Cited by 124Schizophrenia research and treatmentNeuroendocrine regulation and behaviorOlfactory and Sensory Function Studies

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Effects of single dose intranasal oxytocin on social cognition in schizophrenia

Davis, Michael C., Lee, Junghee, Horan, William P., Clarke, Angelika D., McGee, Mark R., Green, Michael F., Marder, Stephen R.·2013·Schizophrenia Research

DOI 10.1016/j.schres.2013.04.023

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Abstract

Deficits in social cognition are common in schizophrenia and predict poor community functioning. Given the current limitations of psychosocial treatments and the lack of pharmacological treatments for social cognitive deficits, the development of novel therapeutic agents could greatly enhance functional recovery in schizophrenia. This study evaluated whether a single dose of intranasal oxytocin acutely improves social cognitive functioning in schizophrenia. Twenty-three male veterans with schizophrenia completed baseline assessments of social cognition that were divided into lower-level (facial affect perception, social perception, detection of lies) and higher-level (detection of sarcasm and deception, empathy) processes. One week later, patients received the same battery after being randomized to a single dose of 40 IU intranasal oxytocin or placebo. Though the groups did not differ significantly on the social cognition composite score, oxytocin improved performance for the higher-level social cognitive tasks (Cohen's d=1.0, p=0.045). Subjects were unable to accurately guess which treatment they had received. The improvements found in higher-level social cognition encourage further studies into the therapeutic potential of oxytocin in schizophrenia.

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Authors: Davis, M. C., Lee, J., Horan, W. P., Clarke, A. D., McGee, M. R., Green, M. F., & Marder, S. R.
Affiliations: University of California, Los Angeles (US)
Mental Illness Research, Education and Clinical Centers (US)
ORCID: Davis, Michael C.
Lee, Junghee
Horan, William P.
Green, Michael F.
Marder, Stephen R.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2013-07
Volume: 147
Issue: 2-3
Pages: 393-397
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2013.04.023
OpenAlex: W2156784242
Semantic Scholar: d1ad461fe2ca502ac557d8923274b6ca9c690779
Cited by: 124
References: 33
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 3 · 2019: 12 · 2018: 7 · 2017: 17 · 2016: 14 · 2015: 19 · 2014: 18 · 2013: 8
FWCI: 13.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: intranasal oxytocin, schizophrenia
MeSH terms: Administration, Intranasal, Adolescent, Adult, Aged, Cognition, Double-Blind Method, Empathy, Humans, Male, Middle Aged, Neuropsychological Tests, Oxytocin, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Social Behavior, Social Perception, Young Adult, Theory of Mind

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Effects of single dose intranasal oxytocin on social cognition in schizophrenia

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