Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain
Open accessAbstract
Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains unknown when adult-born DGCs become involved in the cognitive processes. During neurogenesis, immature DGCs display distinctive physiological characteristics while undergoing morphological maturation before final integration into the neural circuits. The survival and activity of the adult-born DGCs can be influenced by the experience of the animal during a critical period when newborn DGCs are still immature. To assess the temporal importance of adult neurogenesis, we developed a transgenic mouse model that allowed us to transiently reduce the numbers of adult-born DGCs in a temporally regulatable manner. We found that mice with a reduced population of adult-born DGCs at the immature stage were deficient in forming robust, long-term spatial memory and displayed impaired performance in extinction tasks. These results suggest that immature DGCs that undergo maturation make important contributions to learning and memory.
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Adult-born neurons can influence hippocampus-dependent learning and memory.
“These adult-born neurons can influence certain forms of hippocampus-dependent learning and memory formation3536.”
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- Authors
- Deng, W., Saxe, M. D., Gallina, I. S., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-10-28
- Volume
- 29
- Issue
- 43
- Pages
- 13532-13542
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2787190
- OpenAlex
- W2075257572
- Cited by
- 493
- References
- 3
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 16 · 2023: 11 · 2022: 10 · 2021: 28 · 2020: 23 · 2019: 19 · 2018: 27 · 2017: 37 · 2016: 36 · 2015: 46 · 2014: 39 · 2013: 47 · 2012: 34
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health (NS-05050217)
- National Institute on Aging (AG 020938, R01AG020938)
- National Institute of Neurological Disorders and Stroke (R01NS052842, R01NS050217, NS-05052842, NS 05050217)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, dentate gyrus granule cells, hippocampus, neuronal maturation, spatial memory, learning, memory extinction, transgenic mouse model, critical period, long-term memory formation
- MeSH terms
- Animals, Brain, Conditioning, Classical, Extinction, Psychological, Fear, Female, Intermediate Filament Proteins, Learning, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Neurons, Neuropsychological Tests, Space Perception, Time Factors, Maze Learning, Dentate Gyrus, Mice, Adult Stem Cells, Nestin
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