Cited by 2,140Pharmaceutical and Antibiotic Environmental ImpactsPesticide Residue Analysis and SafetyAntibiotic Use and Resistance

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Occurrence of antibiotics in the aquatic environment

Hirsch, Roman, Ternes, Thomas, Haberer, Klaus, Kratz, Karl-Ludwig·1999·Science of The Total Environment

DOI 10.1016/s0048-9697(98)00337-4

Open this paper in CoChat — free account

Abstract

The recent monitoring of drug residues in the aquatic environment has gained much interest as many pharmaceutical compounds can frequently be found in sewage treatment plant (STP) effluents and river water at concentrations up to several microgram/l. This article describes the analysis of various water samples for 18 antibiotic substances, from the classes of macrolid antibiotics, sulfonamides, penicillins and tetracyclines. Samples were preconcentrated via lyophilization and quantified using HPLC-electrospray-tandem-mass spectrometry. The investigated STP effluents and surface water samples showed frequent appearance of an erythromycin degradation product, roxithromycin and sulfamethoxazole with concentrations up to 6 micrograms/l. Neither tetracyclines nor penicillins could be detected at concentration levels above 50 and 20 ng/l, respectively. From the large number of ground water samples that were taken from agricultural areas in Germany, no contamination by antibiotics was detected except for two sites. This indicates that intake from veterinary applications to the aquatic environment is of minor importance.

Integrity signals

Registry

Crossref · 10.1016/s0048-9697(98)00337-4

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Occurrence of drugs in German sewage treatment plants and rivers
Ternes, T. A. (1998) · Water Research · doi:10.1016/s0043-1354(98)00099-2 · Cited by 3,502
Occurrence, fate and effects of pharmaceutical substances in the environment- A review
Halling-Sørensen, B., Nors Nielsen, S., Lanzky, P. F., Ingerslev, F., Holten Lützhøft, H. C., & Jørgensen, S. E. (1998) · Chemosphere · doi:10.1016/s0045-6535(97)00354-8 · Cited by 3,285
The fate of pharmaceutical chemicals in the aquatic environment
Richardson, M. L., & Bowron, J. M. (1985) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1985.tb04922.x · Cited by 759
Occurrence and Distribution of Pharmaceutical Organic Compounds in the Groundwater Downgradient of a Landfill (Grindsted, Denmark)
Holm, J. V., Rügge, K., Bjerg, P. L., & Christensen, T. H. (1995) · Environmental Science & Technology · doi:10.1021/es00005a039 · Cited by 407
Determination of antibiotics in different water compartments via liquid chromatography–electrospray tandem mass spectrometry
Hirsch, R., Ternes, T. A., Haberer, K., Mehlich, A., Ballwanz, F., & Kratz, K. L. (1998) · Journal of Chromatography A · doi:10.1016/s0021-9673(98)00335-5 · Cited by 390
Reduction in the antibacterial effect of oxy-tetracycline in sea water by complex formation with magnesium and calcium
Lunestad, B., & Goksøyr, J. (1990) · Diseases of Aquatic Organisms · doi:10.3354/dao009067 · Cited by 182
Methods for the determination of neutral drugs as well as betablockers and β 2 -sympathomimetics in aqueous matrices using GC/MS and LC/MS/MS
Ternes, T. A., Hirsch, R., Mueller, J., & Haberer, K. (1998) · Fresenius Journal of Analytical Chemistry · doi:10.1007/s002160051083 · Cited by 151
Nachweis von Arzneimittelrückständen in Kläranlagen und Fliessgewässern
Stumpf, M., Ternes, T. A., Haberer, K., Seel, P., & Baumann, W. (1996) · Vom Wasser · Cited by 115
Effect on plants of sulphadimethoxine used in intensive farming (Panicum miliaceum, Pisum sativum and Zea mays)
Migliore, L., Brambilla, G., Cozzolino, S., & Gaudio, L. (1995) · Agriculture Ecosystems & Environment · doi:10.1016/0167-8809(94)00549-t · Cited by 111
Nachweis von natürlichen und synthetischen Östrogenen in Kläranlagen und Fliessgewässern
Stumpf, M., Ternes, T. A., Haberer, K., & Baumann, W. (1996) · Vom Wasser · Cited by 100

