Mitochondrial DNA damage and atherosclerosis

Yu, Emma P.K.; Bennett, Martin R.

doi:10.1016/j.tem.2014.06.008

Cited by 124Mitochondrial Function and PathologyAtherosclerosis and Cardiovascular DiseasesAutophagy in Disease and Therapy

Mitochondrial DNA damage and atherosclerosis

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Yu, Emma P.K., Bennett, Martin R.·2014·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2014.06.008

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Abstract

Mitochondria are often regarded as the cellular powerhouses through their ability to generate ATP, the universal fuel for metabolic processes. However, in recent years mitochondria have been recognised as critical regulators of cell death, inflammation, metabolism, and the generation of reactive oxygen species (ROS). Thus, mitochondrial dysfunction directly promotes cell death, inflammation, and oxidative stress and alters metabolism. These are key processes in atherosclerosis and there is now evidence that mitochondrial DNA (mtDNA) damage leads to mitochondrial dysfunction and promotes atherosclerosis directly. In this review we discuss the recent evidence for and mechanisms linking mtDNA defects and atherosclerosis and suggest areas of mitochondrial biology that are potential therapeutic targets.

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TLR9 interaction with mtDNA activates NF-kB signaling and increases pro-inflammatory cytokine expression.
“Interaction of TLR9 with mtDNA activates the nuclear factor kappa B (NF-jB) signaling and increases the expression of other pro-inflammatory cytokines such as tumor necrosis factor-a (TNF-a), interleukin (IL)-6, IL-1b (Julian et al, 2013;Yu & Bennett, 2014;Zhang et al, 2014).”
From Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency (2018) · cites this paper as Yu & Bennett, 2014

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Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570 · see citing works
“Indeed, mitochondria are one of the major sites of ROS generation and enhanced mitochondrial ROS has been associated with chronic inflammatory conditions 37 .”
Metabolism of vascular smooth muscle cells in vascular diseases
Shi, J., Yang, Y., Cheng, A., Xu, G., & He, F. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00220.2020 · Cited by 366 · see citing works
Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease
Castellani, C. A., Longchamps, R. J., Sun, J., Güallar, E., & Arking, D. E. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.06.004 · Cited by 350 · see citing works
“In CVD, mtDNA-CN was associated with the activation of proatherogenic genes, atherogenesis, plaque instability, thrombosis via LDL oxidation, and altered electrophysiology (Aggarwal and Makielski, 2013; Berliner and Heinecke, 1996; Erusalimsky, 2009; Jain et al., 2013; Liu et al., 2010; Lo et al., 2005; Sánchez-Santos…”
Background
Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?
van Horssen, J., van Schaik, P. E. M., & Witte, M. E. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.050 · Cited by 289 · see citing works
Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
Rodríguez‐Nuevo, A., Díaz‐Ramos, A., Noguera, E., Díaz‐Sáez, F., Duran, X., Muñoz, J. P., Romero, M., Plana, N., Sebastián, D., Tezze, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201796553 · Cited by 207 · see citing works
“Interaction of TLR9 with mtDNA activates the nuclear factor kappa B (NF-j B) signaling and increases the expression of other pro-inflammatory cytokines such as tumor necrosis factor-a (TNF-a ), interleukin (IL)-6, IL-1 b (Julian et al , 2013; Yu & Bennett, 2014; Zhang et al , 2014).”
Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs
Kang, E., Wang, X., Tippner-Hedges, R., Ma, H., Folmes, C. D. L., Gutiérrez, N. M., Lee, Y., Dyken, C. V., Ahmed, R., Li, Y., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.02.005 · Cited by 216 · see citing works
“…suggests that mtDNA mutations increase in frequency in a variety of aged human tissues, leading to a pathogenic loss of respiratory capacity (Yu and Bennett, 2014), the extent and role of detectable high-level heteroplasmic or homoplasmicmtDNAmutations remains uncertain (Schon et al., 2012).”
