The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Effects of intranasal oxytocin on emotional face processing in women
Open accessAbstract
The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity to social and emotional stimuli in healthy men. The present study aimed to investigate the effect of intranasally administered OXT on brain activity in response to social emotional stimuli of varying valence in women. In a functional magnetic-resonance imaging study, sixteen women were presented with fearful, angry, happy and neutral facial expressions after a single dose of 24IU OXT or a placebo administration in a within-subject design. Group analysis revealed that the blood-oxygen-level-dependent (BOLD) signal was enhanced in the left amygdala, the fusiform gyrus and the superior temporal gyrus in response to fearful faces and in the inferior frontal gyrus in response to angry and happy faces following OXT treatment. This effect was independent of fixation pattern to specific sections of the facial stimuli as revealed by eye tracking and independent of basal plasma levels of OXT, estradiol, and progesterone. The results are at odds with the previously reported effects found in men. Future studies should include both sexes to determine a possible sexual dimorphism in the neural effects of OXT, considering gonadal steroids and OXT receptor affinity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“task-based fMRI has often shown opposite findings in males and females namely in terms of amygdala activation.14, 15”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes.13, 14, 47, 48, 49”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes.13, 14, 47, 48, 49”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [14]
In the citing paper
“while it has been demonstrated that OXT decreases amygdala activity in response to fear in men (Kirsch et al., 2005), it appears to increase amygdala activity to similar stimuli in women (Domes et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Domes et al., 2010
In the citing paper
“separate OXT-application studies in humans have indicated that there may be differential amygdala reactivity to fearful faces and fearful/threatening scenes in men (14, 15) and women (16, 17).”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [16]
In the citing paper
“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [16]
In the citing paper
“Generally, in healthy subjects pro-social feelings, including generosity and trust (6–8), social communication and emotional recognition (9,10), self-perception (11), and social interactions with offspring are altered by OT(12).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [9]
In the citing paper
“our sample was restricted to males, given the role of sex hormones on OXT neural effect's (Domes et al, 2010), and may not generalize to females.”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Domes et al, 2010
In the citing paper
“but increases it in women (11, 12).”
From Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice (2018) · cites this paper as [11]
In the citing paper
“Second, OXT has been shown to have differential effects on emotional responding in males and females (Domes et al, 2010).”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Domes et al, 2010
In the citing paper
“Interestingly, one study on human participants found that the BOLD signals in the amygdala in women, unlike in men, actually increase when viewing fearful faces (Domes et al., 2010).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Domes et al., 2010
In the citing paper
“Moreover, previous studies have shown differential effects of OT on male and female participants (e.g.Domes et al., 2010;Feldman et al., 2010).”
From OT promotes closer interpersonal distance among highly empathic individuals (2015) · cites this paper as Domes et al., 2010
In the citing paper
“We cannot exclude the possibility that this may have influenced our results, although similar effects of OT on amygdala reactivity previously were found in females tested in the follicular phase (Domes et al, 2010) and luteal phase (Bertsch et al, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Domes et al, 2010
In the citing paper
“even to increase reactivity in the amygdala during the processing of fearful faces in females [19].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [19]
In the citing paper
“is in agreement with recent experimental evidence pointing to the sex-dimorphic effects of OT nasal spray in humans [19], [45] [56], [57].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [19]
In the citing paper
“Third, our study used only male subjects, and there is evidence that male and female subjects respond differently to oxytocin (Domes et al., 2010).”
From Oxytocin decreases aversion to angry faces in an associative learning task (2010) · cites this paper as Domes et al., 2010
Citations
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
The distributed human neural system for face perception
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01482-0 · Cited by 4,891
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
A unifying view of the basis of social cognition
GALLESE, V, KEYSERS, C., & RIZZOLATTI, G. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.002 · Cited by 2,236
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Self-citationA differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
The fusiform face area: a cortical region specialized for the perception of faces
Kanwisher, N., & Yovel, G. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1934 · Cited by 1,718
Cited by
Sorted by citations
Items 101–200 of 523
Oxytocin and the social brain: Neural mechanisms and perspectives in human research
Kanat, M., Heinrichs, M., & Domes, G. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.003 · Cited by 122
“In an initial study, a sample of healthy women received intranasal OT or a placebo before viewing emotional or neutral face stimuli in an MRI scanner (Domes et al., 2010a).”
