Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes

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Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

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The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.

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Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

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Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.

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Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.

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Untitled work

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Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations

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Molecular Genetics of Alzheimer's Disease

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Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia

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Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

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Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells

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Genetic Polymorphisms and Oxidative Stress in Heart Failure

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ApoE polymorphism in a small Mediterranean island: Relationships with plasma lipids, lipoproteins and LDL particle size

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Apolipoproteins, the Lipid Hypothesis, and Ischemic Heart Disease

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Biophysical analysis of progressive C-terminal truncations of human apolipoprotein E4: insights into secondary structure and unfolding properties.

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Single Effects of Apolipoprotein B, (a), and E Polymorphisms and Interaction between Plasminogen Activator Inhibitor-1 and Apolipoprotein(a) Genotypes and the Risk of Coronary Artery Disease in Czech Male Caucasians

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Plasma and hepatic apoE isoproteins of nonhuman primates. Differences in apoE among humans, apes, and New and Old World monkeys.

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Enhanced binding activity of an apolipoprotein E mutant, apo E5, to LDL receptors on human fibroblasts

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The relation of plasma triglyceride, apolipoprotein B, and high-density lipoprotein cholesterol to postheparin lipoprotein lipase activity is dependent on apolipoprotein E polymorphism

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Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity.

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Hypertriglyceridemia and Lower LDL Cholesterol Concentration in Relation to Apolipoprotein E Phenotypes in Myotonic Dystrophy

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Apolipoprotein E Polymorphism and Brain Morphology in Mild Cognitive Impairment

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APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

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Is ε4 allele of apolipoprotein associated with more severe end‐organ damage in essential hypertension?

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Investigation of completed suicide and genes involved in cholesterol metabolism

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Impaired catabolism of very low-density lipoprotein-triglyceride in a family with primary hypertriglyceridemia

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Pro-inflammatory Cytokines Modulate Glial Apolipoprotein E Secretion

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Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late‐Onset Alzheimer′s Disease: Focus on APOE Gene

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Frequencies of apolipoproteins E5 and E7 in apparently healthy Japanese

Tsuchiya, S., Yamanouchi, Y., Onuki, M., Yamakawa, K., Miyazaki, R., Taya, T., Kondo, I., Ohnuki, M., & Hamaguchi, H. (1985) · The Japanese Journal of Human Genetics · doi:10.1007/bf01907964 · Cited by 21

Quantitative assessment of apolipoprotein E genotypes by image analysis of PCR–RFLP fragments

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Apolipoprotein-E2 and Hyperlipoproteinemia in Noninsulin-Dependent Diabetes Mellitus*

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Accumulation of apoE-enriched triglyceride-rich lipoproteins in patients with coronary artery disease

Barbagallo, C. M., Rizzo, M., Noto, D., Frasheri, A., Pernice, V., Rubino, A., Pieri, D., Pinto, V., Cefalu, A. B., Giordano, C. S. D. S., et al. (2006) · Metabolism · doi:10.1016/j.metabol.2006.01.005 · Cited by 19

Gender differences in a Type 2 (non-insulin-dependent) diabetic population with respect to apolipoprotein E phenotype frequencies

Boemi, M., James, R. W., Romagnoli, F., Gerber, P., Pometta, D., & Fumelli, P. (1993) · Diabetologia · doi:10.1007/bf00399955 · Cited by 18

A microtiter plate assay for determining apolipoprotein E genotype and discovery of a rare allele

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Apolipoprotein E polymorphism and lipoproteins in insulin-treated diabetes mellitus

Winocour, P. H., Tetlow, L. J., Durrington, P. N., Ishola, M., Hillier, V. F., & Anderson, D. C. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90173-1 · Cited by 18

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

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Metabolic Dysfunction-Associated Steatotic Liver Disease: From a Very Low-Density Lipoprotein Perspective

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Dyslipidemia: Genetics, lipoprotein lipase and HindIII polymorphism

Rojas, M. P., Prieto, C., Bermúdez, V., Garicano, C., Nava, T. N., Martínez, M. S., Salazar, J. J., Rojas, E., Pérez, A., Vicuña, P. M., et al. (2018) · F1000Research · doi:10.12688/f1000research.12938.2 · Cited by 17

Apolipoprotein E in diet-induced obesity: a paradigm shift from conventional perception

Kyriakos, E., Eleni, A., Constantinou, C., Hatziri, A., Kalogeropoulou, C., Xepapadaki, E., & Zvintzou, E. (2018) · Journal of Biomedical Research · doi:10.7555/jbr.32.20180007 · Cited by 17

Gene environment interaction and plasma triglyceride levels: the crucial role of lipoprotein lipase

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The allele interaction between apolipoprotein ɛ2 and ɛ4 in Taiwanese Alzheimer's disease patients

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ROLE OF THE ENTEROHEPATIC CIRCULATION OF BILE SALTS IN LIPOPROTEIN METABOLISM

Cooper, A. D. (1999) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70051-0 · Cited by 18

Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses

Dilliott, A. A., Sunderland, K. M., McLaughlin, P. M., Roberts, A., Evans, E. C., Abrahão, A., Binns, M. A., Black, S. E., BORRIE, M. J., Casaubon, L. K., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.04.011 · Cited by 18

The number of cysteine residues per mole in apolipoprotein E affects systematically synchronous neural interactions in women’s healthy brains

Leuthold, A. C., Mahan, M. Y., Stanwyck, J. J., Georgopoulos, A., & Georgopoulos, A. P. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3464-x · Cited by 16

Distribution of apolipoprotein E between apo B- and non apo B-containing lipoproteins according to apo E phenotype

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Apolipoprotein E phenotypes in patients with coronary artery disease.

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Rapid isolation of apolipoprotein E from human plasma very low density lipoproteins by molecular sieve high performance liquid chromatography

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Ferroptosis: A new strategy for targeting Alzheimer’s disease

Qiang, R. R., Xiang, Y., Zhang, L., Bai, X. Y., Zhang, D., Li, Y. J., Yang, Y. L., & Liu, X. L. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105773 · Cited by 15

Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects

Topić, A., Spasojević‐Kalimanovska, V., Zeljković, A., Vekić, J., & Jelić‐Ivanović, Z. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.11.013 · Cited by 15

Site-specific effects of apolipoprotein E expression on diet-induced obesity and white adipose tissue metabolic activation

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Association of Apo E gene polymorphism with HDL level in Tehranian population

DANESHPOUR, M. S., Hedayati, M., Eshraghi, P., & Azizi, F. (2010) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.200900207 · Cited by 15

The Number of Cysteine Residues per Mole in Apolipoprotein E Is Associated With the Severity of PTSD Re-Experiencing Symptoms

Peterson, C. K., James, L. M., Anders, S. L., Engdahl, B. E., & Georgopoulos, A. P. (2015) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13090205 · Cited by 16

A simple approach for human recombinant apolipoprotein E4 expression and purification

Argyri, L., Skamnaki, V. T., Stratikos, E., & Chroni, A. (2011) · Protein Expression and Purification · doi:10.1016/j.pep.2011.06.011 · Cited by 17

Bile acid metabolism in familial dysbetalipoproteinaemia: studies in subjects with the apolipoprotein E‐2/2 phenotype

Angelin, B., Holmquist, L., Leijd, B., & Einarsson, K. (1990) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1990.tb02261.x · Cited by 15

Association of hypercholesterolemia and apolipoprotein E4 in school children

Yanagi, H., Shimakura, Y., Yamanouchi, Y., Watanabe, Y., Tsuchiya, S., & Hamaguchi, H. (1990) · Clinical Genetics · doi:10.1111/j.1399-0004.1990.tb03579.x · Cited by 15

Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features

Matsunaga, A., & Saito, T. (2025) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.65393 · Cited by 14

Lipoproteins and apolipoproteins in human pleural effusions.

Pfalzer, B., Hamm, H., Beisiegel†, U., & Ostendorf, P. (1992) · PubMed · Cited by 14

Apolipoprotein E phenotypes in hyperlipidaemic patients and their implications for treatment

Janus, E. D., Grant, S., Lintott, C. J., & Wardell, M. R. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90038-3 · Cited by 15

[40] Intra- and extracellular modifications of apolipoproteins

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ApoE deficiency: Markedly decreased levels of cellular ApoE mRNA

Anchors, J. M., Gregg, R. E., Law, S. W., & Brewer, H. B. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(86)80510-1 · Cited by 13

Idenitification and characterization of a new variant of apolipoprotein E (apo E-Kochi).

SUEHIRO, T., YOSHIDA, K., YAMANO, T., & OHNO, F. (1990) · Japanese Journal of Medicine · doi:10.2169/internalmedicine1962.29.587 · Cited by 17

Effects of fenofibrate on apolipoprotein kinetics in patients with coexisting dysbetalipoproteinemia and heterozygous familial hypercholesterolemia

Tremblay, A. J., Lamarche, B., Ruel, I. L., Hogue, J., Deshaies, Y., Gagné, C., & Couture, P. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.037 · Cited by 13

A silent mutation of Niemann-Pick C1-like 1 and apolipoprotein E4 modulate cholesterol absorption in primary hyperlipidemias

Lupattelli, G., Pisciotta, L., VUONO, S. D., Siepi, D., Bellocchio, A., Melis, F., Bertolini, S., Pirro, M., & Mannarino, E. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2012.12.003 · Cited by 12

Increased Prevalence of Apolipoprotein E3/E4 Genotype among Swedish Renal Transplant Recipients

Roussos, L., Florén, C., Carlson, J. A., Svensson, P. J., Wallmark, A., & Ekberg, H. (1999) · The Nephron journals/Nephron journals · doi:10.1159/000045469 · Cited by 13

