The mitogen-activated protein kinase signal transduction pathway

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature · doi:10.1038/354494a0 · Cited by 789

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

Dent, P., Lavoinne, A., Nakielny, S., Caudwell, F. B., Watt, P., & Cohen, P. (1990) · Nature · doi:10.1038/348302a0 · Cited by 519

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

Schlaepfer, D. D., Hanks, S. K., Hunter, T., & Geer, P. V. D. (1994) · Nature · doi:10.1038/372786a0 · Cited by 1,595

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543

Mitogen-activated protein kinases in apoptosis regulation

Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

Gutkind, J. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1839 · Cited by 812

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

Canagarajah, B. J., Khokhlatchev, A., Cobb, M. H., & Goldsmith, E. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80351-7 · Cited by 729

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

Kallunki, T., Su, B., Tsigelny, I., Sluss, H. K., Dérijard, B., Moore, G., Davis, R., & Karin, M. (1994) · Genes & Development · doi:10.1101/gad.8.24.2996 · Cited by 642

Raf meets Ras: completing the framework of a signal transduction pathway

Avruch, J., Zhang, X.-F., & Kyriakis, J. M. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90005-1 · Cited by 577

Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures

Stanciu, M., Wang, Y., Kentor, R., Burke, N., Watkins, S., Kress, G., Reynolds, I., Klann, E., Angiolieri, M. R., Johnson, J. W., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.12200 · Cited by 539

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., & Kornfeld, K. (1999) · Genes & Development · doi:10.1101/gad.13.2.163 · Cited by 439

Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo

Fisher, G. J., Talwar, H. S., Lin, J., Lin, P., McPhillips, F., Wang, Z., Li, X., Wan, Y., Kang, S., & Voorhees, J. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2153 · Cited by 392

Role of Ras and Mapks in TGFβ signaling

Mulder, K. M. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00026-x · Cited by 348

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

Rogatsky, I., Logan, S. K., & Garabedian, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2050 · Cited by 297

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling

Yamauchi, K., Milarski, K. L., Saltiel, A. R., & Pessin, J. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.664 · Cited by 263

Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction

Allen, L. T., Tosetto, M., Miller, I. S., O’Connor, D. P., Penney, S. C., Lynch, I., Keenan, A. K., Pennington, S. R., Dawson, K. A., & Gallagher, W. M. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.01.019 · Cited by 245

Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells

Pattabiraman, P. P., & Rao, P. V. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00317.2009 · Cited by 189

Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7

Bardwell, L., Cook, J. G., Chang, E. C., Cairns, B. R., & Thorner, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3637 · Cited by 161

The Extracellular Signal-Regulated Kinase Pathway Phosphorylates AML1, an Acute Myeloid Leukemia Gene Product, and Potentially Regulates Its Transactivation Ability

Tanaka, T., Kurokawa, M., Ueki, K., Tanaka, K., Imai, Y., Mitani, K., Okazaki, K., Sagata, N., Yazaki, Y., Shibata, Y., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3967 · Cited by 152

Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade

Kotzka, J., Müller-Wieland, D., Roth, G., Kremer, L., Munck, M., Schürmann, S., Knebel, B., & Krone, W. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32079-4 · Cited by 146

Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica.

Janssen, Y. M., Marsh, J. P., Absher, M. P., Hemenway, D., Vacek, P. M., Leslie, K. O., Borm, P. J., & Mossman, B. T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50063-1 · Cited by 113

Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis

Opavsky, M. A., Martino, T., Rabinovitch, M., Penninger, J., Richardson, C., Petric, M., Trinidad, C., Butcher, L., Chan, J., & Liu, P. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213971 · Cited by 91

Hypochlorous Acid Stimulation of the Mitogen-Activated Protein Kinase Pathway Enhances Cell Survival

Midwinter, R. G., Vissers, M. C. M., & Winterbourn, C. C. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2530 · Cited by 90

Coordinated Regulation of Radioadaptive Response by Protein Kinase C and p38 Mitogen-Activated Protein Kinase

Shimizu, T., Kato, T., Tachibana, A., & Sasaki, M. S. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4582 · Cited by 73

ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase

Yu, C. F., Roshan, B., Liu, Z.-X., & Cantley, L. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104493200 · Cited by 63

Role of extracellular signal-regulated kinase signal transduction pathway in anxiety

Ailing, F., Fan, L., Li, S., & Manji, S. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.018 · Cited by 48

UV-mediated Regulation of the Anti-senescence Factor Tbx2

Abrahams, A., Mowla, S., Parker, M. I., Goding, C. R., & Prince, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705651200 · Cited by 45

Protective effects of tyndallized Lactobacillus�acidophilus IDCC 3302 against UVB‑induced photodamage to epidermal keratinocytes cells

Im, A., Lee, B., Kang, D., & Chae, S. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4161 · Cited by 32

ERK1/2 are involved in low potassium-induced apoptotic signaling downstream of ASK1-p38 MAPK pathway in cultured cerebellar granule neurons

Yamagishi, S., Matsumoto, T., Numakawa, T., Yokomaku, D., Adachi, N., Hatanaka, H., Yamada, M., Shimoke, K., & Ikeuchi, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.041 · Cited by 22

ERK signaling is required for eye-specific retino-geniculate segregation

Naska, S., Cenni, M. C., Menna, E., & Maffei, L. (2004) · Development · doi:10.1242/dev.01212 · Cited by 14

Mammalian Nemo-like kinase enhances .BETA.-catenin-TCF transcription activity in human osteosarcoma and neuroblastoma cells

YASUDA, J., & ICHIKAWA, H. (2007) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.83.16 · Cited by 6

Growth‐inhibitory Effects of N, N‐Diethyl‐2‐[4‐(phenylmethyl)phenoxy]‐ethanamine‐HCl Combined with Cisplatin on Human Ovarian Cancer Cells Inoculated into Nude Mice

Hiramatsu, H., Kikuchi, Y., Kudoh, K., Kita, T., Tode, T., & Nagata, I. (1997) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1997.tb00321.x · Cited by 5

Exercise and type 2 diabetes

Borghouts, L. (2021) · doi:10.26481/dis.20000211lb · Cited by 2