Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces.
Abstract
In line with animal models indicating sexually dimorphic effects of oxytocin (OXT) on social-emotional processing, a growing number of OXT-administration studies in humans have also reported sex-dependent effects during social information processing. To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86-43 males) with a backward-masking emotional face paradigm. Results showed that while OXT suppressed inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli in men it increased them in women. In women increased anterior cingulate reactivity during subliminal threat processing was also positively associated with trait anxiety. On the network level, sex-dependent effects were observed on amygdala, anterior cingulate and inferior frontal gyrus functional connectivity that were mainly driven by reduced coupling in women following OXT. Our findings demonstrate that OXT produces sex-dependent effects even at the early stages of social-emotional processing, and suggest that while it attenuates neural responses to threatening social stimuli in men it increases them in women. Thus in a therapeutic context OXT may potentially produce different effects on anxiety disorders in men and women.
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A growing number of findings suggest sex-dependent effects of oxytocin on social cognition.
“Based on a growing number of findings suggesting sex-dependent effects of OXT on social cognition (Chen et al., 2016; Gao et al., 2016; Luo et al., 2017), the second experiment additionally explored whether OXT differentially affects empathic processing in men and women.”
From Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity (2018) · cites this paper as Luo et al., 2017
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Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Hurlemann, R., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00512 · Cited by 78 · see citing works
Self-citationThe impact of oxytocin on stress: the role of sex
Love, T. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.018 · Cited by 56 · see citing works
- Authors
- Luo, L., Becker, B., Geng, Y., Zhao, Z., Gao, S., Zhao, W., Yao, S., Zheng, X., Ma, X., Gao, Z., Hu, J., & Kendrick, K. M.
- Affiliations
- University of Electronic Science and Technology of China (CN)
- Corresponding author
- Kendrick, Keith M.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 162
- Pages
- 127-137
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2751943248
- Semantic Scholar
- 7edf1e5158fd1e45fa2045578000ee7052d93f42
- Cited by
- 79
- References
- 92
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 15 · 2021: 17 · 2020: 12 · 2019: 12 · 2018: 10 · 2017: 1
- FWCI
- 13.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31530032, 91632117)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, sex differences, subliminal processing, emotional face processing, threatening faces, social-emotional processing, inferior frontal gyrus, anterior cingulate cortex, anterior insula, amygdala, functional connectivity, trait anxiety, anxiety disorders, intranasal administration
- MeSH terms
- Adolescent, Adult, Double-Blind Method, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Oxytocin, Sex Characteristics, Visual Perception, Young Adult
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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