Cited by 2,144Redox biology and oxidative stressDNA Repair MechanismsEffects of Radiation Exposure

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ROS and the DNA damage response in cancer

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Srinivas, Upadhyayula Sai, Tan, Bryce W.Q., Vellayappan, Balamurugan A., Jeyasekharan, Anand D.·2019·Redox Biology

DOI 10.1016/j.redox.2018.101084PMC PMC6859528

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Abstract

Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-containing molecules that can induce DNA damage and affect the DNA damage response (DDR). There is unequivocal pre-clinical and clinical evidence that ROS influence the genotoxic stress caused by chemotherapeutics agents and ionizing radiation. Recent studies have provided mechanistic insight into how ROS can also influence the cellular response to DNA damage caused by genotoxic therapy, especially in the context of Double Strand Breaks (DSBs). This has led to the clinical evaluation of agents modulating ROS in combination with genotoxic therapy for cancer, with mixed success so far. These studies point to context dependent outcomes with ROS modulator combinations with Chemotherapy and radiotherapy, indicating a need for additional pre-clinical research in the field. In this review, we discuss the current knowledge on the effect of ROS in the DNA damage response, and its clinical relevance.

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Surfing the p53 network
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 1×
“p53 is a well-studied tumor suppressor that is mutated in over 50% of all cancers [87,88], and affects multiple cellular responses to DNA U.”
Background
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · cited 1×
“This response includes DNA damage recognition, activation of checkpoints, cell cycle arrest, and eventually final outcomes of repair, apoptosis and immune clearance [4,5].”
Background
Radiobiology for the Radiologist.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · cited 1×
“Depending on the nature of the lesion in DNA, specific pathways are activated to facilitate identification of the damaged regions and their repair [2,3].”
Background
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303 · cited 1×
“to eventual T-cell mediated killing [116].”
Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,263
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555

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Callejas, B. E., Mendoza-Rodríguez, M., Cruz, O. V., Reyes-Martínez, S., Sánchez-Barrera, C. Á., Rodríguez‐Sosa, M., Delgado‐Buenrostro, N. L., Martínez‐Saucedo, D., Chirino, Y. I., León‐Cabrera, S., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32626 · Cited by 40
“The role played by neutrophils in inflammation-associated cancer relates to their strong capacity to produce ROS, which cause DNA damage.(22,23) To evaluate the activity of neutrophils infiltrated in colon tissue, we determined the expression of 8-hydroxyguanosine (8-Oxo-Gua), a well-known marker”
Background
Dietary Thiols: A Potential Supporting Strategy against Oxidative Stress in Heart Failure and Muscular Damage during Sports Activity
Brancaccio, M., Mennitti, C., Cesaro, A., Fimiani, F., Moscarella, E., Caiazza, M., Gragnano, F., Ranieri, A., D’Alicandro, G., Tinto, N., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249424 · Cited by 40
“In particular, ROS promote against DNA different dangerous action [38,39] such as: deoxyribose oxidation, strand breakage, removal of nucleotides, modification of bases and DNA-protein crosslinks; on the other hand, ROS also exhibits a dangerous action against protein [40], for example: increased susceptibility of the…”
Background
Emerging Applications of Ultrasound-Contrast Agents in Radiation Therapy
Lacerda, Q., Tantawi, M., Leeper, D. B., Wheatley, M. A., & Eisenbrey, J. R. (2021) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2021.01.032 · Cited by 40
DNA Damage/Repair Management in Cancers
Alhmoud, J. F., Woolley, J. F., Moustafa, A. A., & Mallei, M. I. (2021) · doi:10.1201/9781003180449-12 · Cited by 40
Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity
Ruszkiewicz, J. A., Bürkle, A., & Mangerich, A. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102037 · Cited by 42
“Thus, dysregulation of NAD + -dependent homeostasis is often deleterious and linked to diseases and cancer (4, 194, 195).”