Background
Mitochondrial DNA in the regulation of innate immune responses
Fang, C., Wei, X., & Wei, Y. (2015) · Protein & Cell · doi:10.1007/s13238-015-0222-9 · Cited by 169 · see citing works
“Mitochondrial DNA, similar to that of its bacterial ancestor’s, consists of a circular loop and contains significant number of unmethylated DNA as CpG islands (Yu and Bennett, 2014).”
Influential
Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
Chen, B., Li, H., Ou, G., Ren, L., Yang, X., & Zeng, M. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1974-z · Cited by 159 · see citing works
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases
Pham, P. T., Fukuda, D., Nishimoto, S., Kim‐Kaneyama, J., Lei, X., Takahashi, Y., Sato, T., Tanaka, K., Suto, K., Kawabata, Y., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab249 · Cited by 151 · see citing works
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
Yang, L., Youngblood, H. A., Wu, C., & Zhang, Q. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00197-z · Cited by 143 · see citing works
Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation
Chiong, M., Cartes-Saavedra, B., Norambuena‐Soto, I., Mondaca‐Ruff, D., Morales, P. E., García-Miguel, M., & Mellado, R. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00072 · Cited by 137 · see citing works
“Mitochondria has four compartments: the outer mitochondrial membrane (OMM), the intermembrane space (IMS), the inner mitochondrial membrane (IMM), and the mitochondrial matrix (Scheffler, 2001).”
Background
Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still’s disease
Hu, Q., Shi, H., Zeng, T., Liu, H., Su, Y., Cheng, X., Ye, J., Yin, Y., Liu, M., Zheng, H. W., et al. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1800-z · Cited by 134 · see citing works
The sensing of mitochondrial DAMPs by non-immune cells
Rodríguez‐Nuevo, A., & Antonio Zorzano, A. (2019) · Cell Stress · doi:10.15698/cst2019.06.190 · Cited by 113 · see citing works
“Several studies have reported the relevance of circulating or extracellular mtDNA in TLR9dependent inflammation in diseases such as rheumatoid arthritis [122], atherosclerosis [10, 123], acute liver injury [71], and Streptococcus pneumoniae infections [124], among others [10, 62, 125–129].”
Background
Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease
Fetterman, J. L., Holbrook, M., Westbrook, D. G., Brown, J. A., Feeley, K. P., Bretón‐Romero, R., Linder, E. A., Berk, B. D., Weisbrod, R. M., Widlansky, M. E., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0372-y · Cited by 106 · see citing works
“Damage to mitochondrial DNA has been shown to mediate mitochondrial dysfunction including alterations in calcium handling, oxidant-mediated activation of cell stress pathways, and metabolic disturbances [5, 11, 12, 18].”
Background
Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine
Fang, C., Mo, F., Liu, L., Du, J., Luo, M., Men, K., Na, F., Wang, W., Yang, H., & Wei, X. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0456-1 · Cited by 99 · see citing works
“islands.(20) Given that mtDNA lacks the repair proteins and protective histones found in nuclear DNA (nDNA), mtDNA is more easily attacked by reactive oxygen species (ROS),(21,22) which are byproducts of mitochondrial respiration.”
Background
Sleep and biological aging: A short review
Carroll, J., & Prather, A. A. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.021 · Cited by 93 · see citing works
The role of mitochondrial DNA damage in the development of atherosclerosis
Yu, E., & Bennett, M. R. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.011 · Cited by 90 · see citing works
Self-citation
PM2.5 aggravates the lipid accumulation, mitochondrial damage and apoptosis in macrophage foam cells
Liu, J., Liang, S., Du, Z., Zhang, J., Sun, B., Zhao, T., Yang, X., Shi, Y., Duan, J., & Sun, Z. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.03.045 · Cited by 89 · see citing works
Mitochondrial Dysfunction in Vascular Wall Cells and Its Role in Atherosclerosis
Salnikova, D. I., Orekhova, V. A., Grechko, A. V., Starodubova, A. V., Bezsonov, E. E., Попкова, Т. В., & Orekhov, A. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168990 · Cited by 84 · see citing works
“Mitochondrial oxidative stress can exacerbate mitochondrial dysfunction by damaging mtDNA and organelle structures therefore forming a vicious cycle [14,16].”