Show all 32 references

Research works printed but not linked: 12

Berger, 1986, Persistence of drugs occurring in liquid manure in the food chain, Archive fuer Lebensmittelhygiene, 37, 99
BGVV; Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinaermedizin. Berlin, Germany: Public Relations Department, Bulletin 17/96, 1996.
Boehm, 1996, Effects of residues of antiinfectives in animal excrements upon slurry management and upon soil, Dtsch tierärztl Wschr, 103, 264
Hirsch, 1996, Determination of betablockers and β-sympathomimetics in the aquatic environment, Vom Wasser, 87, 263
Malik, 1994, Incidence of drug and metal resistance in E. coli strains from sewage water and soil, Chem Environ Res, 3, 3
Pandey, 1993, Antibiotic resistant coliform bacteria in drinking water, J Environ Biol, 14, 267
Qiting, 1988, Combination process of anaerobic digestion and ozonization technology for treating wastewater from antibiotics production, Water Treat, 3, 285
Roth HJ, Fenner H. Struktur-Bioreaktivität-Wirkungsbezogene Eigenschaften, 2nd ed. Stuttgart: Georg Thieme Verlag, 1994:65–68.
Stumpf, 1996, Determination of pharmaceutics in sewage plants and river water, Vom Wasser, 86, 291
Stumpf, 1996, Determination of natural and synthetic estrogens in sewage plants and river water, Vom Wasser, 87, 251
Suzaki, 1979, Resistance of mycoplasma pneumoniae to macrolid and analogous antibiotics, Sci Rep Res Inst Tohoku Univ [Med], 26, 71
Van der Heide, 1984, Geneesmiddelen en milieu, Pharmaceutisch Weekblad, 119, 936

