BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY

Lowell, MD, PhD, B. B.; Flier, MD, J. S.

doi:10.1146/annurev.med.48.1.307

Cited by 237Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY

Lowell, MD, PhD, B. B., Flier, MD, J. S.·1997·Annual Review of Medicine

DOI 10.1146/annurev.med.48.1.307

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Abstract

Brown adipose tissue is distinguished by its unique capacity for uncoupled mitochondrial respiration, which is highly regulated by sympathetic nerve activity. Because of this, energy expenditure in brown fat is capable of ranging over many orders of magnitude. The fact that the function of brown adipose tissue is impaired in obese rodents and that transgenic mice with decreased brown fat develop obesity demonstrates the importance of brown fat in maintaining nutritional homeostasis. However, the role of brown fat in humans is less clear. beta 3-Adrenergic receptors are found on brown adipocytes, and treatment with beta 3-selective agonists markedly increases energy expenditure and decreases obesity in rodents. Whether beta 3-selective agonists will be effective anti-obesity agents in humans is presently under investigation.

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Mice with genetically reduced brown adipose tissue mass are prone to obesity.
“mice with genetically reduced brown adipose tissue (BAT) mass are prone to obesity [53].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [53]

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Effects of Intravenously Infused Leptin on Insulin Sensitivity and on the Expression of Uncoupling Proteins in Brown Adipose Tissue1
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Authors: Lowell, M., & Flier, M.
Affiliations: Division of Endocrinology, Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215;, and
Venue: Annual Review of Medicine
Publisher: Annual Reviews
Published: 1997-02
Volume: 48
Issue: 1
Pages: 307-316
ISSN: 0066-4219 (ISSN-L)
1545-326X
DOI: 10.1146/annurev.med.48.1.307
OpenAlex: W2033159113
Cited by: 237
References: 70
Citations by year: 2026: 4 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 15 · 2020: 9 · 2019: 5 · 2018: 15 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 6 · 2012: 8
FWCI: 2.06
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08dk002119-05, 5r01dk046930-10)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 46930, DK 49569, R01DK049569, DK-02119)
Topics: Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: brown adipose tissue, beta3-adrenergic receptor, obesity, energy expenditure, sympathetic nervous system, brown adipocytes, anti-obesity drugs, nutritional homeostasis
MeSH terms: Animals, Adipose Tissue, Brown, Energy Metabolism, Humans, Mice, Obese, Mice, Transgenic, Obesity, Receptors, Adrenergic, beta, Receptors, Adrenergic, beta-3, Mice, Rats

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BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY

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