Background
Mitochondrial Dysfunction in Cardiovascular Diseases
Yang, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051917 · Cited by 86 · see citing works
“Elevated ROS levels in atherosclerotic plaques have been linked to increased oxidative stress and inflammation [83].”
Intra-Peritoneal Administration of Mitochondrial DNA Provokes Acute Lung Injury and Systemic Inflammation via Toll-Like Receptor 9
Zhang, L., Deng, S., Zhao, S., Ai, Y., Zhang, L., Pan, P., Su, X., Tan, H., & Wu, D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091425 · Cited by 78 · see citing works
“MtDNA, similar to that of its bacterial ancestors, consists of a circular loop and contains a significant amount of un-methylated DNA present as CpG islands [14].”
Background
Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care
Carroll, J., Bower, J. E., & Ganz, P. A. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00580-3 · Cited by 79 · see citing works
PCSK9: A novel inflammation modulator in atherosclerosis?
Tang, Z., Li, T., Peng, J., Zheng, J., Li, T., Liu, L., Jiang, Z., & Zheng, X. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27254 · Cited by 73 · see citing works
“A positive bi‐directional interaction was demonstrated between PCSK9 and mitochondrial DNA (mtDNA) damage in VSMCs treated with LPS (Ding et al., 2016). mtDNA damage leads to inflammation, oxidative stress, and apoptosis, which directly contribute to atherosclerosis (Yu & Bennett, 2014, 2016).”
Background
Protective Mechanisms of Mitochondria and Heart Function in Diabetes
Aon, M. A., Tocchetti, C. G., Bhatt, N., Paolocci, N., & Cortassa, S. C. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6123 · Cited by 70 · see citing works
“Another important mechanism of hyperglycemic damage involves alterations in mitochondrial DNA (mtDNA) that encodes 37 genes, among them 13 essential OxPhos components (198), thus potentially causing energetic failure and contributing to atherosclerosis (215).”
Association between leukocyte mitochondrial DNA content and risk of coronary heart disease: A case-control study
Chen, S., Xie, X., Wang, Y., Gao, Y., Xie, X., Yang, J., & Ye, J. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.08.051 · Cited by 70 · see citing works
“MtDNA content decrease leads to excess mitochondrial ROS production and subsequently causes transactivation of proatherogenic genes such as plasminogen activator inhibitor-1 (PAI-1), transforming growth factor b1(TGF-b1), vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1), sugges…”
Background
Research progress on the pharmacological effects of berberine targeting mitochondria
Fang, X., Wu, H., Wei, J., Miao, R., Zhang, Y., & Tian, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.982145 · Cited by 72 · see citing works
Control of mitochondrial function and cell growth by the atypical cadherin Fat1
Cao, L. L., Riascos‐Bernal, D. F., Chinnasamy, P., Dunaway, C. M., Hou, R., Pujato, M. A., O'Rourke, B. P., Miskolci, V., Guo, L., Hodgson, L., et al. (2016) · Nature · doi:10.1038/nature20170 · Cited by 67 · see citing works
Emerging role of mitochondria in airborne particulate matter-induced immunotoxicity
Sharma, J., Parsai, K., Raghuwanshi, P., Ali, S. A., Tiwari, V., Bhargava, A., & Mishra, P. K. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116242 · Cited by 66 · see citing works
Mechanisms of Atherosclerosis Induced by Postprandial Lipemia
Zhao, Y., Liu, L., Yang, S., Liu, G., Pan, L., Gu, C., Wang, Y., Li, D. X., Zhao, R., & Wu, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.636947 · Cited by 62 · see citing works
