Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with experimental diabetes
Abstract
The dietary administration of 5% Spirulina maxima (SM) during four weeks to diabetic mice, starting one week after a single dose of alloxan, 250 mg/Kg body weight, prevented fatty liver production in male and female animals. The main action of SM was on triacylglycerol levels in serum and liver. There was also a moderate hypoglycemia in male mice. The thiobarbituric acid reactive substances also decreased in serum and liver after SM administration. There was also a decrease in the percentage of HDL in diabetic mice that was reverted by the SM administration. The sum of LDL + VLDL percentages was also partially normalized in diabetic animals by the SM administration. An additional observation was the lower incidence of adherences between the liver and the intestine loops in the diabetic mice treated with SM compared with diabetic mice without SM. Male and female mice showed differences to diabetes susceptibility and response to SM, the female being more resistant to diabetes induction by alloxan and more responsive to the beneficial effects of SM. It is worth future work of SM on humans looking for better quality of life and longer survival of diabetic patients.
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In alloxan-induced diabetic mice, 5% spirulina decreased hepatic triacylglycerols and improved serum HDL and lowered serum LDL and VLDL.
“With administration of 5% spirulina, hepatic triacylglycerols decreased. Improvement in serum HDL and lowered serum LDL as well as VLDL was also noted.28”
From Effects of spirulina on weight loss and blood lipids: A review (2020) · cites this paper as [28]
Blue-green algae are recognized for protective effects against viral and bacterial infections, cancer, allergy, diabetes, inflammation, and hyperlipidemia.
“They are recognized for their protective effects against viral and bacterial infections, cancer, allergy, diabetes, inflammation and hyperlipidemia [26–29].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [27]
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- Authors
- Rodrı́guez-Hernández, A., Blé-Castillo, J. L., Juárez-Oropeza, M. A., & Dı́az-Zagoya, J. C.
- Affiliations
- Mexican Social Security Institute (MX)
- Universidad Nacional Autónoma de México (MX)
- ORCID
- Juárez-Oropeza, M.A.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 69
- Issue
- 9
- Pages
- 1029-1037
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2053043202
- Cited by
- 80
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 6
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- Spirulina maxima, hepatic steatosis, experimental diabetes, alloxan-induced diabetes, triglycerides, serum lipids, HDL cholesterol, LDL cholesterol, VLDL, lipid peroxidation, TBARS, hypoglycemia, sex differences, dietary supplementation, ICR mice
- MeSH terms
- Tissue Adhesions, Animals, Bacterial Proteins, Blood Glucose, Cholesterol, Diabetes Mellitus, Experimental, Diet, Disease Models, Animal, Fatty Liver, Female, Lipoproteins, Liver, Male, Sex Characteristics, Triglycerides, Thiobarbituric Acid Reactive Substances, Mice, Spirulina
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