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Cited by 528Schizophrenia research and treatmentCardiac Health and Mental HealthCardiovascular Health and Risk Factors

A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls

Goff, Donald C., Sullivan, Lisa M., McEvoy, Joseph P., Meyer, Jonathan M., Nasrallah, Henry A., Daumit, Gail L., Lamberti, Steven, D'Agostino, Ralph B. +3 more·2005·Schizophrenia Research
DOI 10.1016/j.schres.2005.08.010
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Abstract

Objective Standardized mortality rates are elevated in schizophrenia compared to the general population. The incidence of coronary heart disease (CHD) and the relative contribution of CHD to increased mortality in schizophrenia patients are not clear, despite recent concerns about metabolic complications of certain atypical antipsychotics. Method Ten-year risk for CHD was calculated for 689 subjects who participated in the Clinical Trials of Antipsychotic Treatment Effectiveness (CATIE) Schizophrenia Trial at baseline using the Framingham CHD risk function and were compared with age-, race- and gender-matched controls from the National Health and Nutrition Examination Survey (NHANES) III. Results Ten-year CHD risk was significantly elevated in male (9.4% vs. 7.0%) and female (6.3% vs. 4.2%) schizophrenia patients compared to controls (p = 0.0001). Schizophrenia patients had significantly higher rates of smoking (68% vs. 35%), diabetes (13% vs. 3%), and hypertension (27% vs. 17%) and lower HDL cholesterol levels (43.7 vs. 49.3 mg/dl) compared to controls (p < 0.001). Only total cholesterol levels did not differ between groups. Ten-year CHD risk remained significantly elevated in schizophrenia patients after controlling for body mass index (p = 0.0001). Conclusions These results are consistent with recent evidence of increased cardiac mortality in schizophrenia patients. While the impact of cigarette smoking is clear, the relative contributions to cardiac risk of specific antipsychotic agents, diet, exercise, and quality of medical care remain to be clarified.

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  • The excess risk of cardiovascular disease in CATIE patients was partly explained by higher frequency of cigarette smoking, although relative contributions of specific antipsychotic agents, diet, exercise, and quality of medical care remain to be clarified.

    “The excess risk was concluded to be partly explained by a higher frequency of cigarette smoking, although the relative contributions to cardiac risk of specific antipsychotic agents, diet, exercise, and quality of medical care remain to be clarified.”

    From Excess early mortality in schizophrenia. (2014) · cites this paper as Goff et al. 2005

  • Goff et al. 2005 compared CATIE patients with matched controls and found higher risk of cardiovascular disease among patients.

    “Goff et al. (2005) compared patients with schizophrenia included in the Clinical Trials of Antipsychotic Treatment Effectiveness (CATIE) study with matched controls and found a higher risk of cardiovascular disease among the patients.”

    From Excess early mortality in schizophrenia. (2014) · cites this paper as Goff et al. 2005

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Authors
Goff, D. C., Sullivan, L. M., McEvoy, J. P., Meyer, J. M., Nasrallah, H. A., Daumit, G. L., Lamberti, S., D'Agostino, R. B., Stroup, T. S., Davis, S., & Lieberman, J. A.
Affiliations
Harvard University (US)
Corresponding author
Goff, Donald C.
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2005-12
Volume
80
Issue
1
Pages
45-53
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2005.08.010
OpenAlex
W2096463856
Cited by
528
References
5
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 15 · 2021: 19 · 2020: 16 · 2019: 27 · 2018: 21 · 2017: 19 · 2016: 30 · 2015: 31 · 2014: 31 · 2013: 41 · 2012: 36
FWCI
19.81
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01mh90001-21-0-0)
  • National Institute of Mental Health (N01 MH90001)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
schizophrenia, coronary artery disease
MeSH terms
Adolescent, Adult, Aged, Coronary Disease, Diabetes Mellitus, Female, Humans, Hypertension, Cholesterol, HDL, Male, Middle Aged, Risk Factors, Schizophrenia, Smoking, Antipsychotic Agents, Body Mass Index, Prevalence, Sex Distribution

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