Cited by 49Medicinal Plants and NeuroprotectionNeurological Disorders and TreatmentsAlzheimer's disease research and treatments

Spirulina maxima Extract Prevents Neurotoxicity via Promoting Activation of BDNF/CREB Signaling Pathways in Neuronal Cells and Mice

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Koh, Eun-Jeong, Seo, Young-Jin, Choi, Jia, Lee, Hyeon Yong, Kang, Do-Hyung, Kim, Kui-Jin, Lee, Boo-Yong·2017·Molecules

Abstract

Spirulina maxima is a microalgae which contains flavonoids and other polyphenols. Although Spirulina maxima 70% ethanol extract (SM70EE) has diverse beneficial effects, its effects on neurotoxicity have not been fully understood. In this study, we investigated the neuroprotective effects of SM70EE against trimethyltin (TMT)-induced neurotoxicity in HT-22 cells. SM70EE inhibited the cleavage of poly-ADP ribose polymerase (PARP). Besides, ROS production was decreased by down-regulating oxidative stress-associated enzymes. SM70EE increased the factors of brain-derived neurotrophic factor (BDNF)/cyclic AMPresponsive elementbinding protein (CREB) signalling pathways. Additionally, acetylcholinesterase (AChE) was suppressed by SM70EE. Furthermore, we investigated whether SM70EE prevents cognitive deficits against scopolamine-induced neurotoxicity in mice by applying behavioral tests. SM70EE increased step-through latency time and decreased the escape latency time. Therefore, our data suggest that SM70EE may prevent TMT neurotoxicity through promoting activation of BDNF/CREB neuroprotective signaling pathways in neuronal cells. In vivo study, SM70EE would prevent cognitive deficits against scopolamine-induced neurotoxicity in mice.

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  • SM70EE inhibits AChE activity and PARP cleavage, and increases expression of p-CREB, p-TrkB and BDNF, promoting activation of BDNF/CREB neuroprotective signaling pathways in HT-22 neuronal cells.

    “SM70EE is able to inhibit AChE activity and PARP cleavage, and increase the expression of p-CREB, p-TrkB and BDNF, promoting the activation of BDNF/CREB neuroprotective signaling pathways in HT-22 neuronal cells [67].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [67]

  • 70% ethanol extract of S. maxima (SM70EE) prevents trimethyltin (TMT) neurotoxicity, such as oxidative stress, neurotransmitter dysfunction and neuronal death.

    “Another study showed that 70% ethanol extract of S. maxima (SM70EE) prevents trimethyltin (TMT) neurotoxicity, such as oxidative stress, neurotransmitter dysfunction and neuronal death.”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [67]

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Authors
Koh, E.-J., Seo, Y.-J., Choi, J., Lee, H. Y., Kang, D.-H., Kim, K.-J., & Lee, B.-Y.
Affiliations
  • CHA University (KR)
  • Seowon University (KR)
  • Korea Institute of Ocean Science and Technology (KR)
Corresponding author
  • Kim, Kui-Jin
  • Lee, Boo-Yong
Venue
Molecules
Publisher
MDPI AG
Published
2017-08-17
Volume
22
Issue
8
Pages
1363
ISSN
1420-3049 (ISSN-L)
OpenAlex
W2745663256
Cited by
49
References
36
Citations by year
2026: 5 · 2025: 10 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 1
FWCI
6.50
Type
journal article
Language
en
Open access
Locations
  • Molecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Spirulina maxima, neuroprotection, neurotoxicity, trimethyltin, acetylcholinesterase inhibition, oxidative stress, reactive oxygen species, scopolamine-induced neurotoxicity, cognitive impairment, HT22 cells, ethanol extract, microalgae
MeSH terms
Animals, Cell Extracts, Cell Line, Flavonoids, Gene Expression Regulation, Humans, Neurons, Poly(ADP-ribose) Polymerases, Signal Transduction, Neuroprotective Agents, Brain-Derived Neurotrophic Factor, Neurotoxicity Syndromes, CREB-Binding Protein, Mice, Spirulina, Polyphenols

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