BackgroundInfluential
DNA damage response in neurodevelopment and neuromaintenance
Qing, X., Zhang, G., & Wang, Z. (2022) · FEBS Journal · doi:10.1111/febs.16535 · Cited by 42
HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway
Li, B., Peng, W.-Q., Liu, Y., Guo, L., & Tang, Q. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112731 · Cited by 38
Radiation-Induced Intestinal Injury: Molecular Mechanisms and Therapeutic Status
Gao, D., Zhang, H., Sun, W., Wang, H., & Wang, H. (2024) · DNA and Cell Biology · doi:10.1089/dna.2024.0105 · Cited by 40
“…factor that regulates the expression of downstream genes, participating in maintaining cellular genomic stability, regulating the cell cycle and apoptosis processes (Gudkov & Komarova, 2003; Srinivas et al., 2019), and playing a crucial biological role in the occurrence of RIII (Nie et al., 2022).”
Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging
Zhou, N.-J., Bao, W.-Q., Zhang, C., Jiang, M., Liang, T.-L., Ma, G.-Y., Liu, L., Pan, H., & Li, R.-Z. (2025) · npj Aging · doi:10.1038/s41514-025-00250-z · Cited by 45
“Oxidative stress also activates key signaling pathways, such as p53 and ATM/ATR, promoting cell cycle arrest and apoptosis.”
An assessment of serum oxidative stress and antioxidant parameters in patients undergoing treatment for cervical cancer
Shrivastava, A., Mishra, S. P., Pradhan, S., Choudhary, S., Singla, S., Zahra, K., & Aggarwal, L. M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.037 · Cited by 39
Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms
Moslehi, M., Rezaei, S., Talebzadeh, P., Ansari, M. J., Jawad, M. A., Jalil, A. T., Rastegar‐Pouyani, N., Jafarzadeh, E., Taeb, S., & Najafi, M. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13725 · Cited by 39
“and DNA damage, immune cells also upregulate several pro-oxidant enzymes to potentiate ROS generation.(51)”
Background
Advances in Anti-Cancer Activities of Flavonoids in Scutellariae radix: Perspectives on Mechanism
Gu, Y., Zheng, Q., Fan, G., & Liu, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911042 · Cited by 40
“Therefore, it is feasible to kill cancer cells selectively by promoting excess ROS production and inducing mitochondrial dysfunction [19].”
Background
Mild hypothermia alleviates oxygen−glucose deprivation/reperfusion-induced apoptosis by inhibiting ROS generation, improving mitochondrial dysfunction and regulating DNA damage repair pathway in PC12 cells
Zhou, T., Mo, J., Xu, W., Hu, Q., Liu, H., Fu, Y., & Jiang, J. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01799-w · Cited by 38
“In addition, DNA damage is defined as physical or chemical changes in DNA within cells that affect the interpretation and transmission of genetic information [13].”
Background
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke
Zheng, H., Guo, X., Kang, S., Li, Z., Tian, T., Li, J., Wang, F., Yu, P., Chang, S., & Chang, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05688-1 · Cited by 39
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Li, Y., He, B., Zhang, C., He, Y., Xia, T., & Zeng, C. (2023) · Nutrients · doi:10.3390/nu15061340 · Cited by 38
“Then, the extracted RNA was reversely transcribed into cDNA according to the requirements of the reverse transcription kit (Takara Biotechnology, Dalian, China).”
