Cited by 355Stress Responses and CortisolAdrenal Hormones and DisordersCircadian rhythm and melatonin

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Cortisol pulsatility and its role in stress regulation and health

YOUNG, E, ABELSON, J, LIGHTMAN, S·2004·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2004.07.001

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Abstract

One of the classic characteristics of the human stress response is the wide inter-individual variation. Although there is much current interest in the genetic and environmental contributions to these differences, studies on human subject have been sparse and characterised by methodological problems. The major factor that is rarely taken into account is the intrinsic rhythmicity of hypothalamo-pituitary-adrenal activity, not simply the classic diurnal variation but also the endogenous pulsatility which is similar to, but much less well recognized than, the rhythms found within the reproductive and growth hormone axes. In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease.

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Authors: YOUNG, E., ABELSON, J., & LIGHTMAN, S.
Affiliations: University of Michigan (US)
Bristol Royal Infirmary (GB)
Corresponding author: YOUNG, E
ORCID: ABELSON, J
LIGHTMAN, S
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2004-07
Volume: 25
Issue: 2
Pages: 69-76
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2004.07.001
OpenAlex: W2075627423
Cited by: 355
References: 28
Citations by year: 2026: 8 · 2025: 10 · 2024: 8 · 2023: 15 · 2022: 15 · 2021: 15 · 2020: 19 · 2019: 14 · 2018: 15 · 2017: 18 · 2016: 23 · 2015: 26 · 2014: 21 · 2013: 33 · 2012: 15
FWCI: 3.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Explore Bristol Research (submittedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Funders: National Institute of Mental Health (MH 52724, MH 01931, R01MH050030, MH50030, K05MH001931)
National Center for Research Resources (M-01RR00042, M01RR000042)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: hypothalamic-pituitary-adrenal axis, stress response, interindividual variability, diurnal cortisol rhythm
MeSH terms: Animals, Circadian Rhythm, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Periodicity, Pituitary-Adrenal System, Pulsatile Flow, Stress, Physiological

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Cortisol pulsatility and its role in stress regulation and health

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