The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The ipsilateral CA3 subfield displays neurodegeneration, chronic BBB disruption and generates the spontaneous seizures in the present model (Li et al., 2008; Reschke et al., 2021).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Reschke et al., 2021
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This could be due to ongoing spontaneous seizure-induced breaches in BBB integrity (Reschke et al., 2021; Greene et al., 2022).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Reschke et al., 2021
Experimental — accuracy not yet measuredIn the citing paper
“Moreover, there is disruption of the blood–brain barrier after seizures sufficient to allow passage of macromolecules between the blood and brain (Van Vliet et al., 2007; Reschke et al., 2021).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Reschke et al., 2021
In the citing paper
“The ipsilateral CA3 subfield displays neurodegeneration, chronic BBB disruption and generates the spontaneous seizures in the present model (Li et al., 2008; Reschke et al., 2021).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Reschke et al., 2021
In the citing paper
“This likely reflects the early and transient large-scale opening of the BBB in the hours following SE in the model (Michalak et al., 2013; Reschke et al., 2021).”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Reschke et al., 2021
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452
A brain-specific microRNA regulates dendritic spine development
Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975
Oligonucleotide therapies for disorders of the nervous system
Khorkova, O., & Wahlestedt, C. (2017) · Nature Biotechnology · doi:10.1038/nbt.3784 · Cited by 179
Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways
van Wageningen, S., Kemmeren, P., Lijnzaad, P., Margaritis, T., Benschop, J. J., de Castro, I. J., van Leenen, D., Groot Koerkamp, M. J. A., Ko, C. W., Miles, A. J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.021 · Cited by 133
Flagged first, then by citations
Research works printed but not linked: 42
- Levin, 2019, Treating disease at the RNA level with oligonucleotides, N. Engl. J. Med., 380, 57, 10.1056/NEJMra1705346 · DOI · Paper page
- Devinsky, 2018, Epilepsy, Nat. Rev. Dis. Primers, 4, 18024, 10.1038/nrdp.2018.24 · DOI
- Löscher, 2020, The holy grail of epilepsy prevention: preclinical approaches to antiepileptogenic treatments, Neuropharmacology, 167, 107605, 10.1016/j.neuropharm.2019.04.011 · DOI
- Henshall, 2016, MicroRNAs in epilepsy: pathophysiology and clinical utility, Lancet Neurol., 15, 1368, 10.1016/S1474-4422(16)30246-0 · DOI
- McNeill, 2012, MicroRNAs shape the neuronal landscape, Neuron, 75, 363, 10.1016/j.neuron.2012.07.005 · DOI · Paper page
- McKiernan, 2012, Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis, PLoS ONE, 7, e35921, 10.1371/journal.pone.0035921 · DOI · Paper page
- Hébert, 2010, Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration, Hum. Mol. Genet., 19, 3959, 10.1093/hmg/ddq311 · DOI
- Tan, 2013, MicroRNA-128 governs neuronal excitability and motor behavior in mice, Science, 342, 1254, 10.1126/science.1244193 · DOI · Paper page
- Jimenez-Mateos, 2012, Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects, Nat. Med., 18, 1087, 10.1038/nm.2834 · DOI
- Reschke, 2017, Potent anti-seizure effects of locked nucleic acid antagomirs targeting miR-134 in multiple mouse and rat models of epilepsy, Mol. Ther. Nucleic Acids, 6, 45, 10.1016/j.omtn.2016.11.002 · DOI
- Gao, 2019, Silencing microRNA-134 alleviates hippocampal damage and occurrence of spontaneous seizures after intraventricular kainic acid-induced status epilepticus in rats, Front. Cell. Neurosci., 13, 145, 10.3389/fncel.2019.00145 · DOI
- Gaughwin, 2011, Stage-specific modulation of cortical neuronal development by Mmu-miR-134, Cereb. Cortex, 21, 1857, 10.1093/cercor/bhq262 · DOI
- Elmén, 2008, LNA-mediated microRNA silencing in non-human primates, Nature, 452, 896, 10.1038/nature06783 · DOI · Paper page
- Jimenez-Mateos, 2015, Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus, Brain Struct. Funct., 220, 2387, 10.1007/s00429-014-0798-5 · DOI
- Straarup, 2010, Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates, Nucleic Acids Res., 38, 7100, 10.1093/nar/gkq457 · DOI
- van Vliet, 2007, Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy, Brain, 130, 521, 10.1093/brain/awl318 · DOI · Paper page
- Shlosberg, 2010, Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury, Nat. Rev. Neurol., 6, 393, 10.1038/nrneurol.2010.74 · DOI · Paper page
- Lublinsky, 2019, Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage, EBioMedicine, 43, 460, 10.1016/j.ebiom.2019.04.054 · DOI
- Rüber, 2018, Evidence for peri-ictal blood-brain barrier dysfunction in patients with epilepsy, Brain, 141, 2952, 10.1093/brain/awy242 · DOI
