Microbe-host interactions: Influence of the gut microbiota on the enteric nervous system

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614

The gut flora as a forgotten organ

O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791

The enteric nervous system and neurogastroenterology

Furness, J. B. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.32 · Cited by 1,619

Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes

Bordenstein, S. R., & Theis, K. R. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002226 · Cited by 1,240

Microbiota and neurodevelopmental windows: implications for brain disorders

Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01796.x · Cited by 1,018

Membrane vesicles traffic signals and facilitate group activities in a prokaryote

Mashburn, L. M., & Whiteley, M. (2005) · Nature · doi:10.1038/nature03925 · Cited by 844

The enteric nervous system and gastrointestinal innervation: integrated local and central control

Furness, J. B., Callaghan, B. P., Rivera, L. R., & Cho, H.-J. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_3 · Cited by 827

Small molecules from the human microbiota

Donia, M. S., & Fischbach, M. A. (2015) · Science · doi:10.1126/science.1254766 · Cited by 760

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

The microbiota-gut-brain axis: from motility to mood

Margolis, K. G., Cryan, J. F., & Mayer, E. A. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.066 · Cited by 999

Gut microbiome and aging: physiological and mechanistic insights

Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586

Gut microbiota-derived short-chain fatty acids and their role in human health and disease

Mukhopadhya, I., & Louis, P. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01183-w · Cited by 628

Microbiota-derived metabolites as drivers of gut–brain communication

Ahmed, H., Leyrolle, Q., Koistinen, V., Kärkkäinen, O., Layé, S., Delzenne, N., & Hanhineva, K. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2102878 · Cited by 462

Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease

Sun, M.-F., & Shen, Y.-Q. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.004 · Cited by 445

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Kanmani, S., & Koo, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207551 · Cited by 392

Neuronal programming by microbiota regulates intestinal physiology

Obata, Y., Castaño, Á., Boeing, S., Bon‐Frauches, A. C., Fung, C., Fallesen, T. L., de Agüero, M. G., Yılmaz, B., Lopes, R., Huseynova, A., et al. (2020) · Nature · doi:10.1038/s41586-020-1975-8 · Cited by 365

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347

Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia

Vicentini, F., Keenan, C. M., Wallace, L. E., Woods, C., Cavin, J., Flockton, A. R., Macklin, W. B., Belkind‐Gerson, J., Hirota, S. A., & Sharkey, K. A. (2021) · Microbiome · doi:10.1186/s40168-021-01165-z · Cited by 345

The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes

Jacobson, A. R., Yang, D., Vella, M., & Chiu, I. M. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-00368-1 · Cited by 320

Hirschsprung disease — integrating basic science and clinical medicine to improve outcomes

Heuckeroth, R. O. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.149 · Cited by 315

Interplay between the gut-brain axis, obesity and cognitive function

Agustí, A., García-Pardo, M. P., López-Almela, I., Campillo, I., Maes, M., Romaní-Pérez, M., & Sanz, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00155 · Cited by 294

The microbiome, immunity, and schizophrenia and bipolar disorder.

Dickerson, F., Severance, E., & Yolken, R. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.010 · Cited by 268

Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function

Schneider, S., Wright, C. M., & Heuckeroth, R. O. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121515 · Cited by 239

The human microbiome in disease and pathology

Manos, J. (2022) · Apmis · doi:10.1111/apm.13225 · Cited by 252

You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan

Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200

Functional circuits and signal processing in the enteric nervous system

Fung, C., & Berghe, P. V. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03543-6 · Cited by 220

The gut, its microbiome, and the brain: connections and communications

Gershon, M. D., & Margolis, K. G. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143768 · Cited by 219

Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders

Rastelli, M., Knauf, C., & Cani, P. D. (2018) · Obesity · doi:10.1002/oby.22175 · Cited by 191

Postbiotics as the new frontier in food and pharmaceutical research

Sabahi, S., Rad, A. H., Maleki, L. A., Sangtarash, N., Ozma, M. A., Karimi, A., Hosseini, H., & Abbasi, A. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2056727 · Cited by 177

Probiotics: Potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan

Snigdha, S., Ha, K., Tsai, P., Dinan, T. G., Bartos, J. D., & Shahid, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107978 · Cited by 173

Understanding the Gut–Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders

Zheng, Y., Bonfili, L., Wei, T., & Eleuteri, A. M. (2023) · Nutrients · doi:10.3390/nu15214631 · Cited by 175

Nutritional Support of Neurodevelopment and Cognitive Function in Infants and Young Children—An Update and Novel Insights

