Genetic modulation of oxytocin sensitivity: A pharmacogenetic approach
Open accessAbstract
Intranasal administration of the neuropeptide oxytocin has been shown to influence a range of complex social cognitions and social behaviors, and it holds therapeutic potential for the treatment of mental disorders characterized by social functioning deficits such as autism, social phobia and borderline personality disorder. However, considerable variability exists in individual responses to oxytocin administration. Here, we undertook a study to investigate the role of genetic variation in sensitivity to exogenous oxytocin using a socioemotional task. In a randomized, double-blind, placebo-controlled experiment with a repeated-measures (crossover) design, we assessed the performance of 203 men on an emotion recognition task under oxytocin and placebo. We took a haplotype-based approach to investigate the association between oxytocin receptor gene variation and oxytocin sensitivity. We identified a six-marker haplotype block spanning the promoter region and intron 3 that was significantly associated with our measure of oxytocin sensitivity. Specifically, the TTCGGG haplotype comprising single-nucleotide polymorphisms rs237917-rs2268498-rs4564970-rs237897-rs2268495-rs53576 is associated with increased emotion recognition performance under oxytocin versus placebo, and the CCGAGA haplotype with the opposite pattern. These results on the genetic modulation of sensitivity to oxytocin document a significant source of individual differences with implications for personalized treatment approaches using oxytocin administration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some individuals show heterogeneous responses to oxytocin, which may involve interaction with OXTR genetic polymorphisms.
“Some individuals have heterogeneous responses to OXT (22, 23), which may involve interaction with OXTR genetic polymorphisms (24–27).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [26]
Several studies suggest that oxytocin effects on behavior and brain function are modulated by OXTR genotype.
“Several studies indeed suggest that oxytocin effects on behavior54–56 and brain function57–59 are modulated by OXTR genotype.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Self-citationHeinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Self-citationOxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Self-citationOxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Self-citationInsel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044 · see citing works
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
Recognition of Emotions in Autism: A Formal Meta-Analysis
Uljarevic, M., & Hamilton, A. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1695-5 · Cited by 824 · see citing works
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909579106 · Cited by 812 · see citing works
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799 · see citing works
Self-citationOxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · see citing works
Self-citationOxytocin and social affiliation in humans
Feldman, R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.008 · Cited by 767 · see citing works
Dudbridge, F. (2008) · Human Heredity · doi:10.1159/000119108 · Cited by 607 · see citing works
Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
Gregory, S. G., Connelly, J. J., Towers, A. J., Johnson, J., Biscocho, D., Markunas, C. A., Lintas, C., Abramson, R. K., Wright, H. H., Ellis, P., et al. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-62 · Cited by 576 · see citing works
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · see citing works
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549 · see citing works
Self-citationEffects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · see citing works
Self-citationDifferent amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487 · see citing works
Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
HEINRICHS, M., & DOMES, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00428-7 · Cited by 479 · see citing works
Self-citationBakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2008) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsn004 · Cited by 474 · see citing works
Oxytocin selectively improves empathic accuracy
Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., & Ochsner, K. N. (2010) · Psychological Science · doi:10.1177/0956797610383439 · Cited by 442 · see citing works
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425 · see citing works
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.34 · Cited by 383 · see citing works
Emotion recognition in borderline personality disorder-a review of the literature.
Domes, G., Schulze, L., & Herpertz, S. (2009) · Journal of Personality Disorders · doi:10.1521/pedi.2009.23.1.6 · Cited by 373 · see citing works
Self-citationGuastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366 · see citing works
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349 · see citing works
Self-citationKim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, C., Suh, E. M., Graham, K., & Taylor, S. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010830107 · Cited by 341 · see citing works
Genetics of Human Social Behavior
Ebstein, R. P., Israel, S., Chew, S. H., Zhong, S., & Knafo, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.020 · Cited by 323 · see citing works
Self-citationDer Mehrdimensionale Befindlichkeitsfragebogen (MDBF)
Heinrichs, M., & Nater, U. M. (2002) · Zeitschrift für Klinische Psychologie und Psychotherapie · doi:10.1026//1616-3443.31.1.66 · Cited by 302 · see citing works
Self-citationKogan, A., Saslow, L. R., Impett, E. A., Oveis, C., Keltner, D., & Rodrigues Saturn, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112658108 · Cited by 279 · see citing works
Chen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., & Heinrichs, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113079108 · Cited by 268 · see citing works
Self-citationAccurate identification of fear facial expressions predicts prosocial behavior.
