Cited by 208Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Chapter 2 PKMζ, LTP maintenance, and the dynamic molecular biology of memory storage

Sacktor, Todd Charlton·2008·Progress in Brain Research

Open this paper in CoChat — free account

Abstract

How memories persist is a fundamental neurobiological question. The most commonly studied physiological model of memory is long-term potentiation (LTP). The molecular mechanisms of LTP can be divided into two phases: induction, triggering the potentiation; and maintenance, sustaining the potentiation over time. Although many molecules participate in induction, very few have been implicated in the mechanism of maintenance. Understanding maintenance, however, is critical for testing the hypothesis that LTP sustains memory storage in the brain. Only a single molecule has been found both necessary and sufficient for maintaining LTP--the brain-specific, atypical PKC isoform, protein kinase Mzeta (PKMzeta). Although full-length PKC isoforms respond to transient second messengers, and are involved in LTP induction, PKMzeta is a second messenger-independent kinase, consisting of the independent catalytic domain of PKCzeta, and is persistently active to sustain LTP maintenance. PKMzeta is produced by a unique PKMzeta mRNA, which is generated by an internal promoter within the PKCzeta gene and transported to the dendrites of neurons. LTP induction increases new PKMzeta synthesis, and the increased level of PKMzeta then enhances synaptic transmission by doubling the number of postsynaptic AMPA receptors (AMPAR) through GluR2 subunit-mediated trafficking of the receptors to the synapse. PKMzeta mediates synaptic potentiation specifically during the late-phase of LTP, as PKMzeta inhibitors can reverse established LTP when applied several hours after tetanization in hippocampal slices or 1 day after tetanization in vivo. These studies set the stage for testing the hypothesis that the mechanism of LTP maintenance sustains memory storage. PKMzeta inhibition in the hippocampus after learning eliminates the retention of spatial memory. Once the PKMzeta inhibitor has been eliminated, the memory is still erased, but new spatial memories can be learned and stored. Similar results are found for conditioned taste aversion when the inhibitor is injected in the insular neocortex. Thus PKMzeta is the first molecule found to be a component of the long-term memory trace.

