Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing of the clock gene period 1 in rat hippocampus

Conway‐Campbell, B. L .; Sarabdjitsingh, R. A.; McKenna, M. A.; Pooley, J. R.; Kershaw, Y. M.; Meijer, O. C.; De Kloet, E. R.; Lightman, S. L .

doi:10.1111/j.1365-2826.2010.02051.x

Cited by 137Circadian rhythm and melatoninStress Responses and CortisolEstrogen and related hormone effects

Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing of the clock gene period 1 in rat hippocampus

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Conway‐Campbell, B. L ., Sarabdjitsingh, R. A., McKenna, M. A., Pooley, J. R., Kershaw, Y. M., Meijer, O. C., De Kloet, E. R., Lightman, S. L .·2010·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2010.02051.xPMC PMC4968637

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Abstract

In vivo glucocorticoid (GC) secretion exhibits a distinctive ultradian rhythmicity. The lipophilic hormone can rapidly diffuse into cells, although only the pulse peak is of sufficient amplitude to activate the low affinity glucocorticoid receptor (GR). Discrete pulses readily access brain regions such as the hippocampus where GR expression is enriched and known to regulate neuronal function, including memory and learning processes. In the present study, we have tested the hypothesis that GR brain targets are responsive to ultradian GC rhythmicity. We have used adrenalectomised rats replaced with pulses of corticosterone to determine the transcriptional effects of ultradian pulses in the hippocampus. Confocal microscopy confirmed that each GC pulse results in transient GR nuclear localisation in hippocampal CA1 neurones. Concomitant GR activation and DNA binding was demonstrated by synthetic glucocorticoid response element oligonucleotide binding, and verified for the Clock gene Period 1 promoter region by chromatin immunoprecipitation assays. Strikingly each GC pulse induced a ‘burst’ of transcription of Period 1 measured by heterogeneous nuclear RNA quantitative polymerase chain reaction. The net effect of pulsatile GC exposure on accumulation of the mature transcript was also assessed, revealing a plateau of mRNA levels throughout the time course of pulsatile exposure, indicating the pulse timing works optimally for steady state Per1 expression. The plateau dropped to baseline within 120 min of the final pulse, indicating a relatively short half‐life for hippocampal Per1. The significance of this strict temporal control is that any perturbation to the pulse frequency or duration would have rapid quantitative effects on the levels of Per1. This in turn could affect hippocampal function, especially circadian related memory and learning processes.

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The ultradian rhythm of the glucocorticoid secretion and the time course of target gene regulation
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Glucocorticoid Ultradian Rhythmicity Directs Cyclical Gene Pulsing of the Hippocampal CLOCK Gene Period 1.
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Circadian Clock Genes Are Regulated by Rhythmic Corticosterone at Physiological Levels in the Rat Hippocampus
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Hippocampal Fast Glutamatergic Transmission Is Transiently Regulated by Corticosterone Pulsatility
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The ultradian rhythm of glucocorticoid secretion and the time course of target gene regulation
Merkulov, V. M., Klimova, N. V., & Merkulova, T. I. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.18699/vj15.027

Authors: Conway‐Campbell, B. L., Sarabdjitsingh, R. A., McKenna, M. A., Pooley, J. R., Kershaw, Y. M., Meijer, O. C., De Kloet, E. R., & Lightman, S. L.
Affiliations: Leiden University Medical Center (NL)
University of Bristol (GB)
ORCID: Sarabdjitsingh, R. A.
Pooley, J. R.
Kershaw, Y. M.
Meijer, O. C.
Lightman, S. L .
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2010-09-15
Volume: 22
Issue: 10
Pages: 1093-1100
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2010.02051.x
PMC: PMC4968637
OpenAlex: W2127035635
Cited by: 137
References: 47
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 10 · 2017: 12 · 2016: 18 · 2015: 17 · 2014: 12 · 2013: 5 · 2012: 10
FWCI: 3.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Explore Bristol Research (publishedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Funders: Wellcome Trust (089647, 089647/Z/09/Z)
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Biotechnology and Biological Sciences Research Council (BB/H015779/1)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: glucocorticoid receptor, circadian clock, hippocampus, CA1 neurons, transcriptional bursting, mRNA half-life, glucocorticoid response element, adrenalectomy
MeSH terms: Activity Cycles, Adrenalectomy, Animals, Corticosterone, Gene Expression Regulation, Glucocorticoids, Hippocampus, Periodicity, Promoter Regions, Genetic, Receptors, Glucocorticoid, Rats, Sprague-Dawley, Response Elements, Rats, Period Circadian Proteins

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Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing of the clock gene period 1 in rat hippocampus

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