BackgroundResultInfluentialSelf-citationLawson, E. A., Holsen, L. M., Santin, M., Meenaghan, E. M., Eddy, K. T., Becker, A. E., Herzog, D. B., Goldstein, J. M., & Klibanski, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1702 · Cited by 121
Oxytocin in the socioemotional brain: implications for psychiatric disorders
Kirsch, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pkirsch · Cited by 123
Sex, Receptors, and Attachment: A Review of Individual Factors Influencing Response to Oxytocin
MacDonald, K. S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00194 · Cited by 119
“…gender-dependent effects have been demonstrated in some single-dose studies (Hurlemann et al., 2010), including studies of effects on they amygdala (Domes et al., 2010; Rupp et al., 2012), and interpersonal behavior (Liu et al., 2012) but – consistent with the variability in this literature – many…”
BackgroundResultOverview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121
Oxytocin and postpartum depression: Delivering on what's known and what's not
Kim, S., Soeken, T. A., CROMER, S. J., Martinez, S. R., Hardy, L. R., & Strathearn, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.11.009 · Cited by 121
The Associations Between Oxytocin and Trauma in Humans: A Systematic Review
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00154 · Cited by 126
“The results generally showed that OXT favors fear-related responses; this fact is also an accepted finding in studies conducted with healthy participants (Domes et al., 2010).”
ResultTauber, M., Mantoulan, C., Copet, P., Jauregui, J., Demeer, G., Diene, G., Rogé, B., Laurier, V., Ehlinger, V., Arnaud, C., et al. (2011) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-6-47 · Cited by 117
“OT appears to be the main neurohormone to explain empathy and theory of mind (TOM) [8-14].”
BackgroundOxytocin indexes relational distress following interpersonal harms in women
Tabak, B. A., McCullough, M. E., Szeto, A., Mendez, A. J., & McCabe, P. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.004 · Cited by 116
“, 2010), and enhanced neural activation for both positive and negatively valenced emotional stimuli in women (Domes et al., 2010).”
BackgroundHormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face
Scheele, D., Plota, J., Stoffel-Wagner, B., Maier, W., & Hurlemann, R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv157 · Cited by 116
“However, in light of accumulating evidence implying sexual-dimorphic effects of OXT on reproductive behavior, social cognition and emotional processing (Domes et al., 2010; Lischke et al., 2012; Fischer-Shofty et al., 2013; Lynn et al., 2014; Preckel et al., 2014; Rilling et al., 2014; Scheele et al., 2014b; Yao et al…”
BackgroundGordon, I., Jack, A., Pretzsch, C. M., Vander Wyk, B., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2016) · Scientific Reports · doi:10.1038/srep35054 · Cited by 114
Riem, M. M. E., Bakermans‐Kranenburg, M. J., Huffmeijer, R., & van IJzendoorn, M. H. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.023 · Cited by 114
“For example, Domes et al. (2007b) found that oxytocin reduces amygdala activation during exposure to happy, fearful and angry facial expressions, with no significant effect of valence (but see Domes et al., 2010).”
BackgroundOxytocin and Autism: A Systematic Review of Randomized Controlled Trials
Preti, A., Melis, M., Siddi, S., Vellante, M., Doneddu, G., & Fadda, R. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.0040 · Cited by 118
“In women, increased amygdala reactivity to threatening or fearful scenes was found after oxytocin administration, compared with placebo (Domes et al. 2010; Lischke et al. 2012).”
Oxytocin facilitates social approach behavior in women
Preckel, K., Scheele, D., Kendrick, K. M., Maier, W., & Hurlemann, R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00191 · Cited by 111
Goldman, M. B., Gomes, A. M., Carter, C. S., & Lee, R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2193-8 · Cited by 112
“Furthermore, some oxytocin effects vary markedly by gender (Domes et al. 2010), but our sample was too small to address gender effects.”
