Cited by 151Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

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Variant in oxytocin receptor gene is associated with amygdala volume

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Furman, Daniella J., Chen, Michael C., Gotlib, Ian H.·2011·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2010.12.004PMC PMC3104107

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Abstract

The oxytocin system plays a significant role in modulating stress responses in animals and humans; perturbations in this system may contribute to the pathogenesis of psychiatric disorder. Attempts to identify clinically relevant genetic variants in the oxytocin system have yielded associations between polymorphisms of the oxytocin receptor (OXTR) gene and both autism and major depression. To date, however, little is known about how such variants affect brain structures implicated in these disorders. Applying a manual tracing procedure to high-resolution structural magnetic resonance images, amygdala volumes were measured in 51 girls genotyped on OXTR rs2254298(G>A), a single nucleotide polymorphism associated with psychopathology. Results of this study indicate that despite having greater gray matter volume, participants homozygous for the G allele were characterized by smaller volumes of both left and right amygdala than were carriers of the A allele. A subsequent whole-brain voxel-based morphometry analysis revealed additional genotype-mediated volumetric group differences in the posterior brain stem and dorsomedial anterior cingulate cortex. These findings highlight one neurobiological pathway by which oxytocin gene variants may increase risk for psychopathology. Further research is needed to characterize the mechanism by which this polymorphism contributes to anatomical variability and to identify functional correlates of these alterations in regional brain volume.

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RETRACTED: Epigenetic modification of the oxytocin gene is associated with gray matter volume and trait empathy in mothers
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Retracted
Right Posterior Insula and Putamen Volume Mediate the Effect of Oxytocin Receptor Polygenic Risk for Autism Spectrum Disorders on Reward Dependence in Healthy Adults
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Is Oxytocin Relevant for the Affective Disorders?
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Authors: Furman, D. J., Chen, M. C., & Gotlib, I. H.
Affiliations: Stanford University (US)
Corresponding author: Furman, Daniella J.
ORCID: Furman, Daniella J.
Chen, Michael C.
Gotlib, Ian H.
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2011-07
Volume: 36
Issue: 6
Pages: 891-897
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2010.12.004
PMC: PMC3104107
OpenAlex: W2040710885
Cited by: 151
References: 38
Citations by year: 2026: 2 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 21 · 2015: 13 · 2014: 12 · 2013: 14 · 2012: 20
FWCI: 24.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (MH74849, R01MH074849)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: oxytocin receptor gene, amygdala volume, single nucleotide polymorphisms, gray matter volume, brain structure, psychopathology, stress response, autism spectrum disorder, major depressive disorder, anterior cingulate cortex
MeSH terms: Adolescent, Amygdala, Brain Stem, Child, Depression, Female, Genotype, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Menarche, Organ Size, Risk, Receptors, Oxytocin, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide

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Variant in oxytocin receptor gene is associated with amygdala volume

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