BackgroundInfluential
Zwitterionic, Stimuli-Responsive Liposomes for Curcumin Drug Delivery: Enhancing M2 Macrophage Polarization and Reducing Oxidative Stress through Enzyme-Specific and Hyperthermia-Triggered Release
Basak, S., & Das, T. K. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01579 · Cited by 38
Anticancer effects and possible mechanisms of lycopene intervention on N-methylbenzylnitrosamine induced esophageal cancer in F344 rats based on PPARγ1
Cui, L., Xu, F., Wu, K., Li, L., Qiao, T., Li, Z., Chen, T., & Sun, C. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173230 · Cited by 38
Dynamics of replication origin over-activation
Fu, H., Redon, C. E., Thakur, B. L., Utani, K., Sebastian, R., Jang, S., Gross, J., Mosavarpour, S., Marks, A. B., Zhuang, S. Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23835-0 · Cited by 40
In situ observation of mitochondrial biogenesis as the early event of apoptosis
Shao, C., Zhou, X., Miao, Y., Wang, P., Zhang, Q., & Huang, Q. (2021) · iScience · doi:10.1016/j.isci.2021.103038 · Cited by 38
“…stress response by changing the expression of related nuclear genes, and certain level of ROS can save cells by maintaining energy metabolism (Srinivas et al., 2019); but when the ROS level exceeds the tolerant threshold, ROS can then induce the transition of mitochondrial membrane…”
Background
Inhibition of Growth of Colon Tumors and Proliferation of HT‐29 Cells by Warburgia ugandensis Extract through Mediating G0/G1 Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation
Zhang, Y., Chen, G., Zhuang, X., & Guo, M. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8807676 · Cited by 40
“In cancer cells, several factors including the increased metabolism, dysfunction of mitochondria, up-regulation of a number of well-known oncogenes (c-myc, k-ras, and BRAC1), hypoxia, and signaling associated with ROS production may promote the generation of ROS [24, 25].”
Background
Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target
Gillson, J., El-Aziz, Y. S. A., Leck, L. Y. W., Jansson, P. J., Pavlakis, N., Samra, J. S., Mittal, A., & Sahni, S. (2022) · Cancers · doi:10.3390/cancers14143528 · Cited by 38
LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway
Wei, C., Zhang, X., Peng, D., Zhang, X., Guo, H., Lu, Y., Luo, L., Wang, B., Li, Z., He, Y., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05393-5 · Cited by 37
ATM–ESCO2–SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex
Fu, J., Zhou, S., Xu, H., Liao, L., Shen, H., Du, P., & Zheng, X. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad533 · Cited by 41
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Dai, Y., & Chen, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1708358 · Cited by 44
“Excessive ROS not only causes direct tissue damage but also promotes monocyte polarization toward pro-in ﬂ ammatory M1 macrophages, aberrant activation of effector T cells, and full activation of the NLRP3 in ﬂ ammasome (243, 244).”
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Lama-Sherpa, T. D., & Shevde, L. A. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0665 · Cited by 37
“In addition, in conditions of chronic inflammation, ROS can downregulate BER by activating the inflammasome (64).”
Background
The β2-adrenergic receptor-ROS signaling axis: An overlooked component of β2AR function?
Rambacher, K. M., & Moniri, N. H. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113690 · Cited by 37
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Cal, M., Matyjaszczyk, I., Litwin, I., Augustyniak, D., Ogórek, R., Ko, Y. H., & Ułaszewski, S. (2020) · Cells · doi:10.3390/cells9051161 · Cited by 37
BiVO4/Fe3O4@polydopamine superparticles for tumor multimodal imaging and synergistic therapy
Wang, Z., Wang, G., Kang, T., Liu, S., Wang, L., Zou, H., Chong, Y., & Liu, Y. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00802-x · Cited by 37
Microbial Associations with Pancreatic Cancer: A New Frontier in Biomarkers
Stasiewicz, M., Kwaśniewski, M., & Karpiński, T. M. M. (2021) · Cancers · doi:10.3390/cancers13153784 · Cited by 39
“, cell growth, proliferation, genomic instability) [84].”
Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL‐7702 cells
Hacıoğlu, C. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22974 · Cited by 37
3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and abating DNA damage
Owumi, S. E., Najophe, E. S., & Otunla, M. T. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-21075-3 · Cited by 40
“When RONS are present at overwhelming concentrations, they hinder the innate antioxidant defense system, causing oxidative stress, DNA damage, and peroxidation of cellular lipids and protein, leading to cellular dysfunction (Pizzino et al. 2017; Srinivas et al. 2019; Su et al. 2019).”
Background
Intelligent design of polymer nanogels for full-process sensitized radiotherapy and dual-mode computed tomography/magnetic resonance imaging of tumors
Zhang, C., Tu, W., Chen, X., Xu, B., Li, X., Hu, C., Shen, M., Song, S., Jiang, C., Yao, S., et al. (2022) · Theranostics · doi:10.7150/thno.70346 · Cited by 37
“The induced oxidative stress can significantly influence the genetic stability, protein expression and cell cycle distribution, thereby making the cells more susceptible to the further RT treatment [33, 34].”