BackgroundOxytocin in schizophrenia: a review of evidence for its therapeutic effects
MacDonald, K. S., & Feifel, D. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00634.x · Cited by 117
“testosterone) may moderate OT’s effects (176); (c) sex is an important factor in the natural history of schizophrenia (177) and (d) studies indicate that sex moderates OT levels (160,170), stress-based (178,179) and behavioural aspects of OT (159), the effect of OT on the brain in face processing tasks (51,52), as wel…”
BackgroundOpposing effects of oxytocin on moral judgment in males and females
Scheele, D., Striepens, N., Kendrick, K. M., Schwering, C., Noelle, J., Wille, A., Schlaepfer, T. E., Maier, W., & Hurlemann, R. (2014) · Human Brain Mapping · doi:10.1002/hbm.22605 · Cited by 109
“Sex-dimorphic effects of OXT have been reported in several previous studies [Domes et al., 2010; Preckel et al., 2014; Rilling et al., 2014] and might be related to sex differences in human OXT receptor distributions.”
ResultDitzen, B., Nater, U. M., Schaer, M., La Marca, R., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss083 · Cited by 112
“However, substantial sex differences might be expected here, as women show different amygdala activation in response to OT than men (Domes et al., 2010).”
BackgroundSelf-citationOxytocin in metabolic homeostasis: implications for obesity and diabetes management
Ding, C., Leow, M. K., & Magkos, F. (2018) · Obesity Reviews · doi:10.1111/obr.12757 · Cited by 115
“It has been demonstrated that intranasal oxytocin differentially activates brain networks involved in social and emotional information processing in women when compared with men, suggesting important sexual differences in the central effects of oxytocin (136).”
BackgroundApicella, C. L., Cesarini, D. A., Johannesson, M., Dawes, C. T., Lichtenstein, P., Wallace, B., Beauchamp, J. P., & Westberg, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011153 · Cited by 110
“Israel et al [28] reported some results suggestive of sex specific effects and there is also evidence of sex differences in the effects of OXT from both animal studies [40] and human studies [41].”
ResultPlasma oxytocin concentrations following MDMA or intranasal oxytocin in humans
Kirkpatrick, M. G., Francis, S. M., Lee, R., de Wit, H., & Jacob, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.006 · Cited by 106
“Several studies report that IN-OT increases plasma OT levels although the pharmacokinetics of intranasally administered OT are not fully understood (Domes et al., 2010; Gossen et al., 2012; Striepens et al., 2013).”
BackgroundLinnen, A.-M., Ellenbogen, M. A., Cardoso, C., & Joober, R. (2012) · Stress · doi:10.3109/10253890.2011.631154 · Cited by 104
“…administration studies have been conducted on male samples, it is imperative that similar research be conducted in women, especially in light of recent evidence suggesting that the effects of oxytocin on fear-related information processing may differ in women relative to men (Domes et al. 2010).”
BackgroundEngert, V., Koester, A. M., Riepenhausen, A., & Singer, T. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.029 · Cited by 103
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women
Bethlehem, R. A. I., Lombardo, M. V., Lai, M.-C., Auyeung, B., Crockford, S. K., Deakin, J., Soubramanian, S., Sule, A., Kundu, P., Voon, V, et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.72 · Cited by 96
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes (Domes et al., 2010; Riem et al., 2012; Rilling et al., 2013; Ebner et al., 2016; Gao et al., 2016).”
Quintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102
Early life stress modulates oxytocin effects on limbic system during acute psychosocial stress
Grimm, S., Pestke, K., Feeser, M., Aust, S., Weigand, A., Wang, J., Wingenfeld, K., Pruessner, J. C., Marca, R. L., Böker, H., et al. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu020 · Cited by 106
“However, we decided against an inclusion of female subjects since several previous studies suggested greater acute HPA and autonomic responses in men (Kudielka and Kirschbaum, 2005) as well as sex- specific OXT effects (Domes et al., 2010).”
Role of oxytocin in the control of stress and food intake
Onaka, T., & Takayanagi, Y. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12700 · Cited by 102
Intranasal oxytocin effects on social cognition: A critique
Evans, S. L., Dal Monte, O., Noble, P., & Averbeck, B. B. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.008 · Cited by 97
“Three other studies, however, have not replicated this finding in female participants (Domes et al., 2010; Lischke et al., 2012a, 2012b).”
InfluentialOxytocin Gene Polymorphisms Influence Human Dopaminergic Function in a Sex-Dependent Manner
Love, T. M., Enoch, M.-A., Hodgkinson, C. A., Peciña, M., Mickey, B., Koeppe, R. A., Stohler, C. S., Goldman, D., & Zubieta, J.-K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.033 · Cited by 97
“Reports of sex differences in oxytocin functioning are not limited to animal models; for instance, empathy triggered oxytocin release is higher in women than in men (92) and intranasal oxytocin attenuates amygdala responses to emotional stimuli in men (93, 94) but enhances activity in this region in women (95).”
BackgroundOxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99
Koch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98
Oxytocin decreases aversion to angry faces in an associative learning task
Evans, S., Shergill, S. S., & Averbeck, B. B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.110 · Cited by 97
“Third, our study used only male subjects, and there is evidence that male and female subjects respond differently to oxytocin (Domes et al ., 2010).”
Sasayama, D., Hattori, K., Teraishi, T., Hori, H., Ota, M., Yoshida, S., Arima, K., Higuchi, T., Amano, N., & Kunugi, H. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.016 · Cited by 96
“Previous studies suggest that effects of peripheral and intranasal oxytocin may differ between men and women (Domes et al., 2010; Rubin et al., 2011; Rubin et al., 2010).”
Hormonal Mechanisms for Regulation of Aggression in Human Coalitions
Flinn, M. V., Ponzi, D., & Muehlenbein, M. P. (2012) · Human Nature · doi:10.1007/s12110-012-9135-y · Cited by 97
“Although some have suggested that the peptide hormone oxytocin underpins generalized prosocial behavior in humans (Domes et al. 2010; Kosfeld et al. 2005; Zak et al. 2005), others suggest that oxytocin motivates affiliative behavior toward specific in-group targets (de Dreu et al.”
BackgroundKinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men
Lieberz, J., Scheele, D., Spengler, F. B., Matheisen, T., Schneider, L., Stoffel‐Wagner, B., Kinfe, T. M., & Hurlemann, R. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0582-6 · Cited by 95
Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
Bate, S., Cook, S. J., Duchaine, B., Tree, J. J., Burns, E. J., & Hodgson, T. L. (2013) · Cortex · doi:10.1016/j.cortex.2013.08.006 · Cited by 94
“Notably, a modulation in activity in the FFA has been reported while participants recognize emotional expressions under oxytocin conditions (Domes et al., 2007, 2010; Kirsch et al., 2005; Labuschagne et al., 2010; Petrovic, Kalisch, Singer, & Dolan, 2008), and it is likely that increased activity…”
Slattery, D. A., & Neumann, I. D. (2010) · Pharmaceuticals · doi:10.3390/ph3030702 · Cited by 94
“A series of human studies have shown that intra-nasal administration of OXT has improves processing of facial cues, both positive and negative, as well as decreasing amygdala activity to fearful faces [118–121].”
BackgroundWang, D., Yan, X., Li, M., & Ma, Y. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx085 · Cited by 86
“…on STG activity might be independent of the valence of the processes, as we found that IN-OT increased STG activity was contributed by studies examining positive (Voorthuis et al., 2014; Rilling et al., 2014) or negative processes (Domes et al., 2010; Riem et al., 2011; Lischke et al., 2012).”
BackgroundEpigenetic modification of OXT and human sociability
Haas, B. W., Filkowski, M. M., Cochran, R. N., Denison, L., Ishak, A., Nishitani, S., & Smith, A. K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602809113 · Cited by 91
“OT administration is associated with increased fusiform gyrus activity (45) and OXTR methylation is associated with fusiform gyrus reactivity to emotional facial expressions (6).”
BackgroundSex-specific associations between peripheral oxytocin and emotion perception in schizophrenia
Rubin, L. H., Carter, C. S., Drogos, L. L., Jamadar, R., Pournajafi‐Nazarloo, H., Sweeney, J. A., & Maki, P. M. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.06.002 · Cited by 91
“Intranasal oxytocin increases amygdala activity during emotional face processing in females (Domes et al., 2010), but reduces amygdala activity in men (Domes et al.”
BackgroundHu, J., Qi, S., Becker, B., Luo, L., Gao, S., Gong, Q., Hurlemann, R., & Kendrick, K. M. (2015) · Human Brain Mapping · doi:10.1002/hbm.22760 · Cited by 98
“Thus although OXT has been shown to influence amygdala, insula and fusiform and superior temporal gyri responses to emotional faces [Domes et al., 2007, 2010; Gamer et al., 2010; Kirsch et al., 2005] there was no evidence for this, at least in the context of the neutral expression face switching to…”
BackgroundXu, P., Peng, S., Luo, Y., & Gong, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.023 · Cited by 102
Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward
Bradley, E., & Woolley, J. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.007 · Cited by 92
“…influence expression of OXTR in the brain as well as central oxytocin release (Gabor et al., 2012), and intranasal oxytocin administration may have differing effects on amygdala reactivity (Domes et al., 2010; Lischke et al., 2012) and salience of social cues (Gao et al., 2016) in men and women.”
