Cited by 111Schizophrenia research and treatmentPhysical Activity and HealthMental Health and Psychiatry

The effects of physical exercise in schizophrenia and affective disorders.

Malchow, Berend, Reich-Erkelenz, Daniela, Oertel-Knöchel, Viola, Keller, Katriona, Hasan, Alkomiet, Schmitt, Andrea, Scheewe, Thomas W., Cahn, Wiepke +2 more·2013·European Archives of Psychiatry and Clinical Neuroscience

Abstract

Affective and non-affective psychoses are severe and frequent psychiatric disorders. Amongst others, they not only have a profound impact on affected individuals through their symptomatology, but also regarding cognition, brain structure and function. Cognitive impairment influences patients' quality of life as well as their ability to work and being employed. While exercise therapy has been implemented in the treatment of psychiatric conditions since the days of Kraepelin and Bleuler, the underlying mechanisms have never been systematically studied. Since the early 1990s, studies emerged examining the effect of physical exercise in animal models, revealing stimulation of neurogenesis, synaptogenesis and neurotransmission. Based on that body of work, clinical studies have been carried out in both healthy humans and in patient populations. These studies differ with regard to homogenous study samples, sample size, type and duration of exercise, outcome variables and measurement techniques. Based on their review, we draw conclusions regarding recommendations for future research strategies showing that modern therapeutic approaches should include physical exercise as part of a multimodal intervention programme to improve psychopathology and cognitive symptoms in schizophrenia and affective disorders.

Integrity signals

Registry

Crossref · 10.1007/s00406-013-0423-2

Cites

160 of 160 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • There is a distinct lack of systematic investigations into the relationship between AE and neuroplasticity, hippocampal functioning, and its impact on cognitive dysfunctions in psychiatric disorders such as MDD or schizophrenia.

    “Despite this, there is a distinct lack of systematic investigations (both animal and human) into the relationship between AE and neuroplasticity, hippocampal functioning, and its impact on cognitive dysfunctions in psychiatric disorders such as MDD (Malchow et al., 2013) or schizophrenia (Sommer and Kahn, 2015).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Malchow, B., Reich-Erkelenz, D., Oertel-Knöchel, V., Keller, K., Hasan, A., Schmitt, A., Scheewe, T. W., Cahn, W., Kahn, R. S., & Falkai, P.
Affiliations
  • Ludwig-Maximilians-Universität München (DE)
  • University of Göttingen (DE)
  • Universidade de São Paulo (BR)
  • Windesheim University of Applied Sciences (NL)
  • University Medical Center Utrecht (NL)
Corresponding author
Malchow, Berend
Venue
European Archives of Psychiatry and Clinical Neuroscience
Published
2013-07-20
Volume
263
Issue
6
Pages
451-467
ISSN
  • 0003-9373 (ISSN-L)
  • 0940-1334
  • 1433-8491
OpenAlex
W2052275405
Cited by
111
References
158
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 17 · 2016: 12 · 2015: 15 · 2014: 6 · 2013: 1
FWCI
1.54
Type
journal article
Language
en
Open access
closed
Locations
  • European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • GRO (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • OPUS (Augsburg University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
physical activity, schizophrenia, mood disorders, exercise therapy, cognitive impairment, neurogenesis, synaptogenesis, neurotransmission, multimodal intervention, animal models of psychosis, quality of life
MeSH terms
Brain, Humans, Schizophrenia, Exercise, Mood Disorders, Neurogenesis, Neuroimaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review