The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Microglial senescence: does the brain's immune system have an expiration date?
Abstract
Microglia are seen as the sentries in the CNS who provide a first line of defense whenever there is injury or disease. Microglia and related perivascular macrophages perform various functions, ranging from immunological surveillance to neuroprotection. Recent work in the aged human brain has provided morphological evidence of structural deterioration of microglia, and work in rodents suggests that microglia are subject to replicative senescence (loss of mitotic ability after repeated rounds of replication). Together these observations raise the possibility that old age, and perhaps other factors (genetic and epigenetic) adversely affect viability and self-renewal capacity of microglia, resulting in the generation of senescent and/or dysfunctional cells. Such attrition of the brain's immune system could contribute to the development of neurodegenerative disease by diminishing glial neuroprotection.
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“The ageing brain is also characterised by structural and functional changes to microglial cells, which are the resident immune cell population of the central nervous system (CNS) and are the CNS equivalent of macrophages. They are activated by brain injury and local and systemic inflammation and become primed (hyper-responsive) to small stimuli with ageing, which can potentially cause damage and”
From Frailty in elderly people (2013) · cites this paper as [27]
In the citing paper
“Aged microglia display a dystrophic phenotype118–120. It is also known that ageing, similar to neurodegeneration, induces a hypersensitive, pro-inflammatory microglial phenotype that some have referred to as ‘primed microglia’26.”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [119]
In the citing paper
“References 118 and 119 propose that microglial senescence is important for age-related decline in cognitive function.”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [119]
Citations
Cites
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
Self-citationMicroglia as neuroprotective, immunocompetent cells of the CNS
Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919
Self-citationTurnover of resident microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., & Gordon, S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90500-2 · Cited by 709
Dystrophic microglia in the aging human brain
Streit, W. J., Sammons, N. W., Kuhns, A. J., & Sparks, D. L. (2004) · Glia · doi:10.1002/glia.10319 · Cited by 705
Self-citationPriller, J., Flügel, A., Wehner, T., Boentert, M., Haas, C. A., Prinz, M., Fernández-Klett, F., Prass, K., Bechmann, I., de Boer, B. A., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1356 · Cited by 637
Lectin binding by resting and reactive microglia
Streit, W. J., & Kreutzberg, G. W. (1987) · Journal of Neurocytology · doi:10.1007/bf01795308 · Cited by 496
Self-citationAmeboid microglia as effectors of inflammation in the central nervous system
Giulian, D. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180123 · Cited by 482
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ
Lassmann, H., Bancher, C., Breitschopf, H., Węgiel, J., Bobinski, M., Jellinger, K. A., & Wísniewski, H. M. (1994) · Acta Neuropathologica · doi:10.1007/bf00294257 · Cited by 464
Microglial phenotype: is the commitment reversible?
Schwartz, M., Butovsky, O., Brück, W., & Hanisch, U.-K. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2005.12.005 · Cited by 434
Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin
Streit, W. J., & Kreutzberg, G. W. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902680209 · Cited by 387
Self-citationMicroglia and inflammatory mechanisms in the clearance of amyloid β peptide
Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R. (2002) · Glia · doi:10.1002/glia.10153 · Cited by 381
Altered antigen expression of microglia in the aged rodent CNS
Perry, V. H., Matyszak, M. K., & Fearn, S. (1993) · Glia · doi:10.1002/glia.440070111 · Cited by 364
Bone marrow derived elements and resident microglia in brain inflammation
Lassmann, H., Schmied, M. C., Vass, K., & Hickey, W. F. (1993) · Glia · doi:10.1002/glia.440070106 · Cited by 349
Microglia and Alzheimer's disease pathogenesis
Streit, W. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20093 · Cited by 335
Self-citationMicroglial cell population dynamics in the injured adult central nervous system
Ladeby, R., Wirenfeldt, M., Garcia-Ovejero, D., Fenger, C., Dissing-Olesen, L., Dalmau, I., & Finsen, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.009 · Cited by 334
Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy
Graeber, M. B., Tetzlaff, W., Streit, W. J., & Kreutzberg, G. W. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90585-x · Cited by 333
Self-citationIneffective phagocytosis of amyloid-β by macrophages of Alzheimer's disease patients