Does oxytocin affect mind-reading? A replication study
Radke, S., & de Bruijn, E. R. A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.006 · Cited by 82
Oxytocin specifically enhances valence-dependent parasympathetic responses
Gamer, M., & Büchel, C. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.007 · Cited by 86
“Since oxytocin seems to have differential effects on the neural circuitry involved in face processing in women (Domes et al., 2010), our data might not generalize to females.”
BackgroundRocchetti, M., Radua, J., Paloyelis, Y., Xenaki, L., Frascarelli, M., Caverzasi, E., Politi, P., & Fusar‐Poli, P. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12185 · Cited by 83
OT promotes closer interpersonal distance among highly empathic individuals
Perry, A., Mankuta, D., & Shamay-Tsoory, S. G. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu017 · Cited by 86
“Moreover, previous studies have shown differential effects of OT on male and female participants (e.g. Domes et al. , 2010; Feldman et al. , 2010).”
The many faces of oxytocin: Implications for psychiatry
Zik, J. B., & Roberts, D. L. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.048 · Cited by 91
Oxytocin’s effect on resting-state functional connectivity varies by age and sex
Ebner, N. C., Chen, H., Porges, E., Lin, T., Fischer, H., Feifel, D., & Cohen, R. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.03.013 · Cited by 84
Prehn, K., Kazzer, P., Lischke, A., Heinrichs, M., Herpertz, S. C., & Domes, G. (2013) · Psychophysiology · doi:10.1111/psyp.12042 · Cited by 81
Self-citationOxytocin increases empathy to pain when adopting the other-but not the self-perspective
Abu-Akel, A., Palgi, S., Klein, E., Decety, J., & Shamay-Tsoory, S. (2015) · Social Neuroscience · doi:10.1080/17470919.2014.948637 · Cited by 83
“…size, dosage, and waiting time corresponded to those previously used in experiments designed to investigate the effect of the intranasal administration of OT on behavior in humans (Domes et al., 2010; Guastella et al., 2010; Kirsch et al., 2005; Kosfeld, Heinrichs, Zak, Fischbacher, & Fehr, 2005).”
MethodNose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols
Alabsi, W., Eedara, B. B., Encinas-Basurto, D., Polt, R. L., & Mansour, H. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091870 · Cited by 88
Potential of Oxytocin in the Treatment of Schizophrenia
Shilling, P. D., & Feifel, D. (2016) · CNS Drugs · doi:10.1007/s40263-016-0315-x · Cited by 84
Improving social perception in schizophrenia: The role of oxytocin
Fischer-Shofty, M., Brüne, M., Ebert, A., Shefet, D., Levkovitz, Y., & Shamay‐Tsoory, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.006 · Cited by 83
Plasencia, G., Luedicke, J., Pournajafi‐Nazarloo, H., Carter, C. S., & Ebner, N. C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104419 · Cited by 87
“However, the evidence regarding sex differences in amygdala response to OT administration remains mixed (Domes et al., 2010), with other studies reporting increased amygdala reactivity in both males and females after OT administration (Koch et al.”
ResultLonstein, J. S., Maguire, J. L., Meinlschmidt, G., & Neumann, I. D. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12188 · Cited by 89
Frijling, J. L. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1302652 · Cited by 94
Ellenbogen, M. A., Linnen, A., Grumet, R., Cardoso, C., & Joober, R. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01278.x · Cited by 82
Oxytocin enhances attention to the eye region in rhesus monkeys
Dal Monte, O., Noble, P. L., Costa, V. D., & Averbeck, B. B. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00041 · Cited by 80
“ORIGINAL RESEARCH ARTICLE published: 03 March 2014 doi: 10.3389/fnins.2014.00041 Oxytocin enhances attention to the eye region in rhesus monkeys”
BackgroundInfluentialChen, X., Hackett, P. D., DeMarco, A. C., Feng, C., Stair, S., Haroon, E., Ditzen, B., Pagnoni, G., & Rilling, J. K. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9411-7 · Cited by 81
“2005), while increasing women’s amygdala response to fearful faces and negative scenes (Domes et al. 2010).”