- Jimenez-Mateos, 2015, microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus, Sci. Rep., 5, 17486, 10.1038/srep17486 · DOI · Paper page
- Michalak, 2013, Spatio-temporally restricted blood-brain barrier disruption after intra-amygdala kainic acid-induced status epilepticus in mice, Epilepsy Res., 103, 167, 10.1016/j.eplepsyres.2012.10.006 · DOI · Paper page
- Keaney, 2015, Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier, Sci. Adv., 1, e1500472, 10.1126/sciadv.1500472 · DOI
- Li, 2008, Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice, J. Clin. Invest., 118, 571
- Jiang, 2016, Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy, Prog. Brain Res., 226, 81, 10.1016/bs.pbr.2016.04.012 · DOI
- Buono, 2004, Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility, Epilepsy Res., 58, 175, 10.1016/j.eplepsyres.2004.02.003 · DOI
- Akarsu, 1998, Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2, Epilepsy Res., 30, 63, 10.1016/S0920-1211(97)00092-2 · DOI
- Iwasa, 2017, Excitotoxicity-induced prostaglandin D2 production induces sustained microglial activation and delayed neuronal death, J. Lipid Res., 58, 649, 10.1194/jlr.M070532 · DOI
- Liang, 2005, Prostaglandin D2 mediates neuronal protection via the DP1 receptor, J. Neurochem., 92, 477, 10.1111/j.1471-4159.2004.02870.x · DOI
- Gross, 2016, MicroRNA-mediated downregulation of the potassium channel Kv4.2 contributes to seizure onset, Cell Rep., 17, 37, 10.1016/j.celrep.2016.08.074 · DOI
- Morris, 2018, Spared CA1 pyramidal neuron function and hippocampal performance following antisense knockdown of microRNA-134, Epilepsia, 59, 1518, 10.1111/epi.14475 · DOI
- Sambandan, 2017, Activity-dependent spatially localized miRNA maturation in neuronal dendrites, Science, 355, 634, 10.1126/science.aaf8995 · DOI
- Wetherington, 2008, Astrocytes in the epileptic brain, Neuron, 58, 168, 10.1016/j.neuron.2008.04.002 · DOI
- Janssen, 2013, Treatment of HCV infection by targeting microRNA, N. Engl. J. Med., 368, 1685, 10.1056/NEJMoa1209026 · DOI
- Wang, 2017, MicroRNA-134 plasma levels before and after treatment with valproic acid for epilepsy patients, Oncotarget, 8, 72748, 10.18632/oncotarget.20292 · DOI
- McArdle, 2017, “TORNADO” – Theranostic One-Step RNA Detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid, Sci. Rep., 7, 1750, 10.1038/s41598-017-01947-2 · DOI
- Kullmann, 2014, Gene therapy in epilepsy—is it time for clinical trials?, Nat. Rev. Neurol., 10, 300, 10.1038/nrneurol.2014.43 · DOI
- Schindelin, 2012, Fiji: an open-source platform for biological-image analysis, Nat. Methods, 9, 676, 10.1038/nmeth.2019 · DOI · Paper page
- Jassal, 2020, The reactome pathway knowledgebase, Nucleic Acids Res., 48, D498
- Yu, 2016, ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization, Mol. Biosyst., 12, 477, 10.1039/C5MB00663E · DOI
- Yu, 2012, clusterProfiler: an R package for comparing biological themes among gene clusters, OMICS, 16, 284, 10.1089/omi.2011.0118 · DOI · Paper page
- Vuokila, 2020, Chronic regulation of miR-124-3p in the perilesional cortex after experimental and human TBI, Int. J. Mol. Sci., 21, 2418, 10.3390/ijms21072418 · DOI
- Almeida Silva, 2020, Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice, Mol. Brain, 13, 114, 10.1186/s13041-020-00653-x · DOI
Cited by
Sorted by citations
Epigenetic genes and epilepsy — emerging mechanisms and clinical applications
Van Loo, K. M. J., Carvill, G. L., Becker, A. J., Conboy, K., Goldman, A. M., Kobow, K., Lopes-Cendes, I., Reid, C. A., van Vliet, E. A., & Henshall, D. C. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00693-y · Cited by 68
Self-citationBrain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Brindley, E., Heiland, M., Mooney, C., Diviney, M., Mamad, O., Hill, T. D. M., Yan, Y., Venø, M. T., Reschke, C. R., Batool, A., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1230942 · Cited by 21
Self-citation
Metadata
- Authors
- Reschke, C. R., Silva, L. F. A., Vangoor, V. R., Rosso, M., David, B., Cavanagh, B. L., Connolly, N. M. C., Brennan, G. P., Sanz-Rodriguez, A., Mooney, C., Batool, A., Greene, C., Brennan, M., Conroy, R. M., Rüber, T., Prehn, J. H. M., Campbell, M., Pasterkamp, R. J., & Henshall, D. C.
- ORCID
- Henshall, David C.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 29
- Issue
- 6
- Pages
- 2041-2052
- ISSN
- 1525-0016
- PMC
- PMC8178478
- Cited by
- 42
- References
- 5
- Language
- en
- Licence
- Funders
- Science Foundation Ireland (13/IA/1891, 11/TIDA/B1988, SFI/14/ADV/RC2721, 17/TIDA/5002, 16/RC/3948)
- Seventh Framework Programme
- Irish Research Council
- European Regional Development Fund
- Health Research Board
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- European Commission Seventh Framework Programme for Research and Technological Development Health (602130)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