Sorted by citations

Items 201–300 of 1,001

Adsorption of organic micropollutants onto biochar: a review of relevant kinetics, mechanisms and equilibrium
Tong, Y., McNamara, P. J., & Mayer, B. K. (2019) · Environmental Science Water Research & Technology · doi:10.1039/c8ew00938d · Cited by 321
Analysis of veterinary antibiotic residues in swine wastewater and environmental water samples using optimized SPE-LC/MS/MS
Tong, L., Li, P., Wang, Y., & Zhu, K. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.10.051 · Cited by 313
“…Ger man group detected res i dues of CAP in one sew age treat ment plant efflu ent and one small river in south ern Ger many at con centra tions of 0.56 and 0.06 lg L¡1, respec tively (Hirsch et al., 1999), although the use of CAP in live stock breed ing has been banned since 1994 in the US and EU.”
BackgroundInfluential
Occurrence, Transformation, and Fate of Antibiotics in Municipal Wastewater Treatment Plants
Zhang, T., & Li, B. J. (2011) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643380903392692 · Cited by 323
“Erythromycin-H2O is a main metabolite of erythromycin that is highly unstable under strong acidic condition (Göbel et al., 2004; Hirsch et al., 1999; McArdell et al., 2003; Yang and Carlson, 2004).”
BackgroundInfluential
Occurrence of selected pharmaceuticals at drinking water purification plants in Japan and implications for human health
Simazaki, D., Kubota, R., Suzuki, T., Akiba, M., Nishimura, T., & Kunikane, S. (2015) · Water Research · doi:10.1016/j.watres.2015.02.059 · Cited by 325
“Twelve pharmaceuticals were detected in drinking water in Germany, including phenazone (antiinflammatory drug), carbamazepine, iopamidol (contrast agent), and clofibric acid (metabolite of lipid regulator).”
Background
Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes
Laville, N., Aı̈t-Aı̈ssa, S., Góméz, E., Casellas, C., & Porcher, J. (2003) · Toxicology · doi:10.1016/j.tox.2003.11.002 · Cited by 313
“(beta-blocker) 0.59 2 Surface water Ternes, 1998 0.29 1 STP effluent Hirsch et al., 1999 0.01–0.09 0.03–0.3 STP effluent Andreozzi et al., 2003”
BackgroundInfluential
Preliminary investigation on the environmental occurrence and effects of antibiotics used in aquaculture in Italy
Lalumera, G. M., Calamari, D., Galli, P., Castiglioni, S., Crosa, G. A., & Fanelli, R. (2003) · Chemosphere · doi:10.1016/j.chemosphere.2003.08.001 · Cited by 312
“are commonly used in aquaculture, both prophylactically and to treat disease (Bjørklund et al., 1991; Primavera et al., 1993; Hirsch et al., 1999).”
Background
Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river
Li, D., Yang, M., Hu, J., Liren, R., Zhang, Y., & Li, K. (2007) · Environmental Toxicology and Chemistry · doi:10.1897/07-080.1 · Cited by 315
“On the other hand, it has been reported that leaching of antibiotics from excess sludge was also an important pathway into water bodies when the sludge is used as fertilizer on farmlands [25]; however, in this study, the target compounds adsorbed by activated sludge were less than 1% of those discharged into aquatic e…”
Background
Effects of erythromycin, tetracycline and ibuprofen on the growth of Synechocystis sp. and Lemna minor
Pomati, F., Netting, A. G., Calamari, D., & Neilan, B. A. (2004) · Aquatic Toxicology · doi:10.1016/j.aquatox.2004.02.001 · Cited by 310
Trace Determination of Macrolide and Sulfonamide Antimicrobials, a Human Sulfonamide Metabolite, and Trimethoprim in Wastewater Using Liquid Chromatography Coupled to Electrospray Tandem Mass Spectrometry
Göbel, A., McArdell, C. S., Suter, M. J. ‐., & Giger, W. (2004) · Analytical Chemistry · doi:10.1021/ac0496603 · Cited by 310
Sulfamethoxazole abatement by means of ozonation
Dantas, R. F., Contreras, S., Sans, C., & Esplugas, S. (2008) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2007.05.034 · Cited by 308
Adsorption of Pharmaceutical Antibiotics on Template-Synthesized Ordered Micro- and Mesoporous Carbons
Ji, L., Liu, F., Xu, Z., Zheng, S., & Zhu, D. (2010) · Environmental Science & Technology · doi:10.1021/es903716s · Cited by 315
Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan
Lin, A. Y., Yu, T., & Lateef, S. K. (2009) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2009.01.108 · Cited by 316
BIODEGRADABILITY PROPERTIES OF SULFONAMIDES IN ACTIVATED SLUDGE
Ingerslev, F., & Halling‐Sørensen, B. (2000) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620191011 · Cited by 306
“Ternes and co-workers measured up to 1 mg/L of sulfamethoxasole in German sewage water [32].”
Background
Antibiotic Resistance Gene Abundances Associated with Waste Discharges to the Almendares River near Havana, Cuba
Graham, D. W., Olivares-Rieumont, S., Knapp, C. W., Lima, L., Werner, D., & Bowen, E. J. (2010) · Environmental Science & Technology · doi:10.1021/es102473z · Cited by 311
A review of antibiotics and antibiotic resistance genes (ARGs) adsorption by biochar and modified biochar in water
Du, L., Ahmad, S., Liu, L., Wang, L., & Tang, J. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159815 · Cited by 306
Determination of 81 pharmaceutical drugs by high performance liquid chromatography coupled to mass spectrometry with hybrid triple quadrupole–linear ion trap in different types of water in Serbia
Petrović, M., Škrbić, B. D., Živančev, J., Ferrando‐Climent, L., & Barceló, ‪. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.08.079 · Cited by 317
Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: Occurrence, distribution and ecological risks
Zhang, R., Tang, J., Li, J., Zheng, Q., Liu, D., Chen, Y., Zou, Y., Chen, X., Luo, C., & Zhang, G. (2012) · Environmental Pollution · doi:10.1016/j.envpol.2012.11.008 · Cited by 304
“, and China (Hirsch et al., 1999; Kolpin et al., 2002; McArdell et al., 2003; Xu et al., 2007; Zou et al., 2011).”
Occurrence of sulfonamide antimicrobials in private water wells in Washington County, Idaho, USA
Batt, A. L., Snow, D. D., & Aga, D. S. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.01.029 · Cited by 303
Fate and mobility of pharmaceuticals in solid matrices
Drillia, P., Stamatelatou, Κ., & Lyberatos, G. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.01.032 · Cited by 296