InfluentialLebowitz, E. R., Leckman, J. F., Feldman, R., Zagoory‐Sharon, O., McDonald, N. M., & Silverman, W. K. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.12.007 · Cited by 80
Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces.
Luo, L., Becker, B., Geng, Y., Zhao, Z., Gao, S., Zhao, W., Yao, S., Zheng, X., Ma, X., Gao, Z., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.08.079 · Cited by 79
“In contrast to previous studies reporting effects of OXT on amygdala reactivity in separate samples of men and women during explicit (Domes et al., 2010; Kirsch et al., 2005; Lischke et al., 2012b) and subliminal (Kanat et al.”
BackgroundResultInfluentialOxytocin and socioemotional aging: current knowledge and future trends
Ebner, N. C., Maura, G. M., MacDonald, K., Westberg, L., & Fischer, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00487 · Cited by 78
“…2005; Domes et al., 2007a; Petrovic et al., Frontiers in Human Neuroscience www.frontiersin.org August 2013 | Volume 7 | Article 487 | 3 2008; Singer et al., 2008; Labuschagne et al., 2010; Riem et al., 2011; Zink and Meyer-Lindenberg, 2012; cf. Huffmeijer et al., 2012; but see Domes et al., 2010).”
BackgroundBürkner, P., Williams, D. R., Simmons, T. C., & Woolley, J. D. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx053 · Cited by 82
Sex-Related Differences in Plasma Oxytocin Levels in Humans
Marazziti, D., Baroni, S., Mucci, F., Piccinni, A., Moroni, I., Giannaccini, G., Carmassi, C., Massimetti, E., & Dell’Osso, L. (2019) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901915010058 · Cited by 80
Calcagnoli, F., Stubbendorff, C., Meyer, N., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.012 · Cited by 77
The rehabilitation of face recognition impairments: a critical review and future directions
Bate, S., & Bennetts, R. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00491 · Cited by 76
Feeser, M., Fan, Y., Weigand, A., Hahn, A., Gärtner, M., Böker, H., Grimm, S., & Bajbouj, M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.12.015 · Cited by 74
Antisocial oxytocin: Complex effects on social behavior
Beery, A. K. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.11.006 · Cited by 74
The other side of the coin: oxytocin decreases the adherence to fairness norms
Radke, S., & de Bruijn, E. R. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00193 · Cited by 73
“Importantly, however, the current study is based on data suggesting a time window of up to 100–120 minutes in CSF after intranasal neuropeptide administration (Born et al., 2002) and OXT effects for at least 90 min (e.g., Domes et al., 2010; Gamer et al., 2010; Gamer and Büchel, 2012).”
BackgroundOxytocin makes females, but not males, less forgiving following betrayal of trust
Yao, S., Zhao, W., Cheng, R., Geng, Y., Luo, L., & Kendrick, K. M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571400090x · Cited by 74
“In line with this, there is also evidence that OXT has gender specific modulatory effect on emotional face processing (Kirsch et al., 2005; Domes et al., 2010) and during social cooperation interactions (Rilling et al.”
BackgroundOxytocin and vasopressin: Social neuropeptides with complex neuromodulatory functions
Benarroch, E. E. (2013) · Neurology · doi:10.1212/wnl.0b013e31828cfb15 · Cited by 74
“OXT increased the activity of the left amygdala, brainstem, temporal poles, superior temporal gyrus, fusiform gurus, and insula in response to fearful faces and increased activity of the inferior frontal gyrus in response to angry or happy faces.(67) OXT decreased activation of the right amygdala and increased activat…”
BackgroundChang, S. W. C., & Platt, M. L. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.006 · Cited by 71
“Interestingly, one study on human participants found that the BOLD signals in the amygdala in women, unlike in men, actually increase when viewing fearful faces (Domes et al., 2010).”
BackgroundOxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Alvares, G. A., Chen, N. T. M., Balleine, B. W., Hickie, I. B., & Guastella, A. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.018 · Cited by 71
“As sexually dimorphic effects of oxytocin have previously been described (Domes et al., 2010), and possible interactions between fluctuating levels of estrogen”
BackgroundRubin, L. H., Connelly, J. J., Reilly, J. L., Carter, C. S., Drogos, L. L., Pournajafi‐Nazarloo, H., Ruocco, A. C., Keedy, S., Matthew, I., Tandon, N., et al. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.10.003 · Cited by 72
“Consistent with this idea, intranasal OT has sex-divergent effects on amygdala activity in response to emotion face processing (28, 30).”