Background
Isolinderalactone sensitizes oxaliplatin-resistance colorectal cancer cells through JNK/p38 MAPK signaling pathways
Kwak, A., Park, J. W., Lee, S., Lee, J., Seo, J., Yoon, G., Lee, M., Choi, J., & Shim, J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154383 · Cited by 39
Comparison of antibacterial activity and cytotoxicity of silver nanoparticles and silver-loaded montmorillonite and saponite
Gil-Korilis, A., Cojocaru, M., Berzosa, M., Gamazo, C., Andrade, N. J., & Ciuffi, K. J. (2023) · Applied Clay Science · doi:10.1016/j.clay.2023.106968 · Cited by 38
Tumor microenvironment remodeling in oral cancer: Application of plant derived-natural products and nanomaterials
Budi, H. S., & Farhood, B. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116432 · Cited by 40
Roles of NRF2 in DNA damage repair
Li, J., Xu, C. S., & Liu, Q. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00834-5 · Cited by 36
“These mechanisms mainly consist of direct repair, base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), non-homologous end joining (NHEJ), and homologous recombination (HR) [1, 3].”
Background
Betulinic acid in the treatment of breast cancer: Application and mechanism progress
Mu, H., Sun, Y., Yuan, B., & Wang, Y. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105617 · Cited by 36
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Rong, X., Tang, Y., Cao, S., Xiao, S., Wang, H., Zhu, B., Huang, S., Adeli, M., Rodriguez, R. D. D., Cheng, C., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c00911 · Cited by 36
Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR
Schuhwerk, H., & Brabletz, T. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.11.009 · Cited by 35
Antitumor activity of Polygonatum sibiricum polysaccharides
Lai, W., Ning, Q., Wang, G., Gao, Y., Liao, S., & Tang, S. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01511-3 · Cited by 39
“Additionally, some studies have suggested that high levels of reactive oxygen species (ROS) and particular inflammatory cytokines in the body are closely linked to tumor development (Srinivas et al. 2019; Zhao et al. 2021).”
A combined ANXA2-NDRG1-STAT1 gene signature predicts response to chemoradiotherapy in cervical cancer
Buttarelli, M., Babini, G., Raspaglio, G., Filippetti, F., Battaglia, A., Ciucci, A., Ferrandina, G., Petrillo, M., Marino, C., Mancuso, M., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1268-y · Cited by 37
“On the whole, these data are particularly important in light of recent reports underlining a key role of dysregulated ROS in mediating chemoresistance and radio-resistance in clinical oncology [43].”
Background
A New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance
Goetting, I., Jendrossek, V., & Matschke, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228563 · Cited by 37
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Kwak, M. S., Rhee, W. J., Lee, Y. J., Kim, H. S., Kim, Y. H., Kwon, M. K., & Shin, J. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101858 · Cited by 37
Flurochloridone induces Sertoli cell apoptosis through ROS-dependent mitochondrial pathway
Sun, W., Ni, Z., Li, R., Chang, X., Li, W., Yang, M., & Zhou, Z. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112183 · Cited by 36
The prognostic outcome of ‘type 2 diabetes mellitus and breast cancer’ association pivots on hypoxia-hyperglycemia axis
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“Within this tumor promoting micro-environment, the build-up of ROS triggers DNA damage [194], and coupled with this, HIF1 also mediates inflammation promoting activities [195, 196].”
Background
Redox Control of the Dormant Cancer Cell Life Cycle
Li, B., Huang, Y., Ming, H., Nice, E. C., Xuan, R., & Huang, C. (2021) · Cells · doi:10.3390/cells10102707 · Cited by 35
“Early studies of redox biology encouraged the notion that ROS are the toxic byproduct in cell metabolism, while recent advances provide provocative insights into their role as intracellular signaling molecules at a low physiological level [23,24].”