The environmental release and fate of antibiotics
Manzetti, S., & Ghisi, R. (2014) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2014.01.005 · Cited by 309
Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment
Pérez, S., Eichhorn, P., & Aga, D. S. (2005) · Environmental Toxicology and Chemistry · doi:10.1897/04-211r.1 · Cited by 297
“For instance, approximately 15% of sulfamethoxazole is excreted from the human body in its original form, while the fraction of unchanged trimethoprim amounts to about 60% [3].”
Background
Multi-walled carbon nanotube/amino-functionalized MIL-53(Fe) composites: Remarkable adsorptive removal of antibiotics from aqueous solutions
Xiong, W., Zeng, Z., Li, X., Zeng, G., Xiao, R., Yang, Z., Zhou, Y., Zhang, C., Cheng, M., Hu, L., et al. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.07.084 · Cited by 292
Aerobic biodegradation of the sulfonamide antibiotic sulfamethoxazole by activated sludge applied as co-substrate and sole carbon and nitrogen source
Müller, E., Schüssler, W., Horn, H., & Lemmer, H. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.02.070 · Cited by 302
Occurrence and risks of antibiotics in the Laizhou Bay, China: Impacts of river discharge
Zhang, R., Zhang, G., Zheng, Q., Tang, J., Chen, Y., Xu, W., Zou, Y., & Chen, X. (2012) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2012.03.002 · Cited by 297
“The most antibiotics selected in this study were also widely present in surface waters in Europe, the USA, and in China (Hirsch et al., 1999; Kolpin et al., 2002; McArdell et al., 2003; Xu et al., 2007; Zou et al., 2011).”
Background
Occurrence and risk assessment of antibiotics in water and lettuce in Ghana
Azanu, D., Styrishave, B., Darko, G., Weisser, J. J., & Abaidoo, R. C. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.11.287 · Cited by 301
Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam
Dương, H. A., Pham, N. H., Nguyen, H. T., Hoang, T. T., Pham, H. V., Pham, V. C., Berg, M. D. V., Giger, W., & Alder, A. C. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.03.009 · Cited by 294
“Concerning antimicrobial agents, several studies on their occurrence in wastewater and surface water have been published (Hirsch et al., 1999; Golet et al., 2002, 2003; Kolpin et al., 2002; Calamari et al., 2003; Giger et al., 2003; McArdell et al., 2003; Miao et al., 2004; Renew and Huang, 2004; Gobel et al., 2005, 2…”
Background
Analytical methods for tracing pharmaceutical residues in water and wastewater
Fatta‐Kassinos, D., Achilleos, A., Nikolaou, A. D., & Meriç, S. (2007) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2007.02.001 · Cited by 290
Removal of emerging contaminants from municipal wastewater with an integrated membrane system, MBR–RO
Dolar, D., Gros, M., Rodríguez‐Mozaz, S., Moreno, J., Comas, J., Rodríguez‐Roda, I., & Barceló, ‪. (2012) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2012.03.029 · Cited by 289
Review of the Occurrence of Anti-infectives in Contaminated Wastewaters and Natural and Drinking Waters
Segura, P. A., François, M., Gagnon, C., & Sauvé, S. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.11776 · Cited by 298
“Rivers in which the majority of the flow is composed of WWTP effluent will have a lower diluting power (some rivers are composed of up to 75–80% of WWTP discharges), and anti-infective concentrations downstream will be approximately constant, depending on other attenuation processes such as photolysis or sorption (Ben…”
Background
The potential impact of veterinary and human therapeutic agents in manure and biosolids on plants grown on arable land: a review
Jjemba, P. K. (2002) · Agriculture Ecosystems & Environment · doi:10.1016/s0167-8809(01)00350-4 · Cited by 287
Antibiotics in the aquatic environment of Vietnam: Sources, concentrations, risk and control strategy
Binh, V. N., Dang, N., Anh, N. T. K., Ky, L. X., & Thai, P. K. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.01.061 · Cited by 300
“…sources: municipal (hospital and 60 municipal sewage including a large part from household use and disposal) (Bound and Voulvoulis, 61 2005; Tong et al., 2011), agriculture (aquaculture, husbandry) (Hirsch et al., 1999; Lin et al., 2008), 62 and pharmaceutical industry (Phillips et al., 2010).”
Background
Pharmaceuticals in the Environment in Italy: Causes, Occurrence, Effects and Control
Zuccato, E., Castiglioni, S., Fanelli, R., Reitano, G., Bagnati, R., Chiabrando, C., Pomati, F., Rossetti, C., & Calamari, D. (2005) · Environmental Science and Pollution Research · doi:10.1065/espr2006.01.004 · Cited by 291
Degradation kinetics and mechanism of β-lactam antibiotics by the activation of H2O2 and Na2S2O8 under UV-254nm irradiation
He, X., Mezyk, S. P., Michael, I., Fatta‐Kassinos, D., & Dionysiou, D. D. (2014) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2014.07.008 · Cited by 284
Occurrence and distribution of sulfonamides, tetracyclines, quinolones, macrolides, and nitrofurans in livestock manure and amended soils of Northern China
Hou, J., Wan, W., Mao, D., Wang, C., Mu, Q., Qin, S., & Luo, Y. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3632-y · Cited by 282
“In recent years, with the rapid development of animal husbandry, veterinary antibiotics comprised 70% of the world’s antibiotic consumption for the purposes of illness prevention and growth promotion (Hirsch et al. 1999; Kummerer 2009).”
Background
Wastewater treatment and emerging contaminants: Bibliometric analysis
Chen, Y., Lin, M., & Zhuang, D. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133932 · Cited by 300
Antibiotics in the Hong Kong metropolitan area: Ubiquitous distribution and fate in Victoria Harbour
Minh, T. B., Leung, H. W., Loi, I., Chan, W. H., So, M. K., Mao, J., Choi, D., Lam, J. C. W., Zheng, G. J.-S., Martin, M., et al. (2009) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2009.02.004 · Cited by 285
Determination of penicillin G and its degradation products in a penicillin production wastewater treatment plant and the receiving river
Li, D., Yang, M., Hu, J., Zhang, Y., Chang, H., & Jin, F. (2007) · Water Research · doi:10.1016/j.watres.2007.07.016 · Cited by 281
Degradation of tetracycline by photo-Fenton process—Solar irradiation and matrix effects