Integrity signals

Registry

Crossref · 10.1016/s0079-6123(07)00002-7

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
Nishizuka, Y. (1988) · Nature · doi:10.1038/334661a0 · Cited by 4,138
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · cited 2×
“How does newly synthesized PKMz affect only specific, activated synapses? One possibility is that the kinase might be involved in the process of synaptic tagging and capture (Sossin, 1996; Frey and Morris, 1997; Sajikumar et al., 2005).”
Background
Molecular Biology of Learning: Modulation of Transmitter Release
Kandel, E. R., & Schwartz, J. H. (1982) · Science · doi:10.1126/science.6289442 · Cited by 1,551
CREB AND MEMORY
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462
Schemas and Memory Consolidation.
Tse, D., Langston, R. F., Kakeyama, M., Bethus, I., Spooner, P. A., Wood, E. R., Witter, M. P., & Morris, R. G. M. (2007) · Science · doi:10.1126/science.1135935 · Cited by 1,244
Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions
Newton, A. C. (2001) · Chemical Reviews · doi:10.1021/cr0002801 · Cited by 963
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.
Inoue, M., Kishimoto, A., Takai, Y., & Nishizuka, Y. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41010-6 · Cited by 863
Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity
Okamoto, K.-I., Nagai, T., Miyawaki, A., & Hayashi, Y. (2004) · Nature Neuroscience · doi:10.1038/nn1311 · Cited by 854
Storage of spatial information by the maintenance mechanism of LTP
Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006) · Science · doi:10.1126/science.1128657 · Cited by 848
Self-citation
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm
Newton, A. C. (2003) · Biochemical Journal · doi:10.1042/bj20021626 · Cited by 799
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
Dash, P. K., Hochner, B., & Kandel, E. R. (1990) · Nature · doi:10.1038/345718a0 · Cited by 747
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734
Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo
Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695
The structure, expression, and properties of additional members of the protein kinase C family.
Ono, Y., Fujii, T., Ogita, K., Kikkawa, U., Igarashi, K., & Nishizuka, Y. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68732-0 · Cited by 692
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692
NF-κB functions in synaptic signaling and behavior
Meffert, M. K., Chang, J. M., Wiltgen, B. J., Fanselow, M. S., & Baltimore, D. (2003) · Nature Neuroscience · doi:10.1038/nn1110 · Cited by 691
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.
Takai, Y., Kishimoto, A., Inoue, M., & Nishizuka, Y. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41009-x · Cited by 595
NSF Binding to GluR2 Regulates Synaptic Transmission
Nishimune, A., Isaac, J. T. R., Molnár, E., Noël, J., Nash, S. R., Tagaya, M., Collingridge, G. L., Nakanishi, S., & Henley, J. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80517-6 · Cited by 545
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
Alberini, C. M., Ghirardl, M., Metz, R., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90386-7 · Cited by 523
Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.
Ono, Y., Fujii, T., Ogita, K., Kikkawa, U., Igarashi, K., & Nishizuka, Y. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3099 · Cited by 500
Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism
Lledo, P. M., Hjelmstad, G. O., Mukherji, S., Soderling, T. R., Malenka, R. C., & Nicoll, R. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11175 · Cited by 456
Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation.
Sacktor, T. C., Osten, P., Valsamis, H. A., Jiang, X., Naik, M. U., & Sublette, M. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8342 · Cited by 450
Self-citation
Protein kinase Mζ is necessary and sufficient for LTP maintenance
Ling, D. S. F., Benardo, L. S., Serrano, P. A., Blace, N., Kelly, M. T., Crary, J. F., & Sacktor, T. C. (2002) · Nature Neuroscience · doi:10.1038/nn829 · Cited by 419
Self-citation
CREB and the formation of long-term memory
Yin, J. C. P., & Tully, T. P. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80082-1 · Cited by 399
Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors
Song, I., Kamboj, S. K., Xia, J., Dong, H., Liao, D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80548-6 · Cited by 399
Neurobiology: Memory and molecular turnover
Crick, F. (1984) · Nature · doi:10.1038/312101a0 · Cited by 392
The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs
Osten, P., Srivastava, S., Inman, G. J., Vilim, F. S., Khatri, L., Lee, L. M., States, B. A., Einheber, S., Milner, T. A., Hanson, P. I., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80518-8 · Cited by 358
Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ
Shema, R., Sacktor, T. C., & Dudai, Y. (2007) · Science · doi:10.1126/science.1144334 · Cited by 353
Self-citation
Distributed Encoding and Retrieval of Spatial Memory in the Hippocampus
Moser, M., & Moser, E. I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07535.1998 · Cited by 349
Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD
Sajikumar, S. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.003 · Cited by 345
Can molecules explain long-term potentiation?
Sanes, J. R., & Lichtman, J. W. (1999) · Nature Neuroscience · doi:10.1038/10154 · Cited by 336
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1
Cammalleri, M., Lütjens, R., Berton, F., King, A. R., Simpson, C., Francesconi, W., & Sanna, P. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2336098100 · Cited by 314
PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories
Serrano, P. A., Friedman, E., Kenney, J., Taubenfeld, S. M., Zimmerman, J., Hanna, J., Alberini, C. M., Kelley, A. E., Maren, S., Rudy, J. W., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060318 · Cited by 267
Self-citation
Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse
Traynelis, S. F., Silver, R. A., & Cull-Candy, S. G. (1993) · Neuron · doi:10.1016/0896-6273(93)90184-s · Cited by 264
Protein Kinase Mζ Synthesis from a Brain mRNA Encoding an Independent Protein Kinase Cζ Catalytic Domain
Hernandez, A. I., Blace, N., Crary, J. F., Serrano, P. A., Leitges, M., Libien, J. M., Weinstein, G., Tcherapanov, A., & Sacktor, T. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307065200 · Cited by 264
Self-citation
Phosphatidylinositol 3-Kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal CA1 Region
Sanna, P. P., Cammalleri, M., Berton, F., Simpson, C., Lütjens, R., Bloom, F. E., & Francesconi, W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03359.2002 · Cited by 254
Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation.
Lang, C., Barco, A., Zablow, L., Kandel, E. R., Siegelbaum, S. A., & Zakharenko, S. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407581101 · Cited by 245
Calcium-Permeable AMPA Receptor Plasticity Is Mediated by Subunit-Specific Interactions with PICK1 and NSF
Gardner, S. M., Takamiya, K., Xia, J., Suh, J., Johnson, R. C., Yu, S., & Huganir, R. L. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.026 · Cited by 245
Persistent Phosphorylation by Protein Kinase Mζ Maintains Late-Phase Long-Term Potentiation
Serrano, P. A., Yao, Y., & Sacktor, T. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5132-04.2005 · Cited by 226
Self-citation
Integrin-driven actin polymerization consolidates long-term potentiation
Kramár, E. A., Lin, B., Rex, C. S., Gall, C. M., & Lynch, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601354103 · Cited by 221
Evidence for Involvement of Protein Kinase C (PKC)-ζ and Noninvolvement of Diacylglycerol-Sensitive PKCs in Insulin-Stimulated Glucose Transport in L6 Myotubes*
Bandyopadhyay, G. K., Standaert, M. L., Galloway, L. C., Moscat, J., & Farese, R. V. (1997) · Endocrinology · doi:10.1210/endo.138.11.5473 · Cited by 218
Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms
Opazo, P., Watabe, A. M., Grant, S. G. N., & O'Dell, T. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03679.2003 · Cited by 215
Synaptic Tagging and Cross-Tagging: The Role of Protein Kinase M in Maintaining Long-Term Potentiation But Not Long-Term Depression
Sajikumar, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1104-05.2005 · Cited by 199
Toward a Molecular Explanation for Long-Term PotentiationPreprint
Sweatt, J. D. (1999) · Learning & Memory · doi:10.1101/lm.6.5.399 · Cited by 193
Spatial and temporal changes in signal transduction pathways during LTP.
Thomas, K. L., Laroche, S., Errington, M., Bliss, T., & Hunt, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90040-x · Cited by 186
Protein synthesis-dependent formation of protein kinase Mzeta in long- term potentiation
Osten, P., Valsamis, L., Harris, A. Z., & Sacktor, T. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02444.1996 · Cited by 173
Self-citation
Are Adult Learning Mechanisms Also Used for Development?
Kandel, E. R., & O’Dell, T. J. (1992) · Science · doi:10.1126/science.1411522 · Cited by 168
Memory from A to Z: keywords, concepts, and beyond
(2003) · Choice Reviews Online · doi:10.5860/choice.41-0062 · Cited by 163
Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster
Drier, E. A., Tello-Ruiz, M. K., Cowan, M. N., Wu, P., Blace, N., Sacktor, T. C., & Yin, J. C. P. (2002) · Nature Neuroscience · doi:10.1038/nn820 · Cited by 161
Self-citation
Inactivating one hippocampus impairs avoidance of a stable room-defined place during dissociation of arena cues from room cues by rotation of the arena
Cimadevilla, J. M., Wesierska, M., Fenton, A. A., & Bureš, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051628398 · Cited by 158
Bidirectional Regulation of Protein Kinase Mζ in the Maintenance of Long-Term Potentiation and Long-Term Depression
Hrabětová, S., & Sacktor, T. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05324.1996 · Cited by 156
Self-citation
Molecular Mechanisms For Memory: Second-Messenger Induced Modifications Of Protein Kinases In Nerve Cells
Schwartz, J. H., & Greenberg, S. M. (1987) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.10.030187.002331 · Cited by 155
Beyond Memory, Navigation, and Inhibition: Behavioral Evidence for Hippocampus-Dependent Cognitive Coordination in the Rat
Wesierska, M., Dockery, C. A., & Fenton, A. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3962-04.2005 · Cited by 150
Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3–kinase inhibitor, wortmannin
Kelly, A. M., & Lynch, M. A. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00169-0 · Cited by 145
Regulation of Protein Kinase Mζ Synthesis by Multiple Kinases in Long-Term Potentiation
Kelly, M., Crary, J. F., & Sacktor, T. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5612-06.2007 · Cited by 144
Self-citation
Protein kinase Mζ enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors
Ling, D. S. F., Benardo, L. S., & Sacktor, T. C. (2006) · Hippocampus · doi:10.1002/hipo.20171 · Cited by 138
Self-citation
Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia
Sutton, M. A., & Carew, T. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81152-6 · Cited by 137
The common structure and activities of four subspecies of rat brain protein kinase C family
