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Cited by 310

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

A play in four acts: Staphylococcus aureus abscess formation

Open access
Cheng, Alice G., DeDent, Andrea C., Schneewind, Olaf, Missiakas, Dominique·2011·Trends in Microbiology
DOI 10.1016/j.tim.2011.01.007
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Abstract

Staphylococcus aureus is an important human pathogen that causes skin and soft tissue abscesses. Abscess formation is not unique to staphylococcal infection and purulent discharge has been widely considered a physiological feature of healing and tissue repair. Here we present a different view, whereby S. aureus deploys specific virulence factors to promote abscess lesions that are distinctive for this pathogen. In support of this model, only live S. aureus are able to form abscesses, requiring genes that act at one or more of four discrete stages during the development of these infectious lesions. Protein A and coagulases are distinctive virulence attributes for S. aureus, and humoral immune responses specific for these polypeptides provide protection against abscess formation in animal models of staphylococcal disease.

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Crossref · 10.1016/j.tim.2011.01.007

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Metadata

Authors
Cheng, A. G., DeDent, A. C., Schneewind, O., & Missiakas, D.
Venue
Trends in Microbiology
Publisher
Elsevier BV
Published
2011-05
Volume
19
Issue
5
Pages
225-232
ISSN
0966-842X (ISSN-L)
DOI
10.1016/j.tim.2011.01.007
OpenAlex
W1975256163
Cited by
310
References
75
FWCI
2.04
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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