Bautitz, I. R., & Nogueira, R. F. P. (2006) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2006.09.009 · Cited by 276
Simultaneous determination of four classes of antibiotics in sediments of the Pearl Rivers using RRLC–MS/MS
Yang, J., Ying, G., Zhao, J., Tao, R., Su, H., & Chen, F. (2010) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2010.03.049 · Cited by 271
Photochemical degradation of oxytetracycline: Influence of pH and role of carbonate radical
Liu, Y., He, X., Duan, X., Fu, Y., & Dionysiou, D. D. (2015) · Chemical Engineering Journal · doi:10.1016/j.cej.2015.04.048 · Cited by 270
Ozonation of Wastewater: Rate of Ozone Consumption and Hydroxyl Radical Yield
Nöthe, T., Fahlenkamp, H., & von Sonntag, C. (2009) · Environmental Science & Technology · doi:10.1021/es900825f · Cited by 268
Short-term tests with a pilot sewage plant and biofilm reactors for the biological degradation of the pharmaceutical compounds clofibric acid, ibuprofen, and diclofenac
Zwiener, C., & Frimmel, F. H. (2003) · The Science of The Total Environment · doi:10.1016/s0048-9697(03)00002-0 · Cited by 274
Removing pharmaceuticals and endocrine‐disrupting compounds from wastewater by photocatalysis
Dalrymple, O. K., Yeh, D. H., & Trotz, M. A. (2007) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.1657 · Cited by 272
Distribution and ecological risk of antibiotics in a typical effluent–receiving river (Wangyang River) in north China
Jiang, Y., Li, M., Guo, C., An, D., Xu, J. F., Zhang, Y., & Xi, B. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.04.075 · Cited by 270
Pharmaceuticals and personal care products in water and wastewater: a review of treatment processes and use of photocatalyst immobilized on functionalized carbon in AOP degradation
Oluwole, A. O., Omotola, E. O., & Olatunji, O. S. (2020) · BMC Chemistry · doi:10.1186/s13065-020-00714-1 · Cited by 276
Interactions of Fluoroquinolone Antibacterial Agents with Aqueous Chlorine: Reaction Kinetics, Mechanisms, and Transformation Pathways
Dodd, M. C., Shah, A. D., von Gunten, U., & Huang, C. (2005) · Environmental Science & Technology · doi:10.1021/es050054e · Cited by 267
Fate of veterinary antibiotics in a macroporous tile drained clay soil
Kay, P., Blackwell, P. A., & Boxall, A. B. A. (2004) · Environmental Toxicology and Chemistry · doi:10.1897/03-374 · Cited by 271
“A limited amount of information is available on concentrations of these compounds in soil [5], surface water, and groundwater [6,7].”
Background
A review of the pharmaceutical exposome in aquatic fauna
Miller, T. H., Bury, N. R., Owen, S. F., MacRae, J. I., & Barron, L. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.04.012 · Cited by 275
Ubiquitous occurrence of sulfonamides in tropical Asian waters
Shimizu, A., Takada, H., Koike, T., Takeshita, A., Saha, M., Rinawati, Nakada, N., Murata, A., Suzuki, T., Suzuki, S., et al. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.02.027 · Cited by 270
“…Watkinson et al., 2007), Europe (Spain: 12–650 ng/L (García-Galán et al., 2010, 2011); Switzerland: 430 ng/L (Göbel et al., 2005); Germany: 400 ng/L (Hirsch et al., 1999), the US (135–261 ng/L; Spongberg and Witter, 2008), and Canada (243 ng/L; Table 2 Accuracy of antibiotics concentrations by…”
Background
Trace determination of β-lactam antibiotics in surface water and urban wastewater using liquid chromatography combined with electrospray tandem mass spectrometry
Cha, J., Yang, S., & Carlson, K. H. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.02.086 · Cited by 258
Pharmaceuticals residues and xenobiotics contaminants: Occurrence, analytical techniques and sustainable alternatives for wastewater treatment
de Oliveira, M., Frihling, B. E. F., Velasques, J., Filho, F. J. C. M., Cavalheri, P. S., & Migliolo, L. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135568 · Cited by 274
Occurrences and regional distributions of 20 antibiotics in water bodies during groundwater recharge
Ma, Y., Li, M., Wu, M., Li, Z., & Liu, X. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.02.100 · Cited by 263
Detection of clinically relevant antibiotic-resistance genes in municipal wastewater using real-time PCR (TaqMan)
Volkmann, H., Schwartz, T., Bischoff, P., Kirchen, S., & Obst, U. (2003) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2003.10.014 · Cited by 256
Extraction and determination of sulfonamides, macrolides, and trimethoprim in sewage sludge
Göbel, A., Thomsen, A., McArdell, C. S., Alder, A. C., Giger, W., Theiß, N., Löffler, D., & Ternes, T. A. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.05.051 · Cited by 258
Enhanced photocatalytic degradation of norfloxacin in aqueous Bi2WO6 dispersions containing nonionic surfactant under visible light irradiation
Tang, L., Wang, J., Zeng, G., Liu, Y., Deng, Y., Zhou, Y., Tang, J., Wang, J., & Guo, Z. H. (2015) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2015.12.044 · Cited by 251
Occurrence and risk assessment of multiple classes of antibiotics in urban canals and lakes in Hanoi, Vietnam
Trần, N. H., Hoang, L., Nghiem, L. D., Nguyen, N. M. H., Ngo, H. H., Guo, W., Trịnh, Q. T., Mai, N. H., Chen, H., Nguyen, D. D., et al. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.07.092 · Cited by 256
Determination of drug residues in water by the combination of liquid chromatography or capillary electrophoresis with electrospray mass spectrometry
Ahrer, W., Scherwenk, E., & Buchberger, W. W. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)01187-0 · Cited by 250
Mapping of drinking water research: A bibliometric analysis of research output during 1992–2011
Fu, H., Wang, M.-H., & Ho, Y. (2012) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2012.11.061 · Cited by 256
“They were also the categories with the highest growth rate and the most energy in recent years, with many kinds of treatment and protection technologies in these categories used as measures to solve problems (Mackenzie et al., 1994; Hirsch et al., 1999).”
Background
Occurrence and fate of most prescribed antibiotics in different water environments of Tehran, Iran
