The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
Open accessAbstract
Children's Hospital Medical Center/Harvard Medical School, Boston, MA 021 15,' Institut fur Humangenetik und Genetische Poliklinik der Philipps-Universitat Marburg, Bahnhofstrasse 7A, West Germany,' Gladstone Foundation Laboratories, San Francisco, CA 94 140; Cardiovascular Research Institute, University of California, San Francisco, CA 941 43; Health Science Center, University of Texas, Dallas, T X 74235,5 Lipid Research Center, Washington University School of Medicine, St. Louis, M O 63110; Harborview Medical Center, Seattle, WA 98104; and Columbia College of Physicians and Surgeons, New York, NY 10032*
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The two genotypes combine into six common APOE genotypes, ε22, ε32, ε42, ε33, ε43 and ε44, corresponding to six plasma apoE phenotypes: apoE22, apoE32, apoE42, apoE33, apoE43 and apoE44 [14].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [14]
In the citing paper
“There are three common APOE alleles in the general population defined as: APOE ɛ2, APOE ɛ3, and APOE ɛ4 [2].”
From Discovery of a Missense Mutation (Q222K) of the APOE Gene from the Australian Imaging, Biomarker and Lifestyle Study (2023) · cites this paper as [2]
In the citing paper
“Apolipoprotein E (apoE) is one of the key apolipoproteins in blood lipid transport.”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
Citations
Cites
Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777
Self-citationPolymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
UTERMANN, G., HEES, M., & STEINMETZ, A. (1977) · Nature · doi:10.1038/269604a0 · Cited by 666
Self-citationZannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
Self-citationWindler, E. E. T., Kovanen, P. T., Chao, Y. S., Brown, M. S., Havel, R. J., & Goldstein, J. L. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70487-6 · Cited by 456
Self-citationInnerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433
Self-citationSherrill, B. C., Innerarity, T. L., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85951-3 · Cited by 426
Self-citationDeterminants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.
Windler, E. E. T., Chao, Y. S., & Havel, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70811-4 · Cited by 365
Self-citationWindler, E., Chao, Y., & Havel, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70647-4 · Cited by 365
Self-citationEffect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.
Shelburne, F. A., Hanks, J., Meyers, W., & Quarfordt, S. H. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109710 · Cited by 358
(1981) · PubMed · Cited by 341
Self-citation
Research works printed but not linked: 2
- Utermann, G., A. Steinmetz, and W. Weber. 1982. Polymorphism of human apolipoprotein E: genetic control and gene frequencies. Am. J. Hum. Genet. In press.
- Sherrill, 1980, Addition of E-apoprotein to cholesterol-rich fluorescent lipid dispersion increases liver recognition and uptake, Circulation., 62, 44
Cited by
Sorted by citations
Items 401–435 of 435
Simple micromethods for determination of isoforms of apolipoproteins.
Harake, B. (1991) · Scholarship at UWindsor (University of Windsor)
Genetic Risk Factors for Complex Forms of Alzheimer’s Disease
Bellenguez, C., & Lambert, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-72938-1_4
Issa, M. H. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.9.2018.tde-02022018-101833
Estrogen Receptor β Regulates Brain Signaling Involved in Depression
Chhibber, A. (2016) · KU ScholarWorks (The University of Kansas)
A New Variant of Apolipoprotein E (apo E-Kochi) in a Hyperlipidemic Subject with Broad-beta Band
Suehiro, T., Yoshida, K., TAKAMATSU, K., Kawada, M., Hisatake, K., Yasuoka, N., Kishino, W., Shigetoshi, U. G. A., Mizutani, Y., Yamano, T., et al. (1986) · The Journal of Japan Atherosclerosis Society · doi:10.5551/jat1973.14.3_743
Lipoproteins, apoprotein A-1 containing particles and the development of atherosclerosis
Vallance, D. T. (1993) · UCL Discovery (University College London)
Strattan, L. E. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.097
전신적인 발진성, 결절성 황색종을 동반한 제3형 고지단백혈증 1예
김은영, 서기우, 김정은, Cho, E., 이왕수, 김치정, & 이갑석 (2009)
Apo D and Apo E Levels in Autism Spectrum DisordersPreprint
Esnafoğlu, E., & Cırrık, S. (2021) · Research Square · doi:10.21203/rs.3.rs-562010/v1
