Cardiovascular disease and the biology of aging

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075

Empagliflozin in heart failure with a preserved ejection fraction

Anker, S. D., Butler, J., Filippatos, G., Ferreira, J. P., Bocchi, E., Böhm, M., Brunner–La Rocca, H.-P., Choi, D.-J., Chopra, V., Chuquiure-Valenzuela, E., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2107038 · Cited by 4,874

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

Genome-wide methylation profiles reveal quantitative views of human aging rates

Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734

Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease

Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683

DNA methylation GrimAge strongly predicts lifespan and healthspan

Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., et al. (2019) · Aging · doi:10.18632/aging.101684 · Cited by 2,540

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease

Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045

Extension of murine life span by overexpression of catalase targeted to mitochondria

Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

Bock, K. D., Γεωργιάδου, Μ., Schoors, S., Kuchnio, A., Wong, B. W., Cantelmo, A. R., Quaegebeur, A., Ghesquière, B., Cauwenberghs, S., Eelen, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.037 · Cited by 1,589

Epidemiology of heart failure with preserved ejection fraction

Dunlay, S. M., Roger, V. L., & Redfield, M. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.65 · Cited by 1,548

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science · doi:10.1126/science.aag1381 · Cited by 1,536

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1574 · Cited by 1,520

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016) · Science · doi:10.1126/science.aaf6659 · Cited by 1,195

Cardioprotection and lifespan extension by the natural polyamine spermidine

Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4132 · Cited by 1,105

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology · doi:10.1186/s13059-019-1824-y · Cited by 1,025

Large-Artery Stiffness in Health and Disease

Chirinos, J. A., Segers, P., Hughes, T. M., & Townsend, R. R. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.07.012 · Cited by 1,014

Mitochondrial dysfunction in pathophysiology of heart failure

Zhou, B., & Tian, R. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120849 · Cited by 961

Identification of seven loci affecting mean telomere length and their association with disease

CARDIoGRAM consortium, Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2528 · Cited by 933

Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis

Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791

Cross talk between mitochondria and NADPH oxidases

Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783

Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

Zink, F., Stacey, S. N., Norddahl, G. L., Frigge, M. L., Magnusson, O. T., Jonsdottir, I., Thorgeirsson, T. E., Sigurdsson, A., Gudjonsson, S. A., Gudmundsson, J., et al. (2017) · Blood · doi:10.1182/blood-2017-02-769869 · Cited by 777

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Nature · doi:10.1038/nature14300 · Cited by 770

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang‐Verzosa, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12458 · Cited by 738

Measuring In Vivo Mitophagy

Sun, N., Yun, J., Liu, J., Malide, D. A., Liu, C., Rovira, I. I., Holmström, K. M., Fergusson, M. M., Yoo, Y. H., Combs, C. A., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.009 · Cited by 718

The Failing Heart Relies on Ketone Bodies as a Fuel

Aubert, G., Martin, O. J., Horton, J. L., Lai, L., Vega, R. B., Leone, T. C., Koves, T. R., Gardell, S. J., Krüger, M., Hoppel, C. L., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.017355 · Cited by 716

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction

Doughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710

The Burden of Cardiovascular Disease in the Elderly: Morbidity, Mortality, and Costs

Yazdanyar, A. R., & Newman, A. B. (2009) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.07.007 · Cited by 668

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Schoors, S., Bruning, U., Missiaen, R., Queiroz, K. C. S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A. R., Christen, S., Goveia, J., et al. (2015) · Nature · doi:10.1038/nature14362 · Cited by 646

Endothelial to Mesenchymal Transition in Cardiovascular Disease

Kovacic, J. C., Dimmeler, S., Harvey, R. P., Finkel, T., Aïkawa, E., Krenning, G., & Baker, A. H. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.089 · Cited by 639

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

Liao, X., Sluimer, J. C., Wang, Y., Subramanian, M., Brown, K., Pattison, J. S., Robbins, J., Martinez, J., & Tabas, I. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.022 · Cited by 627

The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: A multicenter randomized trial

Nassif, M. E., Windsor, S. L., Borlaug, B. A., Kitzman, D. W., Shah, S. J., Tang, F., Khariton, Y., Malik, A. O., Khumri, T., Umpierrez, G., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01536-x · Cited by 618

