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Secreted microRNAs: a new form of intercellular communication

Chen, Xi, Liang, Hongwei, Zhang, Junfeng, Zen, Ke, Zhang, Chen-Yu·2012·Trends in Cell Biology
DOI 10.1016/j.tcb.2011.12.001
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Abstract

In multicellular organisms, cell-to-cell communication is of particular importance for the proper development and function of the organism as a whole. Intensive studies over the past three years suggesting horizontal transfer of secreted microRNAs (miRNAs) between cells point to a potentially novel role for these molecules in intercellular communication. Using a microvesicle-dependent, or RNA-binding protein-associated, active trafficking system, secreted miRNAs can be delivered into recipient cells where they function as endogenous miRNAs, simultaneously regulating multiple target genes or signaling events. In this Opinion, we summarize recent literature on the biogenesis and uptake of secreted miRNAs, propose a possible working model for how secreted miRNAs might be sorted and transferred between cells and speculate on their biological significance.

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Metadata

Authors
Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C.-Y.
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2012-03
Volume
22
Issue
3
Pages
125-132
ISSN
0962-8924
DOI
10.1016/j.tcb.2011.12.001
Cited by
690
References
6
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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