Cited by 138Neuroscience and Neuropharmacology ResearchTreatment of Major DepressionAmino Acid Enzymes and Metabolism

Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity

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Lau, C. Geoffrey, Takeuchi, Koichi, Rodenas-Ruano, Alma, Takayasu, Yukihiro, Murphy, Jessica, Bennett, Michael V.L., Zukin, R. Suzanne·2009·Biochemical Society Transactions

Abstract

NMDARs (N-methyl-D-aspartate receptors) are critical for synaptic function throughout the CNS (central nervous system). NMDAR-mediated Ca2+ influx is implicated in neuronal differentiation, neuronal migration, synaptogenesis, structural remodelling, long-lasting forms of synaptic plasticity and higher cognitive functions. NMDAR-mediated Ca2+ signalling in dendritic spines is not static, but can be remodelled in a cell- and synapse-specific manner by NMDAR subunit composition, protein kinases and neuronal activity during development and in response to sensory experience. Recent evidence indicates that Ca2+ permeability of neuronal NMDARs, NMDAR-mediated Ca2+ signalling in spines and induction of NMDAR-dependent LTP (long-term potentiation) at hippocampal Schaffer collateral–CA1 synapses are under control of the cAMP/PKA (protein kinase A) signalling cascade. Thus, by enhancing Ca2+ influx through NMDARs in spines, PKA can regulate the induction of LTP. An emerging concept is that activity-dependent regulation of NMDAR-mediated Ca2+ signalling by PKA and by extracellular signals that modulate cAMP or protein phosphatases at synaptic sites provides a dynamic and potentially powerful mechanism for bi-directional regulation of synaptic efficacy and remodelling.

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Authors
Lau, C. G., Takeuchi, K., Rodenas-Ruano, A., Takayasu, Y., Murphy, J., Bennett, M. V. L., & Zukin, R. S.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Zukin, R. Suzanne
Venue
Biochemical Society Transactions
Published
2009-11-19
Volume
37
Issue
6
Pages
1369-1374
ISSN
  • 0300-5127 (ISSN-L)
  • 1470-8752
OpenAlex
W2022873534
Cited by
138
References
86
Citations by year
2026: 13 · 2025: 14 · 2024: 11 · 2023: 11 · 2022: 15 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 5
FWCI
2.07
Type
journal article
Language
en
Open access
Locations
  • Biochemical Society Transactions (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NS-20752, R01NS020752)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
NMDA receptor, calcium signaling, synaptic plasticity, long-term potentiation, dendritic spines, cAMP/PKA signaling, protein kinase A, NMDA receptor subunit composition, calcium permeability, protein phosphatase, synaptic remodeling
MeSH terms
Animals, Calcium, Isoenzymes, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Cyclic AMP-Dependent Protein Kinases, Calcium Signaling, Dendritic Spines

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