The effect of intranasal administration of oxytocin on fear recognition
Abstract
The oxytocinergic system has recently been placed amongst the most promising targets for various psychiatric treatments due to its role in prosocial behavior and anxiety reduction. Although recent studies have demonstrated a general effect of administration of oxytocin on emotion recognition, no study to date has examine the effect of oxytocin on each emotion separately. In the present study, a double-blind placebo-controlled crossover design was used in a dynamic facial expression task, in order to assess the effects of administration of oxytocin on emotion recognition. A single dose of oxytocin or a placebo was administered intranasally to 27 healthy male subjects 45 min prior to task performance. The results showed that a single intranasal administration of oxytocin, as opposed to the placebo, improved the subjects' ability to recognize fear, but not other emotions. These results suggest a specific role for oxytocin in fear recognition, which could be relevant for clinical disorders that manifest deficits in processing emotional facial expressions, particularly fear.
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It is possible that oxytocin acts on different cortical regions important for processing threatening stimuli and thereby improves affective empathy for fear.
“it is possible that OXT modulates different cortical regions that are important for processing threatening stimuli, and thereby improves affective empathy for fear (Fischer-Shofty et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Fischer-Shofty et al., 2010
Intranasal administration of OT decreases amygdala activation to fearful faces.
“decrease amygdala activation to fearful faces (21–23)”
From Oxytocin and the development of parenting in humans (2010) · cites this paper as [21]
Oxytocin administration has also been observed to improve recognition of positive facial expressions but not negative.
“Oxytocin administration has also been observed to improve recognition of positive facial expressions but not negative (Marsh et al., 2010, but see Fischer-Shofty et al., 2010).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Fischer-Shofty et al., 2010
Oxytocin enhances recognition of fear but not other emotions in morphed emotional faces.
“enhanced recognition of fear but not other emotions (Fischer-Shofty et al., 2010)”
From Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions (2013) · cites this paper as Fischer-Shofty et al., 2010
Some studies have reported enhanced empathic accuracy towards only positive or negative emotions, some found the effect strongest for difficult items, and others the opposite.
“Some have reported enhanced empathic accuracy towards only positive (Di Simplicio et al., 2009;Marsh et al., 2010) or negative emotions (Fischer-Shofty et al., 2010), some have found that the effect is strongest for difficult items (Domes et al., 2007) and others the opposite (Guastella et al., 2010;Schulze et al., 2011).”
From Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions (2013) · cites this paper as Fischer-Shofty et al., 2010
Intranasal OT selectively enhances the recognition of fear and happiness.
“intranasal OT selectively enhances the recognition of fear and happiness [10], [11], [12]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [10]
Findings from studies using lower level tasks administered after OT ingestion (RTs to emotion stimuli and emotion recognition tasks) tend to be mixed and sometimes inconsistent.
“findings from studies using lower level tasks administered after OT ingestion (RTs to emotion stimuli and emotion recognition tasks, for example) tend to be mixed and sometimes inconsistent [13], [10], [14], [11], [12].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [10]
Previous studies have shown that the enhancing effect of OT nasal spray on the processing of faces is independent of the sex of stimuli faces.
“However, it is worth noting that previous studies have shown that the enhancing effect of OT nasal spray on the processing of faces is independent of the sex of stimuli faces [10], [34], [12].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [10]
Oxytocin had no effect on mood.
“Consistent with most previous studies, we found no effects of oxytocin on mood (Di Simplicio et al., 2009, Fischer-Shofty et al., 2010, Kirsch et al., 2005, Marsh et al., 2010).”
From Oxytocin decreases aversion to angry faces in an associative learning task (2010) · cites this paper as Fischer-Shofty et al., 2010
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- Authors
- Fischer-Shofty, M., Shamay-Tsoory, S. G., Harari, H., & Levkovitz, Y.
- Affiliations
- University of Haifa (IL)
- Shalvata Mental Health Center (IL)
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 48
- Issue
- 1
- Pages
- 179-184
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2039279599
- Cited by
- 184
- References
- 70
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 10 · 2017: 18 · 2016: 9 · 2015: 19 · 2014: 13 · 2013: 27 · 2012: 18
- FWCI
- 19.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, intranasal administration, fear recognition, emotion recognition, facial expressions, oxytocinergic system, anxiety, prosocial behavior, placebo-controlled crossover trial
- MeSH terms
- Administration, Intranasal, Adult, Affect, Analysis of Variance, Double-Blind Method, Facial Expression, Fear, Humans, Male, Oxytocics, Oxytocin, Photic Stimulation, Reaction Time, Cross-Over Studies, Recognition, Psychology, Young Adult
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