Kadosh, K. C., Muhardi, L., Parikh, P., Basso, M., Mohamed, H. J. J., Prawitasari, T., Samuel, F. O., Ma, G., & Geurts, J. M. W. (2021) · Nutrients · doi:10.3390/nu13010199 · Cited by 206

Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications

Checa-Ros, A., Jeréz-Calero, A., Molina-Carballo, A., Campoy, C., & Muñoz-Hoyos, A. (2021) · Nutrients · doi:10.3390/nu13010249 · Cited by 164

The enteric nervous system in gastrointestinal disease etiology

Holland, A. M., Bon‐Frauches, A. C., Keszthelyi, D., Melotte, V., & Boesmans, W. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03812-y · Cited by 172

The enteric nervous system promotes intestinal health by constraining microbiota composition

Rolig, A. S., Mittge, E. K., Ganz, J., Troll, J. V., Melancon, E., Wiles, T. J., Alligood, K., Stephens, W. Z., Eisen, J. S., & Guillemin, K. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000689 · Cited by 152

Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders

Karakan, T., Özkul, C., Akkol, E. K., Bilici, S., Sobarzo‐Sánchez, E., & Capasso, R. (2021) · Nutrients · doi:10.3390/nu13020389 · Cited by 159

Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration

Raimondi, I., Izzo, L., Tunesi, M., Comar, M., Albani, D., & Giordano, C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00435 · Cited by 150

Interaction of the Vagus Nerve and Serotonin in the Gut–Brain Axis

Hwang, Y. K., & Oh, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031160 · Cited by 136

Antibiotic-induced dysbiosis of the microbiota impairs gut neuromuscular function in juvenile mice

Caputi, V., Marsilio, I., Filpa, V., Cerantola, S., Orso, G., Bistoletti, M., Paccagnella, N., De Martin, S., Montopoli, M., Dall'Acqua, S., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13965 · Cited by 124

Host‐microbe interaction in the gastrointestinal tract

Parker, A., Lawson, M. A., Vaux, L., & Pin, C. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13926 · Cited by 127

Redefining the IBDs using genome-scale molecular phenotyping

Furey, T. S., Sethupathy, P., & Sheikh, S. Z. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0118-x · Cited by 120

Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system

KUWAHARA, A., MATSUDA, K., KUWAHARA, Y., ASANO, S., INUI, T., & MARUNAKA, Y. (2020) · Biomedical Research · doi:10.2220/biomedres.41.199 · Cited by 112

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

Cowan, C. S. M., Hoban, A. E., Ventura‐Silva, A. P., Dinan, T. G., Clarke, G. A., & Cryan, J. F. (2017) · BioEssays · doi:10.1002/bies.201700172 · Cited by 110

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice

Bistoletti, M., Caputi, V., Baranzini, N., Marchesi, N., Filpa, V., Marsilio, I., Cerantola, S., Terova, G., Baj, A., Grimaldi, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212856 · Cited by 109

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

Tan, C., Yan, Q., Ma, Y., Fang, J., & Yang, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1015175 · Cited by 120

Visceral pain: gut microbiota, a new hope?

Pusceddu, M. M., & Gareau, M. G. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0476-7 · Cited by 102

Gut Microbiota in Acute Ischemic Stroke: From Pathophysiology to Therapeutic Implications

Battaglini, D., Pimentel‐Coelho, P. M., Robba, C., dos Santos, C. C., Cruz, F. F., Pelosi, P. P., & Rocco, P. R. M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00598 · Cited by 100

Autism Spectrum Disorders and the Gastrointestinal Tract: Insights into Mechanisms and Clinical Relevance

Hung, L. Y., & Margolis, K. G. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00857-1 · Cited by 96

The Gut Microbiome Feelings of the Brain: A Perspective for Non-Microbiologists

Lerner, A., Neidhöfer, S., & Matthias, T. (2017) · Microorganisms · doi:10.3390/microorganisms5040066 · Cited by 97

Gut : liver : brain axis: the microbial challenge in the hepatic encephalopathy

Mancini, A., Campagna, F., Amodio, P., & Tuohy, K. M. (2018) · Food & Function · doi:10.1039/c7fo01528c · Cited by 89

Role of gut microbiota-derived signals in the regulation of gastrointestinal motility

Zheng, Z., Tang, J., Hu, Y., & Zhang, W. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.961703 · Cited by 94

The microbiota-gut-brain axis: Focus on the fundamental communication pathways

Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 91

The Rice Microbiome: A Model Platform for Crop Holobiome

Kim, H., & Lee, Y. (2019) · Phytobiomes Journal · doi:10.1094/pbiomes-07-19-0035-rvw · Cited by 86

Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model mice

Chen, Y., Li, Y., Fan, Y., Chen, S., Chen, L., Chen, Y., & Chen, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2302310 · Cited by 92

Advances in Enteric Neurobiology: The “Brain” in the Gut in Health and Disease

Kulkarni, S., Ganz, J., Bayrer, J. R., Becker, L. S., Bogunovic, M., & Rao, M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1663-18.2018 · Cited by 85

Gut Microbiota and Bone Health

Quach, D., & Britton, R. A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-66653-2_4 · Cited by 85

Necrotizing enterocolitis

Sanchez, J. B., & Kadrofske, M. M. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13569 · Cited by 81

Human resident gut microbe Bacteroides thetaiotaomicron regulates colonic neuronal innervation and neurogenic function

Aktar, R., Parkar, N., Stentz, R., Baumard, L., Parker, A., Goldson, A. J., Brion, A., Carding, S. R., Blackshaw, L. A., & Peiris, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1766936 · Cited by 89

A Novel Prebiotic Blend Product Prevents Irritable Bowel Syndrome in Mice by Improving Gut Microbiota and Modulating Immune Response

Chen, Q., Ren, Y., Lu, J., Bartlett, M., Chen, L., Zhang, Y., Guo, X., & Liu, C. (2017) · Nutrients · doi:10.3390/nu9121341 · Cited by 78

Impact of selected environmental factors on microbiome of the digestive tract of ruminants

Cholewińska, P., Górniak, W., & Wojnarowski, K. (2021) · BMC Veterinary Research · doi:10.1186/s12917-021-02742-y · Cited by 81

Diabetes-induced mechanophysiological changes in the small intestine and colon

Zhao, M., Liao, D., & Zhao, J. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i6.249 · Cited by 77

Microbiota–gut–brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system

He, Y., Wang, K., Su, N., Yuan, C., Zhang, N., Hu, X., Fu, Y., & Zhao, F. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70099 · Cited by 83

Gut, Microbiome, and Brain Regulatory Axis: Relevance to Neurodegenerative and Psychiatric Disorders

Stefano, G. B., Pilonis, N., Ptáček, R., Raboch, J., Vňuková, M., & Kream, R. M. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0589-2 · Cited by 74

Nerves in gastrointestinal cancer: from mechanism to modulations

Vaes, N., Idris, M., Boesmans, W., Alves, M. M., & Melotte, V. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00669-9 · Cited by 68

Gut microbiota-driven neuroinflammation in Alzheimer's disease: from mechanisms to therapeutic opportunities

Lei, W., Cheng, Y., Liu, X., Gao, J., Zhu, Z., Ding, W., Xu, X., Li, Y., Ling, Z., Jiang, R., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582119 · Cited by 68

Our Mental Health Is Determined by an Intrinsic Interplay between the Central Nervous System, Enteric Nerves, and Gut Microbiota

Dicks, L. M. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010038 · Cited by 74

Stress and the gut-brain axis: an inflammatory perspective

Morys, J., Małecki, A., & Nowacka-Chmielewska, M. M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1415567 · Cited by 81

Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease

Ballway, J. W., & Song, B.-J. (2021) · Antioxidants · doi:10.3390/antiox10030384 · Cited by 72

The enteric nervous system undergoes significant chemical and synaptic maturation during adolescence in mice

Parathan, P., Wang, Y., Leembruggen, A. J. L., Bornstein, J. C., & Foong, J. P. P. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.10.011 · Cited by 64

Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research

Chang, L., Lorenzo, C. D., Farrugia, G., Hamilton, F. A., Mawe, G. M., Pasricha, P. J., & Wiley, J. W. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.12.010 · Cited by 62

Gut Bacteria and Neuropsychiatric Disorders

Dicks, L. M. T., Hurn, D., & Hermanus, D. (2021) · Microorganisms · doi:10.3390/microorganisms9122583 · Cited by 63

Exploring the microbiome in health and disease

Scotti, E., Boué, S., Sasso, G. L., Zanetti, F., Belcastro, V., Poussin, C., Sierro, N., Battey, J. N. D., Gimalac, A., Ivanov, N. V., et al. (2017) · Toxicology Research and Application · doi:10.1177/2397847317741884 · Cited by 56

Synbiotic yogurt containing konjac mannan oligosaccharides and Bifidobacterium animalis ssp. lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota

Li, T., Yan, Q., Wen, Y., Liu, J., Sun, J. G., & Jiang, Z. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19449 · Cited by 52

