Cited by 737Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorPosttraumatic Stress Disorder Research

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Sex differences in stress-related psychiatric disorders: Neurobiological perspectives

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Bangasser, Debra A., Valentino, Rita J.·2014·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2014.03.008PMC PMC4087049

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Abstract

Stress is associated with the onset and severity of several psychiatric disorders that occur more frequently in women than men, including posttraumatic stress disorder (PTSD) and depression. Patients with these disorders present with dysregulation of several stress response systems, including the neuroendocrine response to stress, corticolimbic responses to negatively valenced stimuli, and hyperarousal. Thus, sex differences within their underlying circuitry may explain sex biases in disease prevalence. This review describes clinical studies that identify sex differences within the activity of these circuits, as well as preclinical studies that demonstrate cellular and molecular sex differences in stress responses systems. These studies reveal sex differences from the molecular to the systems level that increase endocrine, emotional, and arousal responses to stress in females. Exploring these sex differences is critical because this research can reveal the neurobiological underpinnings of vulnerability to stress-related psychiatric disorders and guide the development of novel pharmacotherapies.

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Authors: Bangasser, D. A., & Valentino, R. J.
Affiliations: Temple University (US)
Children's Hospital of Philadelphia (US)
ORCID: Bangasser, Debra A.
Valentino, Rita J.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2014-08
Volume: 35
Issue: 3
Pages: 303-319
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2014.03.008
PMC: PMC4087049
OpenAlex: W2078229830
Cited by: 737
References: 350
Citations by year: 2026: 84 · 2025: 71 · 2024: 87 · 2023: 62 · 2022: 61 · 2021: 78 · 2020: 63 · 2019: 63 · 2018: 66 · 2017: 37 · 2016: 40 · 2015: 16 · 2014: 9
FWCI: 2.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: PHS
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: sex differences, stress-related psychiatric disorders, post-traumatic stress disorder, depression, stress system, neuroendocrine stress response, corticolimbic circuitry, hyperarousal, sex differences in disease prevalence
MeSH terms: Animals, Arousal, Mental Disorders, Brain, Corticotropin-Releasing Hormone, Humans, Sex Characteristics, Stress, Psychological

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Sex differences in stress-related psychiatric disorders: Neurobiological perspectives

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