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Occurrence of antibiotics in the aquatic environment
Abstract
The recent monitoring of drug residues in the aquatic environment has gained much interest as many pharmaceutical compounds can frequently be found in sewage treatment plant (STP) effluents and river water at concentrations up to several microgram/l. This article describes the analysis of various water samples for 18 antibiotic substances, from the classes of macrolid antibiotics, sulfonamides, penicillins and tetracyclines. Samples were preconcentrated via lyophilization and quantified using HPLC-electrospray-tandem-mass spectrometry. The investigated STP effluents and surface water samples showed frequent appearance of an erythromycin degradation product, roxithromycin and sulfamethoxazole with concentrations up to 6 micrograms/l. Neither tetracyclines nor penicillins could be detected at concentration levels above 50 and 20 ng/l, respectively. From the large number of ground water samples that were taken from agricultural areas in Germany, no contamination by antibiotics was detected except for two sites. This indicates that intake from veterinary applications to the aquatic environment is of minor importance.
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Ultimate biodegradation and elimination of antibiotics in inherent tests
Gartiser, S., Urich, E., Alexy, R., & Kümmerer, K. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.08.038 · Cited by 134
Limousy, L., Ghouma, I., Ouederni, A., & Jeguirim, M. (2016) · Environmental Science and Pollution Research · doi:10.1007/s11356-016-7404-8 · Cited by 134
“Furthermore, the consequence of PPs can be observed through their ecotoxicological effects on the bacteriaresistance enhancement (Bailon-Perez et al. 2008; Campos et al. 2001; Costanzo et al. 2005; Hirsch et al. 1999).”
Gardinali, P. R., & Zhao, X. (2002) · Environment International · doi:10.1016/s0160-4120(02)00080-6 · Cited by 134
Estévez, E., Cabrera, M. C., Molina‐Díaz, A., Robles‐Molina, J., & Palacios-Díaz, M. P. (2012) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2012.06.031 · Cited by 133
“One important concern is that the widespread presence of antibiotics may induce resistance in bacterial strains and, in turn, could result in untreatable diseases (Hirsch et al., 1999; Solomons, 1978).”
BackgroundMutiyar, P. K., & Mittal, A. K. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-2702-5 · Cited by 133
“After administration to human and animals, up to 90 % of the antibiotics can be excreted unchanged (Hirsch et al. 1999) and reach to the aquatic environment.”
Removal of antibiotics from water using sewage sludge- and waste oil sludge-derived adsorbents
Ding, R., Zhang, P., Seredych, M., & Bandosz, T. J. (2012) · Water Research · doi:10.1016/j.watres.2012.05.013 · Cited by 133
Direct UV photolysis of propranolol and metronidazole in aqueous solution
Dantas, R. F., da Rocha, O. R. S., Teixeira, A. K. R., Simões, A. S. M., & da Silva, V. L. (2009) · Chemical Engineering Journal · doi:10.1016/j.cej.2009.12.017 · Cited by 132
Halling‐Sørensen, B., Lykkeberg, A. K., Ingerslev, F., Blackwell, P. A., & Tjørnelund, J. (2003) · Chemosphere · doi:10.1016/s0045-6535(02)00766-x · Cited by 133
“Hirsch and colleagues (Hirsch et al., 1999) did not detect tetracyclines above quantification limits of 0.”
BackgroundLC–MS2 trace analysis of antimicrobials in water, sediment and soil
Díaz‐Cruz, M. S., & Barceló, . (2005) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2005.05.005 · Cited by 133
Water remediation by micelle–clay system: Case study for tetracycline and sulfonamide antibiotics
Polubesova, T., Zadaka, D., Groisman, L., & Nir, S. (2006) · Water Research · doi:10.1016/j.watres.2006.04.008 · Cited by 132
Spatiotemporal distribution of pharmaceuticals in the Douro River estuary (Portugal)
Madureira, T. V., Barreiro, J. C., Rocha, M. J., Rocha, E., Cass, Q. B., & Tiritan, M. E. (2010) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2010.07.069 · Cited by 143
Froehlicher, M., Liedtke, A., Groh, K. J., Neuhauss, S. C. F., Segner, H. E., & Eggen, R. I. L. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.04.007 · Cited by 132
“Many pharmaceuticals have been found in sewage treatment plant and river water at concentrations up to several g/L (Hirsch et al., 1999).”
BackgroundAquatic Photochemistry of Nitrofuran Antibiotics
Edhlund, B. L., Arnold, W. A., & McNeill, K. (2006) · Environmental Science & Technology · doi:10.1021/es0606778 · Cited by 132
Kay, P., Blackwell, P. A., & Boxall, A. B. A. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.01.028 · Cited by 132
“Some studies have subsequently measured concentrations of veterinary antibiotics in soil, surface water and groundwater (Hirsch et al., 1999; Hamscher et al., 2002).”
BackgroundMetabolism of 14C-labelled and non-labelled sulfadiazine after administration to pigs
Lamshöft, M., Sukul, P., Zühlke, S., & Spiteller, M. (2007) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-007-1368-y · Cited by 132
Isidori, M., Nardelli, A., Parrella, A., Pascarella, L., & Previtera, L. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.07.078 · Cited by 131
Liu, H., Zhang, J., Bao, N., Cheng, C., Ren, L., & Zhang, C. (2012) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2012.08.015 · Cited by 131
Yu, C. W., Pang, H., Wang, J., Chi, Z., Zhang, Q., Kong, F., Xu, Y., Li, S., & Che, J. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151891 · Cited by 131
Prioritizing veterinary pharmaceuticals for aquatic environment in Korea
Kim, Y., Jung, J., Kim, M., Park, J., Boxall, A. B. A., & Choi, K. (2008) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2008.03.006 · Cited by 130
Oxidation mechanisms of amoxicillin and paracetamol in the photo-Fenton solar process
Guerra, M. M. H., Oller, I., Malato, S., López, A. A., Acevedo‐Merino, A., & Alonso, J. M. Q. (2019) · Water Research · doi:10.1016/j.watres.2019.02.055 · Cited by 130
Occurrence, seasonal variation and risk assessment of antibiotics in the reservoirs in North China
Li, N., Zhang, X., Wu, W., & Zhao, X. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.03.129 · Cited by 130
Effects of Sorbate Speciation on Sorption of Selected Sulfonamides in Three Loamy Soils
Kurwadkar, S., Adams, C. D., Meyer, M. T., & Kolpin, D. W. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060612o · Cited by 128
Metadata
- Authors
- Hirsch, R., Ternes, T., Haberer, K., & Kratz, K.-L.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 225
- Issue
- 1-2
- Pages
- 109-118
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W2029593210
- Cited by
- 2,140
- References
- 32
- Citations by year
- 2026: 19 · 2025: 37 · 2024: 48 · 2023: 54 · 2022: 74 · 2021: 83 · 2020: 100 · 2019: 93 · 2018: 117 · 2017: 103 · 2016: 102 · 2015: 112 · 2014: 121 · 2013: 113 · 2012: 124
- FWCI
- 25.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Science of The Total Environment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Ministry of Environment
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Keywords
- antibiotic residues, aquatic environment, sewage treatment plant effluent, surface water, groundwater contamination, sulfonamides, penicillin, tetracycline, roxithromycin, sulfamethoxazole, veterinary antibiotic use, agricultural land
- MeSH terms
- Agriculture, Animals, Anti-Bacterial Agents, Bacteria, Biodegradation, Environmental, Drug Resistance, Microbial, Erythromycin, Germany, Humans, Sewage, Water Pollutants, Chemical
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