Background
Limonin Alleviates Non-alcoholic Fatty Liver Disease by Reducing Lipid Accumulation, Suppressing Inflammation and Oxidative Stress
Li, Y., Yang, M., Lin, H., Yan, W., Deng, G., Ye, H., Shi, H., Wu, C., Ma, G., Xu, S., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.801730 · Cited by 36
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Huang, J., Zhu, Z., Ji, D., Sun, R., Yang, Y., Liu, L., Shao, Y., Chen, Y., Li, L., & Sun, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.792122 · Cited by 37
“Excessive ROS can damage a variety of biological components and even lead to DNA damage (34, 35).”
Background
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Zhang, C., Wang, C., Yang, Z., Bai, Y., Shukuya, T., Poh, M. E., Ekman, S., Li, J., Xu, Y., & Deng, S. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-318 · Cited by 40
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“Mechanistic studies found that the expression of ROS/ NLRP3 was associated with RISI [33, 34].”
Background
The Risk of Breast Cancer between Western and Mediterranean Dietary Patterns
Tsai, H.-H., Yu, J., Hsu, H.-M., Chu, C.-H., Chang, T.-M., Hong, Z., Feng, A., Fu, C., Hsu, K., Dai, M., et al. (2023) · Nutrients · doi:10.3390/nu15092057 · Cited by 39
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“Excessive ROS can cause damage to cells through mechanisms that involve cell apoptosis, autophagy, and cell arrest [28].”
Background
A double-edged sword: ROS related therapies in the treatment of psoriasis
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“The potential synergy of antioxidant and anticancer therapies remains an area of active research with insufficient available data [50,51,53,74,75,77].”
Background
Gut microbiota and radiation-induced injury: mechanistic insights and microbial therapies
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“6 In parallel, radiation-induced DNA damage activates cell cycle checkpoints and apoptotic pathways through ATM/ATR-p53 signaling.”
Mitophagy’s impacts on cancer and neurodegenerative diseases: implications for future therapies
Huang, J. B., Pham, V. T., Fu, S., Huang, G., Liu, Y., & Zheng, L. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01727-w · Cited by 42
In Vitro Antioxidant Activities of the Aqueous and Methanolic Stem Bark Extracts of Piliostigma thonningii (Schum.)
Moriasi, G. A., Ireri, A. M., & Ngugi, M. P. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20937988 · Cited by 37
“Furthermore, ominous consequences are imminent if growth regulating genes are turned off, as this can lead to uncontrolled growth, forming clusters of cells as evidenced in cancer.(15) The human body employs a vastly complex antioxidant defense mechanism to curb oxidative stress.”
Background
NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1
Lin, L.-C., Lee, H., Chien, P., Huang, Y.-H., Chang, M.-Y., Lee, Y., & Chang, W. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.45706 · Cited by 35
“The combination of β-lapachone with ionizing radiation in NQO1overexpressing MDA-MB-231 cells causes ROS generation, followed by JNK activation, through treatment-induced endoplasmic reticulum stress to trigger mitochondrial apoptotic cell death [11].”
Background
CCN2 Aggravates the Immediate Oxidative Stress–DNA Damage Response following Renal Ischemia–Reperfusion Injury
Valentijn, F. A., Knoppert, S. N., Pissas, G., Rodrigues-Díez, R. R., Márquez‐Expósito, L., Broekhuizen, R., Mokrý, M., Kester, L. A., Falke, L. L., Goldschmeding, R., et al. (2021) · Antioxidants · doi:10.3390/antiox10122020 · Cited by 34
“ROS induce DNA damage and, consequently, lead to a DNA damage response (DDR) to facilitate cell repair and regeneration of the injured tubules through DNA repair or apoptosis [8,9].”
Background
Targeting thioredoxin reductase by micheliolide contributes to radiosensitizing and inducing apoptosis of HeLa cells
Zhang, J., Chen, Y., & Fang, J. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.05.007 · Cited by 35
Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response
Lopez, K. E., & Bouchier‐Hayes, L. (2022) · Cells · doi:10.3390/cells11121887 · Cited by 38
“DSBs arise from both endogenous and exogenous sources, such as free radicals and ionizing radiation, respectively [7,8], as well as V(D)J recombination and class switch recombination (CSR) [9,10].”