Kikkawa, U., Ogita, K., Ono, Y., Asaoka, Y., Shearman, M. S., Fujii, T., Ase, K., Sekiguchi, K., Igarashi, K., & Nishizuka, Y. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80291-0 · Cited by 126
The protein kinase C and protein kinase C related gene families.
Dekker, L., Palmer, R. H., & Parker, P. J. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80103-0 · Cited by 122
A biochemist's view of long-term potentiation.Preprint
Roberson, E., English, J. D., & Sweatt, J. (1996) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.3.1.1 · Cited by 120
Efficient Mammalian Protein Synthesis Requires an Intact F-Actin System
Stapulionis, R., Kolli, S., & Deutscher, M. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24980 · Cited by 109
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation
Biondi, R. M. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.01.005 · Cited by 109
Dendritic Transport and Localization of Protein Kinase Mζ mRNA
Muslimov, I. A., Nimmrich, V., Hernandez, A. I., Tcherepanov, A., Sacktor, T. C., & Tiedge, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409240200 · Cited by 106
Self-citation
Factors regulating the transcriptional elongation activity of RNA polymerase II
Shilatifard, A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.14.1437 · Cited by 104
A Requirement of Nuclear Factor-κB Activation in Fear-potentiated Startle
Yeh, S.-H., Lin, C.-H., Lee, C.-F., & Gean, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206258200 · Cited by 101
Protein synthesis‐dependent LTP in isolated dendrites of CA1 pyramidal cells
Cracco, J., Serrano, P., Moskowitz, S. I., Bergold, P., & Sacktor, T. (2005) · Hippocampus · doi:10.1002/hipo.20078 · Cited by 101
Self-citation
The IκB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus
Merlo, E., Freudenthal, R., & Romano, A. G. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00049-0 · Cited by 99
Passive and active place avoidance as a tool of spatial memory research in rats
Cimadevilla, J. M., Kaminsky, Y., Fenton, A. A., & Bureš, J. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00288-0 · Cited by 99
Activation and substrate specificity of the human protein kinase C α and ζ isoenzymes
Kochs, G., Hummel, R., MEYER, D., Hug, H., Marmé, D., & Sarre, T. F. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18179.x · Cited by 95
Cognitive kinases.
Schwartz, J. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8310 · Cited by 83
Transient decrease in F‐actin may be necessary for translocation of proteins into dendritic spines
Ouyang, Y., Wong, M., Capani, F., Rensing, N., Lee, C., Liu, Q., Neusch, C., Martone, M. E., Wu, J. Y., Yamada, K. A., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04521.x · Cited by 82
Functional inactivation of dorsal hippocampus impairs active place avoidance in rats
Cimadevilla, J. M., Fenton, A. A., & Bureš, J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01019-3 · Cited by 76
Expression and partial characterization of rat protein kinase C‐δ and protein kinase C‐ξ in insect cells using recombinant baculovirus
McGlynn, E., Liebetanz, J., Reutener, S., Wood, J. M., Lydon, N., Hofstetter, H., Vanek, M., Meyer, T., & Fabbro, D. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240490306 · Cited by 69
Behavioral Evidence That Segregation and Representation Are Dissociable Hippocampal Functions
Kubík, Š., & Fenton, A. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1707-05.2005 · Cited by 67
Actin polymerization regulates the synthesis of PKMζ in LTP
Kelly, M. T., Yao, Y., Sondhi, R., & Sacktor, T. C. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.002 · Cited by 64
Self-citation
Discussion
Sossin, W. S. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)20016-5 · Cited by 62
Opposing effects of δ- and ζ-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors
BRAUN, M. U. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00142-1 · Cited by 62
Memory from A to Z: Keywords, Concepts and Beyond
Guha, M. (2003) · Reference Reviews · doi:10.1108/09504120310466090 · Cited by 51
Mechanisms of Potentiation by Calcium-Calmodulin Kinase II of Postsynaptic Sensitivity in Rat Hippocampal CA1 Neurons
Shirke, A. M., & Malinow, R. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.5.2682 · Cited by 47
Evidence for Involvement of Protein Kinase C (PKC)- and Noninvolvement of Diacylglycerol-Sensitive PKCs in Insulin-Stimulated Glucose Transport in L6 Myotubes
Bandyopadhyay, G. K. (1997) · Endocrinology · doi:10.1210/en.138.11.4721 · Cited by 39
Evidence that protein kinase M does not maintain long-term potentiation.
Denny, J. B., Polan-Curtain, J., Rodriguez, S., Wayner, M., & Armstrong, D. L. (1990) · Brain Research · doi:10.1016/0006-8993(90)90130-4 · Cited by 37
Transient translocation of conventional protein kinase C isoforms and persistent downregulation of atypical protein kinase Mζ in long-term depression
Hrabětová, S., & Sacktor, T. C. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00185-1 · Cited by 36
Self-citation
Induction of stable long-term potentiation in the presence of the protein kinase C antagonist staurosporine.
Muller, D., Bittar, P., & Boddeke, H. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90126-r · Cited by 29
Rat Protein Kinase C Zeta Gene Contains Alternative Promoters for Generation of Dual Transcripts with 5′-End Heterogeneity
Marshall, B. S., Price, G., & Powell, C. T. (2000) · DNA and Cell Biology · doi:10.1089/104454900750058071 · Cited by 26
Evidence for a new, high-molecular weight isoform of protein kinase C in rat hippocampus
Sublette, M. E., Naik, M. U., Jiang, X., Osten, P., Valsamis, H. A., Osada, S., Ohno, S., & Sacktor, T. C. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90827-8 · Cited by 15
Self-citation