Mirzaei, R., Yunesian, M., Nasseri, S., Gholami, M., Jalilzadeh, E., Shoeibi, S., & Mesdaghinia, A. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.272 · Cited by 253
Human pharmaceuticals in surface waters
Besse, J.-P., & Garric, J. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.10.012 · Cited by 274
“estrogenic activity Doxycycline 103 IA Antibiotic tetracycline PEC value; antibiotic Confirm occurrence in water; complexing properties of cyclines and possible sorption to suspended matter (Hirsch et al., 1999) Fluoxetine 9 III Antidepressant SSRI Agonist of serotoninergic receptors; high ecotoxicity; P-gp inhibitor…”
Background
Simultaneous extraction and analysis of 11 tetracycline and sulfonamide antibiotics in influent and effluent domestic wastewater by solid-phase extraction and liquid chromatography-electrospray ionization tandem mass spectrometry
Yang, S., Cha, J., & Carlson, K. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.08.027 · Cited by 246
Antibiotic resistance in bacteria from shrimp farming in mangrove areas
Le, T. P. L., Munekage, Y., & Kato, S. (2005) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2005.01.006 · Cited by 243
“Recent studies have shown that many antibiotics persist in the sediment and in the aquatic environment for several months following administration (Björklund et al., 1991; Lunestad et al., 1995; Pouliquen and Le, 1996; Hirsch et al., 1999; Miranda and Zemelman, 2002).”
BackgroundInfluential
Assessing antibiotic sorption in soil: a literature review and new case studies on sulfonamides and macrolides
Wegst-Uhrich, S. R., Navarro, D. A., Zimmerman, L. R., & Aga, D. S. (2014) · Chemistry Central Journal · doi:10.1186/1752-153x-8-5 · Cited by 257
“Thus, sulfonamides have been detected in surface water, ground water, soil pore water [18-20], and drinking water [21] that have been impacted by agricultural and human activities.”
Background
Application of biosorption for penicillin G removal: comparison with activated carbon
Aksu, Z., & Dede, Ö. T. (2004) · Process Biochemistry · doi:10.1016/j.procbio.2004.02.014 · Cited by 241
Transformation of Aromatic Ether- and Amine-Containing Pharmaceuticals during Chlorine Disinfection
Pinkston, K. E., & Sedlak, D. L. (2004) · Environmental Science & Technology · doi:10.1021/es035368l · Cited by 241
The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health
Iwu, C. D., Korsten, L., & Okoh, A. I. (2020) · MicrobiologyOpen · doi:10.1002/mbo3.1035 · Cited by 264
“Β-lactam Ampicillin Remediation of infections caused by bacteria in animals and humans and to improve animal yield (Santos & Ramos, 2016) 60 (Hirsch et al., 1999)”
Background
Determination of acidic pharmaceuticals, antibiotics and ivermectin in river sediment using liquid chromatography–tandem mass spectrometry
Löffler, D., & Ternes, T. A. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.08.089 · Cited by 240
Simultaneous removal and degradation characteristics of sulfonamide, tetracycline, and quinolone antibiotics by laccase-mediated oxidation coupled with soil adsorption
Ding, H., Wu, Y., Zou, B., Lou, Q., Zhang, W., Zhong, J., Lu, L., & Dai, G. (2016) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2015.12.062 · Cited by 240
Generally Overlooked Fundamentals of Bacterial Genetics and Ecology
Summers, A. O. (2002) · Clinical Infectious Diseases · doi:10.1086/340245 · Cited by 238
“A final ecological issue that is gaining prominence is the presence and possible effect of myriad pharmaceutical residues, including antimicrobials, in sources of potable water [35, 84-87].”
Background
Removal of ciprofloxacin using modified advanced oxidation processes: Kinetics, pathways and process optimization
Mondal, S., Saha, A. K., & Sinha, A. K. (2017) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2017.10.091 · Cited by 243
Occurrences and fate of selected human antibiotics in influents and effluents of sewage treatment plant and effluent-receiving river Yamuna in Delhi (India)
Mutiyar, P. K., & Mittal, A. K. (2013) · Environmental Monitoring and Assessment · doi:10.1007/s10661-013-3398-6 · Cited by 243
“2006), groundwater (Hirsch et al. 1999; Lindsey et al. 2001), sediments (Kerry et al.”
Adsorption of ciprofloxacin onto biocomposite fibers of graphene oxide/calcium alginate
Wu, S.-L., Zhao, X., Li, Y., Zhao, C., Du, Q., Sun, J., Wang, Y., Peng, X., Xia, Y., Wang, Z., et al. (2013) · Chemical Engineering Journal · doi:10.1016/j.cej.2013.06.072 · Cited by 237
Selected drugs in solid matrices: a review of environmental determination, occurrence and properties of principal substances
Beausse, J. (2004) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2004.08.005 · Cited by 252
Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)
Kim, J.-W., Ishibashi, H., Yamauchi, R., Ichikawa, N., Takao, Y., Hirano, M., Koga, M., & Arizono, K. (2009) · The Journal of Toxicological Sciences · doi:10.2131/jts.34.227 · Cited by 231
Use and Environmental Occurrence of Antibiotics in Freestall Dairy Farms with Manured Forage Fields
Watanabe, N., Bergamaschi, B. A., Loftin, K. A., Meyer, M. T., & Harter, T. (2010) · Environmental Science & Technology · doi:10.1021/es100834s · Cited by 232
Reconnaissance of selected PPCP compounds in Costa Rican surface waters
Spongberg, A. L., Witter, J. D., Acuña, J. A., Vargas, J. A., Murillo, M., Umaña, G., Gómez, E., & Pérez-Rojas, G. (2011) · Water Research · doi:10.1016/j.watres.2011.10.004 · Cited by 247
Sorption of norfloxacin by lotus stalk-based activated carbon and iron-doped activated alumina: Mechanisms, isotherms and kinetics
Liu, W., Zhang, J., Zhang, C., & Ren, L. (2011) · Chemical Engineering Journal · doi:10.1016/j.cej.2011.03.099 · Cited by 231
Fate of the Antibiotic Sulfamethoxazole and Its Two Major Human Metabolites in a Water Sediment Test
Radke, M., Lauwigi, C., Heinkele, G., Mürdter, T. E., & Letzel, M. (2009) · Environmental Science & Technology · doi:10.1021/es900300u · Cited by 233
Selectively enrichment of antibiotics and ARGs by microplastics in river, estuary and marine waters
Wang, S., Xue, N., Li, W., Zhang, D., Pan, X., & Luo, Y. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134594 · Cited by 230
Antibiotic residue determination in environmental waters by LC-MS