Marine Natural Products: Promising Candidates in the Modulation of Gut-Brain Axis towards Neuroprotection

Fakhri, S., Yarmohammadi, A., Yarmohammadi, M., Farzaei, M. H., & Echeverría, J. (2021) · Marine Drugs · doi:10.3390/md19030165 · Cited by 52

Associations of Probiotic Fermented Milk (PFM) and Yogurt Consumption with Bifidobacterium and Lactobacillus Components of the Gut Microbiota in Healthy Adults

Redondo, N., Gheorghe, A., Díaz, L. E., Villavisencio, B., Marcos, A., & Nova, E. (2019) · Nutrients · doi:10.3390/nu11030651 · Cited by 49

Microbes, metabolites and (synaptic) malleability, oh my! T he effect of the microbiome on synaptic plasticity

Glinert, A., Turjeman, S., Elliott, E., & Koren, O. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12812 · Cited by 48

Manipulation of intestinal dysbiosis by a bacterial mixture ameliorates loperamide-induced constipation in rats

Deng, Y., Li, M., Lü, M., Cong, L., Liu, Y., Zhang, B., He, C., Zheng, P., & Yuan, J. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0062 · Cited by 45

Unveiling the role of gut-brain axis in regulating neurodegenerative diseases: A comprehensive review

Yadav, H., Jaldhi, Bhardwaj, R., Anamika, A., Bakshi, A., Gupta, S., & Maurya, S. K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122022 · Cited by 47

The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis

Bayer, F., Dremova, O., Khuu, M. P., Mammadova, K., Pontarollo, G., Kiouptsi, K., Soshnikova, N. V., May‐Simera, H., Endres, K., & Reinhardt, C. (2021) · Nutrients · doi:10.3390/nu13072198 · Cited by 47

Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders

Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109489 · Cited by 42

Rewiring the Brain Through the Gut: Insights into Microbiota–Nervous System Interactions

Săvulescu-Fiedler, I., Benea, S. N., Căruntu, C., Nancoff, A.-S., Homentcovschi, C., & Bucurica, S. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070489 · Cited by 51

Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy

Slykerman, R. F., Davies, N., Vlčková, K., O’Riordan, K. J., Bassett, S. A., Dekker, J., Schellekens, H., Hyland, N. P., Clarke, G. A., & Patterson, E. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70079 · Cited by 47

Gut Microbiota at the Intersection of Alcohol, Brain, and the Liver

Gupta, H., Suk, K. T., & Kim, D. J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030541 · Cited by 43

Gut microbiota dysbiosis in Alzheimer's disease (AD): Insights from human clinical studies and the mouse AD models

Manfredi, J. N., Gupta, S. K., Vyavahare, S. S., Deák, F., Lu, X., Buddha, L., Wankhade, U. D., Lohakare, J., Isales, C. M., & Fulzele, S. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114778 · Cited by 42

Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis

Kong, X., Liu, J., Liu, K., Koh, M., Tian, R., Hobbie, C., Fong, M., Chen, Q., Zhao, M., Budjan, C., et al. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04524-1 · Cited by 35

Interleukin-17 acts in the hypothalamus reducing food intake

Nogueira, G. A. S., Solon, C., Carraro, R. S., Engel, D. F., Ramalho, A. F. S., Sidarta-Oliveira, D., Gaspar, R. S., Bombassaro, B., Vasques, A. C. J., Geloneze, B., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.12.012 · Cited by 41

Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction

Bassett, S. A., Young, W., Fraser, K., Dalziel, J. E., Webster, J., Ryan, L., Fitzgerald, P., Stanton, C., Dinan, T. G., Cryan, J. F., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50593-3 · Cited by 37

Enteric neuronal cell therapy reverses architectural changes in a novel diphtheria toxin-mediated model of colonic aganglionosis

Bhave, S. M., Arciero, E. J., Baker, C., Ho, W. L. N., Stavely, R. G., Goldstein, A. M., & Hotta, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-55128-4 · Cited by 30

Dietary modulation of gut microbiota for the relief of irritable bowel syndrome

Kim, M.-Y., & Choi, S. (2021) · Nutrition Research and Practice · doi:10.4162/nrp.2021.15.4.411 · Cited by 30

Making Sense of Quorum Sensing at the Intestinal Mucosal Interface

Uhlig, F., & Hyland, N. P. (2022) · Cells · doi:10.3390/cells11111734 · Cited by 30

Without a bug’s life: Germ-free rodents to interrogate microbiota-gut-neuroimmune interactions

Spichak, S., Guzzetta, K. E., O’Leary, O. F., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2018) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2019.08.002 · Cited by 30

The Role of Gut Microbiome in Irritable Bowel Syndrome: Implications for Clinical Therapeutics

Zhao, Y., Zhu, S., Dong, Y., Xie, T., Chai, Z., Gao, X., Dai, Y., & Wang, X. (2024) · Biomolecules · doi:10.3390/biom14121643 · Cited by 32

Enterochromaffin Cells: Sentinels to Gut Microbiota in Hyperalgesia?

Xu, X., Chen, R., Zhan, G., Wang, D., Tan, X., & Xu, H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.760076 · Cited by 31

Microbiome-Specific Statistical Modeling Identifies Interplay Between Gastrointestinal Microbiome and Neurobehavioral Outcomes in Patients With Autism: A Case Control Study

Huang, M., Liu, J., Liu, K., Chen, J., Wei, Z., Feng, Z., Wu, Y., Fong, M., Tian, R., Wang, B., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.682454 · Cited by 29

From gut to brain: unveiling probiotic effects through a neuroimaging perspective—A systematic review of randomized controlled trials

Crocetta, A., Liloia, D., Costa, T., Duca, S., Cauda, F., & Manuello, J. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1446854 · Cited by 32

Regulating the Enteric Nervous System against Obesity in Mice by Electroacupuncture

Ding, D., Chen, Q., Zhong, Z., Xia, X., & Ding, W. (2020) · NeuroImmunoModulation · doi:10.1159/000506483 · Cited by 24

Exploration of the relationship between gut microbiota and fecal microRNAs in patients with major depressive disorder

Chen, H., Chung, Y.-C. E., Chen, H., Liu, Y.-W., Chen, I., Lu, M., Hsiao, F. S., Chen, C.-H., Huang, M., Shih, W., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-24773-7 · Cited by 25

Effects of Rifaximin on Central Responses to Social Stress—a Pilot Experiment

Wang, H., Braun, C., & Enck, P. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0627-2 · Cited by 24

Exploring the potential of probiotics in Alzheimer's disease and gut dysbiosis

Sowmiya, S., Ls, D., Rajendran, P., Harikrishnan, N., & Ankul Singh, S. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.11.004 · Cited by 22

Cellular Immune Signal Exchange From Ischemic Stroke to Intestinal Lesions Through Brain-Gut Axis

Yang, Z., Wei, F., Zhang, B., Luo, Y., Xing, X., Wang, M., Chen, R., Sun, G., & Sun, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.688619 · Cited by 26

The effect of exercise on depression and gut microbiota: Possible mechanisms

Yao, M., Qu, Y., Zheng, Y., & Guo, H. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111130 · Cited by 26

Neuronal lineages derived from the nerve-associated Schwann cell precursors

Kameneva, P., Kastriti, M. E., & Adameyko, I. I. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03609-5 · Cited by 27

Zhizhu decoction alleviates slow transit constipation by regulating aryl hydrocarbon receptor through gut microbiota

Wen, Y., Zhan, Y., Tang, S., Liu, F., Wu, R., Kong, P., Li, Q., & Tang, X. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2157020 · Cited by 23

Hyaluronan: A Neuroimmune Modulator in the Microbiota-Gut Axis

Bosi, A., Banfi, D., Bistoletti, M., Moretto, P., Moro, E., Crema, F., Maggi, F., Karousou, E. G., Viola, M., Passi, A. G., et al. (2021) · Cells · doi:10.3390/cells11010126 · Cited by 19

Vagus nerve and brain–gut communication in neurodegenerative diseases: Mechanism and therapeutic perspectives

Luo, S., Pan, M., Fu, G., Meng, X., Zhao, Z., Yu, H., Yue, G.-X., & Lei, T. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107974 · Cited by 19

Role of sulfidogenic members of the gut microbiota in human disease

Pimenta, A. I., Bernardino, R. M., & Pereira, I. A. C. (2024) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2024.04.003 · Cited by 18

Gastrointestinal Microbiota and the Neural System

Philip, V., & Berčík, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804024-9.00027-6 · Cited by 2

Microbial Modulation of the Development and Physiology of the Enteric Nervous System

Joly, A., Leulier, F., & Vadder, F. D. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.11.007 · Cited by 67

Early life interaction between the microbiota and the enteric nervous system

Foong, J. P. P., Hung, L. Y., Poon, S., Savidge, T., & Bornstein, J. C. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00288.2020 · Cited by 50

Interaction of the Microbiota and the Enteric Nervous System During Development

Foong, J. P. P. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-05843-1_15

Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system

Kabouridis, P. S., & Pachnis, V. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76308 · Cited by 117