Vascular Smooth Muscle Cells Undergo Telomere-Based Senescence in Human Atherosclerosis: Effects of Telomerase and Oxidative Stress

Matthews, C., Gorenne, I., Scott, S., Figg, N., Kirkpatrick, P., Ritchie, A., Goddard, M., & Bennett, M. (2006) · Circulation Research · doi:10.1161/01.res.0000233315.38086.bc · Cited by 615

Autophagy Links Inflammasomes to Atherosclerotic Progression

Razani, B., Feng, C., Coleman, T., Emanuel, R., Wen, H., Hwang, S., Ting, J. P., Virgin, H. W., Kastan, M. B., & Semenkovich, C. F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.011 · Cited by 601

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P., & Ganley, I. G. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.008 · Cited by 591

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

Hoshino, A., Mita, Y., Okawa, Y., Ariyoshi, M., Iwai-Kanai, E., Ueyama, T., Ikeda, K., Ogata, T., & Matoba, S. (2013) · Nature Communications · doi:10.1038/ncomms3308 · Cited by 536

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100492 · Cited by 532

The Aging Epigenome

Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499

Mitochondrial Integrity and Function in Atherogenesis

Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R. M., Hunter, G. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000023921.93743.89 · Cited by 476

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

Grosse, L., Wagner, N., Emelyanov, A., Molina, C., Lacas-Gervais, S., Wagner, K.-D., & Bulavin, D. V. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.002 · Cited by 460

Aging and Autophagy in the Heart

Shirakabe, A., Ikeda, Y., Sciarretta, S., Zablocki, D., & Sadoshima, J. (2016) · Circulation Research · doi:10.1161/circresaha.116.307474 · Cited by 448

Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF

Deng, Y., Xie, M., Li, Q., Xu, X., Ou, W., Zhang, Y., Xiao, H., Yu, H., Zheng, Y., Liang, Y., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317933 · Cited by 420

Mitochondrial Metabolism in Aging Heart

Lesnefsky, E. J., Chen, Q., & Hoppel, C. L. (2016) · Circulation Research · doi:10.1161/circresaha.116.307505 · Cited by 355

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

Lee, J. J., Sánchez-Martínez, Á., Martinez, A., Benincá, C., Mayor, U., Clague, M. J., & Whitworth, A. J. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201801044 · Cited by 353

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

Rana, A., Rera, M., & Walker, D. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216197110 · Cited by 335

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

Labbadia, J. P., & Morimoto, R. I. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.027 · Cited by 322

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

Dikalov, S., Nazarewicz, R. R., Bikineyeva, A. T., Hilenski, L. L., Lassegue, B. P., Griendling, K. K., Harrison, D. G., & Dikalova, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4918 · Cited by 312

Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction

Kumar, A. A., Kelly, D. P., & Chirinos, J. A. (2019) · Circulation · doi:10.1161/circulationaha.118.036259 · Cited by 297

Epigenetic Modifications in Cardiovascular Aging and Diseases

Zhang, W., Song, M., Qu, J. T., & Liu, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312497 · Cited by 296

Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases

Li, Y., Lui, K. O., & Zhou, B. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0023-y · Cited by 287

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

Ren, J. T., & Zhang, Y. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.10.005 · Cited by 281

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

Dai, D., Chen, T., Wanagat, J., Laflamme, M., Marcinek, D. J., Emond, M. J., Ngo, C. P., Prolla, T. A., & Rabinovitch, P. S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00581.x · Cited by 280

A Metabolic Basis for Endothelial-to-Mesenchymal Transition

Xiong, J., Kawagishi, H., Yan, Y., Liu, J., Wells, Q. S., Edmunds, L. R., Fergusson, M. M., Yu, Z., Rovira, I. I., Brittain, E. L., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.010 · Cited by 266

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

Gioscia‐Ryan, R. A., LaRocca, T. J., Sindler, A. L., Zigler, M. C., Murphy, M. P., & Seals, D. R. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.268680 · Cited by 263

The H3K27 demethylase UTX‐1 regulates C. elegans lifespan in a germline‐independent, insulin‐dependent manner

Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256

Autophagy in Cardiovascular Aging

Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312208 · Cited by 239

Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

Tyrrell, D. J., Blin, M. G., Song, J., Wood, S. C., Zhang, M., Beard, D. A., & Goldstein, D. R. (2019) · Circulation Research · doi:10.1161/circresaha.119.315644 · Cited by 230

Energy turnover of vascular endothelial cells

Culic, O., Gruwel, M. L. H., & Schrader, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.1.c205 · Cited by 220

Cigarette Smoke Exposure and Hypercholesterolemia Increase Mitochondrial Damage in Cardiovascular Tissues

Knight-Lozano, C. A., Young, C. G., Burow, D. L., Hu, Z., Uyeminami, D. L., Pinkerton, K. E., Ischiropoulos, H., & Ballinger, S. W. (2002) · Circulation · doi:10.1161/hc0702.103977 · Cited by 217

Sex Differences in Myocardial and Vascular Aging

Ji, H., Kwan, A. C., Chen, M. T., Ouyang, D., Ebinger, J. E., Bell, S. P., Niiranen, T., Bello, N. A., & Cheng, S. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319902 · Cited by 210

Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance

Molina, A. J. A., Bharadwaj, M. S., Horn, C. V., Nicklas, B. J., Lyles, M. F., Eggebeen, J., Haykowsky, M. J., Brubaker, P. H., & Kitzman, D. W. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.03.011 · Cited by 209

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

Ungvari, Z. I., Labinskyy, N., Gupte, S. A., Chander, P. N., Edwards, J. G., & Csiszár, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00012.2008 · Cited by 204

Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier

Doll, D. N., Hu, H., Sun, J., Lewis, S. E., Simpkins, J. W., & Ren, X. (2015) · Stroke · doi:10.1161/strokeaha.115.009099 · Cited by 202

Clinical consequences of clonal hematopoiesis of indeterminate potential

Steensma, D. P. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018020222 · Cited by 194

Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness

Yu, E., Reinhold, J., Yu, H., Starks, L. T., Uryga, A., Foote, K., Finigan, A. J., Figg, N. L., Pung, Y. F., Logan, A., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310042 · Cited by 170

Cardiovascular Disease, Aging, and Clonal Hematopoiesis

Evans, M. A., Sano, S., & Walsh, K. X. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032544 · Cited by 169

Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle

Bowen, T. S., Rolim, N. P. L., Fischer, T., Bækkerud, F. H., Medeiros, A., Werner, S., Brønstad, E., Rognmo, O., Mangner, N., Linke, A., et al. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.239 · Cited by 165

Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.11.002 · Cited by 163

Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults

Rehkopf, D. H., Needham, B. L., Lin, J., Blackburn, E. H., Zota, A. R., Wojcicki, J. M., & Epel, E. S. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002188 · Cited by 155

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

Osonoi, Y., Mita, T., Azuma, K., Nakajima, K., Masuyama, A., Goto, H., Nishida, Y., Miyatsuka, T., Fujitani, Y., Koike, M., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1501132 · Cited by 149

Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials

Gao, L., Mao, Q., Cao, J. J., Wang, Y., Zhou, X., & Li, F. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.10.027 · Cited by 144

TFEB inhibits endothelial cell inflammation and reduces atherosclerosis

Lu, H., Fan, Y., Qiao, C., Liang, W., Hu, W., Zhu, T., Zhang, J., & Chen, Y. E. (2017) · Science Signaling · doi:10.1126/scisignal.aah4214 · Cited by 141

Molecular Mechanisms and Regulation of Mammalian Mitophagy

Choubey, V., Zeb, A., & Kaasik, A. (2021) · Cells · doi:10.3390/cells11010038 · Cited by 127

The road ahead for health and lifespan interventions

Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118

Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

Ammous, F., Zhao, W., Ratliff, S. M., Mosley, T. H., Bielak, L. F., Zhou, X., Peyser, P. A., Kardia, S. L. R., & Smith, J. A. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01035-3 · Cited by 106

Adverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Mellitus–Related Endothelial Dysfunction in Humans

Kizhakekuttu, T. J., Wang, J., Dharmashankar, K., Ying, R., Gutterman, D. D., Vita, J. A., & Widlansky, M. E. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.256024 · Cited by 105

Associations of Body Composition and Physical Activity Level With Multiple Measures of Epigenetic Age Acceleration