Role of macrophage extracellular traps in innate immunity and inflammatory disease
Rasmussen, K. H., & Hawkins, C. L. (2022) · Biochemical Society Transactions · doi:10.1042/bst20210962 · Cited by 62 · see citing works
Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications
Wu, L., Sowers, J. R., Zhang, Y., & Ren, J. T. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac080 · Cited by 63 · see citing works
Glucagon-like peptide-1 receptor agonist dulaglutide prevents ox-LDL-induced adhesion of monocytes to human endothelial cells: An implication in the treatment of atherosclerosis
Chang, W. C., Zhu, F., Zheng, H., Zhou, Z., Miao, P., Zhao, L., & Mao, Z. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.09.021 · Cited by 60 · see citing works
Mitochondrial fidelity and metabolic agility control immune cell fate and function
Sack, M. N. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120845 · Cited by 54 · see citing works
Mitochondrial regulation of macrophage cholesterol homeostasis
Graham, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.010 · Cited by 54 · see citing works
Senescence in Vascular Smooth Muscle Cells and Atherosclerosis
Zha, Y., Zhuang, W., Yang, Y., Zhou, Y., Li, H., & Liang, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.910580 · Cited by 55 · see citing works
“Nevertheless, long-term mtDNA damage leads to mitochondrial dysfunction and more damaging ROS production, which induces cellular senescence and hastens atherosclerosis development (34).”
Background
Nanoparticles and danger signals: Oral delivery vehicles as potential disruptors of intestinal barrier homeostasis
Vita, A. A., Royse, E. A., & Pullen, N. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mir1118-414rr · Cited by 51 · see citing works
The alterations of mitochondrial DNA in coronary heart disease
Hu, H., Lin, Y., Xu, X., Lin, S., Chen, X., & Wang, S. (2020) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2020.104412 · Cited by 51 · see citing works
Copper-dependent biological effects of particulate matter produced by brake systems on lung alveolar cells
Figliuzzi, M., Tironi, M., Longaretti, L., Mancini, A., Teoldi, F., Sangalli, F., & Remuzzi, A. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02812-4 · Cited by 50 · see citing works
Oxidative burden in familial hypercholesterolemia
Mollazadeh, H., Carbone, F., Montecucco, F., Pirro, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26466 · Cited by 47 · see citing works
“Moreover, mtDNA damage induces VSMC apoptosis and accelerates all aspects of atherosclerosis in particular plaque rupture and mitochondrial outer membrane permeabilization (MPTP) opening and apoptosis (Emma & Bennett, 2014).”
Background
Mitochondrial DNA copy number is associated with all‐cause mortality and cardiovascular events in patients with peripheral arterial disease
Koller, A., Fazzini, F., Lamina, C., Rantner, B., Kollerits, B., Stadler, M., Klein-Weigel, P. F., Fraedrich, G., & Kronenberg, F. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13027 · Cited by 47 · see citing works
Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway
Jiang, W., Geng, H., Lv, X., Ma, J., Liu, F., Lin, P., & Yan, C. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07018-5 · Cited by 45 · see citing works
Mechanotranduction Pathways in the Regulation of Mitochondrial Homeostasis in Cardiomyocytes
Liao, H., Qi, Y., Ye, Y., Yue, P., Zhang, D., & Li, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.625089 · Cited by 44 · see citing works
“MtDNA damage further stimulates the production of ROS, forming a vicious cycle and aggravating the damage of CMs (Yu and Bennett, 2014; Lee et al., 2017).”
Background
Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance
Zhang, C., Guan, R., Liao, X., Ouyang, C., Liu, J., Ji, L., & Chao, H. (2020) · Inorganic Chemistry Frontiers · doi:10.1039/d0qi00224k · Cited by 42 · see citing works
Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity
Kausar, S., Yang, L., Abbas, M. N., Hu, X., Zhao, Y., Zhu, Y., & Cui, H. (2020) · Genes · doi:10.3390/genes11010086 · Cited by 40 · see citing works
“Due to common ancestors, DNA of mitochondria shares characteristic features with the bacterial genome, as mitochondrial DNA also consists of unmethylated DNA as CpG islands [6].”
Background
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction
Okui, T., Iwashita, M., Rogers, M. A., Halu, A., Atkins, S. K., Kuraoka, S., Abdelhamid, I., Higashi, H., Ramsaroop, A., Aikawa, M., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315007 · Cited by 41 · see citing works
Mitochondrial DNA Leakage Caused by Streptococcus pneumoniae Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells
Gao, Y., Xu, W., Dou, X., Wang, H., Zhang, X., Yang, S., Liao, H., Hu, X., & Wang, H. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00630 · Cited by 39 · see citing works
“In atherosclerosis, oxidative damage and replication errors are the sources of mtDNA defects, which lead to mitochondrial dysfunction and directly promote atherosclerosis (Yu and Bennett, 2014).”
Background
Circulating cell-free mitochondrial DNA as the probable inducer of early endothelial dysfunction in the prediabetic patient
Alvarado‐Vásquez, N. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.05.010 · Cited by 39 · see citing works
“Recently, a review on the role of mtDNA in the development of atherosclerosiswas published (Yu and Bennett, 2014).”
Background
The Role of Mitochondrial DNA in the Development of Ischemia Reperfusion Injury
Hu, Q., Zhou, Q., Wu, J., Wu, X., & Ren, J. (2018) · Shock · doi:10.1097/shk.0000000000001190 · Cited by 38 · see citing works
Cellular Mechanisms of Human Atherogenesis: Focus on Chronification of Inflammation and Mitochondrial Mutations
Markin, A. M., Sobenin, I. A., Grechko, A. V., Zhang, D., & Orekhov, A. N. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00642 · Cited by 39 · see citing works
Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease
Volobueva, A. S., Grechko, A. V., Yet, S., Sobenin, I. A., & Orekhov, A. N. (2019) · Biomolecules · doi:10.3390/biom9080377 · Cited by 38 · see citing works
“Mitochondrial dysfunction promotes lipolysis and the increase of serum free fatty acids and glycerol [10].”
Background
Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications
Tracy, E. P., Hughes, W. E., Beare, J. E., Rowe, G., Beyer, A., & LeBlanc, A. J. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0031 · Cited by 38 · see citing works
COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity
Jia, Y., Wang, M., Mao, C., Yu, F., Wang, Y., Xiao, R., Jiang, C., Zheng, L., Xu, Q., Zheng, M., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0703-x · Cited by 35 · see citing works
Immunostimulatory role of mitochondrial DAMPs: alarming for pre-eclampsia?
McCarthy, C., & Kenny, L. C. (2016) · American Journal of Reproductive Immunology · doi:10.1111/aji.12526 · Cited by 33 · see citing works
Understanding the intricacies of cellular senescence in atherosclerosis: Mechanisms and therapeutic implications
Ali, I., Zhang, H., Zaidi, S. A. A., & Zhou, G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102273 · Cited by 34 · see citing works
Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis
Dorighello, G. G., Paim, B. A., Kiihl, S. F., Ferreira, M. S., Catharino, R. R., Vercesi, A. E., & Oliveira, H. C. F. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7843685 · Cited by 31 · see citing works
“It has been well recognized that mitochondrial dysfunctions such as opening of the permeability transition pore directly promote inflammation and oxidative stress, phenomena involved in several cardiometabolic diseases [8, 9, 12].”
