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Systematic elucidation of genetic mechanisms underlying cholesterol uptake

Hamilton, Marisa C., Fife, James D., Akinci, Ersin, Yu, Tian, Khowpinitchai, Benyapa, Cha, Minsun, Barkal, Sammy, Thi, Thi Tun, Yeo, Grace H.T., Ramos Barroso, Juan Pablo, Francoeur, Matthew Jake, Velimirovic, Minja, Gifford, David K., Lettre, Guillaume, Yu, Haojie, Cassa, Christopher A., Sherwood, Richard I.·2023·Cell Genomics
DOI 10.1016/j.xgen.2023.100304PMC PMC10203276

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  • Individual cells with disrupted PCSK9 will remain sensitive to the extracellular PCSK9 secreted by neighboring cells, precluding their development of a LDLR-mediated phenotype in this study and in prior pooled CRISPR screens.

    “For example, individual cells with disrupted PCSK9 will remain sensitive to the extracellular PCSK9 secreted by neighboring cells, precluding their development of a LDLR-mediated phenotype in this study and in prior pooled CRISPR screens for LDL uptake or LDLR abundance56,80,93.”

    From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [93]

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Metadata

Authors
Hamilton, M. C., Fife, J. D., Akinci, E., Yu, T., Khowpinitchai, B., Cha, M., Barkal, S., Thi, T. T., Yeo, G. H. T., Ramos Barroso, J. P., Francoeur, M. J., Velimirovic, M., Gifford, D. K., Lettre, G., Yu, H., Cassa, C. A., & Sherwood, R. I.
ORCID
Sherwood, Richard I.
Venue
Cell Genomics
Publisher
Elsevier BV
Published
2023-05
Volume
3
Issue
5
Pages
100304
ISSN
2666-979X
DOI
10.1016/j.xgen.2023.100304
PMC
PMC10203276
Cited by
16
References
21
Language
en
Licence
Funders
  • National Organization for Rare Disorders
  • Qatar Biomedical Research Institute, Hamad Bin Khalifa University
  • National University of Singapore
  • NIH (1R01HG008754, 1R21HG010391, R01HG010372)
  • American Cancer Society
  • American Heart Association

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