Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies

Sigurdsson, Einar M.

doi:10.3233/jad-2008-15202

Cited by 116Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies

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Sigurdsson, Einar M.·2008·Journal of Alzheimer's Disease

DOI 10.3233/jad-2008-15202PMC PMC2757121

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Abstract

Immunotherapies that target the amyloid-beta (Abeta) peptide in Alzheimer's disease (AD) have shown promise in animal and human studies. Although the first clinical trial was halted because of adverse reactions, this approach has been refined and additional trials are underway. Another important target in AD is the neurofibrillary tangles, composed primarily of hyperphosphorylated tau proteins, which correlate well with the degree of dementia. As Abeta and tau pathologies are likely synergistic, targeting both should be more effective and may be essential as early diagnosis prior to cognitive decline is currently not available. Also, Abeta immunotherapy only results in a very limited indirect clearance of tau aggregates in dystrophic neurites, showing the importance of developing a separate therapy that directly targets pathological tau. Our findings in two tangle mouse models indicate that immunization with a phospho-tau derivative reduces aggregated tau in the brain and slows progression of the tangle-related behavioral phenotype. These antibodies enter the brain and bind to pathological tau within neurons. We are currently clarifying further the mechanism of action of this promising therapeutic approach and determining its epitope specificity.

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Antibodies, including anti-tau antibodies, can enter neurons.
“However, several groups have reported that antibodies, including anti-tau antibodies, can enter neurons, and that extracellular tau might be important for the spread of tau pathology227–229.”
From Tau-targeting therapies for Alzheimer disease (2018) · cites this paper as [229]
Extracellular tau might be important for the spread of tau pathology.
“However, several groups have reported that antibodies, including anti-tau antibodies, can enter neurons, and that extracellular tau might be important for the spread of tau pathology227–229.”
From Tau-targeting therapies for Alzheimer disease (2018) · cites this paper as [229]

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Authors: Sigurdsson, E. M.
Affiliations: New York University (US)
Corresponding author: Sigurdsson, Einar M.
ORCID: Sigurdsson, Einar M.
Venue: Journal of Alzheimer's Disease
Publisher: SAGE Publications
Published: 2008-10-07
Volume: 15
Issue: 2
Pages: 157-168
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2008-15202
PMC: PMC2757121
OpenAlex: W1498285003
Cited by: 116
References: 134
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 18 · 2013: 8 · 2012: 7
FWCI: 7.67
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (R01AG020197, AG02197, AG032611, R01AG032611)
National Institute of Diabetes and Digestive and Kidney Diseases (DK075494, R21DK075494)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: tau immunotherapy, pathological tau
MeSH terms: Alzheimer Disease, Humans, Immunotherapy, tau Proteins, Neurodegenerative Diseases

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Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies

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