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Functional magnetic resonance imaging and the neurobiology of vasopressin and oxytocin
Abstract
Functional magnetic resonance imaging is used to assess the roles of vasopressin (AVP) in aggressive motivation and oxytocin (OXT) in maternal behaviour. In the case of aggression, male rats are triggered to show the autonomic signs of impending attack behaviour by simulating a resident/intruder conflict in the bore of the magnet during the imaging session. Intraventricular injection of AVP alone causes robust changes in brain activity mirroring many areas selective for AVP receptor binding and overlapped with many of the same areas activated during aggression. Pretreatment with an orally active AVP V1a receptor antagonist blocks aggression in bench-top studies and suppressed the pattern of brain activation caused by the intruder or administration of AVP. These findings using imaging corroborate and extended our understanding of the neural circuitry of aggression and the role of AVP neurotransmission in agonistic motivation. In the case of maternal behaviour, primiparous dams are imaged during nursing with and without OXT receptor blockade. Suckling alone activates many cortical and subcortical areas. Intracerebroventricular injection of OXT stimulates brain activity in areas selective to OXT receptor binding and overlap with many of the same areas activated during pup suckling. Pretreatment with OXT receptor antagonist suppresses the pattern of brain activation caused by suckling or administration of OXT. The data suggest that OXT may strengthen mother-infant bond formation partly by acting through brain areas involved in regulating olfactory discrimination, emotions and reward.
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Oxytocin binding sites have been found in several rat brain regions that take part in emotion processing.
“OXT binding sites have been observed in different areas of the rats brain that are involved in emotion processing (Febo, Numan & Ferris, 2005;Ferris, 2008;Smeltzer, Cutis, Aragona & Wang, 2006)”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Ferris, 2008
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Metadata
- Authors
- FERRIS, C.
- Affiliations
- Northeastern University (US)
- Corresponding author
- FERRIS, C
- ORCID
- FERRIS, C
- Venue
- Progress in brain research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 305-320
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1550940373
- Cited by
- 75
- References
- 50
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 1 · 2017: 35 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 6
- FWCI
- 7.46
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, oxytocin, aggression, maternal behavior, V1a receptor antagonist, oxytocin receptor antagonist, mother-infant bond, brain activation, intraventricular injection, odor discrimination, reward
- MeSH terms
- Aggression, Amphibians, Amygdala, Animals, Arginine Vasopressin, Birds, Brain, Cerebral Ventricles, Female, Fishes, Magnetic Resonance Imaging, Male, Mammals, Maternal Behavior, Motivation, Oxytocin, Sexual Behavior, Animal, Sex Characteristics, Vasopressins, Rats, Long-Evans, Models, Animal, Rats
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