Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway
Open accessAbstract
We have recently reported in male rats that medial prefrontal cortex (mPFC) neurons that project to the basolateral nucleus of the amygdala (BLA) are resilient to stress-induced dendritic remodeling. The present study investigated whether this also occurs in female rats. This pathway was identified using the retrograde tracer Fast Blue injected into the BLA of ovariectomized female rats with estrogen replacement (OVX + E) and without (OVX + veh). Animals were exposed for 10 days either to 2-h immobilization stress or to home cage rest, after which layer III mPFC neurons that were either retrogradely labeled by Fast Blue or unlabeled were filled with Lucifer Yellow and analyzed for apical dendritic length and spine density. No dendritic remodeling occurred in unlabeled neurons from OVX + veh or OVX + E animals. In BLA-projecting neurons, however, stress had no effect on length in OVX + veh animals, but stressed OVX + E females showed greater dendritic length than controls at intermediate branches. Stress also caused an increase in spine density in all neurons in OVX + veh animals and a spine density increase in BLA-projecting neurons in OVX + E females. Estrogen also increased spine density on BLA-projecting neurons in unstressed animals. These data demonstrate both independent effects of estrogen on pyramidal cell morphology and effects that are interactive with stress, with the BLA-projecting neurons being sensitive to both kinds of effects.
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Estradiol treatment of ovariectomized females increased spine density in medial prefrontal cortex neurons, irrespective of where they were projecting.
“Furthermore, estradiol treatment of ovariectomized (OVX) females increased spine density in mPFC neurons, irrespective of where they were projecting.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [104]
Ovariectomy prevented these chronic restraint stress effects on dendritic length and branching.
“Moreover, ovariectomy prevented these CRS effects on dendritic length and branching.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [104]
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Self-citation
- Authors
- Shansky, R. M., Hamo, C., Hof, P. R., Lou, W., McEwen, B. S., & Morrison, J. H.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Toronto (CA)
- Rockefeller University (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02-05
- Volume
- 20
- Issue
- 11
- Pages
- 2560-2567
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC2951843
- OpenAlex
- W2168578366
- Cited by
- 191
- References
- 58
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 9 · 2021: 17 · 2020: 19 · 2019: 19 · 2018: 11 · 2017: 15 · 2016: 15 · 2015: 15 · 2014: 9 · 2013: 11 · 2012: 10
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-58911, P50MH058911, MH075506, F32MH075506)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- estrogen, stress sensitivity, medial prefrontal cortex, basolateral amygdala, dendritic remodeling, dendritic spine density, restraint stress, sex differences, ovariectomy, estrogen replacement therapy, pyramidal neurons
- MeSH terms
- Amygdala, Animals, Disease Models, Animal, Estrogens, Female, Neural Pathways, Stress, Psychological, Rats, Sprague-Dawley, Prefrontal Cortex, Rats
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