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Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
Open accessAbstract
Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency of iPSC derivation and the fact that most protocols modify the genome to effect cellular reprogramming. Moreover, safe and effective means of directing the fate of patient-specific iPSCs toward clinically useful cell types are lacking. Here we describe a simple, nonintegrating strategy for reprogramming cell fate based on administration of synthetic mRNA modified to overcome innate antiviral responses. We show that this approach can reprogram multiple human cell types to pluripotency with efficiencies that greatly surpass established protocols. We further show that the same technology can be used to efficiently direct the differentiation of RNA-induced pluripotent stem cells (RiPSCs) into terminally differentiated myogenic cells. This technology represents a safe, efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling, and regenerative medicine.
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“Using enhanced green fluorescent protein mRNA, Rossi and colleagues confirmed that nucleoside modifications can strongly enhance protein expression and suppress cytokine secretion.”
From Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals (2015) · cites this paper as [24]
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“Our work principally confirms that conventional unmodified mRNAs are inferior to molecules harboring specific nucleoside modifications as suggested by various recent reports,23,24,25,26,27 however, the picture changes dramatically with a sophisticated sequence-engineering.”
From Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals (2015) · cites this paper as [24]
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“Second, we studied the efficiency and robustness of cellular reprogramming of human fibroblasts to iPSCs with mRNA-encoded transcription factors, which is considered to benefit from prolonged mRNA stability.17,51”
From Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening (2019) · cites this paper as [51]
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Expression of a single transfected cDNA converts fibroblasts to myoblasts
Davis, R. L., Weintraub, H. M., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,388
Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.008 · Cited by 2,728
5'-Triphosphate RNA Is the Ligand for RIG-I
Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science · doi:10.1126/science.1132505 · Cited by 2,474
Reprogramming of human somatic cells to pluripotency with defined factors
Park, I.-H., Zhao, R., West, J. A., Yabuuchi, A., Huo, H., Ince, T. A., Lerou, P. H., Lensch, M. W., & Daley, G. Q. (2008) · Nature · doi:10.1038/nature06534 · Cited by 2,436
Self-citationHuman induced pluripotent stem cells free of vector and transgene sequences
Yu, J., Hu, K., Smuga-Otto, K., Tian, S., Stewart, R., Slukvin, I. I., & Thomson, J. A. (2009) · Science · doi:10.1126/science.1172482 · Cited by 2,386
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C. (2006) · Science · doi:10.1126/science.1132998 · Cited by 2,210
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Hertler, J., Slama, K., Schober, B., Özrendeci, Z., Marchand, V., Motorin, Y., & Helm, M. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac719 · Cited by 35
Preskey, D., Allison, T. F., Jones, M., Mamchaoui, K., & Unger, C. A. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.102 · Cited by 35
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Nsair, A., & MacLellan, W. R. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.013 · Cited by 35
Human Pluripotent Stem Cells: Applications and Challenges in Neurological Diseases
Hibaoui, Y., & Féki, A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00267 · Cited by 35
Koblas, T., Leontovyč, I., Loukotová, Š., Košinová, L., & Saudek, F. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.33 · Cited by 35
Sayed, N., Ospino, F., Himmati, F., Lee, J., Chanda, P. K., Mocarski, E. S., & Cooke, J. P. (2017) · Stem Cells · doi:10.1002/stem.2607 · Cited by 35
Wang, L., Chen, Y., Guan, C., Zhao, Z., Li, Q., Yang, J., Mo, J., Wang, B., Wu, W., Yang, X., et al. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0698-8 · Cited by 35