BackgroundStriepens, N., Matusch, A., Kendrick, K. M., Mihov, Y., Elmenhorst, D., Becker, B., Lang, M., Coenen, H. H., Maier, W., Hurlemann, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.026 · Cited by 71
“The increased plasma OXT concentrations we found following intranasal OXT administration in men are similar to those reported in another study on female subjects (Domes et al., 2010).”
BackgroundResultIntranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw123 · Cited by 72
“However, several studies report that oxytocin may also increase sensitivity to negative social stimuli (e.g. Domes et al., 2010; Striepens et al., 2012).”
BackgroundInfluentialHuffmeijer, R., van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2012) · Gerontology · doi:10.1159/000341333 · Cited by 71
Scantamburlo, G., Hansenne, M., Geenen, V. G., Legros, J., & Ansseau, M. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2014.08.007 · Cited by 72
“Interestingly, OT decreases amygdala reactivity to aversive, threat-related faces [2] in males, but increases amygdala reactivity to similar faces in females [10].”
BackgroundTollenaar, M. S., Chatzimanoli, M., van der Wee, N. J. A., & Putman, P. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.018 · Cited by 68
“These effects are found in a healthy male population, and should be replicated in (sub)clinical populations and in females, as gender difference in the response to oxytocin have been found before (Domes et al., 2010; Lischke et al., 2012b).”
DeMayo, M. M., Song, Y. J. C., Hickie, I. B., & Guastella, A. J. (2017) · Pediatric Drugs · doi:10.1007/s40272-017-0248-y · Cited by 71
“oxytocin results in increased trust [53], attention to the eye region [54], and emotion recognition ([55, 56]; for review see [57]).”
BackgroundThe S cience of Interpersonal Trust
Borum, R. (2010) · Digital Commons - University of South Florida (University of South Florida) · Cited by 69
Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Shin, N. Y., Park, H. Y., Jung, W. H., Park, J. W., Yun, J., Jang, J. H., Kim, S. N., Han, H. J., Kim, S.-Y., Kang, D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.41 · Cited by 69
“…studies have reported an oxytocin-induced reduction in amygdala activity in response to fearful emotion in male subjects (Bethlehem et al, 2013), and a single study observed an oxytocin-induced increase in amygdala activity in response to fearful emotion in female participants (Domes et al, 2009).”
BackgroundWhen Two Become One: The Role of Oxytocin in Interpersonal Coordination and Cooperation
Arueti, M., Perach-Barzilay, N., Tsoory, M. M., Berger, B., Getter, N., & Shamay-Tsoory, S. G. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00400 · Cited by 67
“Other studies (e.g., Domes et al., 2007, 2010; Labuschagne et al., 2010; Baumgartner et al., 2008; Kirsch et al., 2005) have reported that the administration of OT decreases amygdaloid functioning, further supporting the effects of OT treatment and social behavior.”
BackgroundMethodResultInfluentialOxytocin reduces amygdala responses during threat approach
Radke, S., Volman, I., Kokal, I., Roelofs, K., de Bruijn, E. R. A., & Toni, I. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.028 · Cited by 67
“Interpretational issues Future studies need to consider sex differences in the proessing of emotional stimuli (Domes et al., 2010b; Whittle et al., 011) as well as the sexually dimorphic effects of oxytocin adminstration on amygdala reactivity to threat (Domes et al., 2010a; ischke et al., 2012).”
BackgroundSex- and context-dependent effects of oxytocin on social sharing
Ma, X., Zhao, W., Luo, R., Zhou, F., Geng, Y., Xu, L., Gao, Z., Zheng, X., Becker, B., & Kendrick, K. M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.004 · Cited by 68
“Some studies have reported increased activity in the insula in both women (Domes et al., 2010; Riem et al., 2011) and men (Rilling et al.”
Chen, F. S., & Johnson, S. C. (2011) · Social Psychological and Personality Science · doi:10.1177/1948550611410325 · Cited by 68
“, 2007), it increases amygdala reactivity to emotional faces in women (Domes et al., 2010).”