Kresovich, J. K., Garval, E. L., Lopez, A. M. M., Xu, Z., Niehoff, N. M., White, A. J., Sandler, D. P., & Taylor, J. A. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa251 · Cited by 103

DNA methylation-based biomarkers of age acceleration and all-cause death, myocardial infarction, stroke, and cancer in two cohorts: The NAS, and KORA F4

Wang, C., Ni, W., Yao, Y., Just, A. C., Heiss, J. A., Wei, Y., Gao, X., Coull, B. A., Kosheleva, A., Baccarelli, A., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103151 · Cited by 87

Aging is associated with a decline in Atg9b-mediated autophagosome formation and appearance of enlarged mitochondria in the heart

Liang, W., Moyzis, A. G., Lampert, M. A., Diao, R. Y., Najor, R. H., & Gustafsson, Å. B. (2020) · Aging Cell · doi:10.1111/acel.13187 · Cited by 80

Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure

Nambu, H., Takada, S., Fukushima, A., Matsumoto, J., Kakutani, N., Maekawa, S., Shirakawa, R., Nakano, I., Furihata, T., Katayama, T., et al. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172810 · Cited by 73

Age‐related endothelial dysfunction in human skeletal muscle feed arteries: the role of free radicals derived from mitochondria in the vasculature

Park, S. ‐., Kwon, O. S., Andtbacka, R. H. I., Hyngstrom, J. R., Reese, V. R., Murphy, M. P., & Richardson, R. S. (2017) · Acta Physiologica · doi:10.1111/apha.12893 · Cited by 71

The Aging Heart: Mitophagy at the Center of Rejuvenation

Liang, W., & Gustafsson, Å. B. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00018 · Cited by 65

Telomere length in vascular tissues from patients with atherosclerotic disease

Nzietchueng, R., Elfarra, M., Nloga, J., Labat, C., Carteaux, J., Maureira, P., Lacolley, P. J., Villemot, J., & Benetos, A. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0029-1 · Cited by 58

Defective autophagy in vascular smooth muscle cells alters contractility and Ca2+ homeostasis in mice

Michiels, C. F., Fransen, P. F., Munck, D. G. D., Meyer, G. R. Y. D., & Martinet, W. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00659.2014 · Cited by 56

Autophagic Marker MAP1LC3B Expression Levels Are Associated with Carotid Atherosclerosis Symptomatology

Swaminathan, B., Goikuria, H., Vega, R., Antigüedad, A. R., Medina, A. L., Freijo, M. D. M., Vandenbroeck, K., & Alloza, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115176 · Cited by 48

Hutchinson–Gilford Progeria Syndrome: Cardiovascular Pathologies and Potential Therapies

Xu, S., & Jin, Z. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.03.010 · Cited by 26

Renal disease: advances in diagnosis and treatment. Part 1.

Rg, L. (1976) · PubMed · Cited by 3

Insights into US life expectancy stagnation from birth cohort mortality dynamics

Abrams, L., Bramajo, O., van Raalte, A., Myrskylä, M., & Mehta, N. K. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2519356123 · Cited by 6

Mechanisms of long-term decay of tension stiffening

Beeby, A. W., & Scott, R. H. (2006) · Magazine of Concrete Research · doi:10.1680/macr.2006.58.5.255 · Cited by 22

Static Experiment and Finite Element Analysis of a Multitower Cable‐Stayed Bridge with a New Stiffening System

Wang, X., Li, Y., Song, W., et al. (2019) · Advances in Civil Engineering · doi:10.1155/2019/4687370 · Cited by 5

Stiffening in Tubular Junctions—Some New Concepts

Mehrotra, B. L. (1971) · Journal of the Structural Division · doi:10.1061/jsdeag.0003019 · Cited by 1

Behaviour of stiffened cold-formed steel beams-An experimental study

Dar, A. R. (2019) · Materials Today Proceedings · doi:10.1016/j.matpr.2019.11.111 · Cited by 3

On the Stiffening of the Edge of the Hole in an Orthogonally Aeolotropic Plate with a Circular Hole : Continuation-Stiffened with a Flanged Coaming Plate and with the Double Stiffening Plates

NOMURA, Y. (1959) · Bulletin of JSME · doi:10.1299/jsme1958.2.277