Research works printed but not linked: 1

Sossin, 1996, Mechanisms for the generation of synapse specificity in long-term memory: the implications of a requirement for transcription, Trends Neurosci., 19, 215

Sorted by citations

About Sleep's Role in Memory
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110
Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation
Brennan, A. M., Suh, S. W., Won, S. J., Narasimhan, P., Kauppinen, T. M., Lee, H., Edling, Y., Chan, P. H., & Swanson, R. A. (2009) · Nature Neuroscience · doi:10.1038/nn.2334 · Cited by 538

See all 208

Authors: Sacktor, T. C.
Affiliations: State University of New York (US)
Corresponding author: Sacktor, Todd Charlton
ORCID: Sacktor, Todd Charlton
Venue: Progress in Brain Research
Publisher: Elsevier
Published: 2008
Volume: 169
Pages: 27-40
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(07)00002-7
OpenAlex: W1550519555
Cited by: 208
References: 86
Citations by year: 2026: 2 · 2025: 6 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 17 · 2013: 25 · 2012: 24
FWCI: 29.63
Type: book chapter
Language: en
Open access: closed
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: PKMzeta, long-term potentiation, LTP maintenance, memory storage, protein kinase C zeta, dendritic mRNA transport, AMPA receptor trafficking, GluR2 subunit, synaptic potentiation, late-phase LTP, spatial memory, conditioned taste aversion, hippocampus, memory traces
MeSH terms: Animals, Hippocampus, Humans, Memory, Molecular Biology, Protein Kinase C, Long-Term Potentiation, Excitatory Postsynaptic Potentials, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chapter 2 PKMζ, LTP maintenance, and the dynamic molecular biology of memory storage

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks