Historical review: A brief history and personal retrospective of seven-transmembrane receptors

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

Gilman, A. G. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.003151 · Cited by 6,381

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., et al. (2000) · Science · doi:10.1126/science.289.5480.739 · Cited by 5,637

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

Buck, L., & Axel, R. (1991) · Cell · doi:10.1016/0092-8674(91)90418-x · Cited by 4,987

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

Fredriksson, R., Lagerström, M. C., Lundin, L.-G., & Schiöth, H. B. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1256 · Cited by 2,941

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

Samson, M., Libert, F., Doranz, B. J., Rucker, J., Liesnard, C., Farber, C.-M., Saragosti, S., Lapouméroulie, C., Cognaux, J., Forceille, C., et al. (1996) · Nature · doi:10.1038/382722a0 · Cited by 2,886

Seven-transmembrane receptors

Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,701

Three-dimensional model of purple membrane obtained by electron microscopy

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Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling

Ferguson, S. S. G. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01478-9 · Cited by 1,826

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

De Lean, A., Stadel, J. M., & Lefkowitz, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79672-9 · Cited by 1,612

β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes

Luttrell, L. M., Ferguson, S. S. G., Daaka, Y., Miller, W. E., Maudsley, S., Della Rocca, G. J., Lin, F.-T., Kawakatsu, H., Owada, K., Luttrell, D. K., et al. (1999) · Science · doi:10.1126/science.283.5402.655 · Cited by 1,475

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

Walsh, D. A., Perkins, J. P., & Krebs, E. G. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)34204-8 · Cited by 1,445

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

Dohlman, H. G., Thorner, J., Caron, M. G., & Lefkowitz, R. J. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.003253 · Cited by 1,379

G PROTEIN–COUPLED RECEPTOR KINASES

Pitcher, J. A., Freedman, N. J., & Lefkowitz, R. J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.653 · Cited by 1,361

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Dixon, R. A. F., Kobilka, B. K., Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. E., et al. (1986) · Nature · doi:10.1038/321075a0 · Cited by 1,276

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

Lohse, M. J., Benovic, J. L., Codina, J., Caron, M. G., & Lefkowitz, R. J. (1990) · Science · doi:10.1126/science.2163110 · Cited by 1,220

Cyclic GMP Cascade of Vision

Stryer, L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.000511 · Cited by 1,168

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

Strader, C. D., Fong, T. M., Tota, M. R., Underwood, D., & Dixon, R. A. F. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.000533 · Cited by 1,079

On some physiological actions of ergot

Dale, H. H. (1906) · The Journal of Physiology · doi:10.1113/jphysiol.1906.sp001148 · Cited by 1,011

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

Luttrell, L. M., Roudabush, F. L., Choy, E. W., Miller, W. E., Field, M. E., Pierce, K. L., & Lefkowitz, R. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041604898 · Cited by 831

Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin

Shenoy, S. K., McDonald, P. H., Kohout, T. A., & Lefkowitz, R. J. (2001) · Science · doi:10.1126/science.1063866 · Cited by 824

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

McDonald, P. H., Chow, C.-W., Miller, W. E., Laporte, S. A., Field, M. E., Lin, F.-T., Davis, R. J., & Lefkowitz, R. J. (2000) · Science · doi:10.1126/science.290.5496.1574 · Cited by 819

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

Rodbell, M., Birnbaumer, L., Pohl, S. L., & Krans, H. M. J. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62390-7 · Cited by 812

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

Wilden, U., Hall, S. W., & Kühn, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.5.1174 · Cited by 791

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor

Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., Lefkowitz, R. J., & Regan, J. W. (1987) · Science · doi:10.1126/science.2823383 · Cited by 787

Chimeric α 2 -,β 2 -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

Kobilka, B. K., Kobilka, T. S., Daniel, K., Regan, J. W., Caron, M. G., & Lefkowitz, R. J. (1988) · Science · doi:10.1126/science.2836950 · Cited by 763

cDNA eloping of bovine substance-K receptor through oocyte expression system

Masu, Y., Nakayama, K., Tamaki, H., Harada, Y., Kuno, M., & Nakanishi, S. (1987) · Nature · doi:10.1038/329836a0 · Cited by 742

ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*

Robison, G. A., Butcher, R. W., & Sutherland, E. W. (1967) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1967.tb41239.x · Cited by 673

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

Benovic, J. L., Strasser, R. H., Caron, M. G., & Lefkowitz, R. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.2797 · Cited by 662

A family of receptors coupled to guanine nucleotide regulatory proteins

Dohlman, H. G., Caron, M. G., & Lefkowitz, R. J. (1987) · Biochemistry · doi:10.1021/bi00384a001 · Cited by 631

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

Fargin, A., Raymond, J. R., Lohse, M. J., Kobilka, B. K., Caron, M. G., & Lefkowitz, R. J. (1988) · Nature · doi:10.1038/335358a0 · Cited by 597

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

Kjelsberg, M. A., Cotecchia, S., Ostrowski, J., Caron, M. G., & Lefkowitz, R. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45962-5 · Cited by 589

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

Angers, S., Salahpour, A., & Bouvier, M. (2002) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.091701.082314 · Cited by 586

Cloning of the cDNA for the human beta 1-adrenergic receptor.

Frielle, T., Collins, S., Daniel, K. W., Caron, M. G., Lefkowitz, R. J., & Kobilka, B. K. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.7920 · Cited by 575

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

Cotecchia, S., Schwinn, D. A., Randall, R. R., Lefkowitz, R. J., Caron, M. G., & Kobilka, B. K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7159 · Cited by 562

A Quantitative Analysis of Beta-Adrenergic Receptor Interactions: Resolution of High and Low Affinity States of the Receptor by Computer Modeling of Ligand Binding Data

KENT, R. S., DE LEAN, A., & LEFKOWITZ, R. J. (1980) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14062-5 · Cited by 553

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

Attramadal, H., Arriza, J. L., Aoki, C., Dawson, T. M., Codina, J., Kwatra, M. M., Snyder, S. H., Caron, M. G., & Lefkowitz, R. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37125-x · Cited by 547

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

Costa, T., & Herz, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7321 · Cited by 536

Molecular Cloning of the Thyrotropin Receptor

Parmentier, M., Libert, F., Maenhaut, C., Lefort, A., Gérard, C., Perret, J., Van Sande, J., Dumont, J. E., & Vassart, G. (1989) · Science · doi:10.1126/science.2556796 · Cited by 530

The structure of bovine rhodopsin

Hargrave, P. A., McDowell, J. H., Curtis, D. R., Wang, J. K., Juszczak, E., Fong, S.-L., Mohana Rao, J. K., & Argos, P. (1983) · Biophysics of Structure and Mechanism · doi:10.1007/bf00535659 · Cited by 519

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T., Kobilka, T. S., Francke, U., Lefkowitz, R. J., & Caron, M. G. (1987) · Nature · doi:10.1038/329075a0 · Cited by 515

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

Benovic, J. L., Kühn, H., Weyand, I., Codina, J., Caron, M. G., & Lefkowitz, R. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.8879 · Cited by 482

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

Pohl, S. L., Krans, H. M. J., Kozyreff, V., Birnbaumer, L., & Rodbell, M. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62032-0 · Cited by 463

Human dopamine D1 receptor encoded by an intronless gene on chromosome 5

Sunahara, R. K., Niznik, H. B., Weiner, D. M., Stormann, T. M., Brann, M. R., Kennedy, J. L., Gelernter, J. E., Rozmahel, R., Yang, Y., Israel, Y., et al. (1990) · Nature · doi:10.1038/347080a0 · Cited by 462

Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization

Kohout, T. A., & Lefkowitz, R. J. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.9 · Cited by 449

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

Benovic, J. L., DeBlasi, A., Stone, W. C., Caron, M. G., & Lefkowitz, R. J. (1989) · Science · doi:10.1126/science.2552582 · Cited by 444

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

Wilden, U., & Kuehn, H. (1982) · Biochemistry · doi:10.1021/bi00541a032 · Cited by 440

G protein—coupled receptor kinases

Lefkowitz, R. J. (1993) · Cell · doi:10.1016/0092-8674(93)80042-d · Cited by 437

A Model for Arrestin’s Regulation: The 2.8 Å Crystal Structure of Visual Arrestin

Hirsch, J. A., Schubert, C., Gurevich, V. V., & Sigler, P. B. (1999) · Cell · doi:10.1016/s0092-8674(00)80735-7 · Cited by 436

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

Regan, J. W., Kobilka, T. S., Yang-Feng, T. L., Caron, M. G., Lefkowitz, R. J., & Kobilka, B. K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6301 · Cited by 434

Rhodopsin and bacteriorhodopsin: structure—function relationships

Ovchinnikov, Y. A. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)80805-3 · Cited by 433

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.

