fusiform gyrus, superior temporal gyrus, inferior frontal gyrus, estradiol, progesterone, sex steroids, BOLD signal
- MeSH terms
- Administration, Intranasal, Adult, Anger, Emotions, Estradiol, Eye Movements, Facial Expression, Fear, Female, Hormones, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Oxytocin, Photic Stimulation, Progesterone, Social Perception, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