Marsh, A. A., Kozak, M. N., & Ambady, N. (2007) · Emotion · doi:10.1037/1528-3542.7.2.239 · Cited by 265 · see citing works
Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system
Kumsta, R., & Heinrichs, M. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.09.004 · Cited by 265 · see citing works
Self-citationEffects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.007 · Cited by 255 · see citing works
Self-citationPersonalized medicine in psychiatry: problems and promises
Ozomaro, U., Wahlestedt, C., & Nemeroff, C. B. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-132 · Cited by 237 · see citing works
Dadds, M. R., Moul, C., Cauchi, A., Dobson-Stone, C., Hawes, D. J., Brennan, J., & Ebstein, R. E. (2014) · Development and Psychopathology · doi:10.1017/s0954579413000497 · Cited by 230 · see citing works
Self-citationLischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.015 · Cited by 221 · see citing works
Bertsch, K., Gamer, M., Schmidt, B., Schmidinger, I., Walther, S., Kästel, T., Schnell, K., Büchel, C., Domes, G., & Herpertz, S. C. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13020263 · Cited by 214 · see citing works
Self-citationEpigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience
Kumsta, R., Hummel, E., Chen, F. S., & Heinrichs, M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00083 · Cited by 207 · see citing works
Self-citationOxytocin receptor genetic variation promotes human trust behavior
Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., Clarke, E., McCabe, K., & Lipsky, R. H. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00004 · Cited by 207 · see citing works
Kusui, C., Kimura, T., Ogita, K., Nakamura, H., Matsumura, Y., Koyama, M., Azuma, C., & Murata, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6024 · Cited by 196 · see citing works
Liu, X., Kawamura, Y., Shimada, T., Otowa, T., Koishi, S., Sugiyama, T., Nishida, H., Hashimoto, O., Nakagami, R., Tochigi, M., et al. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2009.140 · Cited by 195 · see citing works
Association between the oxytocin receptor gene and amygdalar volume in healthy adults
Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., Takei, K., Suga, M., Yamada, H., Rogers, M. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.019 · Cited by 164 · see citing works
Domes, G., Kumbier, E., Heinrichs, M., & Herpertz, S. C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.254 · Cited by 160 · see citing works
Self-citationVariant in oxytocin receptor gene is associated with amygdala volume
Furman, D. J., Chen, M. C., & Gotlib, I. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.004 · Cited by 151 · see citing works
Emotion recognition and oxytocin in patients with schizophrenia
Averbeck, B. B., Bobin, T., Evans, S., & Shergill, S. S. (2011) · Psychological Medicine · doi:10.1017/s0033291711001413 · Cited by 144 · see citing works
Lerer, E., Levi, S., Israel, S., Yaari, M., Nemanov, L., Mankuta, D., Yirmiya, N., & Ebstein, R. P. (2010) · Autism Research · doi:10.1002/aur.156 · Cited by 104 · see citing works
Self-citationMontag, C., Fiebach, C. J., Kirsch, P., & Reuter, M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.026 · Cited by 97 · see citing works
Personalized medicine in psychiatry
Wium‐Andersen, I. K., Vinberg, M., Kessing, L. V., & McIntyre, R. S. (2016) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2016.1216163 · Cited by 91 · see citing works
Sauer, C., Montag, C., Wörner, C., Kirsch, P., & Reuter, M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.333 · Cited by 89 · see citing works
Schneiderman, I., Kanat‐Maymon, Y., Ebstein, R. P., & Feldman, R. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst142 · Cited by 87 · see citing works