Background
Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS
Alan, P., Vandevoorde, K. R., Joshi, B., Cardoen, B., Gao, G., Mohammadzadeh, Y., Hamarneh, G., & Nabi, I. R. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04585-8 · Cited by 36
“as, above a threshold, to apoptosis and tumor necrosis [9, 10].”
Background
Nanosystems for chemodynamic based combination therapy: Strategies and recent advances
Li, M., Zhang, W., Xu, X., Liu, G., Dong, M., Sun, K., & Zhang, P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1065438 · Cited by 35
“The over produced •OH, one type of cytotoxic reactive oxygen species (ROS), had strong oxidative activity and caused severe oxidative damage to induce tumor apoptosis by phospholipid peroxidation, mitochondrial dysfunctions, and DNA damage (Khan et al., 2012; Srinivas et al., 2019).”
Background
Exploring novel strategies to improve anti-tumour efficiency: The potential for targeting reactive oxygen species
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The future of cancer treatment: combining radiotherapy with immunotherapy
Dagar, G., Gupta, A., Shankar, A., Chauhan, R., Macha, M. A., Bhat, A. A., Das, D., Goyal, R., Bhoriwal, S. K., PANDITA, R. K., et al. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1409300 · Cited by 36
NADPH oxidase inhibition rescues keratinocytes from elevated oxidative stress in a 2D atopic dermatitis and psoriasis model
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Xeroderma Pigmentosum C (XPC) Mutations in Primary Fibroblasts Impair Base Excision Repair Pathway and Increase Oxidative DNA Damage
Fayyad, N., Kobaisi, F., Beal, D. M., Mahfouf, W., Ged, C., Morice‐Picard, F., Fayyad‐Kazan, M., Fayyad‐Kazan, H., Badran, B. M., Rezvani, H. R., et al. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.561687 · Cited by 34
Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction
Giacosa, S., Pillet, C., Séraudie, I., Guyon, L., Wallez, Y., Roelants, C., Battail, C., Evrard, B., Chalmel, F., Barette, C., et al. (2021) · Cancers · doi:10.3390/cancers13030576 · Cited by 43
“ROS are highly active oxygen-containing molecules that can induce DNA doublestrand breaks (DSBs) [81].”
Background
Titanium dioxide dental implants surfaces related oxidative stress in bone remodeling: a systematic review
Abdulhameed, E. A., Al-Rawi, N. H., Omar, M., Khalifa, N., & Samsudin, A. B. R. (2022) · PeerJ · doi:10.7717/peerj.12951 · Cited by 34
“as well as DNA, RNA, and proteins damage (Srinivas et al., 2019).”
Background
Repurposing Sulfasalazine as a Radiosensitizer in Hypoxic Human Colorectal Cancer
Kerkhove, L., Geirnaert, F., Rifi, A. L., Ka, L. L., Gutiérrez, A., Oudaert, I., Corbet, C., Gevaert, T., Dufait, I., & Ridder, M. D. (2023) · Cancers · doi:10.3390/cancers15082363 · Cited by 38
“Lastly, ROS are crucial for the generation of DNA damage following IR [23,26].”