Hernández, F. J., Sancho, J. V., Ibáñez, M., & Guerrero, C. A. (2007) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2007.01.012 · Cited by 229
Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC–MS/MS
Dinh, Q. T., Alliot, F., Moreau-Guigon, E., Eurin, J., Chevreuil, M., & Labadie, P. (2011) · Talanta · doi:10.1016/j.talanta.2011.05.013 · Cited by 229
Rapid analysis of 21 antibiotics of multiple classes in municipal wastewater using ultra performance liquid chromatography-tandem mass spectrometry
Li, B. J., Zhang, T., Xu, Z., & Fang, H. H. P. (2009) · Analytica Chimica Acta · doi:10.1016/j.aca.2009.04.042 · Cited by 234
Occurrence, distribution and bioaccumulation of antibiotics in the Haihe River in China
Gao, L., Shi, Y., Li, W., Liu, J., & Cai, Y. (2012) · Journal of Environmental Monitoring · doi:10.1039/c2em10916f · Cited by 232
Pharmaceuticals as emerging organic contaminants in Umgeni River water system, KwaZulu-Natal, South Africa
Agunbiade, F. O., & Moodley, B. (2014) · Environmental Monitoring and Assessment · doi:10.1007/s10661-014-3926-z · Cited by 235
Study of ciprofloxacin biodegradation by a Thermus sp. isolated from pharmaceutical sludge
Pan, L., Li, J., Chunxing, L., Tang, X., Yu, G., & Wang, Y. (2017) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2017.09.009 · Cited by 225
New insights into the role of organic chelating agents in Fe(II) activated persulfate processes
Han, D., Wan, J., Ma, Y., Wang, Y., Li, Y., Li, D., & Guan, Z. (2015) · Chemical Engineering Journal · doi:10.1016/j.cej.2015.01.106 · Cited by 226
Photocatalytic Degradation of Tetracycline Antibiotics over CdS/Nitrogen-Doped–Carbon Composites Derived from in Situ Carbonization of Metal–Organic Frameworks
Cao, H., Cai, F., Yu, K. L., Zhang, Y.-Q., Lü, J., & Cao, R. (2019) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.9b01685 · Cited by 222
Emerging contaminant degradation and removal in algal wastewater treatment ponds: Identifying the research gaps
Norvill, Z. N., Shilton, A. N., & Guieysse, B. (2016) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2016.03.085 · Cited by 225
“0 µg L-1 in recipient waters downstream of wastewater discharge (Snow et al. 2015; Monteiro and Boxall 2010; Haggard et al. 2006; Hirsch et al. 1999) but surface water concentration in areas of high usage can be much greater (e.g. antibiotics were detected at 40-400 µg L-1 near an agricultural area…”
Direct Photolysis of Human Metabolites of the Antibiotic Sulfamethoxazole: Evidence for Abiotic Back-Transformation
Bonvin, F., Omlin, J., Rutler, R., Schweizer, W. B., Alaimo, P. J., Strathmann, T. J., McNeill, K., & Kohn, T. (2013) · Environmental Science & Technology · doi:10.1021/es303777k · Cited by 221
Determination of multiple pharmaceutical classes in surface and ground waters by liquid chromatography–ion trap–tandem mass spectrometry
Grujić, S. D., Vasiljević, T. M., & Laušević, M. D. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.04.059 · Cited by 241
Antimicrobial Transformation Products in the Aquatic Environment: Global Occurrence, Ecotoxicological Risks, and Potential of Antibiotic Resistance
Löffler, P., Escher, B. I., Baduel, C., Virta, M., & Lai, F. Y. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c09854 · Cited by 234
Degradation of diclofenac sodium using combined processes based on hydrodynamic cavitation and heterogeneous photocatalysis
Bagal, M. V., & Gogate, P. R. (2013) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2013.10.020 · Cited by 219
“Non-steroidal anti-inflammatory drugs (NSADs) are found to gain a special relevance from being the most frequently mentioned environmental contaminants due to the high consumption rate of these drugs [1,2].”
Evaluation of the persistence of transformation products from ozonation of trace organic compounds – A critical review
Hübner, U., von Gunten, U., & Jekel, M. R. (2014) · Water Research · doi:10.1016/j.watres.2014.09.051 · Cited by 231
“They can be found inWWTP effluents worldwide (Hirsch et al., 1999; McArdell et al., 2003; Miao et al., 2004; Watkinson et al., 2009).”
BackgroundInfluential
A preliminary study on the occurrence and behavior of sulfonamides, ofloxacin and chloramphenicol antimicrobials in wastewaters of two sewage treatment plants in Guangzhou, China
Peng, X., Wang, Z., Kuang, W., Tan, J., & Li, K. (2006) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2006.07.001 · Cited by 224
“CAP was detected at 0.56 μg L−1 in Germany (Hirsch et al., 1999).”
BackgroundInfluential
On the occasional biodegradation of pharmaceuticals in the activated sludge process: The example of the antibiotic sulfamethoxazole
Drillia, P., Dokianakis, S. N., Fountoulakis, M. S., Kornaros, M. E., Stamatelatou, Κ., & Lyberatos, G. (2005) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2005.03.009 · Cited by 218
Highly sensitive simultaneous determination of sulfonamide antibiotics and one metabolite in environmental waters by liquid chromatography–quadrupole linear ion trap–mass spectrometry
Díaz‐Cruz, M. S., García-Galán, M. J., & Barceló, ‪. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.03.029 · Cited by 217
Evidence for a Complex Relationship between Antibiotics and Antibiotic-Resistant Escherichia Coli: From Medical Center Patients to a Receiving Environment
Oberlé, K., Capdeville, M. J., Berthe, T., Budzinski, H., & Petit, F. (2012) · Environmental Science & Technology · doi:10.1021/es203399h · Cited by 214
Tracking artificial sweeteners and pharmaceuticals introduced into urban groundwater by leaking sewer networks
Wolf, L., Zwiener, C., & Zemann, M. (2012) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2012.04.059 · Cited by 228
Facile synthesis, characterization of a MnFe2O4/activated carbon magnetic composite and its effectiveness in tetracycline removal
Shao, L., Ren, Z., Zhang, G., & Chen, L. (2012) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2012.03.035 · Cited by 213
Liquid chromatography–(tandem) mass spectrometry of selected emerging pollutants (steroid sex hormones, drugs and alkylphenolic surfactants) in the aquatic environment
de Alda, M. L., Díaz‐Cruz, M. S., Petrović, M., & Barceló, ‪. (2003) · Journal of Chromatography A · doi:10.1016/s0021-9673(03)00509-0 · Cited by 218

