Cited by 2,144Redox biology and oxidative stressDNA Repair MechanismsEffects of Radiation Exposure

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ROS and the DNA damage response in cancer

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Srinivas, Upadhyayula Sai, Tan, Bryce W.Q., Vellayappan, Balamurugan A., Jeyasekharan, Anand D.·2019·Redox Biology

DOI 10.1016/j.redox.2018.101084PMC PMC6859528

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Abstract

Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-containing molecules that can induce DNA damage and affect the DNA damage response (DDR). There is unequivocal pre-clinical and clinical evidence that ROS influence the genotoxic stress caused by chemotherapeutics agents and ionizing radiation. Recent studies have provided mechanistic insight into how ROS can also influence the cellular response to DNA damage caused by genotoxic therapy, especially in the context of Double Strand Breaks (DSBs). This has led to the clinical evaluation of agents modulating ROS in combination with genotoxic therapy for cancer, with mixed success so far. These studies point to context dependent outcomes with ROS modulator combinations with Chemotherapy and radiotherapy, indicating a need for additional pre-clinical research in the field. In this review, we discuss the current knowledge on the effect of ROS in the DNA damage response, and its clinical relevance.

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Surfing the p53 network
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 1×
“p53 is a well-studied tumor suppressor that is mutated in over 50% of all cancers [87,88], and affects multiple cellular responses to DNA U.”
Background
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · cited 1×
“This response includes DNA damage recognition, activation of checkpoints, cell cycle arrest, and eventually final outcomes of repair, apoptosis and immune clearance [4,5].”
Background
Radiobiology for the Radiologist.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · cited 1×
“Depending on the nature of the lesion in DNA, specific pathways are activated to facilitate identification of the damaged regions and their repair [2,3].”
Background
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303 · cited 1×
“to eventual T-cell mediated killing [116].”
Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,263
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555