Background
Cellular senescence and premature aging in Down Syndrome
Peng, L., Baradar, A. A., Aguado, J., & Wolvetang, E. J. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111824 · Cited by 36
Gentle Rhodamines for Live-Cell Fluorescence Microscopy
Liu, T., Kompa, J., Ling, J., Lardon, N., Zhang, Y., Chen, J., Reymond, L., Chen, P. R., Tran, M., Yang, Z., et al. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c00616 · Cited by 33
Sensitization to oxidative stress and G2/M cell cycle arrest by histone deacetylase inhibition in hepatocellular carcinoma cells
Lee, H., Chu, K., Moon, E., Kim, S. S., & Quan, F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.021 · Cited by 33
Prooxidative activity of plumbagin induces apoptosis in human pancreatic ductal adenocarcinoma cells via intrinsic apoptotic pathway
Pandey, K., Tripathi, S. K., Panda, M., & Biswal, B. K. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104788 · Cited by 33
Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol through the Modulation of EGFR and CSC Signaling Pathways
Doan, P., Musa, A., Murugesan, A., Sipilä, V., Candeias, N. R., Emmert‐Streib, F., Ruusuvuori, P., Granberg, K. J., Yli-Harja, O. P., & Kandhavelu, M. (2020) · Cells · doi:10.3390/cells9030681 · Cited by 33
Molecular connections between circadian rhythm and genome maintenance pathways
Kolinjivadi, A. M., Chong, S. T., & Ngeow, J. Y. Y. (2020) · Endocrine Related Cancer · doi:10.1530/erc-20-0372 · Cited by 32
TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure
Sha, C., Chen, L., Li, L., Li, T., Wei, H., Yang, M., Gao, W., Zhao, D., Chen, Q., Liu, Y., et al. (2021) · Aging · doi:10.18632/aging.203080 · Cited by 33
“Levels of ROS higher than physiological levels trigger GCs apoptosis, reduce the transfer of nutrients and survival factors to oocytes, thereby leading to apoptosis, and play a vital role in initiating follicular atresia [37, 38].”
Background
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Zhou, X., Wang, F., Wu, H., Chen, X., Zhang, Y., Lin, J., Cai, Y., Xiang, J., He, N., Hu, Z., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60401 · Cited by 33
“Firstly, ROS induces the mutations of cell DNA, causing damages to multiple components of DNA through the reactive chemical property [58]; secondly, ROS disturbs the normal protein functions by ROS-mediated cleavage of peptide and the nitrosylation of proteins, resulting in the dysfunction of related proteins [59, 60]…”
Background
Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways
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“ROS may cause dNA damage, lipid peroxidation and apoptosis of hepatocytes (40,41).”
Background
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Falnidamol and cisplatin combinational treatment inhibits non-small cell lung cancer (NSCLC) by targeting DUSP26-mediated signal pathways
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“Multiple lines of evidence indicate that excessive ROS may lead to apoptosis in cancer cells [43,44].”
Background
DNA Damage Response Alterations in Ovarian Cancer: From Molecular Mechanisms to Therapeutic Opportunities
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“The most prominent sources of endogenous damage are reactive oxygen species (ROS), which are mostly formed as a byproduct of mitochondrial respiration [16,17].”
Background
Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming
Pateras, I. S., Williams, C., Gianniou, D. D., Margetis, A. T., Avgeris, M., Rousakis, P., Legaki, A., Mirtschink, P., Zhang, W., Panoutsopoulou, K., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03935-9 · Cited by 33
“The cytotoxic effects elicited by common chemotherapeutics including doxorubicin are mainly mediated by the induction of double strand breaks (DSBs) which are the most lethal type of DNA damage.”
BackgroundInfluential
Recent Developments in Nanoparticle‐Based Photo‐Immunotherapy for Cancer Treatment
Guo, Z., Zhu, A. T., Fang, R. H., & Zhang, L. (2023) · Small Methods · doi:10.1002/smtd.202300252 · Cited by 34
Radiotherapy and radiosensitization in breast cancer: Molecular targets and clinical applications
Bhat, V., Pellizzari, S., Allan, A. L., Wong, E., Lock, M., Brackstone, M., Lohmann, A. E., Cescon, D. W., & Parsyan, A. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103566 · Cited by 31
Role of reactive oxygen species in myelodysplastic syndromes
Jing, Q., Zhou, C., Zhang, J., Zhang, P., Wu, Y., Zhou, J., Tong, X., Li, Y., Du, J., & Wang, Y. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00570-0 · Cited by 33
“However, a supraphysiological concentration of H 2 O 2 (above 100 nM) can irreversibly modify and cause permanent impairment of DNA, proteins, or biomole-cules [36, 37], eventually leading to cell growth arrest or even senescence and death, a condition known as OS (Fig.”
