Electrophysiological evidence of corollary discharge dysfunction in schizophrenia during talking and thinking
Abstract
Failure of corollary discharge, a mechanism for distinguishing self-generated from externally-generated percepts, has been posited to underlie certain positive symptoms of schizophrenia, including auditory hallucinations. Although originally described in the visual system, corollary discharge may exist in the auditory system, whereby signals from motor speech commands prepare auditory cortex for self-generated speech. While associated with sensorimotor systems, it might also apply to inner speech or thought, regarded as our most complex motor act. We had four aims in the studies summarized in this paper: (1) to demonstrate the corollary discharge phenomenon during talking and inner speech in human volunteers using event-related brain potentials (ERPs), (2) to demonstrate that the corollary discharge is abnormal in patients with schizophrenia, (3) to demonstrate the role of frontal speech areas in the corollary discharge during talking, and (4) to relate the dysfunction of the corollary discharge in schizophrenia to auditory hallucinations. Using EEG and ERP measures, we addressed each aim in patients with schizophrenia (DSM IV) and healthy control subjects. The N1 component of the ERP reflected dampening of auditory cortex responsivity during talking and inner speech in control subjects but not in patients. EEG measures of coherence indicated inter-dependence of activity in the frontal speech production and temporal speech reception areas during talking in control subjects, b…
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Ford et al. (2004) found that repeated sentences elicited a smaller N1 component when participants engaged in inner speech compared to when they did not.
“Ford et al., found that the sentences elicited a smaller N1-component when participants engaged in inner speech compared to when they did not, consistent with the results of the present study.”
From Neurophysiological evidence of efference copies to inner speech (2017) · cites this paper as Ford and Mathalon, 2004
The few studies that reported sensory attenuation deficits to inner speech in schizophrenia patients did not include a mismatch condition, raising the possibility that these deficits reflect attentional deficits.
“Furthermore, the few studies that did report sensory attenuation deficits to inner speech in patients with schizophrenia did not include a ‘mismatch’ condition, raising the possibility that these sensory attenuation deficits ultimately reflect attentional deficits in the patient group (Ford and Mathalon, 2004; Ford et al., 2001d).”
From Neurophysiological evidence of efference copies to inner speech (2017) · cites this paper as Ford and Mathalon, 2004
Several studies have reported dampened neural response in auditory cortex during inner speech and silently mouthed speech compared with speech perception.
“Several studies have reported dampened neural response in auditory cortex during inner speech and silently mouthed speech compared with speech perception (e.g., Ford and Mathalon, 2004; Agnew et al., 2013).”
From The ConDialInt Model: Condensation, Dialogality, and Intentionality Dimensions of Inner Speech Within a Hierarchical Predictive Control Framework (2019) · cites this paper as Ford and Mathalon, 2004
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- Authors
- Ford, J. M., & Mathalon, D. H.
- Affiliations
- VA Palo Alto Health Care System (US)
- Yale University (US)
- Corresponding author
- Ford, Judith M.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 38
- Issue
- 1
- Pages
- 37-46
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2073086800
- Cited by
- 266
- References
- 4
- Citations by year
- 2026: 22 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 16 · 2021: 4 · 2020: 14 · 2019: 34 · 2018: 7 · 2017: 12 · 2016: 5 · 2015: 22 · 2014: 11 · 2013: 12 · 2012: 12
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh058262-17)
- National Institute of Mental Health (R01MH040052, MH-58262, MH40052)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- corollary discharge, schizophrenia, auditory hallucinations, inner speech, auditory cortex, N1 component, EEG coherence, positive symptoms, event-related potentials
- MeSH terms
- Adult, Auditory Pathways, Auditory Perceptual Disorders, Brain Mapping, Cerebral Cortex, Dominance, Cerebral, Electroencephalography, Evoked Potentials, Auditory, Female, Fourier Analysis, Frontal Lobe, Hallucinations, Humans, Internal-External Control, Male, Middle Aged, Neural Inhibition, Reference Values, Schizophrenia, Schizophrenic Psychology, Signal Processing, Computer-Assisted, Speech, Speech Perception, Temporal Lobe, Thinking
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