Authors: Hirsch, R., Ternes, T., Haberer, K., & Kratz, K.-L.
Affiliations: Johannes Gutenberg University Mainz (DE)
ORCID: Ternes, Thomas
Kratz, Karl-Ludwig
Venue: Science of The Total Environment
Publisher: Elsevier BV
Published: 1999-01
Volume: 225
Issue: 1-2
Pages: 109-118
ISSN: 0048-9697 (ISSN-L)
DOI: 10.1016/s0048-9697(98)00337-4
OpenAlex: W2029593210
Cited by: 2,140
References: 32
Citations by year: 2026: 19 · 2025: 37 · 2024: 48 · 2023: 54 · 2022: 74 · 2021: 83 · 2020: 100 · 2019: 93 · 2018: 117 · 2017: 103 · 2016: 102 · 2015: 112 · 2014: 121 · 2013: 113 · 2012: 124
FWCI: 25.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Science of The Total Environment (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung
Ministry of Environment
Topics: Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Keywords: antibiotic residues, aquatic environment, sewage treatment plant effluent, surface water, groundwater contamination, sulfonamides, penicillin, tetracycline, roxithromycin, sulfamethoxazole, veterinary antibiotic use, agricultural land
MeSH terms: Agriculture, Animals, Anti-Bacterial Agents, Bacteria, Biodegradation, Environmental, Drug Resistance, Microbial, Erythromycin, Germany, Humans, Sewage, Water Pollutants, Chemical

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Occurrence of antibiotics in the aquatic environment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Citations

Cites

Cited by

Related

Metadata

Record

About these checks