Self-citationOxytocin attenuates neural reactivity to masked threat cues from the eyes
Kanat, M., Heinrichs, M., Schwarzwald, R., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.183 · Cited by 77 · see citing works
Self-citationNeurogenetic effects of OXTR rs2254298 in the extended limbic system of healthy Caucasian adults
Tost, H., Kolachana, B., Verchinski, B. A., Bilek, E., Goldman, A. L., Mattay, V. S., Weinberger, D. R., & Meyer-Lindenberg, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.034 · Cited by 77 · see citing works
Peltola, M. J., Yrttiaho, S., Puura, K., Proverbio, A. M., Mononen, N., Lehtimäki, T. J., & Leppänen, J. M. (2014) · Emotion · doi:10.1037/a0035959 · Cited by 76 · see citing works
Pharmacogenomics and Personalized Medicine in Neuropsychiatry
McMahon, F. J., & Insel, T. R. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.004 · Cited by 72 · see citing works
Chen, F. S., & Johnson, S. C. (2011) · Social Psychological and Personality Science · doi:10.1177/1948550611410325 · Cited by 66 · see citing works
Self-citationWalter, N. T., Montag, C., Markett, S. A., Felten, A., Voigt, G., & Reuter, M. (2012) · Brain and Cognition · doi:10.1016/j.bandc.2012.01.003 · Cited by 63 · see citing works
Moons, W. G., Way, B. M., & Taylor, S. E. (2014) · Emotion · doi:10.1037/a0035503 · Cited by 55 · see citing works
Der Mehrdimensionale Befindlichkeitsfragebogen ( MDBF )
Steyer, R. (1997) · Cited by 50 · see citing works
Association between the oxytocin receptor ( OXTR ) gene and children's social cognition at 18 months
Wade, M., Hoffmann, T. J., Wigg, K., & Jenkins, J. M. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12148 · Cited by 47 · see citing works
Pharmacogenomics and Personalized Medicine
(2008) · Methods in pharmacology and toxicology · doi:10.1007/978-1-59745-439-1 · Cited by 47 · see citing works
Tabak, B. A., McCullough, M. E., Carver, C. S., Pedersen, E. J., & Cuccaro, M. L. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst042 · Cited by 33 · see citing works
The association between the oxytocin receptor gene (OXTR) and hypnotizability
Bryant, R. A., Hung, L., Dobson‐Stone, C., & Schofield, P. R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.002 · Cited by 33 · see citing works
Binder, A., García, E., Wallace, C., Gbenga, K., Ben‐Shlomo, Y., Yarnell, J., Brown, P., Caulfield, M. J., Skrabal, F., Kotanko, P., et al. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000209983.28735.33 · Cited by 15 · see citing works
Identification of Genes for a Complex Trait: Examples from Hypertension
Binder, A. (2006) · Current Pharmaceutical Biotechnology · doi:10.2174/138920106775789610 · Cited by 13 · see citing works
Psychobiological Approaches for Anxiety Disorders
(2012) · Wiley eBooks · doi:10.1002/9781119945901 · Cited by 7 · see citing works
Heinrichs, M., Chen, F. S., & Domes, G. (2012) · Wiley eBooks · doi:10.1002/9781119945901.ch8 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity
Spengler, F. B., Schultz, J., Scheele, D., Essel, M., Maier, W., Heinrichs, M., & Hurlemann, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.015 · Cited by 229 · see citing works
Self-citationOxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice
Ferretti, V., Maltese, F., Contarini, G., Nigro, M., Bonavia, A., Huang, H., Gigliucci, V., Morelli, G., Scheggia, D., Managò, F., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.04.070 · Cited by 212 · see citing works
King, L. B., Walum, H., Inoue, K., Eyrich, N. W., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.008 · Cited by 191 · see citing works
Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions
Leppanen, J., Ng, K. W., Tchanturia, K., & Treasure, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.010 · Cited by 188 · see citing works