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“166 Therefore, NPs are low-toxicity and can cause genetic and reproductive toxicity, inflammation, oxidative stress, and cell apoptosis, causing damage at the molecular and genetic levels.”
Background
The Evolutionary Forest of Pancreatic Cancer
Mullen, K. M., Hong, J., Attiyeh, M. A., Hayashi, A., Sakamoto, H., Kohutek, Z. A., McIntyre, C. A., Zhang, H., Makohon-Moore, A. P., Zucker, A., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1541 · Cited by 26
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Tan, Y., Qin, S., Zhang, Z., Liu, Y., Zhou, L., Li, B., Nice, E. C., Zhang, Y., & Jing, J. (2025) · MedComm – Oncology · doi:10.1002/mog2.70009 · Cited by 29
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Wu, Y., Chen, X., Chen, Z., & Ma, Y. (2025) · Marine Drugs · doi:10.3390/md23060258 · Cited by 27
“Iron ions catalyze the lipid peroxidation chain reaction through the Fenton reaction, generate a large number of reactive oxygen species (ROS), and cause membrane structural damage [9–11].”
Understanding the complexity of tumor-associated macrophages: Druggable and therapeutic insights
Li, A.-Q., Huang, F., Talaiti, S., Yang, X. Y., Bi, H., & Fang, J. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.021 · Cited by 26
“These stresses typically lead to DNA damage and are traditionally associated with cell death 72 .”
Iodine‑125 seed radiation induces ROS‑mediated apoptosis, autophagy and paraptosis in human esophageal squamous cell carcinoma cells
Wang, C., Li, T., Zeng, C. H., Fan, R., Wang, Y., Zhu, G., & Guo, J. (2020) · Oncology Reports · doi:10.3892/or.2020.7576 · Cited by 25
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“High levels of ROS can oxidize DNA molecules leading to base oxidization, SSBs and DSBs [9].”
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Lee, H., Chu, K., Moon, E., & Quan, F. (2021) · Journal of Cancer · doi:10.7150/jca.60027 · Cited by 25
“Reactive oxygen species (ROS) are a well-known inducer of DNA damage and a carcinogenic factor, thus many researchers have tried to modulate ROS levels in cancer for its prevention and therapy [4].”
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Exosomes mediated the delivery of ochratoxin A-induced cytotoxicity in HEK293 cells
Zhu, L., Wang, H., Yuhan, J., Zhang, B., Li, H., Asakiya, C., Huang, K., He, X., & Xu, W. (2021) · Toxicology · doi:10.1016/j.tox.2021.152926 · Cited by 24
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Noh, J. K., Woo, S. R., Yun, M., Lee, M. K., Kong, M., Min, S., Kim, S. I., Lee, Y. C., Eun, Y., & Ko, S. (2021) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20289 · Cited by 25
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“ROS in high concentration could induce caspase 3/7 activation, triggering cellular processes associated with cell death (DNA damage with cell cycle arrest in different phases [92], nuclear condensation [93], blockage of DNA synthesis, and autophagy [88]).”
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Tsai, S., Lo, C.-Y., Yu, S.-Y., Chen, G. T. Y., Huang, H., Wang, L., & Liaw, J. (2022) · Nanoscale Research Letters · doi:10.1186/s11671-022-03761-w · Cited by 29
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“The generation of reactive oxygen species (ROS) after the ionization of intracellular compounds is one of the main factors leading to DNA damage [30,31].”
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“Inflammatory factors, ROS and other pathological factors can increase DNA damage under certain physiological conditions (Srinivas et al., 2019).”
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“In addition, as ROS have a short-half life, highly reactivity, and an electronegative oxygen, they can induce DNA damage and affect the DNA damage response [34].”
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“It has been proven that ROS induced DNA damage [32], which further induced senescence by activating cell cycle arrest p53– p21 axis [33].”
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“[15] Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD (2019) ROS and the DNA damage response in cancer.”
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Gong, Q., Li, X., Li, T., Wu, X., Hu, J., Yang, F., & Zhang, X. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202210001 · Cited by 23
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Zhao, X., Zhang, M., Wang, J., Ji, K., Wang, Y., Sun, X., Xu, C., Wang, Q., He, N., Song, H., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.267 · Cited by 27
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Background
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Liu, J., Zhou, T., Dong, X. D., Guo, Q., Zheng, L., Wang, X., Zhang, N., Li, D., Ren, L., Yi, F., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02667-w · Cited by 23
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Background
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“Further, the down-regulation of the repair genes in hypoxia could be linked to the low level of oxidative stress, since several studies have shown that oxidant injury, including H2O2, was able to influence DNA repair responses [16].”
BackgroundInfluential
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Chen, H., Xu, H., Lv, J., Chang, S., Wu, M., Chen, Z.-C., Shi-cheng, Z., He, Y. J., Qian, R., & Li, D. (2023) · ACS Sensors · doi:10.1021/acssensors.3c01203 · Cited by 23
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Sadoughi, F., Dana, P. M., Asemi, Z., & Yousefi, B. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1916876 · Cited by 22
Nanozyme-Powered Giant Unilamellar Vesicles for Mimicry and Modulation of Intracellular Oxidative Stress
Hu, X., Wang, X., Liu, Q., Wu, J., Zhang, H., Khalique, A., Sun, Z., Chen, R., Wei, J., Li, H., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c05512 · Cited by 22
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Qian, Y., Zhang, J., Xu, R., Li, Q., Shen, Q., & Zhu, G. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.204 · Cited by 23
Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage
Zhang, D.-F., Yang, Z., Chen, J., Jin, X., Qiu, Y., Chen, X., Shi, H.-Y., Liu, Z., Wang, M., Liang, G., et al. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03369-0 · Cited by 23
“FAK and ROS can affect DNA damage as well as the DNA damage response (DDR) [36, 37], and unbalanced DNA damage and repair will result in apoptosis and/or senescence [33].”
BackgroundInfluential
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“Free radicals are known mediators of DNA damage through oxidising nucleoside bases, leading to cell-cycle arrest, and either repair or apoptosis [12].”
Background
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“ROS production is strongly associated with the physiology of cancer [41], and most of the current chemotherapy treatments exploit this phenomenon to induce cancer cell death [42,43].”
Background
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Chuang, T., Shao, W., Hsu, S., Lee, S.-L., Kao, M., & Wang, V. (2023) · Molecules · doi:10.3390/molecules28031039 · Cited by 22
“After the H2AX phosphorylation, chromatin remodeling complexes and DNA repair proteins are recruited to DSB sites for DNA repair [7,9,10].”
Background
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Background
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Background
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“ROS-driven DNA damage causes genomic instability and impairs the DNA damage response [88].”
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“, 2017) which is considered as a mediator of DNA damage (Srinivas et al., 2019) and a signal molecule in tumors (Moloney & Cotter, 2018; Carvalho et al.”
Background
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“ROS production is recognized as hallmark of DNA damage (17).”
Background
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“ROSmediated oxidative stress typically leads to oxidation of molecules and cell components, resulting in severe cellular damage, which is also important synergistic anticancer mechanisms in this study.(47,48)”
Background
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Frasinyuk, M. S., Chhabria, D., Kartsev, V. G., Dilip, H., Sirakanyan, S. N., Kirubakaran, S., Petrou, A., Geronikaki, A. A., & Spinelli, D. (2022) · Molecules · doi:10.3390/molecules27144637 · Cited by 21
“, which result in genomic instability through either a single strand or a double strand break in their DNA [1].”
BackgroundInfluential
Shear stress enhances anoikis resistance of cancer cells through ROS and NO suppressed degeneration of Caveolin-1
Chen, X., Xia, Q., Sun, N., Zhou, H., Xu, Z., Yang, X., Yan, R., Li, P., Li, T., Qin, X., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.271 · Cited by 21
A mechanistic study of gold nanoparticles catalysis of O 2 reduction by ascorbate and hydroethidine, investigating reactive oxygen species reactivity
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Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment
Atiakshin, D., Kostin, A. A., Volodkin, A. V., Nazarova, A. A., Шишкина, В. В., Esaulenko, D., Buchwalow, I., Tiemann, M., & Noda, M. (2023) · Pharmaceuticals · doi:10.3390/ph16060817 · Cited by 20