Fiala, M., Lin, J., Ringman, J. M., Kermani-Arab, V., Tsao, G., Patel, A. J., Lossinsky, A. S., Graves, M. C., Gustavson, A. R., Sayre, J. W., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7304 · Cited by 331
Control of glial immune function by neurons
Neumann, H. (2001) · Glia · doi:10.1002/glia.1108 · Cited by 319
The facial nerve axotomy model
Moran, L. B., & Graeber, M. B. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2003.11.004 · Cited by 310
Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1989) · Experimental Neurology · doi:10.1016/0014-4886(89)90111-8 · Cited by 287
Self-citationYang, F., Sun, X., Beech, W. K., Teter, B., Wu, S. S. H., Sigel, J. J., Vinters, H. V., Frautschy, S. A., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 245
Like cops on the beat: the active role of resting microglia
Raivich, G. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.09.001 · Cited by 225
Graeber, M. B., Streit, W. J., Kiefer, R., Schoen, S. W., & Kreutzberg, G. W. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90061-q · Cited by 209
Self-citationThe microglial cytoskeleton: vimentin is localized within activated cellsin situ
Graeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1988) · Journal of Neurocytology · doi:10.1007/bf01189811 · Cited by 178
Self-citationProgressive telomere shortening occurs in cultured rat microglia, but not astrocytes
Flanary, B. E., & Streit, W. J. (2004) · Glia · doi:10.1002/glia.10301 · Cited by 167
Self-citationFlügel, A., Bradl, M., Kreutzberg, G. W., & Graeber, M. B. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1198 · Cited by 155
Gehrmann, J., & Banati, R. B. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199509000-00010 · Cited by 147
Microglia and the Development of Spongiform Change in Creutzfeldt-Jakob Disease
Eitzen, U., Egensperger, R., Kösel, S., Grasbon-Frodl, E., Imai, Y., Bise, K., Kohsaka, S., Mehraein, P., & Graeber, M. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199803000-00006 · Cited by 92
Perivascular microglia defined
Graeber, M. B., & Streit, W. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90020-b · Cited by 91
Self-citationEffect of aging on the microglial response to peripheral nerve injury
Conde, J. R., & Streit, W. J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.012 · Cited by 86
Self-citationβ-Amyloid peptides induce degeneration of cultured rat microglia
Korotzer, A. R., Pike, C. J., & Cotman, C. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90068-x · Cited by 82
Degeneration of microglial cells in frontal and temporal lobes of chronic schizophrenics.
Wierzba‐Bobrowicz, T., Lewandowska, E., Kosno-Kruszewska, E., Lechowicz, W., Pasennik, E., & Schmidt-Sidor, B. (2004) · PubMed · Cited by 65
Microglia in the Regenerating and Degenerating Central Nervous System
Streit, W. (2002) · Springer: New York · doi:10.1007/978-1-4757-4139-1 · Cited by 36
Polazzi, E., & Contestabile, A. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.11.005 · Cited by 36
Effects of axotomy on telomere length, telomerase activity, and protein in activated microglia
Flanary, B. E., & Streit, W. J. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20636 · Cited by 33
Self-citationPolazzi, E., & Contestabile, A. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.351 · Cited by 29
Degradation of oxidized extracellular proteins by microglia
Stolzing, A., Wengner, A. M., & Grune, T. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00003-6 · Cited by 28
THE ORIGIN AND FORMATION OF SENILE PLAQUES
Ferraro, A. (1931) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1931.02230050118006 · Cited by 18
Physiology and Pathophysiology of Microglial Cell Function
Streit, W. J. (2002) · Springer eBooks · doi:10.1007/978-1-4757-4139-1_1 · Cited by 14
Self-citation
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Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
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Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179
Microglia in neurodegenerative disease
Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543
Metadata
- Authors
- Streit, W. J.
- Affiliations
- University of Florida Health (US)
- Corresponding author
- Streit, Wolfgang J.
- ORCID
- Streit, Wolfgang J.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 29
- Issue
- 9
- Pages
- 506-510
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1981310043
- Cited by
- 397
- References
- 42
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 18 · 2020: 22 · 2019: 21 · 2018: 18 · 2017: 18 · 2016: 26 · 2015: 22 · 2014: 23 · 2013: 20 · 2012: 40
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- microglial senescence, replicative senescence, microglia, perivascular macrophages, brain aging, neuroinflammation, neuroprotection, neurodegenerative diseases, immunosenescence
- MeSH terms
- Aging, Animals, Brain, Humans, Cellular Senescence, Microglia
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