Cited by 300Adipose Tissue and MetabolismMitochondrial Function and PathologyPeroxisome Proliferator-Activated Receptors

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Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression

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Jacobsson, A, Stadler, U, Glotzer, M A, Kozak, L P·1985·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(17)36228-2

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Abstract

We have identified cDNAs clones for several cold-inducible mRNAs from the brown adipose tissue of mice. pCIN-1, a plasmid with a 900-base pair insert, encoded the mitochondrial uncoupling protein (UCP) as determined by the ability of the cDNA insert to select, by hybridization, an mRNA that could be translated into a 32,000-Da protein immunoprecipitable with anti-UCP antibodies. Nine tissues were analyzed; however, UCP cDNA hybridized to an mRNA species of 1.6 and 2.0 kilobase pairs only in brown adipose tissue. A maximum induction of 10-fold occurred within 6 h of exposure to cold (5 degrees C). A BamHI restriction fragment polymorphism detected by Southern blot analysis of genomic DNA in recombinant inbred mouse strains allowed us to map the UCP gene to Chromosome 8. The analysis of the UCP gene expression in diabetic (db) and obese (ob) mice maintained at 27 degrees C for 3 days followed by cold exposure for 4 h at 5 degrees C indicated that UCP mRNA levels in mutant mice were unaffected at 27 degrees C and only slightly reduced at 5 degrees C. Accordingly, the inability of diabetic and obese mice to thermoregulate is not associated with a lack of UCP mRNA induction.

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Authors: Jacobsson, A., Stadler, U., Glotzer, M. A., & Kozak, L. P.
Affiliations: Stockholm University (SE)
ORCID: Jacobsson, A
Glotzer, M A
Kozak, L P
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1985-12
Volume: 260
Issue: 30
Pages: 16250-16254
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(17)36228-2
OpenAlex: W1513078811
Cited by: 300
References: 36
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 10 · 2020: 1 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
FWCI: 6.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 12753 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-08431)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: mitochondrial uncoupling proteins, brown adipose tissue, cold-responsive genes, cDNA cloning, gene mapping, chromosome 8, mRNA expression, cold exposure, thermoregulation, diabetic mice, recombinant inbred mouse strains, restriction fragment polymorphism
MeSH terms: Uncoupling Protein 1, Animals, Adipose Tissue, Brown, Carrier Proteins, Cloning, Molecular, Cold Temperature, DNA Transposable Elements, DNA, Mitochondrial, Genes, Ion Channels, Membrane Proteins, Mice, Inbred C57BL, Mice, Mutant Strains, Mitochondria, Molecular Weight, RNA, Messenger, Protein Biosynthesis, Mitochondrial Proteins, Mice

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Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression

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