Steinle, H., Ionescu, T.-M., Schenk, S., Golombek, S., Kunnakattu, S.-J., Oezbek, M. T., Schlensak, C., Wendel, H. P., & Avci‐Adali, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051313 · Cited by 36
Correction of Down syndrome and Edwards syndrome aneuploidies in human cell cultures
Amano, T., Jeffries, E., Amano, M., Ko, A. C., Yu, H., & Ko, M. (2015) · DNA Research · doi:10.1093/dnares/dsv016 · Cited by 32
Transcriptome transfer provides a model for understanding the phenotype of cardiomyocytes
Kim, T. K., Sul, J., Peternko, N. B., Lee, J. H., Lee, M. T., Patel, V. V., Kim, J., & Eberwine, J. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101223108 · Cited by 35
Induced pluripotent stem cell-derived cardiomyocytes as models for genetic cardiovascular disorders
Josowitz, R., Carvajal‐Vergara, X., Lemischka, I. R., & Gelb, B. D. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834598ad · Cited by 34
Development of an All-in-One Inducible Lentiviral Vector for Gene Specific Analysis of Reprogramming
Yamaguchi, T., Hamanaka, S., Kamiya, A., Okabe, M., Kawarai, M., Wakiyama, Y., Umino, A., Hayama, T., Sato, H., Lee, Y.-S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041007 · Cited by 34
López-Serrano, C., Espin, A. T., Hernández, J., Palomo, A. B. A., Osete, J. R., Gasull, X., Edel, M. J., & Navarro, X. (2016) · Cell Transplantation · doi:10.3727/096368916x691312 · Cited by 34
Clinical potential of human-induced pluripotent stem cells
Kumar, D., Anand, T., & Kues, W. A. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9370-9 · Cited by 35
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Yang, Y., Wang, X., Hu, X., Kawazoe, N., Yang, Y., & Chen, G. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b20490 · Cited by 34
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Ihnatovych, I., Nayak, T. K., Ouf, A., Süle, N., Birkaya, B. G., Chaves, L. D., Auerbach, A. L., & Szigeti, K. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0375-z · Cited by 34
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Wang, A. Y. L., & Loh, C. Y. Y. (2019) · Cell Transplantation · doi:10.1177/0963689719886534 · Cited by 35
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Hu, X., Mao, C., Fan, L., Luo, H., Hu, Z., Zhang, S., Yang, Z., Zheng, H., Sun, H., Fan, Y., et al. (2020) · Stem Cells International · doi:10.1155/2020/1061470 · Cited by 36
Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins
Khalil, A. S., Yu, X., Umhoefer, J. M., Chamberlain, C. S., Wildenauer, L. A., Diarra, G. M., Hacker, T. A., & Murphy, W. L. (2020) · Science Advances · doi:10.1126/sciadv.aba2422 · Cited by 34
Moser, P. T., & Ott, H. C. (2014) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000131 · Cited by 36
Induced pluripotent stem cells: origins, applications, and future perspectives
Zhao, J. Y., Jiang, W., Sun, C., Hou, C., Yang, X., & Gao, J. (2013) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1300215 · Cited by 34
Control of Cellular Function by Reversible Photoregulation of Translation
Ogasawara, S. (2014) · ChemBioChem · doi:10.1002/cbic.201402495 · Cited by 34
Recent Advances in Retinal Stem Cell Therapy
Bhattacharya, S., Gangaraju, R., & Chaum, E. (2017) · Current Molecular Biology Reports · doi:10.1007/s40610-017-0069-3 · Cited by 34
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases
Antas, P., Carvalho, C., Cabral-Teixeira, J., de Lemos, L., & Seabra, M. C. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.11.009 · Cited by 34
Netsrithong, R., García-Pérez, L., & Themeli, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1325209 · Cited by 37
Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts
Kim, J., Kim, K.-P., Lim, K., Lee, S. C., Yoon, J., Song, G., Hwang, S. I., Schöler, H. R., Cantz, T., & Han, D. (2015) · Scientific Reports · doi:10.1038/srep15706 · Cited by 34
Widespread genome transcription: New possibilities for RNA therapies
Takahashi, H., & Carninci, P. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.139 · Cited by 34
Pluripotent stem cell-derived cochlear cells: a challenge in constant progress
Czajkowski, A., Mounier, A., Delacroix, L., & Malgrange, B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2950-5 · Cited by 34
Zhang, W., Liu, Y., Chin, J. M., & Phua, K. K. L. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.03.011 · Cited by 33