Background
Significant Association Between Low Mitochondrial DNA Content in Peripheral Blood Leukocytes and Ischemic Stroke
Lien, L., Chiou, H., Yeh, H., Chiu, S., Jeng, J., Lin, H., Hu, C., Hsieh, F., & Wei, Y. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006157 · Cited by 31 · see citing works
“Decreased mtDNA content was reported to result in excess mitochondrial ROS production.(33) Increased production of ROS, in turn, leads to oxidative damage to lipids, proteins, and mtDNA.”
Background
Neutrophil-derived mitochondrial DNA promotes receptor activator of nuclear factor κB and its ligand signalling in rheumatoid arthritis
Contis, A., Mitrovic, S., Lavie, J., Douchet, I., Lazaro, E., Truchetet, M., Goizet, C., Contin‐Bordes, C., Schaeverbeke, T., Blanco, P., et al. (2017) · Rheumatology · doi:10.1093/rheumatology/kex041 · Cited by 30 · see citing works
Honokiol inhibits carotid artery atherosclerotic plaque formation by suppressing inflammation and oxidative stress
Liu, Y., Peng, C., & Wu, A. (2020) · Aging · doi:10.18632/aging.103120 · Cited by 30 · see citing works
“suggested that mitochondria [7], endothelial dysfunction [8], and interplay between inflammation and immune cells [9, 10] are associated with AS progression.”
Background
Mitochondrial [dys]function; culprit in pre-eclampsia?
McCarthy, C., & Kenny, L. C. (2016) · Clinical Science · doi:10.1042/cs20160103 · Cited by 29 · see citing works
Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine
Wang, J., Lin, F., Guo, L., Xiong, X., & Fan, X. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/143145 · Cited by 28 · see citing works
“Mitochondria have been recognised as critical regulators of cell death, generation of ATP, and the generation of reactive oxygen species (ROS), and mtDNA damage leads to mitochondrial dysfunction and promotes atherosclerosis directly [43].”
Background
Effects of simvastatin, ezetimibe and simvastatin/ezetimibe on mitochondrial function and leukocyte/endothelial cell interactions in patients with hypercholesterolemia
Hernández‐Mijares, A., Bañuls, C., Rovira‐Llopis, S., Díaz‐Morales, N., Escribano‐López, I., de Pablo, C., Álvarez, Á., Veses, S., Rocha, M., & Víctor, V. M. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.044 · Cited by 28 · see citing works
“Oxidative stress, mitochondrial dysfunction and inflammation are related to cardiovascular diseases (CVD) and atherogenesis [1].”
Background
Mediating effects of platelet-derived extracellular vesicles on PM2.5-induced vascular endothelial injury
Kong, L., Li, K., Gao, L., Yin, A., Zhou, L., Teng, G., & Huang, P. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110652 · Cited by 28 · see citing works
Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside
Li, S., Hu, Q., Huang, J., Wu, X., & Ren, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6914849 · Cited by 28 · see citing works
“Mitochondrial damage promotes the release of mtDNA into the cytoplasm, consequently activating NLRP3 inflammasome and upregulating IL-1β and IL-18 inflammatory factors by caspase-1 [43, 44].”
Background
Erythrocytes: Member of the immune system that should not be ignored
Ren, Y., Yan, C., & Yang, H. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104039 · Cited by 28 · see citing works
Heteroplasmic Variants of Mitochondrial DNA in Atherosclerotic Lesions of Human Aortic Intima
Sobenin, I. A., Zhelankin, A. V., Khasanova, Z. B., Sinyov, V. V., Medvedeva, L. V., Sagaidak, M. O., Makeev, V. J., Kolmychkova, K. I., Smirnova, A. S., Sukhorukov, V. N., et al. (2019) · Biomolecules · doi:10.3390/biom9090455 · Cited by 29 · see citing works
“The accumulating global data on the mtDNA damage in atherosclerosis [62,63] make this hypothesis plausible, taking in account the role of increased oxidative stress as the mechanistic factor of atherosclerotic risk.”
