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Phases of reprogramming
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“Taken together, these two attributes may act as the source of memory for initial cell identity during a time when the somatic transcriptional program is otherwise mostly repressed and somatic proteins such as CD13 are lost (Polo et al., 2012; David and Polo, 2014).”
From Multi-omic rejuvenation of human cells by maturation phase transient reprogramming (2022) · cites this paper as David and Polo, 2014
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Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., & Yamanaka, S. (2009) · Nature · doi:10.1038/nature08235 · Cited by 1,301
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
Marión, R. M., Strati, K., Li, H., Murga, M., Blanco, R., Ortega, S., Fernandez-Capetillo, O., Serrano, M., & Blasco, M. A. (2009) · Nature · doi:10.1038/nature08287 · Cited by 1,028 · cited 2×
“An example in mouse is telomere elongation back to an embryonic level (Marion et al., 2009b; Stadtfeld et al., 2008b).”
BackgroundA Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C. M., Lim, S. M., Borkent, M., Apostolou, E., Alaei, S., Cloutier, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.039 · Cited by 861
Self-citationDefining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse
Stadtfeld, M., Maherali, N., Breault, D. T., & Hochedlinger, K. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.02.001 · Cited by 823
A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells
Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J., Cowan, C., & Hochedlinger, K. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.08.003 · Cited by 563 · cited 1×
“To overcome this, secondary systems were implemented, and the resultant transgenic fibroblast could be reprogrammed through inducible expression of Oct4, Klf4, Myc and Sox2 (OKMS) (Carey et al., 2010; Maherali et al., 2008; Nagy, 2013; Stadtfeld et al., 2010; Woltjen et al., 2009).”
MethodDeterministic direct reprogramming of somatic cells to pluripotency
Rais, Y., Zviran, A., Geula, S., Gafni, O., Chomsky, E., Viukov, S., Mansour, A. A., Caspi, I., Krupalnik, V., Zerbib, M., et al. (2013) · Nature · doi:10.1038/nature12587 · Cited by 522
Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming
Singhal, N., Graumann, J., Wu, G., Araúzo-Bravo, M. J., Han, D. W., Greber, B., Gentile, L., Mann, M., & Schöler, H. R. (2010) · Cell · doi:10.1016/j.cell.2010.04.037 · Cited by 378 · cited 1×
“The recruitment of the polycomb group, the recruitment of Utx, and the loss of Mbd3 subunit of the NuRD complex have also been identified (Chen et al., 2013; Luo et al., 2013; Mansour et al., 2012; Rais et al., 2013; Singhal et al., 2010; Welstead et al., 2012).”
BackgroundX-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner
Welstead, G. G., Creyghton, M. P., Bilodeau, S., Cheng, A. W., Markoulaki, S., Young, R. A., & Jaenisch, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210787109 · Cited by 194
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Metadata
- Authors
- David, L., & Polo, J. M.
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 12
- Issue
- 3
- Pages
- 754-761
- ISSN
- 1873-5061
- Cited by
- 126
- References
- 8
- Language
- en
- Funders
- Pays-de-la-Loire (2011-12957)
- NHMRC (APP1036587)
- ARC
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