Wang, A. Y. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158148 · Cited by 34
Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis
Qin, N., Paisana, E., Langini, M., Picard, D. J., Malzkorn, B., Custódia, C., Cascão, R., Meyer, F.-D., Blümel, L., Göbbels, S., et al. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac068 · Cited by 33
Kaye, J., Reisine, T., & Finkbeiner, S. M. (2022) · Faculty Reviews · doi:10.12703/r/11-16 · Cited by 37
A novel strategy to derive iPS cells from porcine fibroblasts
Ruan, W., Han, J., Li, P., Cao, S.-Y., An, Y., Lim, B., & Li, N. (2011) · Science China Life Sciences · doi:10.1007/s11427-011-4179-5 · Cited by 34
mRNA Transfection of Mouse and Human Neural Stem Cell Cultures
McLenachan, S., Zhang, D., Palomo, A. B. A., Edel, M. J., & Chen, F. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083596 · Cited by 33
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Wu, Y., Mishra, A., Qiu, Z., Farnsworth, S. L., Tardif, S. D., & Hornsby, P. J. (2012) · Stem Cells International · doi:10.1155/2012/767195 · Cited by 34
Smith, D. K., He, M., Zhang, C., & Zheng, J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.006 · Cited by 34
Human induced pluripotent stem cells: A disruptive innovation
Vos, J. D., Bouckenheimer, J., Sansac, C., Lemaı̂tre, J.-M., & Assou, S. (2016) · Current Research in Translational Medicine · doi:10.1016/j.retram.2016.04.001 · Cited by 37
10th anniversary of iPS cells: the challenges that lie ahead
Aoi, T. (2016) · The Journal of Biochemistry · doi:10.1093/jb/mvw044 · Cited by 33
Hirayama, M., Ko, S. B. H., Kawakita, T., Akiyama, T., Goparaju, S. K., Soma, A., Nakatake, Y., Sakota, M., Chikazawa-Nohtomi, N., Shimmura, S., et al. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-016-0001-8 · Cited by 34
Clayton, Z. E., Sadeghipour, S., & Patel, S. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.038 · Cited by 32
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Isobe, K., Cheng, Z., Nishio, N., Thanasegaran, S., Tanaka, Y., & Ito, S. (2014) · New Biotechnology · doi:10.1016/j.nbt.2014.04.004 · Cited by 33
Kobold, S., Guhr, A., Kurtz, A., & Löser, P. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.03.002 · Cited by 32
Mehta, A. K., Verma, V., Nandihalli, M., Ramachandra, C. J. A., Sequiera, G. L., Sudibyo, Y., Chung, Y., Sun, W. Y., & SHIM, W. S. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103485 · Cited by 33
Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA
Lui, K. O., Zangi, L., & Chien, K. R. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.06.007 · Cited by 32
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Hussein, S. M. I., Nagy, K. V., & Nagy, A. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.37 · Cited by 32
Kadari, A., Lu, M., Li, M., Sekaran, T., Thummer, R. P., Guyette, N., Chu, V., & Edenhofer, F. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt435 · Cited by 32
Human induced pluripotent stem cells for monogenic disease modelling and therapy
Spitalieri, P., Talarico, V. R., Murdocca, M., Novelli, G., & Sangiuolo, F. C. (2016) · World Journal of Stem Cells · doi:10.4252/wjsc.v8.i4.118 · Cited by 34
Urine-derived induced pluripotent stem cells as a modeling tool to study rare human diseases
Shi, L., Cui, Y., Luan, J. Y., Zhou, X., & Han, J. (2016) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2016.01062 · Cited by 33
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Trevisan, M., Desole, G., Costanzi, G., Lavezzo, E., Palù, G., & Barzon, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010206 · Cited by 32
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Self-citationNakanishi, H., & Saito, H. (2020) · Nature Communications · doi:10.1038/s41467-020-15061-x · Cited by 32
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Teng, S., Liu, C., Krettek, C., & Jagodzinski, M. (2013) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2013.0301 · Cited by 32
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Peng, J., & Zeng, X. (2011) · Stem Cell Research & Therapy · doi:10.1186/scrt73 · Cited by 33
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Rao, M. S. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i22.3385 · Cited by 32
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Andreev, D. E., Terenin, I. M., Dmitriev, S. E., & Shatsky, I. N. (2015) · Gene · doi:10.1016/j.gene.2015.12.008 · Cited by 32