Revisiting the impact of OXTR rs53576 on empathy: A population-based study and a meta-analysis
Gong, P., Fan, H., Liu, J., Yang, X., Zhang, K., & Zhou, X. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.005 · Cited by 126 · see citing works
Social Decision-Making and the Brain: A Comparative Perspective
Tremblay, S., Sharika, K. M., & Platt, M. L. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.007 · Cited by 105 · see citing works
Cai, Q., Feng, L., & Yap, K. Z. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12627 · Cited by 77 · see citing works
The endocrinology of human caregiving and its intergenerational transmission
Bos, P. A. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000973 · Cited by 70 · see citing works
Kou, J., Zhang, Y., Zhou, F., Sindermann, C., Montag, C., Becker, B., & Kendrick, K. M. (2020) · Psychological Medicine · doi:10.1017/s0033291720003803 · Cited by 63 · see citing works
Oxytocin and anxiety disorders
Gottschalk, M. G., & Domschke, K. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_25 · Cited by 61 · see citing works
Seeley, S. H., Chou, Y., & O'Connor, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.011 · Cited by 42 · see citing works
Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism
Hernandez, L. M., Krasileva, K., Green, S. A., Sherman, L. E., Ponting, C., McCarron, R., Lowe, J. K., Geschwind, D. H., Bookheimer, S. Y., & Dapretto, M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.209 · Cited by 43 · see citing works
Yang, S., Dong, X., Guo, X., Han, Y., Song, H., Gao, L., Dai, W., Su, Y., & Zhang, X. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00221 · Cited by 40 · see citing works
Reuter, M., Montag, C., Altmann, S., Bendlow, F., Elger, C. E., Kirsch, P., Becker, A. J., Schoch, S., Simon, M., Weber, B., et al. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1214174 · Cited by 37 · see citing works
Vizeli, P., & Liechti, M. E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199384 · Cited by 36 · see citing works
Oxytocin receptor gene variation predicts subjective responses to MDMA
Bershad, A. K., Weafer, J. J., Kirkpatrick, M. G., Wardle, M. C., Miller, M. A., & de Wit, H. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1143026 · Cited by 34 · see citing works
Flasbeck, V., Moser, D., Kumsta, R., & Brüne, M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00359 · Cited by 34 · see citing works
Self-citationQuintana, D. S. (2020) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2020.100014 · Cited by 34 · see citing works
Schwaiger, M., Heinrichs, M., & Kumsta, R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.025 · Cited by 34 · see citing works
Self-citationOxytocin and the emergence of individual differences in the social regulation of stress
Chen, F. S., Heinrichs, M., & Johnson, S. C. (2017) · Social and Personality Psychology Compass · doi:10.1111/spc3.12332 · Cited by 29 · see citing works
Self-citationOxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers
Labuschagne, I., Poudel, G. R., Kordsachia, C. C., Wu, Q., Thomson, H. M., Georgiou‐Karistianis, N., & Stout, J. C. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.023 · Cited by 29 · see citing works
Horta, M., Ziaei, M., Lin, T., Porges, E. C., Fischer, H., Feifel, D., Spreng, R. N., & Ebner, N. C. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.01.016 · Cited by 26 · see citing works
The Comprehensive Neural Mechanism of Oxytocin in Analgesia
Yang, L., Chen, K., Yin, X., Liu, D., & Zhu, L. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210826142107 · Cited by 26 · see citing works
The Role of Oxytocin in Alzheimer’s Disease and Its Relationship with Social Interaction