Background
Carbonyl cyanide 3-chlorophenylhydrazone induced the imbalance of mitochondrial homeostasis in the liver of Megalobrama amblycephala: A dynamic study
Zhang, L., Zheng, X., Huang, Y., Ge, Y., Sun, M., Chen, W., Liu, W., & Li, X. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109003 · Cited by 26 · see citing works
Mitochondria as novel mediators linking gut microbiota to atherosclerosis that is ameliorated by herbal medicine: A review
Li, Y., Yang, S., Jin, X., Li, D. X., Lu, J., Wang, X., & Wu, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1082817 · Cited by 26 · see citing works
“Thus, mitochondria are often targeted for bacterial attack and show functional abnormalities, including mitochondrial reactive oxygen species (mtROS)-induced oxidative stress, mitochondrial DNA (mtDNA) mutation and release, and imbalance of mitochondrial dynamics, further contributing to arterial wall cell damage, inf…”
Background
Advances in the study of the molecular biological mechanisms of radiation-induced brain injury.
Chen, G., Li, W. J., Xu, J., Pang, L., Tang, L., Yu, S., Li, A., Ge, H., Huang, R., & Cheng, H. (2023) · PubMed Central · Cited by 23 · see citing works
Dietary modulation of mitochondrial DNA damage: implications in aging and associated diseases
Lam, J., & McKeague, M. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.003 · Cited by 23 · see citing works
Trimetazidine Protects Against Atherosclerosis by Changing Energy Charge and Oxidative Stress
Zheng, S., Du, Y., Peng, Q., Fan, X., Li, J., & Chen, M. (2018) · Medical Science Monitor · doi:10.12659/msm.911317 · Cited by 23 · see citing works
“Recent studies suggested that the development of atherosclerosis is also accompanied by energy depletion [9,10].”
Background
Lack of mitochondrial NADP(H)-transhydrogenase expression in macrophages exacerbates atherosclerosis in hypercholesterolemic mice
Salerno, A. G., Rentz, T., Dorighello, G. G., Marques, A. C., Lorza‐Gil, E., Wanschel, A. C. B. A., de Moraes, A., Vercesi, A. E., & Oliveira, H. C. F. (2019) · Biochemical Journal · doi:10.1042/bcj20190543 · Cited by 22 · see citing works
Altered PPARγ Coactivator-1 Alpha Expression in Abdominal Aortic Aneurysm: Possible Effects on Mitochondrial Biogenesis
Gabrielson, M., Vorkapić, E., Folkesson, M., Welander, M., Matussek, A., Dimberg, J., Länne, T., Skogberg, J., & Wågsäter, D. (2016) · Journal of Vascular Research · doi:10.1159/000446653 · Cited by 21 · see citing works
Next-generation sequencing profiling of mitochondrial genomes in gout
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Self-citation

Authors: Yu, E. P. K., & Bennett, M. R.
Affiliations: University of Cambridge (GB)
Corresponding author: Yu, Emma P.K.
ORCID: Yu, Emma P.K.
Bennett, Martin R.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2014-09
Volume: 25
Issue: 9
Pages: 481-487
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2014.06.008
OpenAlex: W2047242190
Cited by: 124
References: 64
Citations by year: 2026: 8 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 20 · 2019: 13 · 2018: 11 · 2017: 9 · 2016: 11 · 2015: 7 · 2014: 2
FWCI: 0.91
Type: journal article
Language: en
Open access: green
www.repository.cam.ac.uk
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Apollo (University of Cambridge) (acceptedVersion, cc-by-nc-nd)
Apollo (University of Cambridge) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: mitochondrial DNA damage, atherosclerosis, mitochondrial dysfunction, reactive oxygen species, oxidative stress, inflammation, cell death, metabolism, therapeutic target
MeSH terms: Animals, DNA Damage, DNA, Mitochondrial, Humans, Models, Biological, Apoptosis, Oxidative Stress, Atherosclerosis, Mitochondrial Dynamics

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