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Wong, S. Y., Soto, J., & Li, S. (2017) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2017.01.001 · Cited by 32
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de Leeuw, S., & Tackenberg, C. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0161-0 · Cited by 31
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Lei, X., Huang, A., Chen, D., Wang, X., Ji, R.-J., Wang, J., Zhang, Y., Zhang, Y., Lu, S., Zhang, K., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02394-x · Cited by 31
Bazley, F. A., Liu, C. F., Yuan, X., Hao, H., All, A. H., Angeles, A. D. L., Zambidis, E. T., Gearhart, J. D., & Kerr, C. L. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0100 · Cited by 31
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Liu, X., Li, C., Zheng, K., Zhao, X., Xu, X., Yang, A., Yi, M., Tao, H., Xie, B., Qiu, M. S., et al. (2020) · Cell Division · doi:10.1186/s13008-020-00068-z · Cited by 33
Ihnatovych, I., Birkaya, B. G., Notari, E., & Szigeti, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249668 · Cited by 31
Induced Pluripotent Stem Cell Technology: Trends in Molecular Biology, from Genetics to Epigenetics
Maali, A., Maroufi, F., Sadeghi, F., Atashi, A., Kouchaki, R., Moghadami, M., & Azad, M. (2021) · Epigenomics · doi:10.2217/epi-2020-0409 · Cited by 31
Tsujisaka, Y., Hatani, T., Okubo, C., Ito, R., Kimura, A., Narita, M., Chonabayashi, K., Funakoshi, S., Lucena-Cacace, A., Toyoda, T., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.05.003 · Cited by 31
Wang, C., Zhu, K., Li, J., Lai, H., Wang, C., & Lai, H. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s73961 · Cited by 31
Cardiac Cell Therapy: The Next (Re)Generation
Forte, E., Chimenti, I., Barile, L., Gaetani, R., Angelini, F., Ionta, V., Messina, E., & Giacomello, A. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9252-8 · Cited by 32
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Mochiduki, Y., & Okita, K. (2012) · Biotechnology Journal · doi:10.1002/biot.201100356 · Cited by 31
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Amos, P. J., Çağavi, E., & Qyang, Y. (2011) · Cells Tissues Organs · doi:10.1159/000331390 · Cited by 31
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Build to understand: synthetic approaches to biology
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Breckwoldt, K., Weinberger, F., & Eschenhagen, T. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.11.010 · Cited by 31
Induced Pluripotent Stem Cells in Dermatology: Potentials, Advances, and LimitationsPreprint
Bilousova, G., & Roop, D. R. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015164 · Cited by 31
Schaniel, C., Dhanan, P., Hu, B., Xiong, Y., Raghunandan, T., Gonzalez, D. M., Dariolli, R., D'Souza, S. L., Yadaw, A. S., Hansen, J., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.10.005 · Cited by 26
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Metadata
- Authors
- Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., Daley, G. Q., Brack, A. S., Collins, J. J., Cowan, C., Schlaeger, T. M., & Rossi, D. J.
- Affiliations
- Boston Children's Hospital (US)
- Harvard University (US)
- Boston University (US)
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Rossi, Derrick J.
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 7
- Issue
- 5
- Pages
- 618-630
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3656821
- OpenAlex
- W2098597036
- Cited by
- 2,662
- References
- 55
- Citations by year
- 2026: 74 · 2025: 67 · 2024: 89 · 2023: 81 · 2022: 109 · 2021: 153 · 2020: 148 · 2019: 130 · 2018: 178 · 2017: 167 · 2016: 201 · 2015: 208 · 2014: 235 · 2013: 264 · 2012: 288
- FWCI
- 106.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 989 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (U01HL100001)
- National Institute of Dental and Craniofacial Research (RL1DE01902, RL1DE019021)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- synthetic mRNA, somatic cell reprogramming, pluripotency, directed differentiation, myogenesis, antiviral response, disease modeling, regenerative medicine
- MeSH terms
- Cell Differentiation, Cells, Cultured, Humans, RNA, Messenger, Cell Lineage, Induced Pluripotent Stem Cells, Cellular Reprogramming
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