Schwinn, D. A., Lomasney, J. W., Lorenz, W., Szklut, P. J., Fremeau, R. T., Yang-Feng, T. L., Caron, M. G., Lefkowitz, R. J., & Cotecchia, S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39055-6 · Cited by 418

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

Bond, R. A., Leff, P., Johnson, T. D., Milano, C. A., Rockman, H. A., McMinn, T. R., Apparsundaram, S., Hyek, M. F., Kenakin, T. P., Allen, L. F., et al. (1995) · Nature · doi:10.1038/374272a0 · Cited by 416

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

Lomasney, J. W., Cotecchia, S., Lorenz, W., Leung, W. Y., Schwinn, D. A., Yang-Feng, T. L., Brownstein, M., Lefkowitz, R. J., & Caron, M. G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38126-2 · Cited by 405

Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

SHENOY, S. K., & LEFKOWITZ, R. J. (2003) · Biochemical Journal · doi:10.1042/bj20031076 · Cited by 405

β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

Tohgo, A., Pierce, K. L., Choy, E. W., Lefkowitz, R. J., & Luttrell, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106457200 · Cited by 396

β-Arrestin2 Is Critically Involved in CXCR4-mediated Chemotaxis, and This Is Mediated by Its Enhancement of p38 MAPK Activation

Sun, Y., Cheng, Z., Ma, L., & Pei, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207294200 · Cited by 382

Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ

Lodowski, D. T., Pitcher, J. A., Capel, W. D., Lefkowitz, R. J., & Tesmer, J. J. G. (2003) · Science · doi:10.1126/science.1082348 · Cited by 381

Large‐Scale Purification of the Acetylcholine‐Receptor Protein in Its Membrane‐Bound and Detergent‐Extracted Forms from Torpedo marmorata Electric Organ

SOBEL, A., WEBER, M., & CHANGEUX, J. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11874.x · Cited by 374

The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation

Tohgo, A., Choy, E. W., Gesty-Palmer, D., Pierce, K. L., Laporte, S., Oakley, R. H., Caron, M. G., Lefkowitz, R. J., & Luttrell, L. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212231200 · Cited by 359

Cell Surface Receptors: A Short Course on Theory and Methods

Limbird, L. E. (1996) · Springer eBooks · doi:10.1007/978-1-4613-1255-0 · Cited by 353

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

Perez, J. M., Rathz, D. A., Petrashevskaya, N. N., Hahn, H. S., Wagoner, L. E., Schwartz, A., Dorn, G. W., & Liggett, S. B. (2003) · Nature Medicine · doi:10.1038/nm930 · Cited by 333

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

Benovic, J. L., Pike, L. J., Cerione, R. A., Staniszewski, C., Yoshimasa, T., Codina, J., Caron, M. G., & Lefkowitz, R. J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88892-5 · Cited by 320

Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice

Fong, A. M., Premont, R. T., Richardson, R. M., Yu, Y.-R. A., Lefkowitz, R. J., & Patel, D. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112198299 · Cited by 311

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

Shichi, H., & Somers, R. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38026-2 · Cited by 291

Resolution of some components of adenylate cyclase necessary for catalytic activity.

Ross, E. M., & Gilman, A. G. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)66920-6 · Cited by 283

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

Lomasney, J. W., Lorenz, W., Allen, L. F., King, K., Regan, J. W., Yang-Feng, T. L., Caron, M. G., & Lefkowitz, R. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5094 · Cited by 283

G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction

Brady, A. E., & Limbird, L. E. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00239-x · Cited by 263

Purification and characterization of the beta-adrenergic receptor kinase.

