State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challenge
Abstract
Background Even in remission, patients with bipolar disorder (BD) remain sensitive to external stressors that can trigger new episodes. Imitating such stressors by the controlled transient exposure to an emotional stimulus may help to identify brain regions modulating this sensitivity.Methods Transient sadness was induced in 9 euthymic and in 11 depressed subjects with BD. Regional blood flow (rCBF) changes were measured using (15)O-water positron emission tomography.Results Common changes in both groups were increased rCBF in anterior insula and cerebellum and decreased rCBF in dorsal-ventral-medial frontal cortex, posterior cingulate, inferior parietal, and temporal cortices. Decreases in dorsal ventral medial frontal cortices occurred in both groups, but subjects in remission showed a greater magnitude of change. Unique to remitted subjects with BD were rCBF increases in dorsal anterior cingulate and in premotor cortex. Lateral prefrontal rCBF decreases were unique to depressed subjects with BD. At baseline, remitted subjects showed a unique increase in dorsal anterior cingulate and orbitofrontal cortex.Conclusions Common rCBF changes in remitted and depressed subjects identifies potential sites of disease vulnerability. Unique cingulate and orbitofrontal changes both at baseline and with induced sadness seen in the absence of prefrontal rCBF decreases may identify regional interactions important to the euthymic state in this population.
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The pregenual anterior cingulate cortex is associated with internal monitoring and mood states.
“Earlier studies showed that the pgACC was associated with internal monitoring [33, 34] and Mood States [35].”
From State and training effects of mindfulness meditation on brain networks reflect neuronal mechanisms of its antidepressant effect (2016) · cites this paper as [35]
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Self-citation
- Authors
- Krüger, S., Seminowicz, D., Goldapple, K., Kennedy, S. H., & Mayberg, H. S.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- University Health Network (CA)
- Corresponding author
- Krüger, Stephanie
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 54
- Issue
- 11
- Pages
- 1274-1283
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2040533544
- Cited by
- 127
- References
- 70
- Citations by year
- 2023: 3 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 13
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, mood regulation, regional cerebral blood flow, remission, depression, anterior cingulate cortex, orbitofrontal cortex, prefrontal cortex, anterior insula, cerebellum, stress sensitivity, emotional challenges
- MeSH terms
- Adult, Affect, Bipolar Disorder, Brain, Brain Mapping, Female, Humans, Male, Oxygen Radioisotopes, Regional Blood Flow, Remission Induction, Tomography, Emission-Computed
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