Takahashi, J., Yamada, D., Nagano, W., & Saitoh, A. (2023) · Cells · doi:10.3390/cells12202426 · Cited by 25 · see citing works
Mayer, A. V., Wermter, A.-K., Stroth, S., Alter, P., Haberhausen, M., Stehr, T., Paulus, F. M., Krach, S., & Kamp-Becker, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-94407-x · Cited by 23 · see citing works
The Role of Endogenous Oxytocin in Anxiolysis: Structural and Functional Correlates
Lancaster, K., Goldbeck, L., Pournajafi‐Nazarloo, H., Connelly, J. J., Carter, C. S., & Morris, J. P. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.10.003 · Cited by 23 · see citing works
Oxytocin and the stress buffering effect of social company: a genetic study in daily life
Sicorello, M., Dieckmann, L., Moser, D., Lux, V., Luhmann, M., Schlotz, W., & Kumsta, R. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa034 · Cited by 23 · see citing works
Self-citationKey interindividual determinants in MDMA pharmacodynamics
Papaseit, E., Torrens, M., Pérez‐Mañá, C., Muga, R., & Farré, M. (2018) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1424832 · Cited by 20 · see citing works
Bernstein, H., Müller, S., Dobrowolny, H., Wolke, C., Lendeckel, U., Bukowska, A., Keilhoff, G., Becker, A., Trübner, K., Steiner, J. H., et al. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0757-7 · Cited by 19 · see citing works
Wu, J., Dong, Y. H., Zhao, X.-R., He, S., & Zhang, X. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.094 · Cited by 18 · see citing works
Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2
Hovey, D., Henningsson, S., Cortes, D. S., Bänziger, T., Zettergren, A., Melke, J., Fischer, H., Laukka, P., & Westberg, L. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx141 · Cited by 17 · see citing works
Melchers, M., Montag, C., Markett, S. A., Niazy, N., Groß-Bölting, J., Zimmermann, J., & Reuter, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.036 · Cited by 16 · see citing works
Sabino, A. D. V., Chagas, M. H. N., & Osório, F. L. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05493-0 · Cited by 13 · see citing works
Krol, K. M., Monakhov, M. V., Lai, P. S., Ebstein, R. P., Heinrichs, M., & Großmann, T. (2018) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-018-0090-7 · Cited by 15 · see citing works
Self-citationHuetter, F. K., Möhlendick, B., Knop, D., & Siffert, W. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104841 · Cited by 11 · see citing works
Kong, X., Kang, J., & Liu, K. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.08.006 · Cited by 10 · see citing works
Trieu, M., Foster, A. E., Yaseen, Z. S., Beaubian, C., & Calati, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-29876-0_2 · Cited by 12 · see citing works
The role of oxytocin on self‐serving lying
Sindermann, C., Luo, R., Becker, B., Kendrick, K. M., & Montag, C. (2020) · Brain and Behavior · doi:10.1002/brb3.1518 · Cited by 7 · see citing works
Ricchiuti, G., Tuerlinckx, E., Taillieu, A., Prinsen, J., Steyaert, J. G., Boets, B., & Alaerts, K. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811241309621 · Cited by 7 · see citing works
Choi, D., Haruna, T., & Watanuki, S. (2017) · Personality and Individual Differences · doi:10.1016/j.paid.2017.09.001 · Cited by 7 · see citing works
Ansari, D., Lakkimsetti, M., Olaleye, K. T., Bhullar, J. V. K., Shah, R. Z., Arisoyin, A. E., Nadeem, H., Slovik, S. C. S., Habib, F. Z., Abdin, Z. U., et al. (2023) · Cureus · doi:10.7759/cureus.43702 · Cited by 6 · see citing works
Empathic pain: Underlying neural mechanism
Zhang, M.-M., & Chen, T. (2024) · The Neuroscientist · doi:10.1177/10738584241283435 · Cited by 6 · see citing works
Friedlander, E., Yirmiya, N., Laiba, E., Harel‐Gadassi, A., Yaari, M., Feldstein, O., Mankuta, D., & Israel, S. (2019) · Autism Research · doi:10.1002/aur.2111 · Cited by 6 · see citing works