Benovic, J. L., Mayor, F., Staniszewski, C., Lefkowitz, R. J., & Caron, M. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48041-6 · Cited by 248

Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.

Kobilka, B. K., Frielle, T., Dohlman, H. G., Bolanowski, M. A., Dixon, R. A., Keller, P., Caron, M. G., & Lefkowitz, R. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48239-7 · Cited by 245

Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro.

Mickey, J. V., Tate, R., & Lefkowitz, R. J. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41239-8 · Cited by 238

Historical review: Opioid receptors

Snyder, S. H., & Pasternak, G. W. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00066-x · Cited by 221

Arresting developments in heptahelical receptor signaling and regulation

Perry, S. J., & Lefkowitz, R. J. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02239-5 · Cited by 218

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

Benovic, J. L., Mayor, F., Somers, R. L., Caron, M. G., & Lefkowitz, R. J. (1986) · Nature · doi:10.1038/321869a0 · Cited by 211

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.

May, D. C., Ross, E. M., Gilman, A. G., & Smigel, M. D. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36333-0 · Cited by 206

Primary and secondary structure of bovine retinal S antigen (48-kDa protein).

Shinohara, T., Dietzschold, B., Craft, C. M., Wistow, G., Early, J. J., Donoso, L. A., Horwitz, J., & Tao, R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.6975 · Cited by 205

Mammalian .beta.2-adrenergic receptor: purification and characterization

Benovic, J., Shorr, R., Caron, M. G., & Lefkowitz, R. J. (1984) · Biochemistry · doi:10.1021/bi00315a002 · Cited by 203

Receptors and G proteins as primary components of transmembrane signal transduction: Part 1. G-protein-coupled receptors: structure and function

Gudermann, T., N�rnberg, B., & Schultz, G. (1995) · Journal of Molecular Medicine · doi:10.1007/bf00270578 · Cited by 198

Observations on the physiological action of extracts of the supra‐renal bodies

Langley, J. N. (1901) · The Journal of Physiology · doi:10.1113/jphysiol.1901.sp000869 · Cited by 195

Mutagenesis of the beta2-Adrenergic Receptor: How Structure Elucidates Function

Ostrowski, J., Kjelsberg, M. A., Caron, M. G., & Lefkowitz, R. J. (1992) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.32.040192.001123 · Cited by 192

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

Lorenz, W., Inglese, J., Palczewski, K., Onorato, J. J., Caron, M. G., & Lefkowitz, R. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8715 · Cited by 189

β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor

Lin, F.-T., Daaka, Y., & Lefkowitz, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.31640 · Cited by 182

β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis

Povsic, T. J., Kohout, T. A., & Lefkowitz, R. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309968200 · Cited by 174

Functional architecture of the nicotinic acetylcholine receptor: A prototype of ligand-gated ion channels

Devillers-Thiéry, A., Galzi, J. L., Eiselé, J. L., Bertrand, S., Bertrand, D., & Changeux, J. P. (1993) · The Journal of Membrane Biology · doi:10.1007/bf02505755 · Cited by 170

Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.

Shorr, R., Lefkowitz, R. J., & Caron, M. G. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69281-1 · Cited by 164

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

Cotecchia, S., Ostrowski, J., Kjelsberg, M. A., Caron, M. G., & Lefkowitz, R. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45992-3 · Cited by 162

Affinity chromatography of the beta-adrenergic receptor.

Caron, M. G., Srinivasan, Y., Pitha, J., Kociolek, K., & Lefkowitz, R. J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30162-x · Cited by 161

Receptors and G proteins as primary components of transmembrane signal transduction: Part 2. G proteins: structure and function

Nürnberg, B., Gudermann, T. W., & Schultz, G. (1995) · Journal of Molecular Medicine · doi:10.1007/bf00198240 · Cited by 122

Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.

Cerione, R. A., Sibley, D. R., Codina, J., Benovic, J., Winslow, J. W., Neer, E. J., Birnbaumer, L., Caron, M. G., & Lefkowitz, R. J. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90913-0 · Cited by 121

Non-visual GRKs: are we seeing the whole picture?

Willets, J. M., Challiss, R. A. J., & Nahorski, S. R. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.10.003 · Cited by 107

Receptor Mechanisms

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