Authors: Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. A., & Jeyasekharan, A. D.
Affiliations: National University of Singapore (SG)
National University Hospital (SG)
Corresponding author: Jeyasekharan, Anand D.
ORCID: Vellayappan, Balamurugan A.
Jeyasekharan, Anand D.
Venue: Redox Biology
Publisher: Elsevier BV
Published: 2019-07
Volume: 25
Pages: 101084
ISSN: 2213-2317 (ISSN-L)
DOI: 10.1016/j.redox.2018.101084
PMC: PMC6859528
OpenAlex: W2906120852
Cited by: 2,144
References: 153
Citations by year: 2026: 217 · 2025: 396 · 2024: 392 · 2023: 381 · 2022: 335 · 2021: 262 · 2020: 132 · 2019: 26
FWCI: 10.28
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Redox Biology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
National University of Singapore (submittedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Medical Research Council (NMRC/TA/0052/2016)
AstraZeneca
Ministry of Health -Singapore
Meso Scale Diagnostics
National Research Foundation Singapore
Ministry of Education - Singapore
Janssen Pharmaceuticals
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: reactive oxygen species, DNA damage response, cancer, DNA double-strand breaks, genotoxic stress, anticancer agents, ionizing radiation, radiosensitizers, combination therapy, oxidative DNA damage
MeSH terms: Animals, DNA Damage, DNA Repair, Humans, Neoplasms, Tumor Suppressor Protein p53, Apoptosis, Reactive Oxygen Species

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