BackgroundJiang, Y., & Platt, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-25607-1 · Cited by 69
Loth, E., Poline, J.-B., Thyreau, B., Jia, T., Tao, C., Lourdusamy, A., Stacey, D., Cattrell, A., Desrivières, S., Ruggeri, B., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.043 · Cited by 65
“This suggested that OT facilitates social-affective behavior by reducing anxiety, neuroendocrine stress response, or more broadly arousal [(16,17) but see (20) for the opposite effect in women].”
Lukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 65
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62
Wang, T., Shi, C., Li, X., Zhang, P., Liu, B., Wang, H., Wang, Y., Yang, Y., Wu, Y., Li, H., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.012 · Cited by 60
Janeček, M., & Dabrowska, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2889-8 · Cited by 63
“OT (24 IU) was shown to selectively enhance amygdala reactivity to fearful faces and enhance amygdala activity during the processing of fearful facial expressions in females, though had no effect on calmness, alertness and mood scales (Domes et al. 2010).”
Antitumor activity of benzaldehyde.
Kochi, M., Takeuchi, S., Mizutani, T., Mochizuki, K., Matsumoto, Y., & Saito, Y. (1980) · PubMed · Cited by 62
Oxytocin selectively modulates brain response to stimuli probing social synchrony
Lévy, J., Goldstein, A., Zagoory‐Sharon, O., Weisman, O., Schneiderman, I., Eidelman-Rothman, M., & Feldman, R. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.066 · Cited by 63
“For instance, OT increased amygdalar response depending on the valence of social stimuli (Gamer et al., 2010) or on the participants' gender (Domes et al., 2010).”
BackgroundZhang, R., Jia, M., Zhang, J.-S., Xu, X., Shou, X., Zhang, X., Li, L., Li, N., Han, S., & Han, J. (2012) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2012.02.001 · Cited by 61
“…are also known to play important roles in social behavior and cognition, including facial recognition (Rimmele, Hediger, Heinrichs, & Klaver, 2009; Domes et al., 2010), anxiety (Bosch, 2010; Kessler, Bosch, Bunck, Landgraf, & Neumann, 2010) and trust (Kosfeld, Heinrichs, Zak, Fischbacher, & Fehr,…”
BackgroundGenetic modulation of oxytocin sensitivity: A pharmacogenetic approach
Chen, F. S., Kumsta, R., Dvorak, F., Domes, G., Yim, O. S., Ebstein, R. P., & Heinrichs, M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.163 · Cited by 59
Self-citationThe effect of oxytocin on biological motion perception in dogs (Canis familiaris)
Kovács, K., Kis, A., Kanizsàr, O., Hernádi, A., Gácsi, M., & Topál, J. (2016) · Animal Cognition · doi:10.1007/s10071-015-0951-4 · Cited by 59
Oxytocin and anxiety disorders
Gottschalk, M. G., & Domschke, K. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_25 · Cited by 61
Bisagno, V., & Cadet, J. L. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000049 · Cited by 63
“Although very few studies have been conducted in females, intranasal OXY may actually increase amygdala reactivity to negative emotional stimuli in healthy females (Domes et al., 2010).”
BackgroundInfluential
Metadata
- Authors
- Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C.
- Affiliations
- University of Freiburg (DE)
- University of Rostock (DE)
- Universitätsmedizin Rostock (DE)
- Heidelberg University (DE)
- Corresponding author
- Domes, Gregor
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 35
- Issue
- 1
- Pages
- 83-93
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2038181972
- Cited by
- 521
- References
- 58
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 14 · 2023: 18 · 2022: 13 · 2021: 27 · 2020: 21 · 2019: 25 · 2018: 29 · 2017: 45 · 2016: 41 · 2015: 45 · 2014: 53 · 2013: 64 · 2012: 44
- FWCI
- 44.39
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Bundesministerium für Bildung und Forschung (01GW0784)
- Universität Zürich
- Deutsche Forschungsgemeinschaft (Do1312/1-1)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP001-114788)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, intranasal administration, emotional face processing, amygdala, sexual dimorphism, women, facial expressions, fusiform gyrus, superior temporal gyrus, inferior frontal gyrus, estradiol, progesterone, sex steroids, BOLD signal
- MeSH terms
- Administration, Intranasal, Adult, Anger, Emotions, Estradiol, Eye Movements, Facial Expression, Fear, Female, Hormones, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Oxytocin, Photic Stimulation, Progesterone, Social Perception, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