The evolution of electrophoretic mobility of proteins

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Isoform Patterns of Apolipoprotein E in Diabetes Mellitus

Black, S. C., Hewett, S., Kotubi, Y., Brunt, R. V., & Reckless, J. P. D. (1990) · Diabetic Medicine · doi:10.1111/j.1464-5491.1990.tb01437.x · Cited by 13

Interaction Between APOE Genotype and Diabetes in Longevity

Shinohara, M., Suzuki, K., Bu, G., & Sato, N. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210125 · Cited by 12

Neurobiology and the genetics of suicide

Wasserman, D., Marcus, S., Wasserman, J., & Rujescu, D. (2009) · doi:10.1093/med/9780198570059.003.0026 · Cited by 12

Dyslipidemia: Genetics, lipoprotein lipase and HindIII polymorphism

Rojas, M. P., Prieto, C., Bermúdez, V., Garicano, C., Nava, T. N., Martínez, M. S., Salazar, J. J., Rojas, E., Pérez, A., Vicuña, P. M., et al. (2017) · F1000Research · doi:10.12688/f1000research.12938.1 · Cited by 12

Apolipoprotein E Modulates the Metabolism of Apolipoprotein B Containing Lipoproteins by Multiple Mechanisms

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Effects of dextro-thyroxine, a preparation almost free of levo-thyroxine, on thyroid function, serum lipids and apolipoprotein A-I in “Double pre-beta lipoproteinemia”

Pagnan, A., Busnardo, B., ZANETTI, G., Simioni, N., Braggion, M., Ziron, L., & Girelli, M. E. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90022-4 · Cited by 12

Neuronal Cell Apoptosis by a Receptor-Binding Domain Peptide of ApoE4, Not through Low-Density Lipoprotein Receptor-Related Protein

Hagiwara, A., Hashimoto, Y., Niikura, T., Ito, Y., Terashita, K., Kita, Y. A., Nishimoto, I., & Umezawa, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3841 · Cited by 12

Molecular cloning and characterization of the promoter region of the porcine apolipoprotein E gene

Xia, J., Hu, B., Mu, Y., Xin, L., Yang, S., & Li, K. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3182-x · Cited by 11

The metabolic basis of familial hypercholesterolaemia

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Apolipoprotein E Genotype in Korean Schizophrenic Patients

Lee, M. K., Park, A. J., Nam, B. Y., Min, K. J., Kee, B. S., & Park, D. B. (2001) · Journal of Korean Medical Science · doi:10.3346/jkms.2001.16.6.781 · Cited by 11

Apolipoprotein E polymorphism in indigenous Australians: allelic frequencies and relationship with dyslipidaemia

Shaw, J. T. E., Tate, J. R., Kasting, J., Marczak, M., Berkholz, J. R., Lovelock, P. K., Purdie, D. M., Hickman, P. E., & Cameron, D. P. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb127712.x · Cited by 12

Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein phenotype, nor in type IIa or IIb hyperlipoproteinemia

Kempen, H. J. M., Leuven, J. A. G., van der Voort, H. A., de Knijff, P., & Havekes, L. M. (1991) · Metabolism · doi:10.1016/0026-0495(91)90102-3 · Cited by 11

ApoE-2/E-3 ratio of very low density lipoprotein in diabetes mellitus.

SANO, R., Abe, R., Oikawa, S., Fujii, Y., & Toyota, T. (1985) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.146.131 · Cited by 11

Apolipoprotein E Polymorphism in a Healthy Lebanese Population

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Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population

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Triglyceride-rich lipoproteins from apolipoprotein E3/2 subjects with hypertriglyceridemia enhance cholesteryl ester synthesis in human macrophages

Saito, M., Eto, M., & Makino, I. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06026-1 · Cited by 10

Apolipoprotein genes and atherosclerosis

Breslow, J. L. (1992) · Journal of Molecular Medicine · doi:10.1007/bf00235516 · Cited by 10

Apolipoprotein E Polymorphism in 385 Patients on Renal Replacement Therapy in Sweden

Roussos, L., Ekström, U., Ehle, P. N., Öqvist, B., & Florén, C. (2004) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/00365590410033443 · Cited by 10

Apolipoprotein E phenotypes of normo- and hyperlipoproteinemia in Japanese.

SANO, R., Abe, R., Oikawa, S., FUJII, Y., Hori, S., Suzuki, N., Toyota, T., & Gotō, Y. (1988) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.154.297 · Cited by 10

Familial dysbetalipoproteinemic subjects with the E3/E2 phenotype exhibit an E2 isoform with only one cysteine residue

Smit, M., de Knuff, P., Frants, R. R., Klasen, E. C., & Havekes, L. M. (1987) · Clinical Genetics · doi:10.1111/j.1399-0004.1987.tb03298.x · Cited by 10

ApoE isoforms, treatment of diabetes and the risk of coronary heart disease

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Apolipoprotein E: the resilience gene

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