Carrasquillo, M. M., Bu, G., & Nielsen, H. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7309-1_2
Chen, Q., Chen, L., Wang, T., & Kang, D. (2022) · Research Square · doi:10.21203/rs.3.rs-1456007/v1
(1993) · Elsevier eBooks · doi:10.1016/b978-0-12-121070-0.50010-8
An Erroneous Apolipoprotein E-3 Band in High Density Lipoprotein Fractions
Rawlings, A. V., & Deegan, T. (1988) · Springer eBooks · doi:10.1007/978-94-009-1259-5_13
Havekes, L. M., Klasen, E. C., & Utermann, G. (1986) · Springer eBooks · doi:10.1007/978-1-4615-9474-1_26
Self-citationOler, J. R. L., Hoogerheide, E. S. S., Tiago, A. V., & Pinto, J. M. A. (2023) · doi:10.22533/at.ed.4552309053
Batista, J. E. D. S., da Silva, V. S., & Klamt, F. (2023) · doi:10.22533/at.ed.4552309054
Anacardium occidentale L. (ANACARDIACEAE): ANTIBACTERIAL AND ANTIBIOTIC POTENTIATING ACTIVITY
Ulisses, V. R. D. A., Costa, A. R., Coutinho, H. D. M., Pereira, R. L. S., dos Santos, C. A. L., Teles, B. R. D. S., dos Santos, L. B., Silva, L. V., Almeida‐Bezerra, J. W., de Oliveira, M. G., et al. (2023) · doi:10.22533/at.ed.4552309056
de Castro, V. F., Cabral, L. M., & Hoffmann, L. (2023) · doi:10.22533/at.ed.4552309051
la Fuente, A. O. R., Heredia-Rojas, J. A., Rebollar-Téllez, E. A., Noguera-Díaz, P. A., Martínez, P. C. C., & Heredia-Rodríguez, O. (2023) · doi:10.22533/at.ed.4552309055
Principais temas da pesquisa em Ciências Biológicas 2
da Silva, E. (2023) · doi:10.22533/at.ed.455230905 · Cited by 1
TRANSPLANTE MITOCONDRIAL: ASPECTOS TECNOLÓGICOS E APLICAÇÕES CLÍNICAS DA MITOTERAPIA
Albrecht, P. A. C., Galina, A., & Klamt, F. (2023) · doi:10.22533/at.ed.4552309052
Apolipoprotein E Polymorphism And It’s Lifestyle Impact
Thahira, A., Kumar, D. T., Dhanya, M. S., Rasitha, C. H., Rajan, A., Pinchulatha, K., Harisree, H., Deepthi, S., Inbanathan, J., Jeyapal, V., et al. (2024) · Journal Of Advanced Zoology · doi:10.53555/jaz.v45i1.2941
APOE, Pesticides, Environmental Pollutants, and Epigenetics
Biosca-Brull, J., Colomina, M. T., Cabré, M., & Guardia-Escote, L. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_50-1
Genetic Dyslipoproteinemias Associated with Coronary Atherosclerosis
Lee, J., & Burns, T. L. (1987) · Springer eBooks · doi:10.1007/978-1-4613-2305-1_9
Behavioral Aspects of Apolipoprotein E Knockout Mice
Litherland, M. T. (2003)
Olfactory Behavior in ApoE Knockout Mice
Yost, J. (2001) · Journal of Collective Bargaining in the Academy
ApoE and COVID-19 Risk and Long-Term Burden
Tavares-Júnior, J. W. L., Ciurleo, G. C. V., Oriá, R. B., & Braga‐Neto, P. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_56-1
ApoE and COVID-19 Risk and Long-Term Burden
Tavares-Júnior, J. W. L., Ciurleo, G. C. V., Oriá, R. B., & Braga‐Neto, P. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_56
Mahley, R. W. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_2
Self-citationNurmakova, K., Gomes, G.-N. W., & Levine, Z. A. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113494 · Cited by 2
Pek, S. L. T., Dissanayake, S., Chen, H. M., Tai, E. S., & Subramaniam, T. (2026) · Journal of clinical lipidology · doi:10.1016/j.jacl.2026.08.028
Diaconu, R., Pădureanu, V., Radu, R. I., Iovănescu, M. L., Mirea, O., Hădăreanu, D.-R., & Donoiu, I. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1885898
Wenhua, Y., Wenjing, M., Yan, D., Fei, L., Chen, J., Xia, T., Guan, Y., Xin, L., Huang, Y., Guo, Y., et al. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1934307
Characterization of genes involved in the metabolism of atherogenic lipoproteins in the mouse
Hoffer, M. J. V. (1993) · TNO Repository
Metadata
- Authors
- Zannis, V. I., Breslow, J. L., Utermann, G., Mahley, R. W., Weisgraber, K. H., Havel, R. J., Goldstein, J. L., Brown, M. S., Schonfeld, G., Hazzard, W. R., & Blum, C.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1982-08
- Volume
- 23
- Issue
- 6
- Pages
- 911-914
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1770880387
- Cited by
- 436
- References
- 31
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 5 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 12 · 2014: 15 · 2013: 11 · 2012: 11
- FWCI
- 25.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, APOE genotype, nomenclature, genetic variants, lipoprotein metabolism
- MeSH terms
- Apolipoproteins, Apolipoproteins E, Genotype, Humans, Terminology as Topic, Phenotype
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
