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Progression and application of CRISPR-Cas genomic editors

Yang, Li, Tang, Jing, Ma, Xuelei, Lin, Yuan, Ma, Guorong, Shan, Minghai, Wang, Libin, Yang, Yanhui·2021·Methods
DOI 10.1016/j.ymeth.2021.03.013
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Abstract

Base editing technology is an efficient tool for genome editing, particularly in the correction of base mutations. Diverse base editing systems were developed according to the dCas9 or nCas9 linked with different deaminase or reverse transcriptase in the editors, including ABEs, CBEs, PEs and dual-functional of base editor (such as CGBE1, A&C-BEmax, ACBE, etc.). Currently, Base editing technology has been widely applied to various fields such as microorganisms, plants, animals and medicine for basic research and therapeutics. Here, we reviewed the advancement of base editing technology. We also discussed the application of base editors in different areas in the future.

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Metadata

Authors
Yang, L., Tang, J., Ma, X., Lin, Y., Ma, G., Shan, M., Wang, L., & Yang, Y.
Venue
Methods
Publisher
Elsevier BV
Published
2021-10
Volume
194
Pages
65-74
ISSN
1046-2023
DOI
10.1016/j.ymeth.2021.03.013
Cited by
10
References
6
Language
en
Licence
Funders
  • Chinese Academy of Sciences (XAB2019AW11)
  • National Natural Science Foundation of China (81202567, 81560604, 81860470)

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