Background
Stimulus-responsive polysaccharide-based hydrogels: From design to biomedical applications
Li, Y., Ding, X., Hu, H., & Xu, F. (2024) · Precision medicine and engineering. · doi:10.1016/j.preme.2024.100001 · Cited by 35
CTC-neutrophil interaction: A key driver and therapeutic target of cancer metastasis
Hu, C., Long, L., Lou, J., Leng, M., Yang, Q., Xu, X. M., & Zhou, X. W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117474 · Cited by 34
A potent antibacterial and antitumor Zn–4Ag–2Se alloy for biodegradable orthopedic applications
Zhang, M., Li, F., Dai, Y., Lin, J., Zhang, X., Zhang, D., Li, Y., & Wen, C. (2025) · Rare Metals · doi:10.1007/s12598-025-03417-5 · Cited by 32
Interferon-α inducible protein 6 (IFI6) confers protection against ionizing radiation in skin cells
Jia, H., Mo, W., Hong, M. H., Jiang, S., Zhang, Y., He, D., Yu, D., Shi, Y., Cao, J., Xu, X., et al. (2020) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2020.09.003 · Cited by 31
Sour black mulberry (Morus nigra L.) causes cell death by decreasing mutant p53 expression in HT-29 human colon cancer cells
Erden, Y. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101113 · Cited by 32
Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression
Gong, T., Guo, Q., Li, X., Zhang, T., Liu, F.-H., He, X., Lin, B., & Wu, Q. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111533 · Cited by 32
The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review
Qin, X., Xu, X., Hou, X., Liang, R., Chen, L., Hao, Y., Gao, A., Du, X., Zhao, L., Shi, Y., et al. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.2006723 · Cited by 32
“However, surplus free radicals have adverse effects on the body, such as inducing DNA damage and affecting the DNA damage response (DDR) (Ardolino et al. 2011; Panikkanvalappil et al. 2013; Srinivas et al. 2019).”
Background
Good bacteria, oxidative stress and neurological disorders: Possible therapeutical considerations
Soheili, M., Alinaghipour, A., & Salami, M. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120605 · Cited by 33
Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fields
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Licochalcone B Induces ROS-Dependent Apoptosis in Oxaliplatin-Resistant Colorectal Cancer Cells via p38/JNK MAPK Signaling
Kwak, A., Kim, W., Lee, S., Yoon, G., Cho, S., Kim, K.-T., Lee, M., Choi, Y. H., Lee, J., Park, J. W., et al. (2023) · Antioxidants · doi:10.3390/antiox12030656 · Cited by 34
“Apoptosis may be triggered by ROS and/or exposure to xenobiotics such as chemotherapy drugs [15,31].”
BackgroundInfluential

Authors: Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. A., & Jeyasekharan, A. D.
Affiliations: National University of Singapore (SG)
National University Hospital (SG)
Corresponding author: Jeyasekharan, Anand D.
ORCID: Vellayappan, Balamurugan A.
Jeyasekharan, Anand D.
Venue: Redox Biology
Publisher: Elsevier BV
Published: 2019-07
Volume: 25
Pages: 101084
ISSN: 2213-2317 (ISSN-L)
DOI: 10.1016/j.redox.2018.101084
PMC: PMC6859528
OpenAlex: W2906120852
Cited by: 2,144
References: 153
Citations by year: 2026: 217 · 2025: 396 · 2024: 392 · 2023: 381 · 2022: 335 · 2021: 262 · 2020: 132 · 2019: 26
FWCI: 10.28
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Redox Biology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
National University of Singapore (submittedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Medical Research Council (NMRC/TA/0052/2016)
AstraZeneca
Ministry of Health -Singapore
Meso Scale Diagnostics
National Research Foundation Singapore
Ministry of Education - Singapore
Janssen Pharmaceuticals
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: reactive oxygen species, DNA damage response, cancer, DNA double-strand breaks, genotoxic stress, anticancer agents, ionizing radiation, radiosensitizers, combination therapy, oxidative DNA damage
MeSH terms: Animals, DNA Damage, DNA Repair, Humans, Neoplasms, Tumor Suppressor Protein p53, Apoptosis, Reactive Oxygen Species

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ROS and the DNA damage response in cancer

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