Oxytocin promotes lying for personal gain in a genotype-dependent mannerPreprint
Sindermann, C., Luo, R., Becker, B., Kendrick, K. M., & Montag, C. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/361212 · Cited by 5 · see citing works
Drolet, C. E., & Lucas, T. (2020) · Race and Social Problems · doi:10.1007/s12552-020-09303-2 · Cited by 3 · see citing works
The Promise of Intranasal Oxytocin in Treating Borderline Personality Disorder: A Narrative Review
Giannoulis, E., Nousis, C., Eytaxia, L.-A., Kaimakami, O., & Malogiannis, I. A. (2025) · Brain Sciences · doi:10.3390/brainsci15070708 · Cited by 2 · see citing works
Thomas, M. E. (2020) · Preprints.org · doi:10.20944/preprints202007.0003.v1 · Cited by 2 · see citing works
Chuang, J.-Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.572654 · Cited by 1 · see citing works
Kou, J., Zhang, Y., Zhou, F., Sindermann, C., Montag, C., Becker, B., & Kendrick, K. M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/493387 · Cited by 1 · see citing works
Democratic Demands and Citizen Capabilities
Dusso, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-53603-3_1
The relationship between oxytocin pathway genes and personality traits and psychosis characteristics
Haram, M. (2017) · NORA - Norwegian Open Research Archives
Romero‐Martínez, Á., & Moya‐Albiol, L. (2018) · Psiquiatría Biológica · doi:10.1016/j.psiq.2018.02.004
Luckhaus, C., Juckel, G., & Hurlemann, R. (2018) · Der Nervenarzt · doi:10.1007/s00115-018-0615-0
Luckhaus, C., Juckel, G., & Hurlemann, R. (2019) · Der Nervenarzt
The Importance of Experimental Investigation of the CNS Oxytocin System
Boulton, K., & Guastella, A. J. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1759-5_4
Oxytocin - not only a "social" neuropeptide
Brodmann, K. (2016) · doi:10.53846/goediss-5978
Heinrichs, M., & Domes, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-28099-8_452-1
Self-citationHeinrichs, M., & Domes, G. (2020) · Springer eBooks · doi:10.1007/978-3-319-24612-3_452
Self-citationLee, M., Lori, A., Langford, N. A., & Rilling, J. K. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114144 · Cited by 1 · see citing works
- Authors
- Chen, F. S., Kumsta, R., Dvorak, F., Domes, G., Yim, O. S., Ebstein, R. P., & Heinrichs, M.
- Affiliations
- University of British Columbia (CA)
- Ruhr University Bochum (DE)
- University of Konstanz (DE)
- University of Freiburg (DE)
- National University of Singapore (SG)
- Corresponding author
- Chen, F S
- Heinrichs, M
- Venue
- Translational Psychiatry
- Published
- 2015-10-27
- Volume
- 5
- Issue
- 10
- Pages
- e664-e664
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC4930136
- OpenAlex
- W2200924197
- Cited by
- 59
- References
- 72
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 11 · 2019: 5 · 2018: 10 · 2017: 16 · 2016: 6 · 2015: 1
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion, cc-by)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
- Research Bank (Australian Catholic University) (submittedVersion, cc-by)
- National University of Singapore (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- Deutsche Forschungsgemeinschaft (KU 2479/3-1, 5310/1-1, Do1312/2-3, Do1312/2-1, 2479/3-1)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, oxytocin receptor gene, oxytocin receptor, pharmacogenetics, haplotype association, emotion recognition, social cognition, individual differences, personalized treatment
- MeSH terms
- Adult, Double-Blind Method, Emotions, Haplotypes, Humans, Male, Oxytocin, Pharmacogenetics, Social Behavior, Task Performance and Analysis, Genetic Variation, Receptors, Oxytocin, Cross-Over Studies, Polymorphism, Single Nucleotide, Recognition, Psychology, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
