The effects of Spirulina on anemia and immune function in senior citizens
Open accessAbstract
Anemia and immunological dysfunction (i.e. immunosenescence) are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena. Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects. We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia. We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases. Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study. Complete cell count (CCC) and indoleamine 2,3-dioxygenase (IDO) enzyme activity, as a sign of immune function, were determined at baseline and weeks 6 and 12 of supplementation. Thirty study participants completed the entire study and the data obtained were analyzed. Over the 12-week study period, there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes. In addition, mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants. Older women appeared to benefit more rapidly from Spirulina supplements. Similarly, the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation. Spirulina may ameliorate anemia and immunosenescence in older subjects. We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials.
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The intake of Arthrospira platensis supplement favorably affects anemia and immune dysfunction in elderly people with anemia and no history of major chronic diseases.
“The authors suggest that the intake of the supplement favorably affects anemia and immune dysfunction [117].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [117]
Some authors suggest that the use of spirulina dietary supplements may ameliorate anemia.
“Therefore, some authors suggest that the use of spirulina dietary supplements may ameliorate anemia [117,118].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [117]
Eating BGA boosts immunity and guards against inflammatory conditions including colitis, arthritis, and allergic rhinitis in animals and people.
“Studies have demonstrated that BGA consumption promotes immunity and protects against inflammatory diseases such as colitis, arthritis, and allergic rhinitis in animals and humans [39–42].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [39]
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- Authors
- Selmi, C., Leung, P. S., Fischer, L., German, B., Yang, C.-Y., Kenny, T. P., Cysewski, G. R., & Gershwin, M. E.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Gershwin, M Eric
- Venue
- Cellular & Molecular Immunology
- Published
- 2011-01-31
- Volume
- 8
- Issue
- 3
- Pages
- 248-254
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC4012879
- OpenAlex
- W2014151324
- Cited by
- 143
- References
- 43
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 22 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 13 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 4
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cellular and Molecular Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- Spirulina, anemia, immunosenescence, older adults, dietary supplementation, indoleamine 2,3-dioxygenase, immune function, mean corpuscular hemoglobin, white blood cell count, sex differences, dietary intervention
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Anemia, Anti-Inflammatory Agents, Antioxidants, Hemoglobins, Humans, Immunity, Male, Middle Aged, Dietary Supplements, Indoleamine-Pyrrole 2,3,-Dioxygenase, Spirulina
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